Meperidine: profile and news

ASK THE DOCTOR: Side effects from codeine just that, not allergic ... Feb 28, 2006
...tolerate it well. Itching, hives and flushing are common, especially with codeine, morphine and meperidine (Demerol). These symptoms ... - The Patriot Ledger,

Ex-dentist indicted in plot to sell body parts Feb 23, 2006
New Jersey dental board records, Mastromarino surrendered his dental license in November 2000 after he tested positive for cocaine and the narcotic meperidine. ... - NorthJersey.com,

Pain Medicine Scientific Research Highlights Feb 26, 2006
...blood concentrations have been reported for each of the following opioids: methadone, morphine, oxycodone, hydromorphone, hydrocodone, fentanyl, and meperidine ... - Medical News Today (press release),

Cadaver probe centers on ex-doc Jan 29, 2006
According to state dental board records, Mastromarino tested positive for cocaine and the narcotic meperidine, and was arrested for possessing Demerol, a ... - NorthJersey.com,

Heroin may be new menace, but its source is not Jan 28, 2006
A related group of synthetic opiates includes meperidine (known as Demerol), propoxyphene (known as Darvon), and pentazocine (known as Talwin). ... - New Philadelphia Times Reporter,

Extravasation Injury Caused by Propofol Jan 29, 2006
Anesthesia was induced with cleofol 10 mL (premixed with lidocaine) after administration of meperidine 50 mg, and anesthesia was maintained with nitrous oxide ... - Anesthesia & Analgesia (subscription),

New "walking epidural" technique developed at UW Medical Center Nov 30, 2005
Recently, anesthesiologists at University of Washington Medical Center have refined the "walking epidural" technique by using meperidine (Demerol), thus ... - uwnews.org,

Remifentanil for Labor Pain: Is the Drug or the Method the Problem ... Sep 30, 2005
...conclusions. The study was intended to evaluate and compare systemic remifentanil versus meperidine for analgesia during labor. ... - Anesthesia & Analgesia (subscription),

Remifentanil for Labor Pain: Is the Drug or the Method the Problem ... Sep 30, 2005
A higher satisfaction rate in the remifentanil group as compared to meperidine may be the result of our ability to increase the remifentanil dosage up to the ... - Anesthesia & Analgesia (subscription),

Serving the public good Sep 25, 2005
...is sometimes used for the treatment of patients addicted to or depended on heroin or prescription pain medications, such as oxycodone, hydrocodone or meperidine ... - Palladium-Item,

Parkinson's Disease Data From the Aeolus Pharmaceuticals Pipeline ... Sep 20, 2005
4-phenyl-1, 2, 3, 6-tetrahydropyridine, or "MPTP," has been identified in underground laboratory preparations of a potent analog of meperidine (Demerol(TM)). ... - PR Newswire (press release),

The Medical Minute: Pain - the fifth vital sign Aug 31, 2005
...chronic pain. Available narcotics include codeine, hydrocodone, oxycodone, meperidine, morphine, hydromorphone and fentanyl. Several ... - Penn State Live,

Police briefs Aug 24, 2005
He was charged with one count each of illegally obtaining morphine sulphate, meperidine, hydromorphone and fentanyl, all of which are controlled substances. ... - Topeka Capital Journal (subscription),

Methods of Detoxification and Their Role in Treating Patients With ... Aug 23, 2005
...addition, the recent trend of increasing abuse of prescription opioids including oxycodone, propoxyphene, hydrocodone, hydromorphone, and meperidine has been a ... - Journal of American Medical Association (subscription),

Doctor practicing at CRMC under state review Aug 17, 2005
...a patient and her husband indicate that Fortkort prescribed them 11,546 dosage units of schedule II narcotics, namely oxycodone and meperidine; 12,100 units of ... - Shelby Star,

NIDA Responds to Escalating Prescription Drug Abuse Aug 15, 2005
...buprenorphine [Subutex or Suboxone when combined with naloxone] that has much less potent effects than heroin, morphine or Demerol [meperidine]," said Volkow. ... - Psychiatric Times,

Limitations of rapid tranquillisation trial Aug 1, 2005
Petrack, EM, Marx, CM & Wright, MS (1996) Intramuscular ketamine is superior to meperidine, promethazine, and chlorpromazine for paediatric emergency ... - British Journal of Psychiatry (Subscription)

Doctor faces sex, narcotics charges Jul 23, 2005
...a patient and her husband indicate that Fortkort prescribed them 11,546 dosage units of Schedule II narcotics, namely oxycodone and meperidine; 12,100 units of ... - Shelby Star

Tramadol Abuse and Dependence Among Physicians—Reply Apr 26, 2005
2109 for tramadol (alone). It also shows 378 for codeine and 327 for meperidine, other popular opioids in our study. For this and ... - Journal of American Medical Association (subscription)

Pharmacist Charged With Murder In Woman's Overdose Death Apr 15, 2005
2, 2002 until April 28, 2002. The drugs included Hydromorphone, Endocet, Oxycontin, Meperidine and Diazepem, investigators said. ... - Channel Oklahoma.com

Factors Linked to Substance Use Disorder Relapse Among Health Care ... Mar 28, 2005
The use of a major opioid ( eg, fentanyl, sufentanil, morphine, meperidine ) increased the risk of relapse significantly in the presence of a coexisting ... - I-Newswire.com

Why Health Professionals Suffer Drug Relapse Mar 27, 2005
Those who had a psychiatric disorder and used a major opioid such as fentanyl, morphine, sufentanil or meperidine, had nearly a six-times greater risk of ... - Ivanhoe

Inappropriate medication prescribed to elderly Mar 8, 2005
...cited as ''Always avoid'' are: barbiturates, belladonna alkaloids, chlorpropamide, dicyclomine, flurazepam, hyoscyamine, meperidine, meprobamate, pentazocine ... - Helena Independent Record,

DRIVER IN FATAL WRECK HAD DRUGS Mar 3, 2005
...device containing burnt residue, a hypodermic needle, a teaspoon with white residue, a prescription bottle of 100 milligrams of meperidine, a prescription ... - Albuquerque Journal (subscription),

Other information

Indication
Used to control moderate to severe pain.

Pharmacology
Meperidine is a synthetic opiate agonist belonging to the phenylpiperidine class. Meperidine may produce less smooth muscle spasm, constipation, and depression of the cough reflex than equivalent doses of morphine. The onset of action is lightly more rapid than with morphine, and the duration of action is slightly shorter. The chemical structure of Meperidine is similar to local anesthetics. Meperidine is recommended for relief of moderate to severe acute pain and has the unique ability to interrupt postoperative shivering and shaking chills induced by amphotericin B. Meperidine has also been used for intravenous regional anesthesia, peripheral nerve blocks and intraarticular, epidural and spinal analgesia. Meperidine is considered a second-line agent for the treatment of acute pain.

Mechanism Of Action
Meperidine is primarily a kappa-opiate receptor agonist and also has local anesthetic effects. Meperidine has more affinity for the kappa-receptor than morphine. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Meperidine's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

Drug Category
Narcotics; Adjuvants; Analgesics; Opiate Agonists; ATC:N02AB

Brand Names/Synonyms
Centralgin; Demarol; Demerol; Dispadol; Dolantin; Dolcontral; Dolosal; Dolsin; HSDB 3116; Isonipecaine; Lidol; Lydol; Meperidine; Meperidine Hcl; Meperidine Hcl Preservative Free; Meperidol; Methyl Phenylpiperidine Carbonic Acid Ethyl Ester; Nemerol; Operidine; Petantin; Pethanol; Pethidin; Pethidine; Pethidineter; Petydyna; Phetidine; Piperosal; Pipersal; Piridosal

Dosage Forms
SYRUP,TABLET

Absorption
Oral bioavailability is 50-60% in patients with normal hepatic function.

Interactions
Interactions for Meperidine:

Interaction with Other Central Nervous System Depressants: MEPERIDINE SHOULD BE USED WITH GREAT CAUTION AND IN REDUCED DOSAGE IN PATIENTS WHO ARE CONCURRENTLY RECEIVING OTHER NARCOTIC ANALGESICS, GENERAL ANESTHETICS, PHENOTHIAZINES, OTHER TRANQUILIZERS, SEDATIVE-HYPNOTICS (INCLUDING BARBITURATES), TRICYCLIC ANTIDEPRESSANTS AND OTHER CNS DEPRESSANTS (INCLUDING ALCOHOL). RESPIRATORY DEPRESSION, HYPOTENSION, AND PROFOUND SEDATION OR COMA MAY RESULT.

Chemical IUPAC Name
ethyl1-methyl-4-phenyl-piperidine-4-carboxylate

Chemical Formula
C15H21NO2

Half Life
3-5 hours

Drug Type
Approved Drug

# Accession No
APRD00074

CAS Registry Number
57-42-1