Nardil: profile and news

Antidepressants and your libido Feb 28, 2006
...switching to one of the older antidepressant tricyclate drugs such as Elavil or Imipramine, or one of the MAO Inhibitors like Parnate or Nardil, although these ... - Health24.com,

FDA approves first patch to treat depression Feb 28, 2006
Other MAOI drugs on the market include Pfizer Inc.'s Nardil, GlaxoSmithKline Plc's Parnate and Oxford Pharmaceutical Services Inc.'s Marplan, as well as ... - Reuters.uk,

FDA Warning: Using Paxil Raises Birth Defects Risk Dec 8, 2005
MAOI drugs include Nardil (phenelzine sulfate), Parnate (tranylcypromine sulfate), Marplan (isocarboxazid), and other brands. ... - Food Consumer,

Creator of Valium Dies at 97 Sep 30, 2005
Its popularity presaged such tricyclic antidepressants as Elavil and Nardil in the 1980s, followed by the class of drugs that include Prozac, Zoloft and Paxil. ... - Washington Post,

Why should I take a vitamin for my health? Sep 20, 2005
Ginseng: Can cause headache, trembling and manic behavior when combined with the antidepressant Nardil; may interfere with the action of the heart medication ... - MSNBC <**results**>

Parkinson's Disease Jul 5, 2005
...other tranquilizers, tetrabenazine, cinnarizine, flunarizine, amiodarone, bethanechol, pyridostigmine, lithium, valium, prozac, nardil, demerol, amphotericin B ... - Bella Online

Your questions answered by GMTV own resident doctor, Hilary Jones Apr 20, 2005
KAM: Good morning. I've been taking Nardil for 28 years and I feel that they are losing effect. Does the body get immune to them? ... - GMTV,

Depression and your libido Feb 24, 2005
...switching to one of the older antidepressant tricyclate drugs such as Elavil or Imipramine, or one of the MAO Inhibitors like Parnate or Nardil, although these ... - Health24.com,

Other information

Indication
Indicated in the treatment of depression.

Pharmacology
Phenelzine belongs to a class of antidepressants called monoamine oxidase inhibitors (MAOIs). Phenelzine works by irreversibly blocking the action of a chemical substance known as monoamine oxidase (MAO) in the nervous system. Within neurons, MAO appears to regulate the levels of monoamines released upon synaptic firing. Since depression is associated with low levels of monoamines, the inhibition of MAO serves to ease depressive symptoms.

Mechanism Of Action
The irreversible inhibition of MAO by Phenelzine causes an increase in the levels of serotonin, norepinephrine, and dopamine in the neuron, relieving depressive symptoms.

Drug Category
Antidepressants; ATC:N06AF03

Brand Names/Synonyms
Beta-Phenylethylhydrazine; CHEMBANK3273; Fenelzina [Inn-Spanish]; Fenelzyna; Fenelzyna [Polish]; Fenelzyne; Fenelzyne [Polish]; Hydrazine, Phenethyl-; Nardil; Phenalzine; Phenelezine; Phenelzine; Phenelzinum [Inn-Latin]; Phenethylhydrazine; Phenylethyl Hydrazine-Hcl; Phenylethylhydrazine; Stinerval; W-1544; W1544

Dosage Forms
TABLET

Absorption
Readily absorbed after oral administration.

Interactions
Interactions for Phenelzine:

In patients receiving nonselective monoamine oxidase (MOA) inhibitors in combination with serotoninergic agents (e.g., dexfenfluramine, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafexine) there have been reports of serious, sometimes fatal, reactions. Because Nardil is a monoamine oxidase (MAO) inhibitor, Nardil should not be used concomitantly with a serotoninergic agent.

Chemical IUPAC Name
2-hydrazinylethylbenzene

Chemical Formula
C8H12N2

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00099

CAS Registry Number
51-71-8