Lorazepam: profile and news






Advair and a second GlaxoSmithKline asthma drug get stronger ...  07 Mar 2006
The revised warnings apply to Advair and Serevent, Food and Drug Administration spokeswoman Laura Alvey said Monday. Advair is GlaxoSmithKline's ... - San Diego Union Tribune,

Exercise might help Parkinson’s patients  07 Mar 2006
The revised warnings apply to Advair and Serevent, Food and Drug Administration spokeswoman Laura Alvey said Monday. Advair is GlaxoSmithKline ... - The State,

Top Asthma Drugs Get Stronger Warning  07 Mar 2006
Washington, DC — The asthma medication Advair and Serevent will now carry the strongest warnings the FDA can require of prescription drugs. ... - ktla 5,

Bextra - What Did Pfizer Know? - Everything  07 Mar 2006
...belong there.". When asked which drugs he was referring to, Dr Graham identified Accutane, Bextra, Crestor, Meridia and Serevent. He ... - Media Monitors Network,

GSK announces new product labels for Serevent® and Advair®  Mar 3, 2006
...today announced that it has agreed with the US Food and Drug Administration on product labeling for its respiratory products Serevent® Diskus® and Advair ... - WebWire (press release),

Serevent Exposes Blacks to Higher Risk of Asthma-Related Death ...  Feb 22, 2006
A new study has found that GlaxoSmithKline’s (GSK) popular asthma drug, Serevent, (salmeterol), exposes African-American patients to a higher risk of asthma ... - Newsinferno.com,

Asthma Drug Warning Strengthened  Mar 3, 2006
...expanding the airways. There also is a new label for Glaxo's Serevent, which just contains salmeterol. GlaxoSmithKline "is pleased ... - Forbes

Study of asthma drug finds it puts black patients at greater risk ...  Feb 21, 2006
...of medicine, allergy and immunology at the National Jewish Medical and Research Center, led a study that determined the asthma drug Serevent, manufactured by ... - Newstarget.com,

Sepracor: arformoterol offers relief  Feb 16, 2006
In the US, two long-acting beta2-agonists are currently available, namely GlaxoSmithKline's Serevent (salmeterol) and Novartis' Foradil (formoterol), both of ... - Pharmaceutical Business Review

Expert: Asthma-drug warning being blown off  Feb 21, 2006
Those drugs are known by the brand names Serevent, Foradil and Advair — the latter promoted almost constantly in prime-time TV ads aimed at the general public ... - Arizona Daily Star,

Health Notes  Feb 21, 2006
...qualify. If you take Flovent, Combivent, Proventil, Advair, Pulmicort, Serevent, Atrovent or any other inhaler, the program may help. ... - Hampton Union,

More letters  Feb 23, 2006
...of normal. The combined benefits of the Serevent and Flovent in the Advair disk have enormously improved my health. Patients should ... - Arizona Daily Star,

GlaxoSmithKline: Pliva Deal to Boost R&D  Feb 15, 2006
Indeed, sales from these brands - Flovent (fluticasone), Seretide (salmeterol, fluticasone) and Serevent (salmeterol) - accounted for 21.3% of the company's ... - International News Service,

Serevent May Pose Greater Risk of Death to Blacks  Jan 13, 2006
Recently released information about a safety trial on the asthma drug Serevent indicates that blacks who took the drug were four times as likely to have life ... - Newsinferno.com,

Roundup: Diet May Reverse Diabetes; Serevent Poses Danger To Some ...  Jan 10, 2006
The drug is Serevent, and a study by the maker of the drug found a small but significant increase in respiratory- and asthma-related deaths among African ... - NBC 10.com,

Drug Warning For African Americans: Serevent  Jan 10, 2006
A study by the maker of the drug Serevent found a small, but significant, increase in respiratory and asthma related deaths among African American patients. ... - KSDK,

Asthma Drug May Be Deadlier for Blacks  Jan 12, 2006
Jan. 12, 2006 -- Serevent, a widely prescribed inhaled asthma treatment, may pose a special risk to blacks. Newly released details ... - WebMD

Health Notes  Feb 7, 2006
...qualify. If you take Flovent, Combivent, Proventil, Advair, Pulmicort, Serevent, Atrovent or any other inhaler, the program may help. ... - Exeter News-Letter,

Some dangerous drugs get by FDA  Jan 29, 2006
...malathion (Ovide), medroxyprogesterone injections (Depo Provera), mefloquine (Lariam), rosuvastatin (Crestor), salmeyerol (Serevent), sibutramine (Meridia ... - Sarasota Herald-Tribune,

Common Asthma Medication Poses Risk to Black Patients  Jan 11, 2006
More commonly known by its brand name, Serevent, the drug is a member of the beta agonist class of asthma medications, which treat asthma symptoms by relaxing ... - Forbes

Common Asthma Medication Poses Risk to Black Patients  Jan 11, 2006
More commonly known by its brand name, Serevent, the drug is a member of the beta agonist class of asthma medications, which treat asthma symptoms by relaxing ... - HealthCentral.com

DATAMONITOR: Get SMART: Symbicort gives patients the power to ...  Jan 11, 2006
However, recent labeling changes proposed by the FDA to three asthma drugs (Advair/Seretide, Foradil, and Serevent) have significant implications for the ... - PharmaLive.com (press release),

Study: Drug Puts Some Asthma Patients At Risk  Jan 10, 2006
The manufacturer of the drug Serevent found a small, but significant increase in respiratory and asthma-related deaths among black patients. ... - WBAL Channel.com,

People's Pharmacy: Asthma drugs require caution  Jan 7, 2006
Several months ago an expert panel considered whether the asthma drugs Advair, Foradil and Serevent also should be withdrawn from the market. ... - Bryan College Station Eagle,

New Symbicort dose a boon for AstraZeneca?  Jan 11, 2006
DataMonitor said FDA`s recent proposed labeling changes for other asthma drugs, including Advair/Seretide, Foradil and Serevent, could affect Symbicort if it ... - Monsters and Critics.com,

FDA is urging caution about asthma drug use  12 Dec 2005
Several months ago an expert panel considered whether the asthma drugs Advair, Foradil and Serevent also should be withdrawn from the market. ... - Charlotte Observer,

GSK Statement on FDA Proposed Labeling Change for Serevent and ...  Nov 18, 2005
18 /PRNewswire/ -- GlaxoSmithKline disagrees with the FDA's proposed product labeling changes for Serevent and Advair, because they are inconsistent with ... - PR Newswire (press release),

GSK Statement on FDA Proposed Labeling Change for Serevent and ...  Nov 21, 2005
RESEARCH TRIANGLE PARK, NC — GlaxoSmithKline disagrees with the FDA's proposed product labeling changes for Serevent and Advair, because they are ... - Drug Newswire (press release),

(PRN) - GSK Statement on FDA Proposed Labeling Change for Serevent ...  Nov 18, 2005
...(PRN) - Thanksgiving, Biggest Meal of the Year, Could be Key Weapon in Winning War on Childhood Obesity, Family Health ... [+. PRN ... - Bolsamania.com,

GSK Statement on FDA Proposed Labeling Change for Serevent and ...  Nov 18, 2005
RESEARCH TRIANGLE PARK, NC, November 18, 2005 /PRNewswire/ -- GlaxoSmithKline disagrees with the FDA's proposed product labeling changes for Serevent and Advair ... - PharmaLive.com (press release),

GlaxoSmithKline disagrees with FDA decision regarding Advair  Dec 7, 2005
PLC said Friday that it disagrees with proposed labeling changes by the Food and Drug Administration for the British drug maker's Serevent and Advair asthma ... - Newstarget.com,

Glaxo Shares Fall on US Plan to Restrict Advair Use (Update3)  Nov 21, 2005
18, would limit the prescription of Glaxo's Advair and Serevent asthma drugs to patients who didn't respond to other treatments. ... - Bloomberg

Glaxo Shares Fall After FDA Proposes Restricted Advair Use  Nov 21, 2005
18. The proposal would limit Glaxo's Advair and Serevent asthma medications to patients who didn't respond to other treatment. Sales ... - Bloomberg

FDA seeks stronger warning for asthma meds  Dec 1, 2005
A new public health advisory from the Food and Drug Administration cautions users of three asthma medications — Advair Diskus, Serevent Diskus and Foradil ... - Quad City Times,

HealthWrap: 'Serious risks' in 12 Rx's  Dec 8, 2005
...available at consumerreports.org -- are Ovide for head lice; Depo-Provera injections for contraception; Crestor for high cholesterol; Serevent for asthma ... - Science Daily (press release)

Novartis says once-a-day asthma drug works  Nov 29, 2005
Glaxo’s Advair and Serevent, known as salmeterol, carry a “black box� warning on their packaging about one study which showed people taking Serevent had ... - Standard-Speaker,

Consumer Reports Medical Guide & Consumer Reports: Prescription ...  Dec 5, 2005
Depo-Provera), a contraceptive; Mefloquine (Lariam) to prevent malaria; Rosuvastatin (Crestor) for high cholesterol; Salmeterol-- (Serevent) for asthma ... - U.S. Newswire (press release),

Prescription for Trouble: Consumer Reports Examines Weaknesses of ...  Dec 5, 2005
Depo-Provera), a contraceptive; Mefloquine (Lariam) to prevent malaria; Rosuvastatin (Crestor) for high cholesterol; Salmeterol (Serevent) for asthma ... - AScribe

GlaxoSmithKline winded by FDA label clampdown  Nov 24, 2005
24 Nov 2005, 08:46 GMT - GlaxoSmithKline's shares fell almost 5% following the FDA's calls for changes to the labels of asthma drugs Advair and Serevent. ... - Pharmaceutical Business Review

UPDATE 2-US FDA calls for stronger warnings on asthma drugs  Nov 18, 2005
The warnings involve long-acting bronchodilator medicines Advair and Serevent, made by GlaxoSmithKline (GSK.L: Quote, Profile, Research), and Foradil from ... - Reuters

US FDA calls for stronger warnings on asthma drugs  Nov 18, 2005
The warnings involve long-acting bronchodilator medicines Advair and Serevent, made by GlaxoSmithKline , and Foradil from Novartis AG . ... - Reuters AlertNet,

FDA: New Warnings for Three Asthma Drugs  Nov 18, 2005
That quote comes from an FDA public health advisory on the three products -- Advair Diskus, Foradil Aerolizer, and Serevent Diskus. ... - FOX News

GSK says FDA's decision to change asthma drug label puts patients ...  Nov 18, 2005
...disagreement with a decision by US regulator's to change the advice given on the label of its top selling asthma drugs Advair and Serevent, saying they could ... - Forbes

Drug label change wipes £4bn off Glaxo value  Nov 21, 2005
The drugs giant said it disagreed with the FDA, which claimed both Advair and Glaxo's Serevent treatment may make asthma more severe and should not be used as ... - Independent,

Glaxo shares fall on asthma warning  Nov 21, 2005
The new FDA warnings also cover Glaxo's Serevent -- the LABA component of Advair, which is sold as a separate medicine -- as well as Novartis AG's Foradil. ... - Scotsman,

Advair warning won't dent sales -- analyst  Nov 21, 2005
While shares of GlaxoSmithKline slipped 5 percent in the wake of new label warnings for the British firm's asthma drugs Advair Diskus and Serevent Diskus, an ... - United Press International

Asthma Drugs Educe FDA Concern  Nov 18, 2005
The agency is asking the maker of the drugs, Advair Diskus and Serevent Diskus, to add warnings to their labels that these medications "may increase the chance ... - TheStreet.com

FDA Wants Stronger Asthma Drug Warnings  Nov 18, 2005
...death. The agency asked the manufacturers of Advair, Serevent and Foradil to strengthen the warning labels to reflect this risk. ... - Washington Post,

FDA Issues Public Advisory on Three Asthma Medications  Nov 18, 2005
The FDA wants the warnings added to Serevent Diskus (salmeterol xinafoate inhalation powder), Advair Diskus (fluticasone propionate and salmeterol inhalation ... - MedPage Today,

FDA: Limit use of GlaxoSmithKline asthma drugs  Nov 18, 2005
The FDA said Advair Diskus, Serevent Diskus and Foradil Aerolizer, all long-acting beta 2-adrenergic agonists (LABAs), "may increase the chance of severe ... - Philadelphia Business Journal,

FDA: Beef up Advair warning  Nov 19, 2005
The US Food and Drug Administration's Safety Information and Adverse Event Reporting Program said use of Advair Diskus and Serevent Diskus may increase the ... - philly.com,

GlaxoSmithKline "underweight"  Nov 22, 2005
In a research note published yesterday, the analyst mentions that a decline in the sales of the company’s Advair/Serevent drugs due to a probable change in ... - New Ratings

Nomura Cuts GlaxoSmithKline '09 EPS Forecast  Nov 21, 2005
0836 GMT [Dow Jones] Nomura lowers GlaxoSmithKline's (GSK) EPS for '09 to 127.9p from 128.8p, following FDA concerns late Friday over Serevent and Advair. ... - New Ratings

Safety Of Some Prescription Drugs Questioned  Dec 5, 2005
Lariam, to prevent malaria, Meridia, for weight loss, Ovide, for head lice, Premarin and other estrogens to treat symptoms of menopause, Serevent Diskus for ... - KIROtv.com,

FDA restrictions on Advair impacts GlaxoSmithKline shares  Dec 6, 2005
The new FDA warnings also will affect drugs like Serevent, the LABA component of Advair used by Glaxo, which the company also sells as a separate drug. ... - Newstarget.com,

Health Notes  Dec 6, 2005
...qualify. If you take Flovent, Combivent, Proventil, Advair, Pulmicort, Serevent, Atrovent or any other inhaler, the program may help. ... - Exeter News-Letter,

Health news  Nov 20, 2005
...even death. The agency asked the makers of Advair, Serevent and Foradil to strengthen the warning labels to reflect this risk. The ... - Chicago Sun-Times,

GlaxoSmithKline opposes US asthma drug proposals  Nov 18, 2005
GSK said the FDA's proposals for Serevent and Advair were inconsistent with the standard of care for asthma treatment, which could put many patients at risk of ... - Reuters

Glaxo woes nudge London equities lower  Nov 21, 2005
...to £14.22 as investors took profits following the news late on Friday that US drug administrators asked the drugmaker to put warnings on Serevent and Advair ... - Financial Times,

FTSE pressured by GSK but oils limit losses  Nov 21, 2005
...asthma medications. Dealers said they were concerned the warning would hit sales of GSK's asthma treatments Advair and Serevent. CSFB ... - Reuters South Africa,

ASTHMA DRUG WARNING  Nov 18, 2005
The FDA says that while Advair, Serevent and Foradil decrease the frequency of asthma attacks, they make the attacks more severe when they occur. ... - KPVI-TV,

FDA Issues Caution on Bronchodilators  Nov 19, 2005
The FDA says these medicines -- Serevent Diskus, Advair Diskus and Foradil Aerolizer -- may increase the risk of severe asthmatic episodes and increase the ... - HealthCentral.com

FDA Calls For Stronger Warnings on Asthma Drugs  Nov 19, 2005
The agency asked the manufacturers of Advair, Serevent and Foradil to strengthen the warning labels to reflect this risk.The FDA said that even though the ... - All Headline News

FDA: New Warnings for Three Asthma Drugs  Nov 20, 2005
...when those episodes occur.� That quote comes from an FDA public health advisory on the three products -- Advair Diskus, Foradil Aerolizer, and Serevent Diskus ... - LaSalute.net,

FTSE closes down on Glaxo  Nov 22, 2005
...down by 5pc. Dealers said the news could hit sales of the firm's asthma treatments Advair and Serevent in the US. The retail sector ... - Business World,

FDA Calls for Stronger Warnings On Asthma Drugs  Nov 21, 2005
...to their labels. The three drugs are Advair and Serevent, manufactured by GlaxoSmithKline, and Foradil from Novartis AG. The FDA ... - Newsinferno.com,

Glaxo shares fall on asthma warning  Nov 22, 2005
On Friday the US Food and Drug Administration said the warnings involved long-acting bronchodilator medicines Advair and Serevent, made by GlaxoSmithKline, and ... - LaSalute.net,

Long-acting beta 2-adrenergic agonists may make asthma episodes ...  Nov 21, 2005
Diskus ( Fluticasone propionate & Salmeterol inhalation powder ), Foradil Aerolizer ( Formoterol fumarate inhalation powder ), and Serevent Diskus ( Salmeterol ... - Xagena.it,

FDA asks for new warnings on 3 asthma drugs, long-acting beta 2 ...  Nov 19, 2005
The FDA has asked that a new warning be placed on labels of Serevent and Advair (GSK) and Foradil (Novartis). The warning should ... - Medical News Today (press release),

Asthma: relief for the worst wheezers  Nov 14, 2005
The weird, useless cigarettes have made way for the — by comparison — near-magical Symbicort turbohalers, Seretide inhalers and Serevent aerosols. ... - Times Online,

Floor Statement of US Senator Chuck Grassley of Iowa - One-Year ...  Nov 18, 2005
Dr. Graham identified those five drugs – Accutane, Bextra, Crestor, Meridia and Serevent – when asked by my distinguished colleague, Sen. Bingaman. ... - PharmaLive.com (press release),

FDA Releases Long-acting Beta2-adrenergic Agonists Public Health ...  Nov 18, 2005
18, 2005--FDA notified manufacturers of Advair Diskus, Foradil Aerolizer, and Serevent Diskus to update their existing product labels with new warnings and a ... - PharmaLive.com (press release),

UK-Business Summary  Nov 21, 2005
...asthma medications. Dealers said the news could hit sales of GSK's asthma treatments Advair and Serevent in the United States. CSFB ... - Scotsman,

FDA wants warning on asthma drugs  Nov 18, 2005
According to Prudential analyst Timothy Anderson, the FDA's decision could have a material impact on Glaxo. "FDA is asking that Advair/Serevent's labels be ... - MarketWatch


Other information


Indication
For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms

Pharmacology
Lorazepam, a benzodiazepine not transformed to active metabolites, is used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia.

Mechanism Of Action
Lorazepam binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.

Drug Category
Anti-anxiety Agents; Hypnotics and Sedatives; Antiemetics; Anticonvulsants; Benzodiazepines; ATC:N05BA06

Brand Names/Synonyms
.+/-.Lorazepam; Almazine; Alzapam; Anxiedin; Aplacassee; Ativan; Bonatranquan; Delormetazepam; Emotival; Idalprem; L-Lorazepam Acetate; Lorabenz; Lorax; Loraz; Lorazepam; Lorazepam Intensol; Lorsilan; O-Chlorooxazepam; O-Chloroxazepam; Pro Dorm; Psicopax; Punktyl; Quait; Securit; Sedatival; Sedazin; Somagerol; Tavor; Temesta; Wy 4036; Wy-4036; Wypax

Dosage Forms
Tablets and Injection

Absorption
readily absorbed with an absolute bioavailability of 90 %.

Interactions
Interactions for Lorazepam:

Tablets: The benzodiazepines, including lorazepam, produce CNS-depressant effects when administered with such medications as barbiturates or alcohol.

Injection: Lorazepam injection, like other injectable benzodiazepines, produces depression of the central nervous system when administered with ethyl alcohol, phenothiazines, barbiturates, MAO inhibitors, and other antidepressants.When scopolamine is used concomitantly with injectable lorazepam, an increased incidence of sedation, hallucinations, and irrational behavior has been observed.



Chemical IUPAC Name
9-chloro-6-(2-chlorophenyl)-4-hydroxy-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one

Chemical Formula
C15H10Cl2N2O2

Half Life
12 hours

Drug Type
Approved Drug

# Accession No
APRD00116

CAS Registry Number
846-49-1

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