Mifepristone: profile and news

Teva Announces Tentative Approval of Topiramate Tablets, 50 mg  07 Mar 2006
...liability for sales of generic products prior to a final court decision, including that relating to the generic versions of Allegra(R), Neurontin(R), Oxycontin ... - Genetic Engineering News,

Pringle: Psych Drugs Used To Manufacture Insanity  07 Mar 2006
He found Neurontin, a drug with FDA approval for controlling seizures, "was being massively prescribed for anxiety, social phobia, PTSD, social anxiety, mood ... - Scoop.co.nz (press release),

Alba Therapeutics Announces Creation of Development Advisory Board  07 Mar 2006
As the Vice President of Clinical Pharmacology at Parke Davis, he oversaw the exploratory clinical development of drugs such as Neurontin®, Lipitor® and ... - Yahoo! News (press release)

Restless legs or shaky legs: Conditions incongruent  Mar 5, 2006
...the population. Anticonvulsant medications such as valproic acid (Depakote) and gabapentin (Neurontin) can provide some relief. In ... - Fort Wayne Journal Gazette,

Stronger Together Than Apart  Mar 4, 2006
No Medicare Part D drug plan they've checked, she said, covers her more expensive, brand-name drugs, such as Neurontin for bipolar disorder. ... - The Ledger,

Pain medicine may keep jobs in Ann Arbor, Pfizer CEO says  Feb 12, 2006
It’s Pfizer’s successor to Neurontin, which was used mostly for epilepsy, and the company says it is more effective at lower doses and with fewer side ... - Crain's Detroit Business (subscription),

Study Finds Cymbalta® Was As Safe And Well-Tolerated As Routine ...  Feb 20, 2006
The most commonly used prescription pain medications for routine care included Neurontin® (gabapentin), Elavil® (amitriptyline) and Effexor-XR® (venlafaxine ... - Medical News Today (press release),

Jagged little pills  Mar 2, 2006
..."Zoloft, Effexor, Lorazepam, Wellbutrin, Neurontin..." Tyler, a junior, rattles off the labels of the 15 day-glow orange pill bottles that line the top of his ... - Silver Chips Online,

Big money, big fines - it's all hormonal  Feb 23, 2006
Clearly, Pfizer does not want a repeat of its 2004 experience with Neurontin, an anti-seizure medication marketed by Warner-Lambert, which Pfizer acquired in ... - Macleans,

Teva Reports Record Sales and Net Income for the Fourth Quarter ...  Mar 1, 2006
...for sales of generic products prior to a final court decision, including that relating to the generic versions of Allegra®, Neurontin®, Oxycontin® and ... - PharmaLive.com (press release),

SCOLR Pharma Reports Positive Ondansetron Clinical Results, New ...  Feb 16, 2006
Gabapentin is the active ingredient in Neurontin(R), a Pfizer product for neuralgia (neural pain) and as an adjunct treatment of partial seizures associated ... - Genetic Engineering News,

Drugmakers' gifts to doctors raising more US eyebrows  Feb 19, 2006
...paid $430 million in civil and criminal fines to settle charges that a company it had bought in 2000 unfairly marketed the drug Neurontin, including flying ... - AZ Central.com,

Stocks Under $10 Weekly Summary  Feb 24, 2006
...the company should begin its phase III trial in the second quarter for pain medicine Gabapentin, which is a generic version of Pfizer's (PFE:NYSE) Neurontin. ... - TheStreet.com (subscription),

Pfizer seen clearing profit uncertainty at meeting  Feb 10, 2006
They include epilepsy treatment Neurontin, whose fourth-quarter sales plunged 71 percent to $141 million; hypertension drug Accupril, whose quarterly revenue ... - ABC News

Pfizer 2006 profit view disappoints, stock falls  Feb 10, 2006
Fourth-quarter sales of the epilepsy treatment Neurontin plunged 71 percent to $141 million; sales of hypertension drug Accupril fell 74 percent to $44 million ... - Reuters

Pfizer's Lipitor Keeps Top Spot Even as Growth Slows (Update1)  Feb 15, 2006
...copies. For example, sales of Pfizer's Neurontin for epilepsy sales dropped to $639 million in 2005 from $2.7 billion in 2004. The ... - Bloomberg

CLEARLAKE, LAKE COUNTY Families agonize over bizarre murder case  Feb 7, 2006
7. And he noted that Edmonds had smoked marijuana as well as taking Lexapro, an anti-depressant, and Neurontin, a drug to control seizures, Dec. 6. ... - San Francisco Chronicle,

Cops bust marijuana growing operation  Feb 3, 2006
She is accused of possessing 217 pills of the prescription drug Neurontin without a prescription, and she's accused of selling five pills for $10 on Wednesday ... - Munster Times,

Medicare Mailbag ‘Plan D’ questions and answers  Feb 6, 2006
My HMO, Vista Healthplan of South Florida’s Platinum Medicare, will pay for neurontin, which is more expensive but less effective than Lyrica. ... - Grand Junction Sentinel,

Generics Expected to Take Bigger Bite From Top-Selling Drugs ...  Feb 16, 2006
...copies. For example, sales of the Pfizer epilepsy drug Neurontin dropped to $639 million in 2005 from $2.7 billion in 2004. The ... - International News Service,

Medicare Q&A: 'Plan D' questions and answers  Feb 5, 2006
I live on Social Security retirement only and couldn't pay it. My HMO will pay for Neurontin, which is more expensive but less effective than Lyrica. ... - Austin American-Statesman (subscription),

Stocks Under $10 Weekly Summary  Feb 3, 2006
...royalty revenue. Also, DepoMed will run a Phase III trial for a generic version of already patented Neurontin for pain. Positive ... - TheStreet.com (subscription),

Teva Comments on Pfizer Press Release Regarding Azithromycin  09 Feb 2006
...liability for sales of generic products prior to a final court decision, including that relating to the generic versions of Allegra(R), Neurontin(R), Oxycontin ... - Business Wire (press release),

CLEARLAKE, LAKE COUNTY Families agonize over bizarre murder case  Feb 7, 2006
7. And he noted that Edmonds had smoked marijuana as well as taking Lexapro, an anti-depressant, and Neurontin, a drug to control seizures, Dec. 6. ... - San Francisco Chronicle,

Medicare Mailbag ‘Plan D’ questions and answers  Feb 6, 2006
My HMO, Vista Healthplan of South Florida’s Platinum Medicare, will pay for neurontin, which is more expensive but less effective than Lyrica. ... - Grand Junction Sentinel,

Medicare Q&A: 'Plan D' questions and answers  Feb 5, 2006
I live on Social Security retirement only and couldn't pay it. My HMO will pay for Neurontin, which is more expensive but less effective than Lyrica. ... - Austin American-Statesman (subscription),

25 trash bags of medications dumped  Jan 27, 2006
Among medications found in the bags were: Vioxx, Celebrex, Spiriva, Imitrex, Neurontin, Bextra, Paxil, Toprol, Mobic, Maxalt, Topamax, Benicar and Triaz. ... - Pocono Record,

Pfizer Fourth-Quarter and Full-Year 2005 Financial Results Reflect ...  Jan 19, 2006
472 1,008 (53) 1,730 3,302 (48) Bextra (2) 417 * (61) 1,286 * Dynastat 8 14 (44) 34 46 (25) Accupril/Accuretic 44 165 (74) 294 665 (56) Neurontin 141 481 (71 ... - PR Newswire (press release),

Pfizer 4th-Quarter Net Falls 3% as Lipitor Sales Slow (Update2)  Jan 19, 2006
...earnings fell 3 percent on slowing demand for the Lipitor cholesterol drug and plummeting sales of the Celebrex painkiller and Neurontin epilepsy treatment. ... - Bloomberg

Osteoporosis: Pathways to Prevention  Jan 23, 2006
The women were randomly selected to receive daily doses of 300 mg or 900 mg of Neurontin (generic name: gabapentin) or a dummy drug. ... - Saturday Evening Post,

Cops bust marijuana growing operation  Feb 3, 2006
She is accused of possessing 217 pills of the prescription drug Neurontin without a prescription, and she's accused of selling five pills for $10 on Wednesday ... - Munster Times,

Pfizer 4Q Profit Slips As Revenue Falls  Jan 19, 2006
Global sales of high blood pressure treatment Norvasc slipped 1 percent to $1.24 billion, while worldwide sales of epilepsy treatment Neurontin fell 71 percent ... - Houston Chronicle,

Profit at Pfizer Falls By 3% as Sales Slow  Jan 19, 2006
...sales of Norvasc, a drug to treat high blood pressure, slipped 1 percent, to $1.24 billion, while worldwide sales of the epilepsy treatment Neurontin fell 71 ... - New York Times,

Stocks Under $10 Weekly Summary  Feb 3, 2006
...royalty revenue. Also, DepoMed will run a Phase III trial for a generic version of already patented Neurontin for pain. Positive ... - TheStreet.com (subscription),

Drug manufacturers find portfolios age and shrink in sales value  Jan 20, 2006
Zocor. Elsewhere in its portfolio, sales of Pfizer’s Neurontin epilepsy treatment, fell 71 percent owing to generic competition. ... - Manufacturer.com,

Pfizer quarter beats forecasts  Jan 19, 2006
Epilepsy treatment Neurontin saw sales slump 71%, hypertension drug Accupril sank 74%, while sales of arthritis treatment Celebrex tumbled 53% following the ... - Life Style Extra,

Happy Pills Don't Make Me Happy  Jan 20, 2006
Wellbutrin, Neurontin, Seroquel, Depakote, Effexor, Inderal, Trileptal, Paxil, Zyprexa, Lamictal, Abilify -- I've taken them all. ... - Bay Area Indymedia,

Ask the Clinician: Answers to Readers' Questions  Jan 16, 2006
...cluster within periods of time. She was prescribed Neurontin at bedtime for the prevention of migraine... Debra. 7) ...Last Monday I ... - About - News & Issues,

Big Pharma's Reversal of Fortune  Jan 26, 2006
And many of the drugs that made the US companies so successful a decade ago, such as Pfizer's epilepsy treatment Neurontin and antibiotic Zithromax, have lost ... - BusinessWeek

IVAX Shareholders Overwhelmingly Elect to Receive Stock ...  Jan 25, 2006
...potential liability for sales of generic products prior to completion of appellate litigation, including that relating to Allegra(R), Neurontin(R), Oxycontin(R ... - Genetic Engineering News,

Spector claims in deposition he was beaten by police  Jan 28, 2006
The music producer said for eight years he has taken Prozac, Neurontin, Klonopin, tetracycline "for my skin" and "a heavier antacid which is a prescribed ... - North County Times,

Locals say chiropractic key to recovery  Jan 25, 2006
She sought medical help, had an MRI, and has tried many migraine treatments, including Neurontin and steroids injected directly into her head. ... - Clarksville Leaf Chronicle,

Part D crisis came quickly; intervention came slowly  Jan 27, 2006
By Wednesday, she'd run out of Clonazepam and Neurontin, perhaps the most crucial, her pain doctor's office said, of the nearly two dozen drugs she takes daily ... - Palm Beach Post,

Teach your children well  Jan 27, 2006
I had them for five months, terrible. And the only thing that gave me relief was a drug called neurontin. You need it by prescription. ... - Mercury-Register,

From treating blemishes to heart disease, the ins and outs of 'off ...  Jan 30, 2006
More than 2,000 families are taking legal action against Pfizer, for instance, alleging that off-label use of the epilepsy drug Neurontin led to severe ... - Charleston Post Courier (subscription),

Robert L. Zerbe, MD, Joins Aastrom Biosciences' Board of Directors  Jan 17, 2006
Development. In this capacity he led the clinical development programs for a number of key products, including Lipitor(R) and Neurontin(R). ... - Biotech Intelligence (press release),

Phil Spector deposition testimony in civil suit released  Jan 27, 2006
...medications prescribed for him by psychiatrists. Among them, he said, were Prozac, Neurontin and Clonopin. The deposition was taken July ... - Press-Enterprise (subscription),

INVESTOR'S BUSINESS DAILY  Jan 27, 2006
...unit. When Pfizer's epilepsy drug Neurontin lost its patent protection, it launched its own generic version through Greenstone. ... - Investor's Business Daily (subscription)

Former worker sues Genentech over drug marketing  Jan 11, 2006
In 2004, Warner-Lambert pleaded guilty to federal charges that it promoted epilepsy drug Neurontin for off-label uses beginning in the 1990s. ... - San Jose Mercury News,

Pfizer Fourth-Quarter Net Falls 3 Percent; Lipitor Sales Slow  Jan 19, 2006
Demand for Pfizer's Neurontin epilepsy treatment, previously its fifth-best selling drug, fell last year because of generic competition. ... - Bloomberg

Pfizer 4th-Quarter Net Falls 3%; Lipitor Sales Slow (Update1)  Jan 19, 2006
Demand for Pfizer's Neurontin epilepsy treatment, previously its fifth-best selling drug, fell in the quarter on generic competition. ... - Bloomberg

Earnings Preview: Pfizer  Jan 18, 2006
...margin to contract by 2.5 points to 82 percent because of lower sales volumes of Cox-2 inhibitors, the antibiotic Zithromax and epilepsy treatment Neurontin. ... - MSN Money

Pfizer quarterly profit falls, mauled by generics  Jan 19, 2006
They include epilepsy treatment Neurontin, whose fourth-quarter sales plunged 71 percent to $141 million, and hypertension drug Accupril, which fell 74 percent ... - Reuters

Pfizer, Novartis Profits Stall as Demand Slows for Older Drugs  Jan 19, 2006
While Lipitor sales growth slowed, demand for the Neurontin epilepsy treatment, previously Pfizer's fifth-best selling drug, fell 71 percent on generic ... - Bloomberg

Pfizer 4Q profit slips nearly 3 percent  Jan 19, 2006
Global sales of high blood-pressure treatment Norvasc slipped 1 percent to $1.24 billion, while worldwide sales of epilepsy treatment Neurontin fell 71 percent ... - BusinessWeek

Earnings stall for Pfizer and Novartis  Jan 20, 2006
While Lipitor sales growth only slowed, demand for the Neurontin epilepsy treatment, previously the drug maker's fifth-best selling drug, fell 71 percent ... - International Herald Tribune,

Slow demand weighs down Pfizer, Novartis  Jan 20, 2006
Demand for the Neurontin epilepsy treatment fell 71 per cent in the fourth quarter from the year-earlier period on generic competition. ... - Globe and Mail,

Pfizer: Less Bad Is Good Enough  Jan 19, 2006
...in the US The culprits read like a murder inmate's row of generic competition and troubled drugs -- Celebrex down 53%, Bextra down to nothing, Neurontin down 71 ... - MSNBC

No hint of foul play in woman's death, Joplin police say  Jan 13, 2006
...noticed at the time that Aston also had Seroquel, a psychotropic medication effective in treatment of depression and bipolar disorder, and Neurontin, an anti ... - Joplin Globe,

Prescription drug debacle  Jan 16, 2006
1 arbitrarily assigned her to a program that wouldn't cover three of the medications, including Neurontin, which stabilizes her mood. ... - Los Angeles Daily News,

Ask the Clinician: Answers to Readers' Questions  Jan 9, 2006
...her disposal 180 Percocet pills a month, Demerol shots to use as needed, two anti-seizure medications (for she also has seizures), one of those being Neurontin ... - About - News & Issues,

The Down Side of Popping Pills  Jan 11, 2006
Wellbutrin, Neurontin, Seroquel, Depakote, Effexor, Inderal, Trileptal, Paxil, Zyprexa, Lamictal, Abilify, I've taken them all. ... - AlterNet,

Pfizer's profits drop as sales retreat  Jan 19, 2006
Global sales of high blood pressure drug Norvasc slipped 1 per cent to $1.24 billion, while worldwide sales of epilepsy treatment Neurontin fell 71 per cent to ... - Toronto Star,

Pfizer struggles as generics pummel its drugs  Jan 6, 2006
Similarly it is trying to replace the older drug Neurontin, which treats epilepsy and nerve pain, with patent-protected Lyrica. ... - Pittsburgh Post Gazette,

Although specific drug or food interactions with mifepristone have not been studied, on the basis of this drugís metabolism by CYP 3A4, it is possible that ketoconazole, itraconazole, erythromycin, and grapefruit juice may inhibit its metabolism (increasing serum levels of mifepristone). Furthermore, rifampin, dexamethasone, St. Johnís Wort, and certain anticonvulsants (phenytoin, phenobarbital, carbamazepine) may induce mifepristone metabolism (lowering serum levels of mifepristone).

Based on in vitro inhibition information, coadministration of mifepristone may lead to an increase in serum levels of drugs that are CYP 3A4 substrates. Due to the slow elimination of mifepristone from the body, such interaction may be observed for a prolonged period after its administration. Therefore, caution should be exercised when mifepristone is administered with drugs that are CYP 3A4 substrates and have narrow therapeutic range, including some agents used during general anesthesia.