Medroxyprogesterone: profile and news

Regulation of Monocyte Chemoattractant Protein-1 Expression by ...  Feb 8, 2006
Confluent decidual cells were primed for 7 days in either estradiol or estradiol plus medroxyprogesterone acetate to mimic the decidualizing steroidal milieu ... - Am J Pathology (subscription)

PRODUCT MARKETING NEWS  Feb 21, 2006
...women (50 to 79 years of age) during 5 years of treatment with oral conjugated equine estrogens (CEE 0.625 mg) combined with medroxyprogesterone acetate (MPA ... - PharmaLive.com (press release),

New Data from Women's Health Initiative Study Show No Increased ...  Feb 13, 2006
...selected long-term risks and benefits of PREMARIN(R) (conjugated estrogens tablets, USP) and PREMPROTM (conjugated estrogens/medroxyprogesterone acetate tablets ... - Boursorama,

Women's Health Initiative Study Data Show No Increased Risk of ...  Feb 14, 2006
...long-term risks and benefits of Premarin(R) (conjugated estrogens tablets, USP) and Prempro(TM) (conjugated estrogens/medroxyprogesterone acetate tablets). ... - DG News

Transvaginal Sonography of Hematotrachelos and Hematometra Causing ...  Feb 9, 2006
After this delivery she received repeated 400-mg/mL intramuscular injections of medroxyprogesterone acetate (Depo-Provera; Pharmacia & Upjohn, Kalamazoo, MI ... - Journal of Ultrasound in Medicine

FDA Sends Duramed Warning Letter Over Cenestin Ad  Jan 18, 2006
...women (50 to 79 years of age) during 5 years of treatment with oral conjugated equine estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA ... - PharmaLive.com (press release),

Depot contraceptives boost weight in obese teens  Jan 20, 2006
NEW YORK (Reuters Health) - Obese adolescent girls are more likely to gain weight while using depot medroxyprogesterone contraceptives than those using oral ... - Reuters

Depot contraceptives boost obese teens  Jan 22, 2006
Obese adolescent girls are more likely to gain weight while using depot medroxyprogesterone contraceptives than those using oral contraceptives or no hormonal ... - The Age,

Some dangerous drugs get by FDA  Jan 29, 2006
Reports' dirty dozen are: celecoxib (Celebrex), estrogen (when taken alone), isotretinoin (Accutane), malathion (Ovide), medroxyprogesterone injections (Depo ... - Sarasota Herald-Tribune,

The North American Menopause Society Highlights from Jan/Feb  Jan 12, 2006
Medroxyprogesterone acetate inhibits the cardioprotective effect of estrogen in experimental ischemia-reperfusion injury Helen L. Jeanes, BSc, Payong Wanikiat ... - PharmaLive.com (press release),

Forkhead Transcription Factor FOXO1A is Critical for Induction of ...  Jan 30, 2006
Human decidual fibroblast cells were decidualized in vitro for 6 days with medroxyprogesterone, estradiol and dibutyryl cAMP in the presence or absence of a ... - Journal of Endocrinology

Obese Girls Using Depo Provera More Likely To Gain Weight, Study ...  Jan 24, 2006
Obese girls using depot medroxyprogesterone contraceptives, sold as Depo Provera, are more likely to gain weight than nonobese girls using oral contraceptives ... - Kaiser network.org,

Consumer Reports Medical Guide & Consumer Reports: Prescription ...  Dec 5, 2005
...and others) to treat symptoms of menopause; Isotretinoin (Accutane) for severe acne; Malathion (Ovide) for head lice; Medroxyprogesterone injections (Depo ... - U.S. Newswire (press release),

Dr. Bill Elliott: Hormone therapy may be best way to ease hot ...  Nov 21, 2005
All the women in WHI were on a product known as Prempro, a combination of conjugated estrogen and medroxyprogesterone. Many physicians ... - Marin Independent-Journal,

Unopposed Conjugated Equine Estrogens Don't Prevent Peripheral ...  Nov 14, 2005
..."In two trials of conjugated estrogens combined with daily medroxyprogesterone acetate, no effect on clinical peripheral artery disease was identified in ... - DG News

Menopause Society Postmenopausal Hormone Therapy and Breast Cancer ...  Nov 17, 2005
Treatment for climacteric symptoms with 0.625 mg of conjugated equine estrogens daily and 10 mg of medroxyprogesterone acetate for 14 days every third month ... - PharmaLive.com (press release),

Mechanisms of Abruption-Induced Premature Rupture of the Fetal ...  Nov 8, 2005
...interleukin-8 (IL-8) was evaluated in leukocyte-free term decidual cells incubated with estradiol (E 2 ; control) or with E 2 + medroxyprogesterone acetate (to ... - Am J Pathology (subscription)

Teva Reports Third Quarter 2005 Results  Nov 8, 2005
...of 2004. This quarter included the successful US generic launch of Fexofenadine, as well as Medroxyprogesterone PFS. Higher sales ... - Genetic Engineering News,

FDA Approves ANGELIQ(R) to Treat Menopausal Moderate to Severe ...  Oct 2, 2005
...women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg ... - Medical News Today (press release),

FDA Safety Labeling Changes: Camptosar, Keppra, Prempro/Premphase  Sep 21, 2005
...may cause somnolence, fatigue, and behavioral abnormalities in pediatric patients; and use of conjugated estrogens plus medroxyprogesterone acetate tablets is ... - Medscape (subscription)

Estrogen Therapy May Not Increase Breast Cancer Recurrence  Sep 20, 2005
Participants received either postmenopausal hormone therapy (HT; estradiol valerate with or without medroxyprogesterone acetate) or no hormone therapy. ... - PharmaLive.com (press release),

Water In White House Press Room Contaminated!  Sep 13, 2005
Unconfirmed Sources report medroxyprogesterone - the drug used for chemical castration has been found in the White House Press Room water supply. ... - Unconfirmed Sources (satire)

FDA Safety Labeling Changes: Emtriva, FazaClo, Climara/Climara Pro  Sep 14, 2005
Data from the conjugated estrogens/medroxyprogesterone acetate substudy of the WHI showed relative risks of 1.29 for coronary heart disease (95% confidence ... - Medscape (subscription)

THROMBOSIS SECONDARY TO MEDROXYPROGESTERONE IN PATIENT AT RISK FOR ...  Aug 31, 2005
OBJECTIVE: To report a case in which a young woman receiving medroxyprogesterone acetate injections developed deep vein thrombosis (DVT) after prolonged travel ... - The Journal of Pharmacy Technology

FDA Safety Labeling Changes: Activella, Duramorph PF, Nutropin  Sep 7, 2005
Results of the CE/medroxyprogesterone acetate (MPA) substudy of the WHI also revealed an increased risk of breast cancer that increased with duration of use ... - Medscape (subscription)

Castration not an answer for sex offenders  Sep 2, 2005
The drug specified — medroxyprogesterone, a synthetic form of the female hormone progesterone marketed as Depo-Provera — has not been approved for ... - Palm Beach Post,

Women Report Various Symptoms After Stopping Menopause Hormone ...  Aug 25, 2005
WHI) estrogen plus progestin (E + P) trial findings that the overall health risks of taking conjugated equine estrogens and medroxyprogesterone acetate for ... - eMaxHealth.com,

Recurrent Vasomotor Symptoms Common for EPT Users in WHI After ...  Aug 24, 2005
...the study pills, either placebo or estrogen plus progestin therapy (0.625 mg/day conjugated equine estrogens plus 2.5 mg/day medroxyprogesterone acetate), when ... - PharmaLive.com (press release),

FDA Safety Labeling Changes: Arixtra and Alora  Aug 10, 2005
...of the placebo-controlled Women's Health Initiative (WHI) memory substudy, showing treatment with conjugated estrogens plus medroxyprogesterone acetate (CE/MPA ... - Medscape (subscription)

Menopausal hormone therapy, women report various symptoms after ...  Aug 4, 2005
WHI ) estrogen plus progestin ( E + P ) trial findings that the overall health risks of taking conjugated equine Estrogens and Medroxyprogesterone for disease ... - Xagena.it

Chemical castration ruled out for Fort Pierce man found guilty in ...  Aug 3, 2005
The shots of medroxyprogesterone acetate are designed to suppress sexual urges and if freed inmates miss treatments, they are guilty of a felony. ... - Fort Pierce Tribune (subscription)

Isopak announces spiral jet mill results  Aug 1, 2005
Drugs such as amphotericin, fluocinolone acetonide, medroxyprogesterone acetate, bishydroxycoumarin, nitrofurantoin, tolbutamide, and spironolactone have shown ... - in-PharmaTechnologist

Women Report Various Symptoms After Stopping Hormone Therapy  Jul 12, 2005
WHI) estrogen plus progestin (E + P) trial findings that the overall health risks of taking conjugated equine estrogens and medroxyprogesterone acetate for ... - Newswise (press release)

The Cochrane Library newsletter, 2005, issue 3  Jul 19, 2005
The Cochrane Review Authors found that injectable contraceptives that include medroxyprogesterone acetate (DMPA) and estradiol cypionate (E2C) were better ... - EurekAlert

Stopping menopausal therapy revives symptoms in women  Jul 13, 2005
It surveyed 8,405 women at 40 clinical centers who were still taking study pills (conjugated equine estrogens and medroxyprogesterone [CEE + MPA] or placebo ... - NewKerala.com

Women Experience Symptoms After Stopping Hormone Therapy  Jul 12, 2005
Initiative estrogen plus progestin (WHI E + P) trial found the overall health risks of taking conjugated equine estrogens and medroxyprogesterone acetate (CEE ... - Ivanhoe

This Week in JAMA  Jul 12, 2005
8405 women (89.9% of those eligible) who were still taking their study medication (combined conjugated equine estrogens plus medroxyprogesterone acetate [CEE ... - Journal of American Medical Association (subscription)

Partner Violence, Memory and Lung Cancer - Women's Health Research ...  Jul 9, 2005
She will determine whether the effects of estrogen, progesterone and medroxyprogesterone acetate on memory and hippocampal function are influenced by the way ... - I-Newswire.com (press release)

Note to Tom Cruise: It's My Hormones, Stupid!  Jul 9, 2005
...of cancer or heart disease focused only on one type of hormone product (conjugated equine estrogens and the synthetic progestin medroxyprogesterone acetate, or ... - PR Web (press release)

Woman sues companies over cancer  Jul 14, 2005
Barbara Graham began taking the hormone therapy drugs Premarin, Prempro and Medroxyprogesterone Acetate (MPA) in the mid-1990s to treat menopausal symptoms. ... - The Auburn Plainsman Online

Lack of grooming can signal health problem  Jul 16, 2005
...been used. A long acting synthetic progestin such as medroxyprogesterone or megestrol acetate have been used to good effect. These ... - Roanoke Times

No drug-drug interaction studies have been conducted with depo-subQ provera 104.

Aminoglutethimide administered concomitantly with depo-subQ provera 104 may significantly decrease the serum concentrations of MPA.

Laboratory Tests

The pathologist should be advised of progestin therapy when relevant specimens are submitted. The physician should be informed that certain endocrine and liver function tests, and blood components may be affected by progestin therapy:

(a) Plasma and urinary steroid levels are decreased (e.g., progesterone, estradiol, pregnanediol, testosterone, cortisol).

(b) Plasma and urinary gonadotropin levels are decreased (e.g., LH, FSH).

(c) SHBG concentrations are decreased.

(d) T₃-uptake values may decrease.

(e) There may be small changes in coagulation factors.

(f) Sulfobromophthalein and other liver function test values may be increased slightly.

(g) There may be small changes in lipid profiles.