Narcan: profile and news
FDA seeks to avoid confusing drug names Mar 2, 2006
In one documented incident, a patient needing an injection of Narcan was given Norcuron by mistake and went into cardiac arrest. ... - Middle East North Africa Financial Network,
Officials: Heroin abuse rises on Shore Feb 14, 2006
Mulinos said when the ER staff doesn't know how much heroin was injected, then it's difficult to know how much Narcan -- an opioid antagonist -- to administer ... - Delmarva Daily Times,
$8,300,000 Jury awards to patient who suffered brain damage Feb 24, 2006
After Terris slipped into a coma, the hospital did not give her the antidote Narcan. ... "We were unable to say whether the Narcan would have made a difference.". ... - Bridgeton News,
Police probe theft in hospital Feb 7, 2006
Taken were two vials of Narcan, which is used to reverse the effect of drugs used during surgery or of a drug overdose; one dose of Versed, used to reduce ... - Portsmouth Herald News,
Nurses take to the streets Feb 10, 2006
In the area on routine business, he administered the anti-opiate drug narcan as the victim's friend called 911 on the cellphone. ... - Oak Bay News,
Coroner highlights dangers of cocaine after cell death verdict Feb 11, 2006
There should also be a defibrillator. He said he would also ask the ambulance service to consider carrying Narcan, an antidote to heroin. ... - Yorkshire Post Today,
Police probe theft in hospital Feb 7, 2006
Taken were two vials of Narcan, which is used to reverse the effect of drugs used during surgery or of a drug overdose; one dose of Versed, used to reduce ... - Portsmouth Herald News,
Fortunate to be alive Jan 22, 2006
In 2004, 359 people were administered Narcan, an antidote for opioid overdose, by emergency personnel. In the first 10 months of ... - MaineToday.com,
Fighting for the future: The real million dollar baby Jan 27, 2006
The problem is such that, as a matter of routine, state troopers carry with them Narcan, an opiate antidote, to treat people who have overdosed from heroin. ... - Independent,
Female Boxer Offers Hope to a New Mexico Town Short of Heroes Jan 17, 2006
...so ingrained that grandparents teach parents and parents teach children to do drugs together, where state troopers carry the opiate antidote Narcan to revive ... - New York Times,
Sleeping Through Detox Poses Hazards Jan 12, 2006
Naltrexone was administered on day 7, after a naloxone (Narcan) short-acting opioid antagonist challenge confirmed the absence of opioid. ... - Psychiatric Times,
Overdose remedy Nov 21, 2005
Experts say naloxone, known by its trade name, Narcan, may have already saved dozens of lives in the city since the Harm Reduction Coalition, an advocacy group ... - New York Newsday,
County might try methadone treatment to help curb drug use Dec 4, 2005
The department has already trained some guards and medical personnel to use Narcan, an injection that can keep someone from dying during a heroin overdose. ... - Santa Fe New Mexican,
NYC Begins Distributing Naloxone to Treat Overdoses Nov 22, 2005
The New York City health department has provided about $200,000 to the Harm Reduction Coalition to distribute the opiate antidote naloxone (Narcan) to needle ... - JoinTogether.org
Mom accused of giving birth while drunk faces new public intox ... Nov 25, 2005
Reports indicate the baby was not breathing upon birth and had to be administered “Narcan� to counteract any narcotics that may have been present in the ... - Bartlesville Examiner Enterprise,
Reviewer Cameron Woodhead Nov 20, 2005
In Cornelius' capable hands, what could have been the last gasp of a genre in decay becomes a miraculous but painful resuscitation — pure Narcan. ... - The Age (subscription),
Kathy's story a lesson for us all Sep 28, 2005
...fatal. Revived by ambulance officers who administered the Narcan antidote, she woke up, hugged her little boy and went home. But ... - Daily Telegraph,
Kelso boy hospitalized after ingesting narcotic Sep 22, 2005
He said paramedics administered a dose of Narcan. Narcan counters the affects of opiates, a large family of drugs that includes ... - Longview Daily News,
Heroin has become the Shore's "H" bomb Sep 29, 2005
Adverse reactions, if discovered in time, can be treated with life-saving medications such as Narcan, Kelaher said. Narcan reverses ... - Asbury Park Press,
Through the Times With Max Fink, MD Oct 3, 2005
...in narcotics," Fink said. "We did a lot of work with naloxone [Narcan] and with opioids themselves. We studied heroin, narcotic ... - Psychiatric Times,
New York Passes Legislation to Save Hundreds of Lives Aug 31, 2005
Network, that would provide protection for those heroes—doctors, health professionals and even friends and family members—who provide Narcan to those who ... - Common Dreams (press release),
Woman bound over for trial in child abuse case Sep 2, 2005
Reports indicate the baby was not breathing upon birth and had to be administered "Narcan" to counteract any narcotics that may have been present in the baby. ... - Bartlesville Examiner Enterprise,
An OD Revival Story Aug 22, 2005
..."He was blue and gasping for air," Shaun says. "I opened his mouth and he was biting his tongue." Another friend pulled a syringe filled with Narcan out of his ... - Village Voice,
Another OD, but this time no blaring tab headlines Sep 1, 2005
The center has been giving out a new drug, Narcan, also known as Naloxone, which can save lives when administered after an overdose. ... - The Villager,
Coroner’s final ruling raises more suspicion among Wade family Aug 10, 2005
...and sluggish to respond, green sputum was com-ing from his nose and he was non-responsive to any medications— two milligrams of Narcan, 100 milligrams of the ... - Frost Illustrated,
Cops seek dealer of deadly heroin Aug 27, 2005
Paramedics administered the opiate blocker narcan with some positive effect, but the man was struggling to survive on Thursday. ... - Edmonton Sun,
Vancouver heroin death toll rises to six in six days Aug 26, 2005
The panhandler called 911 from a payphone and paramedics administered Narcan, a drug that blocks opiates in the body, to the victim before taking him to ... - Globe and Mail,
The Rescue Drug Debate Jul 15, 2005
He said not only is heroin use rampant, he feels some take too many chances because of a potentially life-saving drug called Narcan. ... - WNEP-TV
Teaching Inmates to Avoid Overdose Jul 26, 2005
Prevention Point does not distribute the anti-overdose drug Narcan to those attending the classes, but may begin doing so at its needle-exchange programs. ... - JoinTogether.org
Heroin deaths spur effort to raise awareness of risks Jul 28, 2005
A 22-year-old man found unconscious in the same Harbor Street apartment was revived with Narcan, a drug that reverses the effect of heroin. ... - Boston Globe
Dewey woman accused of giving birth while drunk Jul 13, 2005
Reports indicate the baby was not breathing upon birth and had to be administered "Narcan" to counteract any narcotics that may have been present in the baby. ... - Bartlesville Examiner Enterprise
Thief takes drugs, wallets at hospital Jul 9, 2005
...only areas, police say. Drugs taken included Narcan, Romazicon, Benadryl, Atropine, Epinephrine and Lidocaine. The suspect is a ... - Carlisle Sentinel
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Thief takes drugs, wallets at hospital Jul 9, 2005
...only areas, police say. Drugs taken included Narcan, Romazicon, Benadryl, Atropine, Epinephrine and Lidocaine. The suspect is a ... - Carlisle Sentinel
Police arrest Middletown man on drug, assault charges Jul 5, 2005
He was later treated by medics and Port Monmouth First Aid members with Narcan, a substance that Morrell said counteracts the effects of heroin. ... - Asbury Park Press
Toddler ingests opium, evacuated to KAF Jun 14, 2005
IV. Then we gave him a shot of narcan," Naylor continued. ... thing.". Narcan is a drug that blocks the effects of opium in the human body. ... - Blackanthem.com
US Soldiers Wounded; Troops Save Infant's Life Jun 14, 2005
...toddler. She said medical personnel at Kandahar administered a dose of Narcan, a drug that blocks the effects of opium. "Within ... - Defenselink.mil
Other information
Indication
Naloxone is indicated for the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol.
Pharmacology
Naloxone is an opiate antagonist and prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine. Naloxone is an essentially pure narcotic antagonist, i.e., it does not possess the "agonistic" or morphine-like properties characteristic of other narcotic antagonists; Naloxone does not produce respiratory depression, psychotomimetic effects or pupillary constriction. In the absence of narcotics or agonistic effects of other narcotic antagonists, it exhibits essentially no pharmacologic activity.
Mechanism Of Action
While the mechanism of action of Naloxone is not fully understood, the preponderance of evidence suggests that Naloxone antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. Recently, naloxone has been shown to bind all three opioid receptors (mu, kappa and gamma) but the strongest binding is to the mu receptor.
Drug Category
Antinarcotic Agents; Depressants; Opiate Antagonists; ATC:V03AB15
Brand Names/Synonyms
En 1530 Base; HSDB 3279; L-Naloxone; N-Allylnoroxymorphone; Nalone; Nalossone [Dcit]; Naloxona [Inn-Spanish]; Naloxone; Naloxone Hcl; Naloxonum [Inn-Latin]; Narcan; Narcanti; Narcon; Narcotic Antagonist;
Dosage Forms
LIQUID
Absorption
Not Available
Interactions
Interactions for Naloxone:
No information provided.
Chemical IUPAC Name
Not Available
Chemical Formula
C19H21NO4
Half Life
30-81 minutes
Drug Type
Approved Drug
# Accession No
APRD00025
CAS Registry Number
465-65-6