Nasalcrom: profile and news

Nasal Sprays Sep 24, 2005
...stuffiness. It is now sold over-the counter as Nasalcrom. Nasalcrom is effective for prevention as well as treatment of allergy symptoms. ... - allergies.about.com <**results**>

Allergy medications: Know your options Jun 25, 2005
Available over-the-counter, the nasal spray cromolyn sodium (NasalCrom, Children's NasalCrom) has no serious side effects but may make the nasal passageways ... - MayoClinic.com

Spring Into Allergy Season Apr 11, 2005
Nasalcrom is a nasal spray that is a mast cell stabilizer and is available over-the-counter and will relieve the sneezing, itching and running nose, but you ... - Parents.com

Dietary changes may help in treatment of allergies Apr 19, 2005
An abundance of over-the-counter antihistamines such as, Similisan eye drops, AllerAide and NASALCROM alleviate allergy symptoms. ... - Billings Gazette

Itching for Some Allergy Relief? Apr 1, 2005
Non-steroidal nasal sprays: NasalCrom (cromolyn sodium) nasal spray which is available without a prescription, can help prevent symptoms of allergic rhinitis ... - FDA.gov

Medicines Help Nip Allergy Season in the Bud Apr 12, 2005
They're very safe but not as effective as nasal corticosteroids. Examples include Nasalcrom nasal spray, and Alomide and Alocril eye drops. - Press-Enterprise (subscription),

Intranasal delivery Mar 11, 2005
Stadol NS nasal spray, Bristol Myers Squibb Co USA), dihydroergotamine (Migranal nasal spray, Novartis Inc), cromolyn sodium (Nasalcrom nasal solution, Fisons ... - Express Pharma Pulse,

Other information

Indication
For the management of patients with bronchial asthma. Also used in the treatment of vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.

Pharmacology
Cromolyn, a synthetic compound, inhibits antigen-induced bronchospasms and, hence, is used to treat asthma and allergic rhinitis. Cromolyn is used as an ophthalmic solution to treat conjunctivitis and is taken orally to treat systemic mastocytosis and ulcerative colitis.

Mechanism Of Action
Cromolyn inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Cromolyn also may reduce the release of inflammatory leukotrienes. Cromolyn may act by inhibiting calcium influx.

Drug Category
Anti-Asthmatic Agents

Brand Names/Synonyms
Aarane; Acide Cromoglicique [Inn-French]; Acido Cromoglicico [Inn-Spanish]; Acidum Cromoglicicum [Inn-Latin]; Alercom; Alerion; Allergocrom; Apo-Cromolyn; Children's Nasalcrom; Colimune; Crolom; Cromoglicic Acid; Cromoglycic Acid; Cromolyn; Cromolyn Nasal Solution; Cromolyn Sodium; Cromoptic; Cromovet; Diethyl Cromoglycicate; Fivent; Gastrocrom; Gastrofrenal; Gen-Cromoglycate; HSDB 3308; Inostral; Intal; Intal Inhaler; Intal Syncroner; Introl; Irtan; Lomudal; Lomupren; Lomusol; Lomuspray; Nalcrom; Nalcron; Nasalcrom; Nasmil; Novo-Cromolyn; Opticrom; Opticron; Pms-Sodium Cromoglycate; Rynacrom; Sodium Cromoglycate; Sofro; Vistacrom; Vividrin

Dosage Forms
CAPSULE; LIQUID; METERED-DOSE (AEROSOL); OINTMENT; POWDER; SOLUTION; SPRAY

Absorption
1%

Interactions
Interactions for Cromolyn:

Drug Interaction During Pregnancy: Cromolyn sodium and isoproterenol were studied following subcutaneous injections in pregnant mice. Cromolyn sodium alone in doses up to 540 mg/kg/day (approximately 340 times the maximum recommended daily inhalation dose in adults on a mg/m² basis) did not cause significant increases in resorptions or major malformations. Isoproterenol alone at a dose of 2.7 mg/kg/day (approximately 7 times the maximum recommended daily inhalation dose in adults on a mg/m² basis) increased both resorptions and malformations. The addition of 540 mg/kg/day of cromolyn sodium (approximately 340 times the maximum recommended daily inhalation dose in adults on a mg/m² basis) to 2.7 mg/kg/day of isoproterenol (approximately 7 times the maximum recommended daily inhalation dose in adults on a mg/m² basis) appears to have increased the incidence of both resorptions and malformations.

Chemical IUPAC Name
5-[3-(2-carboxy-4-oxo-chromen-6-yl)oxy-2-hydroxy-propoxy]-4-oxo-chromene-2-carboxylicacid

Chemical Formula
C23H16O11

Half Life
1.3 hours

Drug Type
Approved Drug

# Accession No
APRD00336

CAS Registry Number
16110-51-3