Methadose: profile and news

'Nosey' suspect arrested for drug Feb 16, 2006
The tissues were later found to be wrapped around tablets of Methadose, a brand of the drug methadone, which is illegal without a prescription. ... - Concord Monitor,

Probed continued into woman's death Feb 11, 2006
BETHLEHEM - Police confirmed a bottle of Methadose prescribed to Daniel Reilly's father, a Troy attorney, was found at the home of Jacqueline Horne, the 29-year ... - Troy Record,

Police and Fire Mar 2, 2006
He was also charged with possession of marijuana and possession of Methadose before being lodged in the Mackinac County Jail. SAULT STE. ... - Sault Ste. Marie Evening News,

Maine State Police blotter Feb 14, 2006
Eicher was arrested and charged with unlawful possession of schedule W drugs (Methadose, Kadian and heroin) and possession of hypodermic apparatuses. ... - VillageSoup Belfast,

Mercer grand jury indicts man on sexual abuse charges Feb 16, 2006
Roger Scott Coffman, 37, 1216 Paradise Camp Road, first-degree wanton endangerment, possession of methadose, drug paraphernalia and prescription medication not ... - Danville Advocate,

Preventing and Reducing Professional Liability Risk Related to ... Jan 12, 2006
...involving scheduled controlled substances include: 1) a patient death with allegations that the amount of methadone (Dolophine, Methadose) prescribed caused ... - Psychiatric Times,

Regional digest Dec 3, 2005
The woman allegedly told police she had refused to provide Mr. Magness a ride to Worcester so he could exchange his prescription Methadose for Vicodin, which ... - Worcester Telegram (subscription),

Bloomfield man faces charges Oct 6, 2005
According to the probable cause, the bottle contained a 10 mg Methadose pill and a chunk of off-white powder wrapped in a piece of pink paper. ... - Linton Daily Citizen,

Through the Times With Max Fink, MD Oct 3, 2005
...with opioids themselves. We studied heroin, narcotic antagonists and methadone [Dolophine, Methadose] in patients.". The federal ... - Psychiatric Times,

DISTRICT COURTS Sep 21, 2005
PERRON, Laura L., 20, Granby, submitted to facts sufficient to warrant a guilty finding on charges of possession of a class B drug (Methadose), possession of a ... - Daily Hampshire Gazette (subscription),

Across the area Aug 24, 2005
...the Aiken County Sheriff's Office and Aiken Public Safety executed a search warrant at 9:55 pm Monday and found Xanax, OxyContin, Methadose and hydrocodone in ... - Augusta Chronicle (subscription),

Knox Co. pharmacy fills boy's ritilin prescription with methadone Jul 11, 2005
Tammy called CVS again. "I told him on the bottle it said the general name for this ritilin on the bottle is methadose. He said wait a minute. ... - WATE.com <**results**>

Calais police arrest 14 in local drug operation Jun 24, 2005
...said. "I met with [the informant] at a prearranged location and [the informant] handed me the methadose [methadone in pill form]. ... - Bangor Daily News,

Alleged Drug Dealers Arrested for Murder of 21-y/o Clements Man Jun 1, 2005
No signs of trauma were noted. However, a number of Methadose pills were discovered inside his vehicle. Witnesses were also found ... - Southern Maryland Online,

Drugs targeted in Deal Island Mar 8, 2005
...police said. Officers arrested John Wesley Thompson, a Dames Quarter resident, on charges of possession of cocaine and methadose. The ... - Delmarva Daily Times,

Cuyahoga Falls --- Theft Feb 17, 2005
Police said he had two pill bottles in his possession; one labeled Methadose that contained two rocklike substances and the other pill bottle was someone ... - Akron Beacon Journal (subscription),

East Gulfport blocks clinic Feb 13, 2005
...severe psychological or physical dependence. It also is sold as Dolophine, Methadose and Amidone. A private company that planned ... - Biloxi Sun Herald,

Other information

Indication
For the treatment of dry cough, drug withdrawal syndrome, opioid type drug dependence,pain

Pharmacology
Methadone is a synthetic opioid analgesic with multiple actions quantitatively similar to those at morphine, the most prominent of which involve the central nervous system and organs composed of smooth muscle. However, Methadone is more active and more toxic than morphine. Methadone is indicated for relief of severe pain, for detoxification treatment of narcotic addiction, and for temporary maintenance treatment of narcotic addiction. The principal actions of therapeutic value are analgesia and sedation and detoxification or temporary maintenance in narcotic addiction. The Methadone abstinence syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, the course is more prolonged, and the symptoms are less severe.

Mechanism Of Action
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Methadone's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability. Methadone has a unique affinity for the NMDA brain receptor. It is believed that NMDA (N-methyl-D-aspartic acid) may regulate psychic dependence and tolerance by exhibiting opioid antagonist-like activity.

Drug Category
Narcotics; Antitussives; Analgesics; Opiate Agonists; ATC:N02AC52; ATC:N07BC02; ATC:R05DA06

Brand Names/Synonyms
Adanon; Adanon hydrochloride; Adolan; Algidon; Algolysin; Algovetin; Althose hydrochloride; Amidon; Amidone; Biscuits; Butalgin; CCRIS 3320; DL-Methadone hydrochloride; DRG-0023; Depridol; Diaminon; Diaminon hydrochloride; Dollies; Dolly; Dolofin hydrochloride; Dolohepton; Dolophin; Dolophin hydrochloride; Dolophine; Dolophine HCL; Fenadon; Fenadone; Heptadon; Heptadone; Heptanon; Ketalgin; Ketalgin hydrochloride; Mecodin; Medicine; Mephenon; Meth; Methadon; Methadone; Methadone HCL; Methadone HCL Intensol; Methadone M; Methadone hydrochloride; Methadone hydrochloride dl-; Methadose; Methaquaione; Miadone; Moheptan; Phenadone; Phenadone hydrochloride; Physeptone; Polamidon; Polamidone; Racemic methadone; Racemic methadone hydrochloride; Tussol:; Westadone; dl-Methadone; (+/-)-Methadone; (+/-)-Methadone hydrochloride; (+/-)-Tussal

Dosage Forms
TABLET

Absorption
Not Available

Interactions
Interactions for Methadone: Interaction with Pentazocine Patients who are addicted to heroin or who are on the methadone maintenance program may experience withdrawal symptoms when given pentazocine. Interaction with Rifampin The concurrent administration of rifampin may possibly reduce the blood concentration of methadone. The mechanism by which rifampin may decrease blood concentrations of methadone is not fully understood although enhanced microsomal drug-metabolized enzymes may influence drug disposition. Interaction with Monoamine Oxidase (MAO) Inhibitors Therapeutic doses of meperidine have precipitated severe reactions in patients concurrently receiving monoamine oxidase inhibitors or those who have received such agents within 14 days. Similar reactions thus far have not been reported with methadone; but if the use of methadone is necessary in such patients, a sensitivity test should be performed in which repeated small incremental doses are administered over the course of several hours while the patient's condition and vital signs are under careful observation. Interaction with Other Central-Nervous-Systern Depressants Methadone should be used with caution and in reduced dosage in patients who are concurrently receiving other narcotic analgesics, general anesthetics, phenothiazines, other tranquilizers, sedative-hypnotics, tricyclic antidepressants, and other CNS depressants (including alcohol). Respiratory depression, hypotension, and profound sedation or coma may result.

Chemical IUPAC Name
6-dimethylamino-4,4-diphenyl-heptan-3-one

Chemical Formula
C21H27NO

Half Life
24-36 hrs.

Drug Type
Approved Drug

# Accession No
APRD00485

CAS Registry Number
76-99-3