Methylprednisolone: profile and news

Methylprednisolone Reduces Pain, Emesis, and Fatigue After Breast ...  Feb 14, 2006
We compared methylprednisolone 125 mg IV (n = 68) and parecoxib 40 mg IV (n = 68) with placebo (n = 68) given before breast augmentation surgery in a randomized ... - Anesthesia & Analgesia (subscription),

Study: Steroid dose doesn't stop pain  Feb 15, 2006
Scientists at Brigham and Women's Hospital gave the treatment of the steroid methylprednisolone, which is supposed to reduce inflammation. ... - United Press International

Intravenous Steroids of Little Help in Acute Sciatica  Feb 15, 2006
One group of patients received a single IV dose of the steroid methylprednisolone. Patients in the other group were injected with an inactive placebo. ... - DG News

FDA Approves EMEND(R) (aprepitant), in Combination with Other ...  Jan 11, 2006
Methylprednisolone: EMEND, when given as a regimen of 125 mg on Day 1 and 80 mg/day on Days 2 and 3, increased the AUC of methylprednisolone, a CYP3A4 substrate ... - Business Wire (press release),

Epidural Won't Lessen Long-Term Shingles Pain  Jan 19, 2006
...received either standard therapy (oral antivirals and analgesics) or standard therapy with one additional injection of steroids (methylprednisolone) plus local ... - Forbes

Shingles, Epidural Injection Does Not Reduce Long-term Pain  Jan 22, 2006
...to standard therapy (oral antivirals and analgesics) or standard therapy with one additional epidural injection of steroids (methylprednisolone) and local ... - Medical News Today (press release),

Epidural Steroid Injection Not Useful for Chronic Shingles Pain  Jan 19, 2006
...standard therapy (oral antivirals and analgesics), and half received standard therapy plus an epidural injection of 80 mg of methylprednisolone acetate and 10 ... - MedPage Today,

Injection Doesn't end Shingles Pain  Jan 19, 2006
...patients to receive either standard treatment with the oral drugs or standard treatment plus a single injection of the steroid methylprednisolone and the local ... - Ivanhoe,

Modified reperfusion in clinical lung transplantation: The results ...  Jan 23, 2006
Methylprednisolone (7 mg/kg) was given to all recipients before surgery. Allograft implantation was performed according to a previously described technique. ... - The Journal of Thoracic and Cardiovascular Surgery

Joint Injections: A Good Idea?  12 Dec 2005
McIlwraith noted that the corticosteroid methylprednisolone acetate can adversely affect cartilage if it is used inappropriately, resulting in decreased ... - TheHorse.com,

Laurels and darts  Nov 17, 2005
...coming to Rutgers, Young directed a neuroscience research team at New York University that discovered the effectiveness of methylprednisolone in treating ... - Daily Targum (subscription),

Rash effected by stressful incident  Nov 8, 2005
My doctor said I had contacted photo-sensitivity, prescribed methylprednisolone (4 mg) and said there would be no need to return. ... - The Spokesman Review,

Iaquinta is axed in contract row  Sep 21, 2005
The Italian Olympic Committee, which is responsible for anti-doping tests in Serie A, said on Wednesday that Zanchi had tested positive for methylprednisolone. ... - CNN International

Zanchi fails doping test  Sep 21, 2005
The Italian Olympic Committee, which is responsible for anti-doping tests in Serie A, said on Wednesday that Zanchi had tested positive for methylprednisolone. ... - Special Broadcasting Service,

Disease Course of Rheumatoid Arthritis Becoming Milder  Sep 6, 2005
To give another example, only 47 injections of methylprednisolone were given among the 179 patients in the oldest cohort (about 26%), compared with 156 ... - MedPage Today,

Investigational Agent Bolsters Kidney Graft Survival and Function  Aug 25, 2005
...basiliximab, an anti-interleukin-2 receptor antibody, followed by adjunctive maintenance therapy with mycophenolate mofetil, methylprednisolone, and prednisone ... - MedPage Today,

Step-by-Step Plan for an Asthma Attack: New Report From Harvard ...  Aug 18, 2005
...attack, increasing your usual inhaled steroid isn't enough; you will also need to take prescription steroid tablets such as prednisone or methylprednisolone. ... - Yahoo News (press release)

Docs Predict Which Patients Will Respond to Plasma Exchange for MS  Aug 12, 2005
IV corticosteroids. 2 Corticosteroid treatment may involve doses of oral prednisone followed by IV methylprednisolone. While these ... - MS Neighborhood,

California Institute for Regenerative Medicine Press Release: ICOC ...  Aug 12, 2005
Dr. Young was part of the team that discovered and established high-dose methylprednisolone as the first effective therapy for spinal cord injuries. ... - Business Wire (press release),

Reflex Sympathetic Dystrophy  Aug 19, 2005
Steroid medications such as prednisone or methylprednisolone can provide good pain relief. Opioid pain medications such as morphine are also effective. ... - rarediseases.about.com

Seizures After a Bier Block with Clonidine and Lidocaine: Is ...  Aug 22, 2005
...al. Bier block with methylprednisolone and lidocaine in CRPS type I: a randomized, double-blinded, placebo-controlled study. Reg ... - Anesthesia & Analgesia (subscription),

Joint Disease  Aug 16, 2005
The three preparations favored at our clinic all have different duration of action and are used accordingly. "Methylprednisolone acetate (MA, a corticosteroid ... - TheHorse.com,

FAMILY DOCTOR: Damage to optic nerve is rarely reversible  Jul 27, 2005
Visual recovery may be accelerated by administering methylprednisolone intravenously, followed by oral prednisolone, but there can be side effects. ... - Canton Repository (subscription)

Travel-Associated Dengue Infections—United States, 2001-2004  Jul 26, 2005
8. Tassniyom S, Vasanawathana S, Chirawatkul A, Rojanasuphot S. Failure of high-dose methylprednisolone in established dengue shock syndrome: a placebo ... - Journal of American Medical Association (subscription)

Severe Protein Losing Enteropathy With Intractable Diarrhea Due to ...  Jul 14, 2005
...dl. Following methylprednisolone pulse therapy at 1000 mg/day for 3 days oral prednisolone was started at a dose of 60 mg/day. Although ... - RedNova.com

AAEP Convention 2004 Wrap-Up: Therapeutic Options  Jul 26, 2005
One study done at Colorado State confirmed that injecting the cortico-steroid methylprednisolone acetate (Depo-Medrol) into normal joints damaged. cartilage. ... - TheHorse.com

The effects of steroids on the occurrence of postoperative atrial ...  Jul 12, 2005
Forty-three patients received 1 g of methylprednisolone before surgery and 4 mg of dexamethasone every 6 hours for 1 day after surgery, and 43 patients ... - The Journal of Thoracic and Cardiovascular Surgery <**results**>

Neuroscientist/activist tackles current i  Jun 28, 2005
It found that high-doses of methylprednisolone, a steroid drug, saved about 20 percent of motor and sensory function when administered soon after a spinal cord ... - NorthJersey.com

Use of Rituximab in Two Unusual Antibody-Mediated Autoimmune ...  Jun 22, 2005
She responded to intravenous methylprednisolone (LSg) and cyclophosphamide (750 mg) but was then found to have a random blood glucose in the diabetic range ... - RedNova.com,

The pharmacokinetic interactions listed below are potentially clinically important. Mutual inhibition of metabolism occurs with concurrent use of cyclosporin and methylprednisolone; therefore, it is possible that adverse events associated with the individual use of either drug may be more apt to occur. convulsions have been reported with concurrent use of methylprednisolone and cyclosporin. Drugs that induce hepatic enzymes such as phenobarbital, phenytoin, and rifampin may increase the clearance of methylprednisolone and may require increased in methylprednisolone dose to achieve the desired response. Drugs such as troleandomycin and ketoconazole may inhibit the metabolism of methylprednisolone and thus decrease its clearance. Therefore, the dose of methylprednisolone should be titrated to avoid steroid toxicity.

Methylprednisolone may increase the clearance of chronic high dose aspirin. This could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when methylprednisolone is withdrawn. Aspirin should be used cautiously in conjunction with corticosteroids in patients suffering from hypoprothrombinemia.

The effect of methylprednisolone on oral anticoagulants is variable. There are reports of enhanced as well as diminished effects of anticoagulant when given concurrently with corticosteroids. Therefore, coagulation indices should be monitored to maintain the desired anticoagulant effect.