Medrol: profile and news

Guillen Won't Need Surgery on Wrist Mar 4, 2006
..."They are going to put him in a splint, give him a cortisone shot and a medrol dose pack (oral anti-inflammatory) and they feel he will be out 7 to 10 days ... - WTOP,

Bobby wakes up on a Sunday Feb 26, 2006
The anti-inflammatory steroid Solu-Medrol out of initial concern (later dismissed) that he might have a spinal cord injury. Dilantin to prevent seizures. ... - Newsday,

Joint Injections: A Good Idea? 12 Dec 2005
Here's an overview: Methylprednisolone acetate (Depo-Medrol)--Longest-lasting of the three; typically used in low-motion joints for degenerative joint disease. ... - TheHorse.com,

Results Reported in Open-Label Pilot Study of Lidoderm(R) in ... Oct 27, 2005
...to the painful wrist region that overlies the carpal tunnel or a single injection of 0.5 cc lidocaine 1% and methylprednisolone acetate (Depo-Medrol(R)) 40 mg ... - PR Newswire (press release),

AAEP Convention 2004 Wrap-Up: Therapeutic Options Jul 26, 2005
One study done at Colorado State confirmed that injecting the cortico-steroid methylprednisolone acetate (Depo-Medrol) into normal joints damaged. cartilage. ... - TheHorse.com <**results**>

NAFDAC Intercepts Fake Products Jun 27, 2005
...vega (slidenafil) 100mg, clotrimazole vaginal, robinax methocarbamol, duovir (lamivudine & zidovudine), water for injection, depo-medrol aqueous suspection as ... - AllAfrica.com,

NAFDAC Intercepts Fake Products 13 Sep 2002
...vega (slidenafil) 100mg, clotrimazole vaginal, robinax methocarbamol, duovir (lamivudine & zidovudine), water for injection, depo-medrol aqueous suspection as ... - AllAfrica.com,

Poison ivy not good for Asselta Jun 2, 2005
On Wednesday, Landau called into a CVS pharmacy on Chestnut Avenue and tried to order a "Solu-Medrol dose pack", claiming the call was from her former employer ... - Bridgeton News,

Get Lyme disease test as next step Apr 28, 2005
...for the condition. How long can I expect this to last and what can I do other than take the Medrol my doctor put me on? Dear Reader ... - The Spokesman Review (subscription)

First-Time Generic Approvals: Sandostatin, Dantrium, Grifulvin V ... Apr 13, 2005
...formulations of methylprednisolone acetate 40 mg/mL and 80 mg/mL injectable suspension (made by Sicor Pharmaceuticals, Inc; brand name Depo-Medrol, made by ... - Medscape (subscription)

SICOR Pharmaceuticals Introduces Methylprednisolone Acetate ... Mar 8, 2005
This product is AB rated to Depo-Medrol®* Injectable Suspension. ... Depo-Medrol® is a registered trademark of Pharmacia & Upjohn Company. - PharmaLive.com (press release),

FDA approves Teva's ANDA for methylprednisolone acetate injectable ... Feb 24, 2005
Teva's methylprednisolone acetate injectable suspension is the AP-rated generic equivalent of Pfizer's Depo-Medrol injection, an anti-inflammatory ... - Globes Online,

Market turnaround aids biotech at close Feb 24, 2005
Pfizer (PFE) rival Teva Pharmaceuticals (TEVA) received US Food and Drug Administration approval for a generic form of Pfizer anti-inflammatory drug Depo-Medrol ... - Investor's Business Daily (subscription)

Teva Announces Approval of Methylprednisolone Acetate Injectable ... Feb 24, 2005
Teva's Methylprednisolone Acetate Injectable Suspension is the AP-rated generic equivalent of Pfizer's Depo-Medrol(R) Injection, an anti-inflammatory ... - Business Wire (press release),

AAEP Convention 2004: Controversies in Therapeutics--Mixed Bag of ... Feb 14, 2005
One study done at Colorado State confirmed that injecting methylprednisolone acetate (Depo-Medrol) into normal joints damaged cartilage. ... - TheHorse.com,

Other information

Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.

Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.

Mechanism Of Action
Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Drug Category
Neuroprotective Agents; Glucocorticoids; Antiemetics; Anti-inflammatory Agents; Adrenergic Agents; ATC:D07AA01; ATC:D07AC14; ATC:D10AA02; ATC:H02AB04

Brand Names/Synonyms
6.Alpha.-Methylprednisolone; 6alpha-Methylprednisolone; A-Methapred; Artisone-Wyeth; BRN 2340300; Besonia; Cortalone; DRG-0050; Delta-Cortef; Depo-Medrol; Dopomedrol; Esametone; Fernisolone-P; Firmacort; HSDB 3127; Lemod; M-Predrol; MEPRDL; Medesone; Medixon; Medlone 21; Medrate; Medrol; Medrol Acetate; Medrol Adt Pak; Medrol Dosepak; Medrone; Mesopren; Metastab; Methyleneprednisolone; Methylprednisolon; Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Sodium Succinate; Methylprednisolone, Pharma; Methylprednisolonum [Inn-Latin]; Meti-Derm; Metilbetasone; Metilprednisolona [Inn-Spanish]; Metilprednisolone [Dcit]; Metrisone; Metrocort; Metysolon; Moderin; NSC-19987; Nirypan; Noretona; Predni N Tablinen; Prednisolone; Prednisolone, Methyl-; Prednol- L; Prelone; Promacortine; Reactenol; Sieropresol; Solomet; Solu-Medrol; Sterane; Summicort;; Suprametil; U 7532; Urbason; Urbasone; Wyacort

Dosage Forms
Tablets, Suspension

Absorption
Oral bioavailability 80-99%

Interactions
Interactions for Methylprednisolone:

The pharmacokinetic interactions listed below are potentially clinically important. Mutual inhibition of metabolism occurs with concurrent use of cyclosporin and methylprednisolone; therefore, it is possible that adverse events associated with the individual use of either drug may be more apt to occur. convulsions have been reported with concurrent use of methylprednisolone and cyclosporin. Drugs that induce hepatic enzymes such as phenobarbital, phenytoin, and rifampin may increase the clearance of methylprednisolone and may require increased in methylprednisolone dose to achieve the desired response. Drugs such as troleandomycin and ketoconazole may inhibit the metabolism of methylprednisolone and thus decrease its clearance. Therefore, the dose of methylprednisolone should be titrated to avoid steroid toxicity.

Methylprednisolone may increase the clearance of chronic high dose aspirin. This could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when methylprednisolone is withdrawn. Aspirin should be used cautiously in conjunction with corticosteroids in patients suffering from hypoprothrombinemia.

The effect of methylprednisolone on oral anticoagulants is variable. There are reports of enhanced as well as diminished effects of anticoagulant when given concurrently with corticosteroids. Therefore, coagulation indices should be monitored to maintain the desired anticoagulant effect.

Chemical IUPAC Name
11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

Chemical Formula
C22H30O5

Half Life
1-3 hours

Drug Type
Approved Drug

# Accession No
APRD00342

CAS Registry Number
83-43-2