Mevacor: profile and news






Mevacor's Future Undecided as an Over-The-Counter Drug  Feb 9, 2006
...with many questions and concerns associated with these drugs being so readily available to patients, the FDA has yet to approve Merck's Mevacor and other ... - PR Newswire (press release),

Could coffee consumption affect cholesterol numbers?  Mar 1, 2006
...going up. I've done everything my doctor suggested, including diet, exercise, Mevacor, Zocor, Lipitor and red yeast rice. Some numbers ... - Daily Press,

Volunteers needed for drug study  Feb 17, 2006
...a study into possible interaction between vitamin E and the cholesterol-reducing drugs simvastatin (often marketed as Zocor) and lovastatin (marketed as Mevacor ... - Corvallis Gazette Times,

Statins To Reduce Cholesterol Levels  Feb 24, 2006
Six statins are currently approved for use in the US: Lipitor® (atorvastatin), Lescol® (fluvastatin), Mevacor® (lovastatin), Pravachol® (pravastatin), Zocor ... - WSOCtv.com,

Grapefruit may sabotage meds  Feb 6, 2006
Zocor, along with Lipitor and Mevacor, are among the hugely popular statin drugs that can zoom to high levels in the blood if taken with a glass of grapefruit ... - Arizona Daily Star,

Bristol-Myers Squibb Seeks To Expand Access To Its Most Recently ...  Feb 19, 2006
...not be taken with the following medicines: ergot medicines, Versed®, Halcion®, Orap®, Propulsid®, Camptosar®, Crixivan®, Mevacor®, Zocor®, rifampin, St ... - Medical News Today (press release),

Pfizer Mulls Cholesterol Drug  Feb 13, 2006
There are five additional statins on the market other than Lipitor: Zocor and Mevacor, both made by Merck; AstraZeneca’s Crestor; Pravachol by Bristol-Myers ... - Red Herring,

New 48 Week Clinical Trial Data Reported Comparing REYATAZ(R) ...  Feb 9, 2006
...should not be taken with the following medicines: ergot medicines, Versed(R), Halcion(R), Orap(R), Propulsid(R), Camptosar(R), Crixivan(R), Mevacor(R), Zocor(R ... - Finanzen.net,

Mevacor's Future Undecided as an Over-The-Counter Drug  09 Feb 2006
...with many questions and concerns associated with these drugs being so readily available to patients, the FDA has yet to approve Merck's Mevacor and other ... - PR Newswire (press release),

New 48 Week Clinical Trial Data Reported Comparing REYATAZ(R) ...  09 Feb 2006
...not be taken with the following medicines: ergot medicines, Versed®, Halcion®, Orap®, Propulsid®, Camptosar®, Crixivan®, Mevacor®, Zocor®, rifampin, St ... - Yahoo! News (press release)

Grapefruit may sabotage meds  Feb 6, 2006
Zocor, along with Lipitor and Mevacor, are among the hugely popular statin drugs that can zoom to high levels in the blood if taken with a glass of grapefruit ... - Arizona Daily Star,

Statins: Do They Lower Risk of Infections?  Jan 25, 2006
Cholesterol-lowering statins, like the drug Mevacor, also may lower the risk of infections, according to a new study. (AP). By DR. RAJESH V. SWAMINATHAN. Jan. ... - ABC News

Call to focus on artery disease  Jan 24, 2006
...treated with medications shown to reduce the risk of heart attack and stroke, such as the popular cholesterol-lowering statin drugs, like Zocor and Mevacor. ... - Pretoria News (subscription),

Drug firms, scientists go back to nature  Jan 10, 2006
...that Dr. Endo originally discovered shares the same basic chemical structure as three of the biggest-selling anticholesterol drugs: Zocor, Pravachol and Mevacor ... - Napa Valley Register,

Statin drugs must carry health warning  Jan 13, 2006
The makers of all the drugs, which include Lipitor, Zocor, Pravachol, Mevacor and Crestor, must include a warning and description of the risk in patient safety ... - Toronto Star,

Health Canada Mandates New Warnings on Statins Regarding Risk of ...  Jan 14, 2006
The manufacturers of Lipitor, Zocor, Pravachol, Mevacor, and Crestor are now required to include an enhanced warning about the potential risks posed to ... - Newsinferno.com,

Glaxo seeks approval to sell obesity drug over the counter  Jan 22, 2006
...camp" was seen by some as a factor in the early 2005 decision by two advisory committees that voted against the over-the-counter switch of Mevacor, a popular ... - Pittsburgh Post Gazette,

A prescription for future success  Jan 31, 2006
This strategy is used 29% of the time. Merck & Co. (merck.com) used this strategy by upgrading statin product Mevacor to Zocor. ... - Med Ad News (subscription),

A pharamacy for the uninsured  Jan 26, 2006
For example, at Adam's, Lipitor, a popular medicine used to lower cholesterol, can be replaced by Mevacor, the generic brand, at 1/4 of the price. ... - Roxborough Review,

Statins ineffective on cancer, studies say  Jan 8, 2006
Statins are the most commonly prescribed medications in the US, and as a result possess unrivaled name recognition: Lipitor, Zocor, Mevacor, Crestor, Pravachol ... - Indianapolis Star,

Greater focus on artery disease needed globally  Jan 11, 2006
...undertreated with medications shown to reduce the risk of heart attack and stroke, such as the popular cholesterol-lowering statin drugs, like Zocor and Mevacor ... - Reuters

Studies: Statins Don't Cut Risk of Colon, Other Cancers  Jan 9, 2006
...studied included atorvastatin (Lipitor, Caduet), cerivastatin (Baycol), fluvastatin (Lescol), lovastatin (Advicor, Altoprev, Mevacor), pravastatin (Pravachol ... - ACS News Center,

Statins' anti-cancer benefit discounted  Jan 15, 2006
...of drugs includes such well-known drugs as Lipitor (atorvastatin), Pravachol (pravastatin), Zocor (simvastatin), Lescol (fluvastatin) and Mevacor (lovastatin). ... - Sun-Sentinel.com,

Far from a cure  Nov 13, 2005
Six months ago, a cholesterol-lowering drug called Mevacor was set to be reclassified as an over-the-counter medicine, a move that would have made the drug ... - Ocala.com,

Some juice, drugs not a good mix  Nov 27, 2005
Grapefruit juice can raise blood levels of some cholesterol-lowering drugs, including Lipitor, Zocor and Mevacor (lovastatin), and increase the risk of side ... - Los Angeles Times,

The little lifesaver  Nov 16, 2005
She hadn’t: it really did work. An active extract that became Mevacor, the first successful statin, was produced in 1978. Even ... - Times Online,

Physicians and Pharmacists See Advantages for OTC Statin Option ...  Dec 5, 2005
..."Our analysts are projecting OTC revenues of more than $500 million in 2007, based largely on switch revenues from Mevacor and Pravachol.". ... - Yahoo! News (press release)

Study: Hope for learning disabled  Nov 13, 2005
Lovastatin, trade-named Mevacor, is one of a family of drugs known collectively as statins that have revolutionized the treatment of high cholesterol. ... - AZ Central.com,

No good evidence that cholesterol drugs lower melanoma risk  Nov 10, 2005
...prescribed to lower cholesterol. Brand names for these drugs include Mevacor, Lipitor, Zocor, Abitrate and Lopid. Earlier research in ... - Dominican Today,

Merck issues plant-closing notices as it trims 7,000 workers  Nov 29, 2005
Kirkland. The plant makes medicines for high blood pressure and other heart problems, including Mevacor, Prinivil and Vasotec. Spokeswoman ... - Newsday,

Merck plants in US, Canada on cost-cut list  Nov 29, 2005
...year, the report said. The plant makes an older cholesterol drug, Mevacor, and two treatments for high blood pressure. Rose said she ... - Reuters

Merck adds UK, Japan plants to cost-cut list  Nov 30, 2005
...of this year. The Kirkland plant makes an older cholesterol drug, Mevacor, and two treatments for high blood pressure. Merck on ... - Reuters

Merck Frosst Canada to eliminate 235 jobs from Montreal plant by ...  Nov 28, 2005
The drug brand names made at Kirkland include Prinivil, Prinzide, Vasotec, Vasoretic and Mevacor, used to treat high blood pressure and heart problems. ... - CBC News,

Merck to axe 7,000 jobs, 235 in Canada  Nov 28, 2005
The three main drugs manufactured in Canada -- Mevacor, Vasotec and Prinivil -- have either lost their patents or will in the next a couple of years. ... - Globe and Mail,

Merck to Cut Workers in Ga., Pa., Canada  Nov 29, 2005
Kirkland. The plant makes medicines for high blood pressure and other heart problems, including Mevacor, Prinivil and Vasotec. Merck ... - Brocktown News,

UW pharmacy professors publish doctors' guide to drug interactions  Nov 30, 2005
For example, if a patient is taking either Zocor or Mevacor, both "statin" drugs used to lower cholesterol, the guide tells the health care provider to be ... - uwnews.org,

Kline Develops Interactive Models to Generate Drug Switch ...  Nov 30, 2005
Other components provide Kline's sales forecasts for the overall market and for specific branded drugs, including Mevacor, Pravachol, Zocor, Lipitor, and Lescol ... - PR Newswire (press release),

Statins may not protect against melanoma  Nov 7, 2005
Statins and fibrates are the most popular drugs prescribed to lower cholesterol. Brand names for the drugs include Mevacor, Lipitor, Zocor, Abitrate and Lopid. ... - Monsters and Critics.com,

Has Lipitor Reached Its Limit?  Nov 15, 2005
One of the recent surprises in the cholesterol market has been the continued use of Mevacor--a weak statin that is available as a cheap generic. ... - Forbes

Choosing Mom's new drug benefit gave me a headache  Nov 17, 2005
If Mom took Lipitor (the most commonly prescribed drug in the country), she would need to know that Mevacor and Lipitor are in the same class, although not ... - Boston Globe,

48-Week Clinical Trial Data Provides Information Regarding ...  Nov 18, 2005
...not be taken with the following medicines: ergot medicines, Versed®, Halcion®, Orap®, Propulsid®, Camptosar®, Crixivan®, Mevacor®, Zocor®, rifampin, St ... - Yahoo! News (press release)

Schaeffer's Top and Bottom Ranked Stocks (PFE, TEVA, UIS)  Nov 16, 2005
...of brand-name heart medications, antibiotics, heartburn treatments, and more, including less-expensive versions of Prozac and cholesterol lowering drug Mevacor ... - Schaeffers Research,

First Data to Show Addition of a Bile Acid Sequestrant (WelChol ...  Nov 15, 2005
...with four commonly prescribed statins - Lipitor(R) (atorvastatin calcium), Zocor(R) (simvastatin), Pravachol(R) (pravastatin sodium) and Mevacor(R) (lovastatin ... - PharmaLive.com (press release),

First Data to Show Addition of a Bile Acid Sequestrant (WelChol ...  Nov 15, 2005
...with four commonly prescribed statins -- Lipitor® (atorvastatin calcium), Zocor® (simvastatin), Pravachol® (pravastatin sodium) and Mevacor® (lovastatin). ... - Market Wire (press release)

48-Week Clinical Trial Data Provides Information Regarding ...  Nov 18, 2005
...should not be taken with the following medicines: ergot medicines, Versed(R), Halcion(R), Orap(R), Propulsid(R), Camptosar(R), Crixivan(R), Mevacor(R), Zocor(R ... - Biotech Intelligence (press release),

FDA Safety Labeling Changes: Hectorol, Mevacor, Pulmicort Respules  Sep 28, 2005
On June 13, the FDA approved safety labeling revisions for lovastatin (Mevacor tablets, made by Merck & Co., Inc.) to advise of certain drug interactions that ... - Medscape (subscription)

Dr. Bill Elliott: Savvy consumers ask for generic drugs  Sep 19, 2005
Once Mevacor was established as a blockbuster drug, other drug companies scrambled to bring their own statins to market.ÊZocor, Lipitor, Crestor and Pravachol ... - Marin Independent-Journal,

AstraZeneca: schizophrenia blockbuster faces generic threat  Sep 30, 2005
...over 150 products in its generic drugs portfolio including other blockbuster products like Lilly's antidepressant Prozac and Merck's cholesterol drug, Mevacor. ... - Pharmaceutical Business Review

Cholesterol Control  Sep 29, 2005
...option that is best for you. Some statins include Crestor, Lescol, Pravachol, Lipitor, Zocor and Mevacor. Over half of adults have ... - WTVY,

New Study Finds Additional LDL-C Drops When WelChol(R) ...  Oct 5, 2005
...with four commonly prescribed statins -- Lipitor® (atorvastatin calcium), Zocor® (simvastatin), Pravachol® (pravastatin sodium) and Mevacor® (lovastatin). ... - Market Wire (press release)

New Study Finds Additional LDL-C Drops When WelChol (Colesevelam ...  Oct 5, 2005
...with four commonly prescribed statins -- Lipitor(R) (atorvastatin calcium), Zocor(R) (simvastatin), Pravachol(R) (pravastatin sodium) and Mevacor(R) (lovastatin ... - DG News

Sleep aid Rozerem available soon  Sep 12, 2005
Are statin users not supposed to eat any grapefruit at all, at any time of day? Grapefruit slows elimination of some statin drugs (Mevacor, Lipitor and Zocor). ... - Charlotte Observer,

Option Activity Watch: EMC Corp., Home Depot, and Teva ...  Sep 28, 2005
The company's US generic products include equivalents of such blockbusters as antidepressant Prozac and cholesterol drug Mevacor. ... - Schaeffers Research,

Plan B predicament has FDA in hot water  Sep 11, 2005
...different for the other statins. A: Grapefruit slows elimination of some statin drugs (Mevacor, Lipitor and Zocor). That means that if ... - Houston Chronicle,

Merck signs unique drug development deal  Sep 16, 2005
These include Mevacor (lovastatin) ,Zocor (simvastatin), Pravachol (pravastatin), Lescol (fluvastatin), Crestor (rosuvastatin), and Lipitor (atorvastatin). ... - in-PharmaTechnologist,

There's Gold In Them There Statins, And Now The Rush Is On  Sep 16, 2005
Merck and Johnson & Johnson (JNJ) launched a joint campaign to get the FDA's OK for OTC sales of Mevacor, a new generic statin. ... - Investor's Business Daily (subscription)

New sleeping pill first to act on melatonin receptors  Sep 17, 2005
But I wonder if the grapefruit interaction is different for the other statins. Grapefruit slows elimination of some statin drugs (Mevacor, Lipitor and Zocor). ... - Bradenton Herald,

'New' drugs too often offer little new  08 Sep 2005
It was actually the fourth drug in its class out of the gate -- after Mevacor, Pravachol and Zocor -- but slick and aggressive marketing made it the market ... - Globe and Mail,

Locking Up Life-Saving Drugs  Sep 6, 2005
Six months ago, a cholesterol-lowering drug called Mevacor was set to be reclassified as an over-the-counter medicine, a move that would have made the drug ... - Hawaii Reporter,

BLOCKING ACCESS TO LIFE-SAVING DRUGS  Aug 31, 2005
Additionally, the statin drug Mevacor would benefit an additional 10 million Americans, if it was available over the counter. The ... - National Center for Policy Analysis,

Whooping cough booster in the works Ask Dr. H Mitchell Hecht  Sep 6, 2005
Res-Q LDL-X is a red yeast rice supplement that contains a natural form of the cholesterol-lowering statin Mevacor in small amounts. ... - Wilkes Barre Times-Leader,

Helpful tips for your everyday life  Aug 25, 2005
The emphasis in treatment is on statin drugs, including Crestor, Lipitor, Zocor, Mevacor and Pravachol, which lower LDL cholesterol and also may help "stabilize ... - USA Weekend

Drug prices for elderly surge ahead in America  Aug 16, 2005
...milligram pills. But there was no increase in the $1.18 wholesale price for several generic versions of Mevacor, an older statin. More ... - International Herald Tribune,

Teva Pharmaceutical to Acquire IVAX Corporation for 3.73 Times ...  Aug 11, 2005
Through its US subsidiary, Teva Pharmaceuticals USA, the company makes about 150 generic products, including equivalents for Prozac and Mevacor. ... - RedNova.com,

Science Journal: US science research may lose place on cutting ...  Aug 12, 2005
...in Belgium. The extract that formed the basis for the cholesterol-lowering drug Mevacor emerged from a lab in Spain. Americans don ... - Pittsburgh Post Gazette,

A Rare Steak a Day Keeps the Cardiologist Away  Aug 22, 2005
...a new level of expansion when the most recent and most successful round of cholesterol-lowering drugs—the statins, such as Lipitor, Mevacor, Zocor, Lescol ... - Lew Rockwell,

Senior Corner: Be ready to choose among drug plans  Aug 16, 2005
A few examples: Lisinopril (Zestril): lowers blood pressure; 100 tablets, 20 mg. Canada: $83.56, US: $31.39; Lovastatin (Mevacor): 100 tablets, 20 mg. ... - Santa Cruz Sentinel,

Omega-3 fatty acids better than statins in reducing death  Aug 11, 2005
There are currently 6 statins on the market: atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor ... - Health Sentinel

The Brains Behind Blockbusters  Jul 28, 2005
..."Too much computer and not enough brain," grumbles former Merck biochemist Alfred Alberts, who helped invent Mevacor, the first successful statin, as well as ... - Science Magazine (subscription)

Cholesterol-reducing statins may cause serious muscle damage in ...  Jul 13, 2005
The medications, which include Lipitor (atorvastatin), Zocor (simvastatin), Mevacor (lovastatin), Lescol and Lescol XL (fluvastatin), Pravachol (pravastatin ... - Canada.com

Health Canada Issues Advisory On Use of Statins  Jul 12, 2005
These medications include Lipitor (atorvastatin), Zocor (simvastatin), Mevacor (lovastatin), Lescol and Lescol XL (fluvastatin), Pravachol (pravastatin) and ... - Halifax Live

'Me-too' drugs can rake in sales  Jul 27, 2005
The first big cholesterol drug in this group was Merck's (up $0.43 to $31.12, Research) Mevacor, which has gone generic and is now known as lovastatin. ... - CNN

Health Insurers Urge Members to Go With Generic Drugs  Jul 27, 2005
Another cholesterol-lowering drug -- Mevacor -- already has a generic, lovastatin, but the drug is considered less potent than other cholesterol medications. ... - RedNova.com

Bristol Selling Rights to Excedrin, Other Products for $660M  Jul 14, 2005
A Food and Drug Administration panel voted in January against switching another cholesterol drug, Mevacor, seemingly dimming the prospects for Pravachol. ... - RedNova.com

Advisory - Health Canada advises consumers about important safety ...  Jul 12, 2005
These medications include Lipitor (atorvastatin), Zocor (simvastatin), Mevacor (lovastatin), Lescol and Lescol XL (fluvastatin), Pravachol (pravastatin) and ... - Canada NewsWire (press release)

Fish oil is better than flaxseed  Jul 7, 2005
These people often require two drugs, generally a statin drug (Lipitor, Mevacor, Zocor, Lescol, Pravachol, Crestor) combined with a triglycerides-lowering drug ... - SunHerald.com

Heart Health - Diet and Cholesterol-Lowering Drugs  Jul 12, 2005
...in a large prevention trial who died from coronary heart disease even though they were taking statin drugs (such as Lipitor, Lescol, Mevacor, Pravachol, Zocor ... - Bella Online

Study said to suggest Crestor is safe  Jul 21, 2005
...reported rate of muscle weakness cases was 2.4 per 10,000 years of patient use, compared to 2.6 for Zocor and Pravachol and 1.8 for Lipitor and Mevacor. - The News Journal


Other information


Indication
For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia; For primary prevention of coronary heart disease

Pharmacology
Lovastatin, an antilipemic agent produced by fermentation of Aspergillus terreus, is the first of a class of lipid-lowering agents known as the HMG-CoA reductase inhibitors. Lovastatin is used to treat hypercholesterolemia, to slow coronary atherosclerosis, and to prevent myocardial infarction and stroke. Lovastatin, like simvastin and unlike pravastatin, is a prodrug, concentrating active drug in the liver during first-pass circulation.

Mechanism Of Action
Lovastatin is a lactone that is readily hydrolyzed in vivo to the corresponding b-hydroxyacid, a potent inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate. The conversion of HMG-CoA to mevalonate is an early step in the biosynthetic pathway for cholesterol.

Drug Category
Antineoplastic Agents; Anticholesteremic Agents; HMG-CoA Reductase Inhibitors; ATC:C10AA02

Brand Names/Synonyms
6alpha-Methylcompactin; Altocor; Altoprev; Artein; Belvas; Cholestra; Closterol; Colevix; Compactin; HSDB 6534; Hipolip; Hipovastin; Lestatin; Lipdip; Lipivas; Lipofren; Lovalip; Lovalord; Lovastatin; Lovastatin [Usan:Ban:Inn]; Lovastatina [Spanish]; Lovastatine [French]; Lovastatinum [Latin]; Lovasterol; Lovastin; Lozutin; MK 803; MK-803; ML-530B; MSD 803; Mevacor; Mevastatin; Mevinacor; Mevinolin; Mevlor; Monacolin K; Nergadan; Paschol; Pravastatin; Rodatin; Rovacor; Sivlor; Taucor; Tecnolip; Teroltrat

Dosage Forms
Tablet

Absorption
30%

Interactions
DRUG INTERACTIONS CYP3A4 Interactions Lovastatin is metabolized by CYP3A4 but has no CYP3A4 inhibitory activity; therefore it is not expected to affect the plasma concentrations of other drugs metabolized by CYP3A4. Potent inhibitors of CYP3A4 (below) increase the risk of myopathy by reducing the elimination of lovastatin. Pharmacokinetics. Itraconazole Ketoconazole Erythromycin Clarithromycin Telithromycin HIV protease inhibitors Nefazodone Cyclosporine Large quantities of grapefruit juice (>1 quart daily) Interactions with lipid-lowering drugs that can cause myopathy when given alone. The risk of myopathy is also increased by the following lipid-lowering drugs that are not potent CYP3A4 inhibitors, but which can cause myopathy when given alone. See WARNINGS, Myopathy/Rhabdomyolysis. Gemfibrozil Other fibrates Niacin (nicotinic acid) (=1 g/day) Other drug interactions Danazol: The risk of myopathy/rhabdomyolysis is increased by concomitant administration of danazol particularly with higher doses of lovastatin (see WARNINGS, Myopathy/Rhabdomyolysis). Amiodarone or Verapamil: The risk of myopathy/rhabdomyolysis is increased when either amiodarone or verapamil is used concomitantly with a closely related member of the HMG-CoA reductase inhibitor class (see WARNINGS, Myopathy/Rhabdomyolysis). Coumarin Anticoagulants: In a small clinical trial in which lovastatin was administered to warfarin treated patients, no effect on prothrombin time was detected. However, another HMG-CoA reductase inhibitor has been found to produce a less than two-second increase in prothrombin time in healthy volunteers receiving low doses of warfarin. Also, bleeding and/or increased prothrombin time have been reported in a few patients taking coumarin anticoagulants concomitantly with lovastatin. It is recommended that in patients taking anticoagulants, prothrombin time be determined before starting lovastatin and frequently enough during early therapy to insure that no significant alteration of prothrombin time occurs. Once a stable prothrombin time has been documented, prothrombin times can be monitored at the intervals usually recommended for patients on coumarin anticoagulants. If the dose of lovastatin is changed, the same procedure should be repeated. Lovastatin therapy has not been associated with bleeding or with changes in prothrombin time in patients not taking anticoagulants. Propranolol: In normal volunteers, there was no clinically significant pharmacokinetic or pharmacodynamic interaction with concomitant administration of single doses of lovastatin and propranolol. Digoxin: In patients with hypercholesterolemia, concomitant administration of lovastatin and digoxin resulted in no effect on digoxin plasma concentrations. Oral Hypoglycemic Agents: In pharmacokinetic studies of MEVACOR in hypercholesterolemic noninsulin dependent diabetic patients, there was no drug interaction with glipizide or with chlorpropamide

Chemical IUPAC Name
[8-[2-(4-hydroxy-6-oxo-oxan-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate

Chemical Formula
C24H36O5

Half Life
5.3 hours

Drug Type
Approved Drug

# Accession No
APRD00370

CAS Registry Number
75330-75-5

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