Nicoderm_CQ: profile and news






Transdermal Patches: An Innovative Drug Delivery System That Has ...  07 Mar 2006
1992. By 1996 it could be purchased OTC (over-the-counter). Available brands include Habitrol, NicoDerm CQ, and Nicotrol. The patch ... - Newsinferno.com,

Loved Ones of Smokers Encouraged to Think Beyond Flowers and Candy ...  Feb 14, 2006
In fact, GSK Consumer Healthcare, marketer of the leading over-the-counter stop smoking products, Nicorette® gum, NicoDerm® CQ® patch and Commit® lozenge ... - PR Newswire (press release),

Multimedia News Release - Loved Ones of Smokers Encouraged to ...  Feb 14, 2006
...by the gift giver with a supportive message and each comes with a $50 gift certificate good towards the purchase of Nicorette gum, NicoDerm CQ patch, and ... - PR Newswire (press release),

Legends to serve as Atlanta grand  Feb 23, 2006
...entertaining exhibit featuring information about the benefits and challenges of quitting smoking and how Nicorette nicotine gum, NicoDerm CQ nicotine patches ... - Motorsport.com,

Nicorette(R), NicoDerm(R) CQ(R) and Commit(R) Combine for Only ...  Jan 25, 2006
...unveiled today the only smoking cessation sponsorship in NASCAR history featuring the brands Nicorette® nicotine gum, NicoDerm® CQ® nicotine patches and ... - Yahoo! News (press release)

Study: Increased Risks for Black Smokers  Jan 30, 2006
...there is actually what's called NRT, which is nicotine replacement therapy, and that is in the form of smoking aids like Nicorette gum, Nicoderm, CQ Patch, and ... - NPR

Smoke-filled self-image  Jan 17, 2006
...fastest. They suggest 4 milligram Nicorette gum, the NicoDerm CQ patch and the NiQuitin CQ lozenges created by Glaxo Smith Kline. ... - Kentucky.com,

FDA Joint Advisory Committee Recommends Approval of Orlistat 60 mg ...  Jan 23, 2006
Its more than 30 well-known brands include the leading smoking cessation products, Nicorette®, NicoDerm® CQ and Commit® as well as many medicine cabinet ... - Yahoo! News (press release)

No-smoking sentiments  12 Dec 2005
As added motivation, the cards include $50 in gift certificates for stop-smoking products, including. the NicoDerm CQ patch, Commit lozenges and Nicorette gum. ... - Los Angeles Daily News,

FDA Joint Advisory Committee Sets Date to Review GlaxoSmithKline ...  Dec 9, 2005
We have a long and successful history of taking prescription products over-the-counter in a responsible manner, as with NicoDerm CQ® and Nicorette®, and we ... - Yahoo! News (press release)

Xenical Switch Proposal Slated For Advisory Committee Review In  Dec 8, 2005
...already has extensive experience with such programs, which have been created for the company’s OTC nicotine replacement therapies Nicorette and NicoDerm CQ. ... - FDA Advisory Committee

Hope and Help for Washington Smokers Looking to Quit as Smoke-Free ...  Dec 8, 2005
GSK Consumer Healthcare's medicinal nicotine products, Nicorette® gum, NicoDerm® CQ® patch, and Commit® lozenge are designed to provide a temporary ... - Yahoo! News (press release)

The Compelling Approach to Helping a Loved One Quit: Speak Softly ...  Nov 15, 2005
...by the gift giver with a supportive message and each comes with a $50 gift certificate good towards the purchase of Nicorette gum, NicoDerm CQ patch, and ... - PR Newswire (press release),

The Compelling Approach to Helping a Loved One Quit: Speak Softly ...  Nov 15, 2005
In fact, GSK Consumer Healthcare, marketer of the leading over- the-counter stop smoking products, Nicorette® gum, NicoDerm® CQ® patch and Commit® lozenge ... - Yahoo! News (press release)

Healthy holidays!: Gifts to put loved ones on the road to fitness  Dec 3, 2005
...and GlaxoSmithKline Consumer Healthcare, marketer of the quit-smoking products Nicorette gum, the NicoDerm CQ patch and Commit lozenges, are offering two ... - Newark Star Ledger,

Ask Dr. Wang  Nov 16, 2005
What television has done for Viagra and other drugs, it has also helped bring Nicoderm CQ or other patches out into the public eye. ... - pride source.com,

New Study Breaks Health Risk Myths About 'Light Smokers'  Oct 4, 2005
...support program -- Individualized Web-based behavioral support program available free to users of Commit, Nicorette and NicoDerm CQ -- Includes customized ... - PR Newswire (press release),

GlaxoSmithKline Consumer Healthcare to Sponsor David Stremme in ...  Oct 6, 2005
Currently there are 12 employees at Chip Ganassi Racing with Felix Sabates using Commit Lozenges, Nicorette nicotine gum or NicoDerm CQ nicotine patches to ... - San Jose Mercury News,

New Aquafresh Extreme Clean Toothpaste Delivers Extreme Experience ...  Oct 7, 2005
...well-known products include such medicine cabinet staples as Abreva®, Aquafresh® toothpastes and toothbrushes, Nicorette®, NicoDerm ® CQ, Oxy®, Sensodyne ... - Hispanic PR Wire (press release),

New Study Breaks Health Risk Myths About 'Light Smokers'  Oct 4, 2005
Thinner, Flexible Patch -- This summer, NicoDerm® CQ® launched a newly redesigned clear patch that is now thinner and more flexible than the previous ... - Yahoo! News (press release)

Patch gets thinner  Aug 4, 2005
The new NicoDerm CQ ThinFlex is 25 percent more flexible than previous patch designs. It moves more easily when you stretch and even swim. ... - Louisville Courier-Journal

New Program Helps Smokers Quit  Jul 12, 2005
...help smokers quit. After lighting up for 23 years, Jane Huth decided to kick the habit. So, she tried Nicoderm CQ. "By the time ... - WTOL

Crowing for Dell  Jul 13, 2005
With Eliza Dushku as the face of the event, the NicoDerm CQ ThinFlex Celebrity Yoga Mat Auction will raise funds for the Campaign for Tobacco-Free Kids. ... - Press-Enterprise (subscription) <**results**>

NicoDerm CQ Gives 'the Patch' a Makeover  Jun 29, 2005
NicoDerm® CQ® has put an attractive new face on "the Patch," by giving it a slimmed down design and a more flexible profile, to help it actually move with you ... - Yahoo News (press release)

NicoDerm CQ Gives 'the Patch' a Makeover  Jun 29, 2005
The new NicoDerm CQ ThinFlex(TM) patch is 25 percent more flexible than the original NicoDerm CQ patch, which was first launched in 1992. ... - PharmaLive.com (press release)

Hollywood Stars Team Up to Help Smokers Quit for Good - and Help ...  Jun 29, 2005
The auction has been organized by NicoDerm® CQ®, the makers of the new slimmer, more flexible ThinFlex(TM) stop smoking patch. ... - Yahoo News (press release)

Hollywood Stars Team Up to Help Smokers Quit for Good - and Help ...  Jun 29, 2005
...place. Eliza Dushku, who recently gave up smoking using the NicoDerm CQ patch, knows all about the challenges of quitting. "Quitting ... - PharmaLive.com (press release)

GlaxoSmithKline Consumer Healthcare Races Towards NASCAR Sponsor ...  Jun 26, 2005
GSK Consumer Healthcare's Nicorette® nicotine gum, NicoDerm® CQ® nicotine patches and Commit® nicotine lozenges became sponsors of Target Chip Ganassi ... - Yahoo News (press release)

GSK Consumer Healthcare Settles Lawsuit With Nicodrops, Inc.  Jun 6, 2005
Bill Slivka, Vice President, Smoking Control, at GlaxoSmithKline (GSK) Consumer Healthcare, said, "Our smoking cessation products -- NicoDerm CQ(R) patch ... - PharmaLive.com (press release),

GlaxoSmithKline Consumer Healthcare Races Towards NASCAR Sponsor ...  Jun 26, 2005
GSK Consumer Healthcare's Nicorette® nicotine gum, NicoDerm® CQ® nicotine patches and Commit® nicotine lozenges became sponsors of Target Chip Ganassi ... - Yahoo News (press release)

New Study Confirms Internet Can Provide Real Support For Smokers ...  Jun 7, 2005
...the widest range of proven products including two strengths of the Commit(R) lozenge; two starting strengths of clear and opaque NicoDerm CQ patches; and two ... - PR Newswire (press release)

New Study Confirms Internet Can Provide Real Support For Smokers ...  Jun 7, 2005
Study participants were randomly assigned to one of two treatment groups after purchasing the NicoDerm® CQ® patch and enrolling in the program: one group ... - Yahoo News (press release)

GSK Consumer Healthcare Settles Lawsuit With Nicodrops, Inc.  Jun 6, 2005
Slivka, Vice President, Smoking Control, at GlaxoSmithKline (GSK) Consumer Healthcare, said, "Our smoking cessation products -- NicoDerm CQ® patch, Nicorette ... - Yahoo News (press release)

GSK, Nicodrops settle over smokers' supplements  Jun 8, 2005
...that reduces nicotine cravings. GlaxoSmithKline makes the NicoDerm CQ patch, Nicorette gum, and Commit lozenge. The lawsuit, which ... - NutraIngredients-usa.com,

Products to help you stop smoking  Jun 2, 2005
...shoulder. Patches must be replaced every 24 hours. Brand names include Nicoderm CQ and Habitrol. Generic patches also are available. ... - MayoClinic.com


Other information


Indication
For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation

Pharmacology
Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Nicotine is a highly addictive substance. Nicotine also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Nicotine inhalers and patches are used to treat smoking withdrawl syndrome. Nicotine is classified as a stimulant of autonomic ganglia.

Mechanism Of Action
Nicotine binds to the nicotinic acetylcholine receptor. Stimulation of nicotinic receptors leads to a variety of cholinergic and adrenergic effects; tachycardia or bradycardia mediated by either stimulation or interference with sympathetic or parasympathetic pathways, stimulation of receptors in the carotic and aortic bodies, release of epinephrine from the adrenal medulla, and stimulation of the chemoreceptor-trigger zone.

Drug Category
Anti-craving Agents; Central Nervous System Agents; Autonomic drugs; Nicotinic Agonists; ATC:N07BA01

Brand Names/Synonyms
Black Leaf; Black Leaf 40; Campbell's Nico-Soap; Commit; Destruxol Orchid Spray; Emo-Nik; Flux Maag; Fumetobac; Habitrol; L-Nicotine; Mach-Nic; Niagara P.A. Dust; Nic-Sal; Nico-Dust; Nico-Fume; Nicocide; Nicoderm; Nicoderm Cq; Nicorette; Nicorette Plus; Nicotin; Nicotina; Nicotine; Nicotine Alkaloid; Nicotine Polacrilex; Nicotrol; Nicotrol Inhaler; Nicotrol Ns; Nikotin; Nikotyna; Ortho N-4 Dust; Ortho N-5 Dust; Prostep; Tendust; Tetrahydronicotyrine, Dl-; Xl All Insecticide

Dosage Forms
Gum, Inhaler, Patches

Absorption
Absorption of nicotine through the buccal mucosa is relatively slow and the high and rapid rise followed by the decline in nicotine arterial plasma concentrations seen with cigarette smoking are not achieved with the inhaler. About 10% of absorbed nicotine is excreted unchanged in urine.

Interactions
Interactions for Nicotine:

Physiological changes resulting from smoking cessation, with or without nicotine replacement, may alter the pharmacokinetics of certain concomitant medications, such as tricyclic antidepressants and theophylline. Doses of these and perhaps other medications may need to be adjusted in patients who successfully quit smoking.



Chemical IUPAC Name
3-(1-methylpyrrolidin-2-yl)pyridine

Chemical Formula
C10H14N2

Half Life
Cotinine has a half life of 15-20 hours, while nicotine has a half life of 1-3 hours

Drug Type
Approved Drug

# Accession No
APRD00200

CAS Registry Number
54-11-5

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