Narcan: profile and news






FDA seeks to avoid confusing drug names  Mar 2, 2006
In one documented incident, a patient needing an injection of Narcan was given Norcuron by mistake and went into cardiac arrest. ... - Middle East North Africa Financial Network,

Officials: Heroin abuse rises on Shore  Feb 14, 2006
Mulinos said when the ER staff doesn't know how much heroin was injected, then it's difficult to know how much Narcan -- an opioid antagonist -- to administer ... - Delmarva Daily Times,

$8,300,000 Jury awards to patient who suffered brain damage  Feb 24, 2006
After Terris slipped into a coma, the hospital did not give her the antidote Narcan. ... "We were unable to say whether the Narcan would have made a difference.". ... - Bridgeton News,

Police probe theft in hospital  Feb 7, 2006
Taken were two vials of Narcan, which is used to reverse the effect of drugs used during surgery or of a drug overdose; one dose of Versed, used to reduce ... - Portsmouth Herald News,

Nurses take to the streets  Feb 10, 2006
In the area on routine business, he administered the anti-opiate drug narcan as the victim's friend called 911 on the cellphone. ... - Oak Bay News,

Coroner highlights dangers of cocaine after cell death verdict  Feb 11, 2006
There should also be a defibrillator. He said he would also ask the ambulance service to consider carrying Narcan, an antidote to heroin. ... - Yorkshire Post Today,

Police probe theft in hospital  Feb 7, 2006
Taken were two vials of Narcan, which is used to reverse the effect of drugs used during surgery or of a drug overdose; one dose of Versed, used to reduce ... - Portsmouth Herald News,

Fortunate to be alive  Jan 22, 2006
In 2004, 359 people were administered Narcan, an antidote for opioid overdose, by emergency personnel. In the first 10 months of ... - MaineToday.com,

Fighting for the future: The real million dollar baby  Jan 27, 2006
The problem is such that, as a matter of routine, state troopers carry with them Narcan, an opiate antidote, to treat people who have overdosed from heroin. ... - Independent,

Female Boxer Offers Hope to a New Mexico Town Short of Heroes  Jan 17, 2006
...so ingrained that grandparents teach parents and parents teach children to do drugs together, where state troopers carry the opiate antidote Narcan to revive ... - New York Times,

Sleeping Through Detox Poses Hazards  Jan 12, 2006
Naltrexone was administered on day 7, after a naloxone (Narcan) short-acting opioid antagonist challenge confirmed the absence of opioid. ... - Psychiatric Times,

Overdose remedy  Nov 21, 2005
Experts say naloxone, known by its trade name, Narcan, may have already saved dozens of lives in the city since the Harm Reduction Coalition, an advocacy group ... - New York Newsday,

County might try methadone treatment to help curb drug use  Dec 4, 2005
The department has already trained some guards and medical personnel to use Narcan, an injection that can keep someone from dying during a heroin overdose. ... - Santa Fe New Mexican,

NYC Begins Distributing Naloxone to Treat Overdoses  Nov 22, 2005
The New York City health department has provided about $200,000 to the Harm Reduction Coalition to distribute the opiate antidote naloxone (Narcan) to needle ... - JoinTogether.org

Mom accused of giving birth while drunk faces new public intox ...  Nov 25, 2005
Reports indicate the baby was not breathing upon birth and had to be administered “Narcan� to counteract any narcotics that may have been present in the ... - Bartlesville Examiner Enterprise,

Reviewer Cameron Woodhead  Nov 20, 2005
In Cornelius' capable hands, what could have been the last gasp of a genre in decay becomes a miraculous but painful resuscitation — pure Narcan. ... - The Age (subscription),

Kathy's story a lesson for us all  Sep 28, 2005
...fatal. Revived by ambulance officers who administered the Narcan antidote, she woke up, hugged her little boy and went home. But ... - Daily Telegraph,

Kelso boy hospitalized after ingesting narcotic  Sep 22, 2005
He said paramedics administered a dose of Narcan. Narcan counters the affects of opiates, a large family of drugs that includes ... - Longview Daily News,

Heroin has become the Shore's "H" bomb  Sep 29, 2005
Adverse reactions, if discovered in time, can be treated with life-saving medications such as Narcan, Kelaher said. Narcan reverses ... - Asbury Park Press,

Through the Times With Max Fink, MD  Oct 3, 2005
...in narcotics," Fink said. "We did a lot of work with naloxone [Narcan] and with opioids themselves. We studied heroin, narcotic ... - Psychiatric Times,

New York Passes Legislation to Save Hundreds of Lives  Aug 31, 2005
Network, that would provide protection for those heroes—doctors, health professionals and even friends and family members—who provide Narcan to those who ... - Common Dreams (press release),

Woman bound over for trial in child abuse case  Sep 2, 2005
Reports indicate the baby was not breathing upon birth and had to be administered "Narcan" to counteract any narcotics that may have been present in the baby. ... - Bartlesville Examiner Enterprise,

An OD Revival Story  Aug 22, 2005
..."He was blue and gasping for air," Shaun says. "I opened his mouth and he was biting his tongue." Another friend pulled a syringe filled with Narcan out of his ... - Village Voice,

Another OD, but this time no blaring tab headlines  Sep 1, 2005
The center has been giving out a new drug, Narcan, also known as Naloxone, which can save lives when administered after an overdose. ... - The Villager,

Coroner’s final ruling raises more suspicion among Wade family  Aug 10, 2005
...and sluggish to respond, green sputum was com-ing from his nose and he was non-responsive to any medications— two milligrams of Narcan, 100 milligrams of the ... - Frost Illustrated,

Cops seek dealer of deadly heroin  Aug 27, 2005
Paramedics administered the opiate blocker narcan with some positive effect, but the man was struggling to survive on Thursday. ... - Edmonton Sun,

Vancouver heroin death toll rises to six in six days  Aug 26, 2005
The panhandler called 911 from a payphone and paramedics administered Narcan, a drug that blocks opiates in the body, to the victim before taking him to ... - Globe and Mail,

The Rescue Drug Debate  Jul 15, 2005
He said not only is heroin use rampant, he feels some take too many chances because of a potentially life-saving drug called Narcan. ... - WNEP-TV

Teaching Inmates to Avoid Overdose  Jul 26, 2005
Prevention Point does not distribute the anti-overdose drug Narcan to those attending the classes, but may begin doing so at its needle-exchange programs. ... - JoinTogether.org

Heroin deaths spur effort to raise awareness of risks  Jul 28, 2005
A 22-year-old man found unconscious in the same Harbor Street apartment was revived with Narcan, a drug that reverses the effect of heroin. ... - Boston Globe

Dewey woman accused of giving birth while drunk  Jul 13, 2005
Reports indicate the baby was not breathing upon birth and had to be administered "Narcan" to counteract any narcotics that may have been present in the baby. ... - Bartlesville Examiner Enterprise

Thief takes drugs, wallets at hospital  Jul 9, 2005
...only areas, police say. Drugs taken included Narcan, Romazicon, Benadryl, Atropine, Epinephrine and Lidocaine. The suspect is a ... - Carlisle Sentinel <**results**>

Thief takes drugs, wallets at hospital  Jul 9, 2005
...only areas, police say. Drugs taken included Narcan, Romazicon, Benadryl, Atropine, Epinephrine and Lidocaine. The suspect is a ... - Carlisle Sentinel

Police arrest Middletown man on drug, assault charges  Jul 5, 2005
He was later treated by medics and Port Monmouth First Aid members with Narcan, a substance that Morrell said counteracts the effects of heroin. ... - Asbury Park Press

Toddler ingests opium, evacuated to KAF  Jun 14, 2005
IV. Then we gave him a shot of narcan," Naylor continued. ... thing.". Narcan is a drug that blocks the effects of opium in the human body. ... - Blackanthem.com

US Soldiers Wounded; Troops Save Infant's Life  Jun 14, 2005
...toddler. She said medical personnel at Kandahar administered a dose of Narcan, a drug that blocks the effects of opium. "Within ... - Defenselink.mil


Other information


Indication
Naloxone is indicated for the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol.

Pharmacology
Naloxone is an opiate antagonist and prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine. Naloxone is an essentially pure narcotic antagonist, i.e., it does not possess the "agonistic" or morphine-like properties characteristic of other narcotic antagonists; Naloxone does not produce respiratory depression, psychotomimetic effects or pupillary constriction. In the absence of narcotics or agonistic effects of other narcotic antagonists, it exhibits essentially no pharmacologic activity.

Mechanism Of Action
While the mechanism of action of Naloxone is not fully understood, the preponderance of evidence suggests that Naloxone antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. Recently, naloxone has been shown to bind all three opioid receptors (mu, kappa and gamma) but the strongest binding is to the mu receptor.

Drug Category
Antinarcotic Agents; Depressants; Opiate Antagonists; ATC:V03AB15

Brand Names/Synonyms
En 1530 Base; HSDB 3279; L-Naloxone; N-Allylnoroxymorphone; Nalone; Nalossone [Dcit]; Naloxona [Inn-Spanish]; Naloxone; Naloxone Hcl; Naloxonum [Inn-Latin]; Narcan; Narcanti; Narcon; Narcotic Antagonist;

Dosage Forms
LIQUID

Absorption
Not Available

Interactions
Interactions for Naloxone:

No information provided.



Chemical IUPAC Name
Not Available

Chemical Formula
C19H21NO4

Half Life
30-81 minutes

Drug Type
Approved Drug

# Accession No
APRD00025

CAS Registry Number
465-65-6

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