Metoprolol: profile and news






Recruitment Temporarily Suspended In An International Phase III ...  Feb 20, 2006
...treatment of patients with metastatic carcinoma of the colon or rectum in combination with the chemotherapy regimens of intravenous 5-fluorouracil/folinic acid ... - Medical News Today (press release),

Chemotherapy and Radiation Therapy May Replace Surgery in Early ...  Mar 3, 2006
Patients had the earliest stages of esophageal cancer and were treated with the chemotherapy agents Platinol® (cisplatin) and 5-fluorouracil, as well as ... - Cancer Consultants (press release),

Single hit chemo guides therapy for larynx cancer  Feb 27, 2006
Ninety-seven patients with stage III and IV larynx cancer were given a single cycle of chemotherapy consisting of cisplatin on day 1 and fluorouracil for 5 days ... - Reuters

Chemotherapy Given Directly to Liver Improves Survival for ...  Feb 27, 2006
...research began in 1996, before chemotherapy drugs such as irinotecan and oxaliplatin were available, both sets of patients received fluorouracil and leucovorin ... - AScribe

Merck KGaA Receives EMEA Positive Opinion for Erbitux in Head and ...  Feb 23, 2006
In a phase 3 study of 442 patients, Erbitux combined with standard chemotherapy (either cisplatin plus 5-fluorouracil or carboplatin plus 5-fluorouracil) is ... - DG News

Pro-Pharmaceuticals to Present Abstract & Poster at Mass ...  Mar 2, 2006
..."The data indicates DAVANAT(R) exhibits broad spectrum enhancement of anti-tumor drugs, including 5-Fluorouracil (5-FU), Irinotecan, and AVASTIN(R) in human ... - Genetic Engineering News,

Oxaliplatin Safely Stopped with FOLFOX Regimen for Colorectal ...  Feb 21, 2006
NEW YORK FEB 20, 2006 (Reuters Health) - Treatment with oxaliplatin, a key component of the leucovorin/fluorouracil regimen (FOLFOX) used for metastatic ... - Cancerpage.com,

SKIN CANCER  Mar 2, 2006
...also avoid surgery. It is called fluorouracil and it is a type of chemotherapy that goes directly on the skin. Dr. Earl Stoddard ... - KPVI-TV,

Subcutaneous Amifostine Feasible During Radiotherapy for Head and ...  Mar 1, 2006
33 consecutive patients treated with accelerated concomitant-boost radiation therapy, 26 of whom also received cisplatin alone or cisplatin plus fluorouracil. ... - Cancerpage.com,

Patients Of UK's Second Biggest Killer To Gain Access To ...  Feb 28, 2006
Determination (FAD), which advocates the use of the potentially life-saving treatment Eloxatin (oxaliplatin) in combination with 5-fluorouracil (5FU) and ... - Medical News Today (press release),

Avastin May Cause Leukoencephalopathy Syndrome  Mar 2, 2006
...the case of a 52-year-old woman with hypertension and metastatic rectal adenocarcinoma who had three cycles of chemotherapy with fluorouracil, leucovorin and ... - Medscape (subscription)

Merck KGaA Receives EMEA Positive Opinion for Erbituxin Head and ...  Feb 23, 2006
In a Phase III study of 442 patients, Erbitux combined with standard chemotherapy (either cisplatin plus 5-fluorouracil or carboplatin plus 5-fluorouracil) is ... - PharmaLive.com (press release),

Visualization of Telomerase Reverse Transcriptase (hTERT) Promoter ...  Feb 14, 2006
...optical methods to measure changes in human telomerase reverse transcriptase (hTERT) gene expression in tumor cells before and after 5-fluorouracil treatment. ... - Journal of Nuclear Medicine

Patients Prefer Xeloda® to 5-Flurouracil in Treatment of ...  Feb 15, 2006
...recently published in the Annals of Oncology, patients with colorectal cancer prefer the chemotherapy agent Xeloda® (capecitabine) to 5-fluorouracil (5-FU) in ... - Cancer Consultants (press release),

Xeloda Shows Benefits as First Choice for Metastatic Breast Cancer ...  Feb 22, 2006
Similarly, first-line capecitabine compares favourably with cyclophosphamide/methotrexate/5-fluorouracil (CMF), with reported response rates of 30% (95% CI, 19 ... - DG News

Adjuvant Docetaxel More Effective Than Vinorelbine for Early ...  Feb 23, 2006
NEW YORK FEB 22, 2006 (Reuters Health) - Docetaxel is more effective than vinorelbine when administered prior to fluorouracil, epirubicin and cyclophosphamide ... - Cancerpage.com,

Mangafodipir appears to increase the cancer-killing ability of ...  Feb 20, 2006
...cells from 10 cancer patients and white blood cells from six control subjects to three chemotherapy drugs--paclitaxel, oxaliplatin, and 5-fluorouracil--in the ... - News-Medical.net,

Xaliproden Reduces Occurrence Of Severe Peripheral Sensory ...  Feb 23, 2006
The trial randomized 649 patients treated with the FOLFOX4 schedule (5-fluorouracil/leucovorin/oxaliplatin) for first-line metastatic colorectal cancer. ... - Medical News Today (press release),

Adjuvant Docetaxel or Vinorelbine with or without Trastuzumab for ...  Feb 22, 2006
...high-risk node-negative cancer to receive three cycles of docetaxel or vinorelbine, followed by (in both groups) three cycles of fluorouracil, epirubicin, and ... - New England Journal of Medicine (subscription),

Recurrence-Free Survival Improved with Taxotere® Compared to ...  Feb 23, 2006
Both groups were then treated with the chemotherapy agents 5-fluorouracil, epirubicin, and cyclophosphamide. Of these patients, 232 were HER2-positive. ... - Cancer Consultants (press release),

CoFactor™ (5,10-methylenetetrahydrofolate) May Enhance Activity ...  Feb 3, 2006
San Diego.[1]. 5-fluorouracil (5-FU) is a commonly used chemotherapy agent in the treatment of colorectal cancer. It is administered ... - Cancer Consultants (press release),

ADVENTRX CoFactor Phase IIb Trial Surpasses 50% Enrollment ...  Feb 14, 2006
...is a folate-based biomodulator being developed to enhance the activity and to reduce the toxicity of the widely used chemotherapy drug, 5-fluorouracil (5-FU). ... - PR Newswire (press release),

Roche Stops Recruiting Patients for Avastin Test (Update3)  Feb 13, 2006
FOLFOX 4 is a therapy that includes Eloxatin combined with two other medications called 5-Fluorouracil and leucovovin, both of which are made by generic ... - Bloomberg

Roche Stops Recruiting Patients for Avastin Study (Update7)  Feb 13, 2006
...used with FOLFOX-4. FOLFOX 4 is a chemotherapy regimen that includes Sanofi's Eloxatin combined with two other medications called 5-Fluorouracil and leucovovin ... - Bloomberg

Roche Stops Recruiting Patients for Avastin Study (Update8)  Feb 13, 2006
...drugs. The Folfox combination includes Sanofi's Eloxatin and with two other generic medications called 5-Fluorouracil and leucovovin. ... - Bloomberg

Common MRI Drug May Help Fight Cancer  Feb 14, 2006
The researchers studied the effects of three chemotherapy drugs -- paclitaxel, oxaliplatin and 5-fluorouracil -- on tumor cells and white blood cells from 10 ... - Forbes

Genentech/Roche: trial delay won't choke Avastin's growth  Feb 13, 2006
...who will be given adjuvant treatment following surgery as one of three regimens: the FOLFOX regimen (oxaliplatin, leucovorin and 5-fluorouracil), FOLFOX plus ... - Pharmaceutical Business Review

Study Sets Treatment Standard for Elderly With Colon Cancer  Feb 10, 2006
...establish the value against colorectal cancer of the chemotherapy regimen known as FOLFOX4, a combination of the standard anticancer drugs 5-fluorouracil (5-FU ... - DG News

Colon cancer chemotherapies OK for elderly  Feb 10, 2006
...value against colorectal cancer of the chemotherapy regimen known as FOLFOX4, a combination of the standard anti-cancer drugs 5-fluorouracil, leucovorin and ... - United Press International

Drugs Increase Chemotherapy's Cancer-Killing Abilities  Feb 14, 2006
...colleagues exposed tumor cells and white blood cells from cancer patients to three chemotherapy drugs -- paclitaxel, oxaliplatin, and 5-fluorouracil -- in the ... - Ivanhoe,

MRI Contrast Agent Enhances Chemotherapy's Cancer Killing  Feb 15, 2006
Cancer Institute. The drugs were Taxol (paclitaxel), Taxotere (docetaxel), Eloxatin (oxaliplatin), and 5-fluorouracil (5FU). In ... - MedPage Today,

Roche halts enrollment in Avastin trial  Feb 13, 2006
...oxaliplatin]) compared to those receiving a regimen of Avastin and the standard chemotherapy combination Folfox (oxaliplatin, 5-fluorouracil, leucovorin), or ... - Pharma Times (subscription),

ADVENTRX to Present at BIO CEO on February 14  Feb 3, 2006
...biomodulator drug being developed to enhance the activity and reduce associated toxicity of the widely used cancer chemotherapeutic agent 5-fluorouracil (5-FU ... - PR Newswire (press release),

Xaliproden May Reduce Side Effect Caused by Eloxatin® in ...  Feb 6, 2006
...included 749 patients with metastatic colorectal cancer who were being treated with the chemotherapy combination FOLFOX (5-fluorouracil, Eloxatin, leucovorin). ... - Cancer Consultants (press release),

CoFactor™ Plus 5-FU Provides Large Response in Metastatic ...  Feb 1, 2006
Cancers Symposium, the addition of CoFactor™ (ANX 510) appears to significantly enhance the activity of the chemotherapy agent 5-fluorouracil (5-FU) in the ... - Cancer Consultants (press release),

Xaliproden May Reduce Side Effect Caused by Eloxatin® in ...  Feb 2, 2006
...has spread to distant sites in the body) who were being treated with the chemotherapy combination referred to as FOLFOX (5-fluorouracil, Eloxatin, leucovorin). ... - Cancer Consultants (press release),

Meta-Analysis Indicates Improved Survival with Addition of ...  Feb 1, 2006
The chemotherapy combination cisplatin (Platinol®) plus 5-FU (fluorouracil) achieved the best results overall (however, this was not consistent in all trials ... - Cancer Consultants (press release),


Other information


Indication
For the treatment of hypertension and angina pectoris

Pharmacology
Metoprolol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA).

Mechanism Of Action
Like betaxolol and atenolol, metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.

Drug Category
Sympatholytics; Antihypertensive Agents; Antiarrhythmic Agents; Adrenergic Agents; ATC:C07AB02; ATC:C07AB52

Brand Names/Synonyms
Beloc; Betaloc; CGP 2175; H 93/26; H-23/96; LOPRESSOR HCT; Lopresor; Lopresoretic; Lopressor; Metoprolol; Metoprolol Tartrate; Metroprolol; Prelis; Selo-Zok; Seloken; Selopral; Toprol; Toprol-Xl

Dosage Forms
Tablets

Absorption
rapid and complete, 50%

Interactions
Interactions for Metoprolol:

Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with extended release metoprolol succinate plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension.



Chemical IUPAC Name
1-[4-(2-methoxyethyl)phenoxy]-3-(1-methylethylamino)propan-2-ol

Chemical Formula
C15H25NO3

Half Life
3-7 hours

Drug Type
Approved Drug

# Accession No
APRD00208

CAS Registry Number
37350-58-6

Home | About | Cancers | Treatment | Medications
Copyright onconews.org 2005.
All Rights Reserved.
Google
 
Web onconews.org