Metadate: profile and news

Replidyne and Forest Laboratories Announce FDA Acceptance for ...  Feb 23, 2006
...an angiotensin receptor blocker indicated for the treatment of hypertension; Benicar* HCT(R) (olmesartan medoxomil hydrochlorothiazide), an angiotensin ... - Finanzen.net,

Myocarditis During Clozapine Treatment  Feb 14, 2006
A number of other drugs, including the sulfonamides, hydrochlorothiazide, the penicillins, and methyldopa, have also been associated with hypersensitivity or ... - Am J Psychiatry (subscription)

Jaundice in a Traveler Returning From India  Feb 17, 2006
...stable type 2 diabetes mellitus, hypertension, and hyperlipidemia for which he has taken metformin, glimepiride, pravastatin, and hydrochlorothiazide for many ... - Medscape (subscription)

Clinical Trials Update: Feb. 13, 2006  Feb 13, 2006
...is conducting a clinical research study to find out if the study drug valsartan plus hydrochlorothiazide (Diovan HCT) is safe and effective for patients who ... - Forbes

Merck profits edge ahead in fourth quarter  Feb 1, 2006
Merck's blood pressure treatment range, headed by Cozaar (losartan) and Hyzaar (losartan and hydrochlorothiazide), advanced 2% to $782 million in the fourth ... - Pharma Times (subscription),

Tennis: No dope when it comes to doping  Jan 31, 2006
Canas was suspended last summer for two years for the prohibitive diuretic hydrochlorothiazide (HCT), while Karatantcheva, 15 years old at the time of the ... - ESPN

Merck profits edge ahead in fourth quarter  Feb 1, 2006
Merck's blood pressure treatment range, headed by Cozaar (losartan) and Hyzaar (losartan and hydrochlorothiazide), advanced 2% to $782 million in the fourth ... - Pharma Times (subscription),

(PZ) Novartis Delivers Strong Performance with Record Results in ...  Jan 18, 2006
This compound has shown powerful additional blood pressure lowering effects when combined with hydrochlorothiazide (diuretic), ramipril (ACE inhibitor) or ... - Houston Chronicle,

Forest Laboratories, Inc. Reports Q3'06 Diluted Earnings Per Share ...  Jan 17, 2006
...an angiotensin receptor blocker indicated for the treatment of hypertension; Benicar* HCT(R) (olmesartan medoxomil hydrochlorothiazide), an angiotensin ... - MSN Money

Treatments for excess parathyroid hormone  Jan 17, 2006
...of patients these days - it is important to drink sufficient fluid daily to prevent dehydration; to avoid medications such as hydrochlorothiazide or lithium ... - Newsday,

Patients, generics get a win  Jan 19, 2006
...have on the new drug application AstraZeneca filed for a drug to control hypertension made up of a combination of Toprol-XL and the diuretic hydrochlorothiazide ... - The News Journal,

Novartis' Rasilez faces barriers to entry  Jan 19, 2006
..."This compound has shown powerful additional blood pressure lowering effects when combined with hydrochlorothiazide (diuretic), ramipril (ACE inhibitor) or ... - United Press International

Murder defendant indicted on new charge  Jan 11, 2006
...on five other counts for possessing the controlled substances of Oxycodone and Acetaminophen, Alprazolam, Penicillin, Hydrochlorothiazide, and Metaxalone ... - Clarke Times Courier,

Loss of taste, smell often tied to high blood pressure, meds  Jan 24, 2006
Types of high blood pressure medications commonly reported to cause taste loss include diuretics (water pills) such as hydrochlorothiazide, and ACE inhibitors ... - Charlotte Observer,

Novartis New Phase III Data With SPP100 (aliskiren, Rasilez) ...  Jan 19, 2006
...and 2002 investigated the safety and efficacy of SPP100 in co-administration with the ACE-inhibitor (ramipril), the diuretic (hydrochlorothiazide - HCTZ) and ... - Biotech Intelligence (press release),

A drug dose model for predicting clinical outcomes in hypertensive ...  Nov 10, 2005
...patients with coronary artery disease to sustained-release verapamil or to atenolol as initial agents, followed by trandolapril or hydrochlorothiazide. ... - HeartZine,

Gedeon Richter and Forest Laboratories Expand Relationship with ...  Nov 28, 2005
...an angiotensin receptor blocker indicated for the treatment of hypertension; Benicar* HCT® (olmesartan medoxomil hydrochlorothiazide), an angiotensin receptor ... - Yahoo! News (press release)

Choosing Mom's new drug benefit gave me a headache  Nov 17, 2005
It's a common generic that many people take, but it's not there. Calling the druggist, we enter its full name hydrochlorothiazide. ... - Boston Globe,

Increased Serum Creatinine More Likely when Nesiritide is Combined ...  Nov 16, 2005
...greater, bumetanide 4 mg or greater, torsemide 80 mg or greater, metolazone 10 mg or greater, chlorothiazide 1000 mg or greater, and hydrochlorothiazide 50 mg ... - DG News

Drugs in Developement  Nov 15, 2005
...two Phase III clinical trials showed strong efficacy as a once-daily oral treatment, as a monotherapy, and in combination with the diuretic hydrochlorothiazide ... - R&D Directions (subscription),

AstraZeneca Provides Additional Support to Hurricane Victims  Nov 17, 2005
...zafirlukast), ARIMIDEX® (anastrozole), ATACAND® (candesartan cilexetil), ATACAND HCT® (candesartan cilexetil-hydrochlorothiazide), CASODEX® (bicalutamide ... - Yahoo! News (press release)

AstraZeneca Provides Additional Support to Hurricane Victims  Nov 17, 2005
ACCOLATE(R) (zafirlukast), ARIMIDEX(R) (anastrozole), ATACAND(R) (candesartan cilexetil), ATACAND HCT(R) (candesartan cilexetil-hydrochlorothiazide), CASODEX(R ... - PR Newswire (press release),

Aging just one cause for loss of taste  Nov 21, 2005
Types of high blood pressure medications commonly reported to cause taste loss include diuretics (water pills) such as hydrochlorothiazide, and ACE inhibitors ... - Charleston Post Courier (subscription),

HISD board pumps up drug policy  Oct 10, 2005
Two diuretics – amiloride and hydrochlorothiazide – are known as water pills used to stimulate the kidneys to produce more urine. ... - News Journal,

Seerat Aziz, MD , Peter W. Callen, MD , Flavio Vincenti, MD and ...  Sep 29, 2005
The nephrology service recommended pyridoxine, hydrochlorothiazide, magnesium, and phosphorous supplementation along with hydration to cause 2 to 3 L of urine ... - Journal of Ultrasound in Medicine

Novartis Phase III Data With SPP100 (Aliskiren) Demonstrates ...  Sep 20, 2005
...results in hypertension released today by Novartis on SPP100 (Aliskiren) as a monotherapy and in co-administration with the diuretic hydrochlorothiazide (HCTZ ... - PR Newswire (press release),

Ranbaxy Receives Final Approval To Market Benazepril Hydrochloride ...  Sep 9, 2005
...that RLL has received approval from the US Food and Drug Administration to manufacture and market Benazepril Hydrochloride and Hydrochlorothiazide Tablets, 5 mg ... - PR Newswire (press release),

Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce ...  Sep 28, 2005
...an angiotensin receptor blocker indicated for the treatment of hypertension; Benicar HCT®(olmesartan medoxomil hydrochlorothiazide), an angiotensin receptor ... - Yahoo! News (press release)

Conflicting diagnoses leave reader confused  Oct 3, 2005
...demonstrable pattern. I have a pacemaker and a defibrillator, take OxyContin, Ambien, Synthroid and hydrochlorothiazide. I have ... - Monterey County Herald,

Hypertension Drug Combination Yields High Rate of Blood Pressure ...  Sep 19, 2005
...remaining 736 people were given the combination pill of irbesartan (an angiotensin II receptor blocker) and a diuretic, hydrochlorothiazide, in increasingly ... - eMaxHealth.com,

Protecting the heart  Sep 29, 2005
Do start with a diuretic in most cases. People with high blood pressure should usually start drug therapy with a diuretic, such as hydrochlorothiazide. ... - St. Paul Asian American Press,

Argentines unfairly singled out over doping, says Coria  Sep 13, 2005
Canas received a two-year suspension after being found guilty of using the prohibited diuretic hydrochlorothiazide (HCT) in Acapulco this year. ... - Reuters.uk,

Molik fights back  Sep 14, 2005
...nandrolone. Canas received a two-year suspension after being found guilty of using the prohibited diuretic hydrochlorothiazide. ... - Melbourne Herald Sun,

Canas is no criminal, says angry Coria  Sep 17, 2005
...recent years. The 27-year-old Canas tested positive for the prohibited diuretic hydrochlorothiazide (HCT) in Acapulco this year. He ... - Reuters.uk,

Novartis Presents Positive Phase III Data on Key Compounds and ...  Sep 19, 2005
III clinical trials showed strong efficacy as a once-daily oral treatment, both as a monotherapy and in combination with the diuretic hydrochlorothiazide (HCTZ ... - PrimeZone (press release),

International Paralympic Committee  Sep 21, 2005
Russian Shooter Victor Stepanov returned an adverse analytical finding in respect of two substances (Propranolol and Hydrochlorothiazide) included in the ... - SFCPressPoint (press release),

Many meds don't mix with the sun  Sep 21, 2005
Q. The prescription bottle containing my fluid pills (hydrochlorothiazide) has a sticker attached that says to avoid prolonged sun exposure. Why? ... - Pioneer Press,

Ritalin may decrease the hypotensive effect of guanethidine. Use cautiously with pressor agents.

Human pharmacologic studies have shown that Ritalin may inhibit the metabolism of coumarin anticoagulants, anticonvulsants (phenobarbital, diphenylhydantoin, primidone), phenylbutazone, and tricyclic drugs (imipramine, clomipramine, desipramine). Downward dosage adjustments of these drugs may be required when given concomitantly with Ritalin.

Serious adverse events have been reported in concomitant use with clonidine, although no causality for the combination has been established. The safety of using methylphenidate in combination with clonidine or other centrally acting alpha-2 agonists has not been systemically evaluated.

 


Chemical IUPAC Name
methyl2-phenyl-2-(2-piperidyl)ethanoate

Chemical Formula
C14H19NO2

Half Life
2.4 hours in children and 2.1 hours in adults

Drug Type
Approved Drug

# Accession No
APRD00657

CAS Registry Number
113-45-1