Macrodantin: profile and news

Help! What do I do about 'honeymoon cystitis'? Nov 14, 2005
...regular basis. The most common antibiotics are Macrodantin, Bactrim, Levoquin, Cipro (in low doses), though there are others as well. - Standard-Speaker,

Help! What do I do about 'honeymoon cystitis'? Sep 6, 2005
...regular basis. The most common antibiotics are Macrodantin, Bactrim, Levoquin, Cipro (in low doses), though there are others as well. - MSNBC

Medical Self-Care Jul 30, 2005
Gantrisin or Azo-Gantrisin. Stubborn infections are sometimes treated with Macrodantin, a more expensive medicine. Some women are ... - Mother Earth News <**results**>

New Oncology Strategy: Molecular Targeting of Cancer Cells Jun 29, 2005
...of other medications associated with peripheral neuropathy such as statins (Pravachol, Lipitor), isoniazid (INH), nitrofurantoin (Macrodantin), or amiodarone ... - RedNova.com,

Taking liver-taxing drugs calls for periodic testing Apr 5, 2005
...nabumetone (Relafen), nefazodone (Serzone), naproxen (Naprosyn, Aleve), nevirapine (Viramune), niacin (Niaspan), nitrofurantoin (Macrodantin), oxaprozin (Daypro ... - Contra Costa Times,

Other information

Indication
For the treatment of infection (urinary tract)

Pharmacology
Nitrofurantoin, a nitrofuran antibacterial agent, is available in microcrystalline and macrocrystalline form to treat urinary tract infections caused by many gram-negative and some gram-positive bacteria.

Mechanism Of Action
Nitrofurantoin inhibits bacterial acetyl-coenzyme A, interfering with the organism's carbohydrate metabolism. The drug also can disrupt bacterial cell wall formation.

Drug Category
Anti-Infectives; Anti-Infectives; ATC:J01XE01

Brand Names/Synonyms
Alfuran; Apo-Nitrofurantoin; Benkfuran; Berkfurin; Ceduran; Chemiofuran; Cistofuran; Cyantin; Cystit; Dantafur; Fua Med; Fuamed; Fur-Ren; Furabid; Furachel; Furadantin; Furadantin Retard; Furadantina Mc; Furadantine; Furadantine Mc; Furadantine-Mc; Furadantoin; Furadoin; Furadoine; Furadonin; Furadonine; Furadontin; Furalan; Furaloid; Furan; Furanite; Furantoin; Furantoina; Furatoin; Furedan; Furina; Furobactina; Furophen T; Furophen T-Caps; Gerofuran; It-Uran; Ituran; Ivadantin; Macpac; Macrobid; Macrodantin; Macrodantina; Macrofuran; Macrofurin; N-Toin; NSC-2107; Nierofu; Nifurantin; Nitoin; Nitrex; Nitrofan; Nitrofur-C; Nitrofuradantin; Nitrofurantoin; Novo-Furantoin; Novofuran; Orafuran; Parfuran; Phenurin; Ro-Antoin; Siraliden; Trantoin; Uerineks; Upiol; Urantoin; Urizept; Uro-Selz; Uro-Tablinen; Urodin; Urofuran; Urofurin; Urolisa; Urolong; Usaf Ea-2; Uvaleral; Welfurin; Zoofurin

Dosage Forms
TABLET

Absorption
Not Available

Interactions
-->Interactions for Nitrofurantoin:

Antacids containing magnesium trisilicate, when administered concomitantly with nitrofurantoin, reduce both the rate and extent of absorption. The mechanism for this interaction probably is adsorption of nitrofurantoin onto the surface of magnesium trisilicate.

Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin. The resulting increase in nitrofurantoin serum levels may increase toxicity, and the decreased urinary levels could lessen its efficacy as a urinary tract antibacterial.

Drug/Laboratory Test Interactions

As a result of the presence of nitrofurantoin, a false-positive reaction for glucose in the urine may occur. This has been observed with Benedictís and Fehlingís solutions but not with the glucose enzymatic test.

Chemical IUPAC Name
1-[(5-nitro-2-furyl)methylideneamino]imidazolidine-2,4-dione

Chemical Formula
C8H6N4O5

Half Life
0.3-1 hour.

Drug Type
Approved Drug

# Accession No
APRD00191

CAS Registry Number
67-20-9