Navelbine: profile and news

Adjuvant Taxotere® and Herceptin® Effective for Breast Cancer ...  07 Mar 2006
Researchers affiliated with the FinHer Study have reported that Taxotere® (docetaxel) is superior to Navelbine® (vinorelbine) when given in addition to 5-FU ... - Cancer Consultants (press release),

Recurrence-Free Survival Improved with Taxotere® Compared to ...  Feb 23, 2006
...with the chemotherapy agent Taxotere® (docetaxel) improves recurrence-free survival compared with the chemotherapy agent Navelbine® (vinorelbine) for the ... - Cancer Consultants (press release),

Drug May Help Curb Breast Cancer  Feb 22, 2006
The researchers randomly assigned half of those women to take Herceptin for nine weeks, along with chemotherapy drugs Taxotere or Navelbine. ... - WebMD

Information on knee pain, breast cancer drugs and protecting bones  Feb 22, 2006
The New England Journal of Medicine reports on a study comparing the drugs Taxotere and Navelbine in early breast cancer. A study ... - 7Online.com,

Breast Cancer Drugs Limit Post-Surgery Recurrence  Feb 22, 2006
22 (HealthDay News) -- A new head-to-head study finds the chemotherapy drug docetaxel (Taxotere) beating another, vinorelbine (Navelbine), in helping extend ... - Forbes

Breast meds limit recurrence  Feb 23, 2006
A new head-to-head study finds the chemotherapy drug docetaxel (Taxotere) beating another, vinorelbine (Navelbine), in helping extend patient survival after ... - Health24.com,

Trails to detect effective breast cancer drugs that reduces ...  Feb 23, 2006
...cancer surgery. The chemotherapy drugs docetaxel (Taxotere) and vinorelbine (Navelbine) are tested to analyze the outcomes. It was ... - MedIndia,

Nitroglycerin May Enhance Chemotherapy for Non-Small Cell Lung ...  Feb 6, 2006
Researchers from Japan have reported that the use of nitroglycerin combined with Navelbine® (vinorelbine) and Platinol® (cisplatin) may improve response ... - Cancer Consultants (press release),

Adjuvant Docetaxel More Effective Than Vinorelbine for Early ...  Feb 23, 2006
...surface area on day 1 of three 21-day cycles, decreased to 80 mg per square meter if necessary for toxicity (n = 502), or vinorelbine (Navelbine, Pierre Fabre ... - Cancerpage.com,

Nitroglycerin May Enhance Chemotherapy for Non-Small Cell Lung ...  Feb 6, 2006
Researchers from Japan have reported that the use of nitroglycerin combined with the chemotherapy drugs Navelbine® (vinorelbine) and Platinol® (cisplatin ... - Cancer Consultants (press release),

Innocent victims of a judgmental attitude  Feb 3, 2006
In certain centres a new drug, Navelbine (a form of vinorelbine), which can be taken by mouth, is now used in some forms of lung cancer almost immediately ... - Times Online,

Nitroglycerin May Enhance Chemotherapy for Non-Small Cell Lung ...  Feb 6, 2006
Researchers from Japan have reported that the use of nitroglycerin combined with Navelbine® (vinorelbine) and Platinol® (cisplatin) may improve response ... - Cancer Consultants (press release),

Nitroglycerin May Enhance Chemotherapy for Non-Small Cell Lung ...  Feb 6, 2006
Researchers from Japan have reported that the use of nitroglycerin combined with the chemotherapy drugs Navelbine® (vinorelbine) and Platinol® (cisplatin ... - Cancer Consultants (press release),

Innocent victims of a judgmental attitude  Feb 3, 2006
In certain centres a new drug, Navelbine (a form of vinorelbine), which can be taken by mouth, is now used in some forms of lung cancer almost immediately ... - Times Online,

Kyowa Hakko Reports Good Progress Towards Full-Year Forecasts  Jan 30, 2006
Business, prescription pharmaceuticals Allelock, an antiallergic agent, Durotep Patch, an analgesic for persistent cancer pain, and Navelbine, an anticancer ... - Genetic Engineering News,

Novel Strategies for Treating Lung Cancer: Chemotherapy  Jan 24, 2006
Institute of Canada) trial JBR-10, [12] which combined cisplatin and vinorelbine for stage IB and II, and ANITA (Adjuvant Navelbine International Trialists ... - Medscape (subscription)

Prostate cancer: awaiting innovation  Dec 8, 2005
Novacea’s recent co-development with Pierre Fabre means that Novacea is likely to investigate the use of its drug DN-101 with oral Navelbine for HRPC. ... - Pharmaceutical Business Review

AstraZeneca's Casodex may get boost  Dec 8, 2005
Insight: Prostate Cancer -- A Prostrate Market Waiting for Innovations," also predicted that Novacea's drugs -- DN-101 and oral Navelbine -- and newer ... - Science Daily (press release)

ADVENTRX Announces Positive FDA Pre-IND Meeting Outcome  Dec 7, 2005
ANX-530 has demonstrated the ability to markedly reduce injection-site irritation in pre-clinical testing, compared to Navelbine(R), GlaxoSmithKline's approved ... - Biotech Intelligence (press release),

Prostate Cancer: New choice for hormone refractory patients  Dec 8, 2005
...s recent co-development with Pierre Fabre means that Novacea is likely to investigate the use of its drug DN-101 with oral Navelbine (vinorelbine) for HRPC. ... - PharmaLive.com (press release),

Premenopausal Women Have Improved Survival with Xyotax® for ...  Nov 11, 2005
...compared Xyotax/Paraplatin®(Paraplatin) to Paraplatin/Taxol (STELLAR3) or Xyotax as a single agent to Gemzar®(gemcitabine)/Navelbine®(vinorelbine) (STELLAR 4 ... - Cancer Consultants (press release),

Gamma-linolenic acid inhibits action of Her-2/neu, responsible for ...  Nov 20, 2005
...with GLA sensitizes breast cancer cells to some chemotherapeutic drugs, such as Paclitaxel ( Taxol ), Docetaxel ( Taxotere ) and Vinorelbine ( Navelbine ). ... - Xagena.it,

ADVENTRX Acquires Additional Oncology Drug Through Exclusive ...  Oct 4, 2005
In preclinical testing, ANX-530 demonstrated markedly reduced vein irritation following repeated IV injections compared with Navelbine(R), GlaxoSmithKline's US ... - Genetic Engineering News,

Study Finds Tarceva Benefits Older Lung Cancer Patients  Sep 19, 2005
The uncontrolled, Phase II results are sufficiently promising to merit a Phase III trial comparing erlotinib with single-agent navelbine in this population ... - Science Daily (press release)

OSI / Genentech / Roche: Tarceva triumphs again  Sep 19, 2005
...suggest that it may be more beneficial to use Tarceva in the first-line setting than currently-used chemotherapy agents such as Pierre Fabre's Navelbine or Eli ... - Pharmaceutical Business Review

Tarceva Found To Benefit Older Lung Cancer Patients  Sep 19, 2005
Following success of the Phase II trials, the Phase III trial would be directed to comparing erlotinib with single-agent navelbine in the above mentioned ... - MedIndia,

Taxol®, Ifex® and Platinol® Effective Second-Line Therapy for ...  Sep 22, 2005
Doxil® (doxorubicin), Ellence®, Navelbine® (vinorelbine), Hycamtin® (topotecan), or biologic agents such as a suramin and retinoic acid have not ... - Cancer Consultants (press release),

Drug may offer hope for older lung cancer patients  Sep 19, 2005
...are sufficiently promising to merit a Phase III trial comparing erlotinib (which is sold under the brand name Tarceva ® ) with single-agent navelbine in this ... - myDNA.com,

Neutropenia During Chemotherapy Associated with Improved Survival ...  Aug 10, 2005
One trial in elderly lung cancer patients (70 years of age or older) compared Navelbine® (vinorelbine) to best supportive care. ... - Cancer Consultants (press release),

Emerging Role of Adjuvant and Neoadjuvant Therapy in Early-Stage ...  Aug 18, 2005
The results of IALT, CALGB, and JBR.10 were confirmed by the successful ANITA (Adjuvant Navelbine International Trialist's Association) trial, presented at ... - Medscape (subscription)

Case Charging Nation's Largest Drug Companies of Defrauding ...  Aug 18, 2005
The prescription drugs mentioned in the complaint include: -- Alkeran -- Blenoxane -- Cytoxan -- Etopophos -- Kytril -- Navelbine -- Paraplatin -- Procrit ... - PR Newswire (press release),

Adjuvant Navelbine®/Platinol® Improves Survival in the Treatment ...  Jul 7, 2005
Final results of a trial evaluating adjuvant Navelbine (vinorelbine)/Platinol (cisplatin) in the treatment of patients with stage II and IIIA non-small cell ... - Cancer Consultants (press release)

New drugs approved  Jul 30, 2005
...government announced last week it would spend $148 million over the next three years to fund the cancer-fighting drugs Herceptin, Navelbine and Taxotere. ... - NorthernLife.ca

Hike in funding for cancer drugs helps  Aug 4, 2005
Helen Gaidatsis will not use Herceptin, Navelbine or Taxotere, the new intravenous cancer drugs the province is now spending $148 million over three years to ... - Sun Tribune

McGuinty government improving access to cancer-fighting drugs  Jul 22, 2005
Herceptin, Navelbine, Taxotere to be funded by the province TORONTO, July 22 /CNW/ - Ontarians with breast, prostate and lung cancer will now have access to ... - Canada NewsWire (press release)

Ontario to fund Herceptin for breast-cancer treatment, two other ...  Jul 22, 2005
...effective. The government will also pay for two other drugs used to fight lung and prostate cancer called Navelbine and Taxotere. ... - Canada.com

Province will pay for cancer drugs  Jul 22, 2005
...chemotherapy more effective. The province will also pay for two drugs used to fight lung and prostate cancer (Navelbine and Taxotere). - National Post

Government in Ontario will pay for three new cancer drugs  Jul 25, 2005
...it funds. The drugs are Herceptin for breast cancer, Navelbine, for lung cancer, and Taxotere for prostate cancer. Smitherman said ... - News-Medical.net

Ontario makes Herceptin widely available  Jul 22, 2005
The government has promised $148-million to pay for Herceptin and two other drugs — Navelbine for lung cancer and Taxotere for prostate cancer. ... - Globe and Mail

Ontario will make Herceptin widely available  Jul 22, 2005
...officer of the University Health Network, which oversees Princess Margaret Hospital, are to announce the funding of two other cancer drugs: Navelbine to treat ... - Globe and Mail

Ontario to pay for cancer drugs  Jul 22, 2005
...breast cancer.". The province will also pay for two other drugs, Navelbine for lung cancer, and Taxotere for prostate cancer. The ... - CBC Toronto

Two more provinces approve costly breast cancer drug Herceptin  Jul 22, 2005
...said Ontario's spending on cancer care will increase up to 70 per cent a year as a result of the new funds for Herceptin as well as Navelbine, a lung cancer ... - Canada.com

Province set to fund new cancer drugs  Jul 22, 2005
...said Smitherman. Navelbine, used to battle lung cancer, and Taxotere, a treatment for prostate cancer, have also been approved. The ... - Ottawa Sun

Acute pulmonary reactions have been reported with NAVELBINE and other anticancer vinca alkaloids used in conjunction with mitomycin. Although the pharmacokinetics of vinorelbine are not influenced by the concurrent administration of cisplatin, the incidence of granulocytopenia with NAVELBINE used in combination with cisplatin is significantly higher than with single-agent NAVELBINE. Patients who receive NAVELBINE and paclitaxel, either concomitantly or sequentially, should be monitored for signs and symptoms of neuropathy. Administration of NAVELBINE to patients with prior or concomitant radiation therapy may result in radiosensitizing effects.

Caution should be exercised in patients concurrently taking drugs known to inhibit drug metabolism by hepatic cytochrome P450 isoenzymes in the CYP3A subfamily, or in patients with hepatic dysfunction. Concurrent administration of vinorelbine tartrate with an inhibitor of this metabolic pathway may cause an earlier onset and/or an increased severity of side effects.

 


Chemical IUPAC Name
Not Available

Chemical Formula
C45H54N4O8

Half Life
27.7-43.6 hours

Drug Type
Approved Drug

# Accession No
APRD00101

CAS Registry Number
71486-22-1