Marinol: profile and news






A Randomized, Double-Blind, Placebo-Controlled Study of ...  Mar 2, 2006
OBJECTIVE: The authors compared the effects of maintenance versus withdrawal of risperidone treatment in children and adolescents with symptoms of disruptive ... - Am J Psychiatry (subscription)

Reducing Nonadherence: New Formulations of Antipsychotic ...  Feb 27, 2006
Available formulations for atypical antipsychotic medications now include liquid preparations (risperidone [Risperdal]) and fast-dissolving oral preparations ... - Psychiatric Times,

Dr. McDougle and Colleagues Reply  Mar 2, 2006
The power analysis was based on the ability to detect a clinically significant difference between risperidone and placebo groups in the primary outcome. ... - Am J Psychiatry (subscription)

A PET Study Evaluating Dopamine D 2 Receptor Occupancy for Long ...  Mar 2, 2006
FRCPC. OBJECTIVE: Long-acting injectable risperidone represents the first clinically available depot atypical antipsychotic. The ... - Am J Psychiatry (subscription)

Treatment-Resistant Bipolar Depression: A STEP-BD Equipoise ...  Feb 9, 2006
...for treatment-resistant bipolar depression and assesses the effectiveness and safety of antidepressant augmentation with lamotrigine, inositol, and risperidone ... - Am J Psychiatry (subscription)

Stephan Heres, MD , John Davis, MD , Katja Maino, MD , Elisabeth ...  Feb 9, 2006
...controlled trials comparing the second-generation antipsychotics aripiprazole, amisulpride, clozapine, olanzapine, quetiapine, risperidone, sertindole, and ... - Am J Psychiatry (subscription)

DRD2 Promoter Region Variation as a Predictor of Sustained ...  Mar 2, 2006
...promoter region polymorphisms (A-241G and –141C Ins/Del) and were randomly assigned to receive 16 weeks of treatment with either risperidone or olanzapine. ... - Am J Psychiatry (subscription)

Neurocognitive Function in Unmedicated Manic and Medicated ...  Feb 8, 2006
...disorder patients were euthymic subjects who were responders from a recently completed clinical trial that tested the efficacy of lithium plus risperidone (N=14 ... - Am J Psychiatry (subscription)

Par Pharmaceutical Reports Sales and Earnings for 2005  Feb 28, 2006
Par was granted tentative approvals for the company's ANDAs for ondansetron HCl tablets in 4 mg, 8 mg, 16 mg and 24 mg strengths, and risperidone 1 mg/mL oral ... - MSN Money

From Bench to Bedside: The Future of Neuroimaging Tools in ...  Feb 27, 2006
...memory challenge. Patients with schizophrenia were switched from conventional antipsychotics to risperidone (Risperdal). Several ... - Psychiatric Times,

In This Issue  Mar 2, 2006
Risperidone is the first of the newer, or "atypical," antipsychotics to become available in a long-acting injectable form. Remington et al. ... - Am J Psychiatry (subscription)

Sildenafil in the Treatment of Antipsychotic-Induced Erectile ...  Mar 2, 2006
N=1), undifferentiated schizophrenia (N=5), and delusional disorder (N=3). They were taking the following antipsychotic medications: risperidone (N=17 ... - Am J Psychiatry (subscription)

Results Of A New Study Show Benefits Of Risperdal® Constaâ„¢ ...  Feb 16, 2006
Following 1 week of treatment with oro-dispersible risperidone tablets, patients were initiated onto treatment with long-acting risperidone 25mg every 2 weeks. ... - Medical News Today (press release),

SG Cowen & Co. Annual Health Care Conference to Webcast Alkermes' ...  Mar 2, 2006
The Company's lead commercial product, RISPERDAL(R) CONSTA(R) ((risperidone) long-acting injection), is the first and only long-acting atypical antipsychotic ... - Genetic Engineering News,

Prevention and Early Interventions  Feb 27, 2006
In a single-blind design, McGorry et al. (2002) compared low-dose risperidone (Risperdal) plus cognitive-behavioral therapy (CBT) with a needs-based ... - Psychiatric Times,

Sudden Akathisia After a Ziprasidone Dose Reduction  Mar 2, 2006
Br J Psychiatry 1989; 154:672–676[Abstract]. Rosebush PI, Kennedy K, Dalton B, Mazurek MF: Protracted akathisia after risperidone withdrawal (letter). ... - Am J Psychiatry (subscription)

Antisaccade Performance in Monozygotic Twins Discordant for ...  Mar 2, 2006
The probands’ treatment included clozapine (N=4), olanzapine (N=2), risperidone (N=1), and none (N=2). Their mean SAPS and SANS scores were 5.22 (SD=3.38 ... - Am J Psychiatry (subscription)

The Schizophrenia Cognition Rating Scale: An Interview-Based ...  Mar 2, 2006
Eight patients were receiving monotherapy with olanzapine, seven with risperidone, 10 with aripiprazole, six with clozapine, three with quetiapine, one with ... - Am J Psychiatry (subscription)

Drug result at odds with explanation  Feb 18, 2006
...owner Hamish Barham stands by his apology to parents Lisa and Gary in which he explained that the liquid antipsychotic Risperdal (risperidone) had been ... - Manawatu Standard,

Next "Step" in Treating Bipolar Depression  Feb 14, 2006
...(p. 210) report that lamotrigine (mood stabilizer), inositol (sugar derivative affecting intracellular signaling), and risperidone (antipsychotic) did not ... - Am J Psychiatry (subscription)

Combo Drug Therapy Won't Improve Schizophrenia Care  Feb 1, 2006
1 (HealthDay News) -- Combining two antipsychotic drugs, clozapine and risperidone, offers no benefit in treating people with severe schizophrenia compared to ... - Forbes

New clues on bipolar causes, treatments  Feb 3, 2006
Two other supplements, inositol, a sugar derivative, and risperidone, an anti-schizophrenic drug, also lifted the effects of the disorder, but less ... - United Press International

Alkermes Reports Third Quarter Fiscal 2006 Financial Results ...  Feb 7, 2006
The profitable quarter was driven by the recognition of manufacturing and royalty revenues related to RISPERDAL(R) CONSTA(R) ((risperidone) long-acting ... - Genetic Engineering News,

Myocarditis During Clozapine Treatment  Feb 14, 2006
...by an intensive case manager. During this time, he was treated with risperidone, olanzapine, and lithium. According to Mr. A’s ... - Am J Psychiatry (subscription)

Pisa Syndrome in a Patient in a Wheelchair Taking Valproic Acid  Feb 14, 2006
His medications were 750 mg bid of valproic acid, 200 mg bid of carbamazepine, and 3 mg bid of risperidone—a regimen that had been stable and unchanged over ... - Am J Psychiatry (subscription)

Biofusion launches spin-out company Genophrenix  Feb 22, 2006
...in the later years. This group include risperidone (Risperdal), olanzapin (Zyprexa), clozapin (Leponex) and Zeldox. The drugs in ... - DrugResearcher.com,

Combining antipsychotic drugs has no benefit for severe ...  Feb 2, 2006
..."If symptom improvement is still limited, the psychiatrist may prescribe a second antipsychotic drug known as risperidone at the same time in an attempt to ... - Canada.com,

New Studies Help Patients With Treatment-Resistant Bipolar ...  Feb 1, 2006
Bipolar Depression: A STEP-BD Equipoise Randomized Effectiveness Trial of Antidepressant Augmentation With Lamotrigine, Inositol, or Risperidone� led by ... - Medical News Today (press release),

Pharmacy guild responds to mislabelled medicine incident  Feb 3, 2006
Two-year-old Emma Leader spent the weekend in hospital after taking a 5mg dose of the mislabelled medicine - anti-psychotic drug risperidone instead of the ... - Stuff.co.nz,

Trust in pharmacies battered  Feb 4, 2006
Two-year-old Emma Leader collapsed and was taken to Palmerston North Hospital after being given a 5ml dose of the antipsychotic drug risperidone labelled as a ... - Manawatu Standard,

Personal Accounts: Scaling Mount Rushmore: Cartography of a Manic ...  Feb 14, 2006
I told her that I had had severe side effects from risperidone, olanzapine, and quetiapine. Was there a new drug? In fact, there was, one called ziprasidone. ... - Psychiatric Services (subscription)

Exploring Treatment Options for Patients with Autism  Feb 6, 2006
While antipsychotic medications such as clozapine (Clozaril®), risperidone (Risperdal®), olanzapine (Zyprexa®), and quetiapine (Seroquel®) may decrease ... - DailyIndia.com,

Pharmacy 'shattered' by mix-up  Jan 31, 2006
Instead, they got another drug, possibly risperidone, an antipsychotic drug often used to treat schizophrenia, hallucinations, delusions and disorganised ... - New Zealand Herald,

Pharmacy faces inquiries over wrong medicine  Feb 2, 2006
She received what is suspected to be the anti-psychotic drug risperidone, from a bottle supposed to contain the steroid prednisolone for her cough. ... - New Zealand Herald,

Combo Drug Therapy Won't Improve Schizophrenia Care  Feb 1, 2006
1 (HealthDay News) -- Combining two antipsychotic drugs, clozapine and risperidone, offers no benefit in treating people with severe schizophrenia compared to ... - HealthCentral.com

Clozaril-Risperdal Duo Lacks Efficacy Against Schizophrenia  Feb 1, 2006
1 - When severe schizophrenia is refractory to Clozaril (clozapine), adding Risperdal (risperidone) to the mix appears to make little difference, a study here ... - MedPage Today,


Other information


Indication
For the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments

Pharmacology
Dronabinol may has complex effects on the central nervous system (CNS), including cannabinoid receptors. Dronabinol may inhibit endorphins in the emetic center, suppress prostaglandin synthesis, and/or inhibit medullary activity through an unspecified cortical action.

Mechanism Of Action
The mechanism of action of dronabinol is not completely understood. It is thought that Cannabinoid receptors in neural tissues may mediate the effects of dronabinol and other cannabinoids. Animal studies with other cannabinoids suggest that dronabinol's antiemetic effects may be due to inhibition of the vomiting control mechanism in the medulla oblongata.

Drug Category
Analgesics; Psychotropic Drugs; Hallucinogens; Antiemetics; ATC:A04AD10

Brand Names/Synonyms
Abbott 40566; CCRIS 4726; DRG-0138; Dea No. 7369; Dea No. 7370; Deltanyne; Dronabinol; Dronabinol [Usan:Inn]; Dronabinolum [Latin]; HSDB 6471; Marinol; Primolut; SP 104; TETRAHYDROCANNABINOL; THC; Tetrahydrocannabinol; Tetrahydrocannabinol Delta9; Tetrahydrocannabinols

Dosage Forms
Capsule

Absorption
90 - 95%

Interactions
Interactions for Dronabinol: In studies involving patients with AIDS and/or cancer, MARINOL (Dronabinol) Capsules has been co-administered with a variety of medications (e.g., cytotoxic agents, anti-infective agents, sedatives, or opioid analgesics) without resulting in any clinically significant drug/drug interactions. Although no drug/drug interactions were discovered during the clinical trials of MARINOL Capsules, cannabinoids may interact with other medications through both metabolic and pharmacodynamic mechanisms. Dronabinol is highly protein bound to plasma proteins, and therefore, might displace other protein-bound drugs. Although this displacement has not been confirmed in vivo, practitioners should monitor patients for a change in dosage requirements when administering dronabinol to patients receiving other highly protein-bound drugs.

Chemical IUPAC Name
Not Available

Chemical Formula
C21H30O2

Half Life
Alpha phase: ~4 hours; Beta phase: 25-36 hours

Drug Type
Approved Drug

# Accession No
APRD00571

CAS Registry Number
8/3/1972

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