Loratadine: profile and news
Cancers seen in SP trial of HIV drug vicriviroc 07 Mar 2006
...in development that will help bring it out of a slump caused by the loss of patent protection on its blockbuster antihistamine Claritin (loratadine) in 2002 ... - Pharma Times (subscription),
8th-grader brings cocaine to school Mar 4, 2006
Principal Raymond O'Malley also found a plastic baggie containing cocaine, a pink cigarette lighter and two small pills in packaging labeled Loratadine. ... - Brockton Enterprise,
Girl, 9, charged with drugs Mar 4, 2006
...baggy of cocaine in the girl's handbag, along with a small white straw, a cigarette lighter, and two pills in packaging labeled Loratadine, an antihistamine. ... - Taunton Gazette,
Guest View: State Misses Chance to Save Cash Feb 16, 2006
With a cost benefit to the patient, the pharmacist could substitute an equally therapeutic alternative like Loratadine. The cost ... - Mountain View Journal,
CAFC Underscores Need to Corroborate Reduction to Practice Feb 7, 2006
Rolabos 827 patent and Medichems 100 patent both claim a process for making loratadine, the active ingredient in the allergy medication Claritin. ... - Patent Baristas,
OTC Decongestant Nothing To Sneeze At Feb 21, 2006
...fever. And the nonsedating antihistamine loratadine (Claritin) is considered the first-line, over-the-counter allergy treatment. ... - CBS News
CombinatoRx Discontinues CRx-140 as an Oral Product Candidate For ... Feb 22, 2006
...neither component alone can achieve. CRx-140 contains a low dose of cyclosporine and loratadine. The target product profile for ... - Genetic Engineering News,
warning on cough medicines Feb 7, 2006
But newer non-drowsy antihistamines -- such as loratadine, found in Claritin -- are ineffective at reducing cough tied to the common cold, Irwin said. ... - NorthJersey.com,
Non-Inventors Sloppy Lab Notebook Cannot Corroborate Reduction to ... Feb 8, 2006
The parties here are sparing over rights to a novel process for making loratadine, the active ingredient of Claratin®. Rolabo filed ... - Patently-O,
New Survey Shows Europeans' Allergy Symptoms Are Most Severe in ... Feb 14, 2006
Products from the company's research efforts include the CLARITIN(R) (loratadine) family of nonsedating antihistamines, NASONEX(R) (mometasone furoate ... - PR Newswire UK (press release),
Need help surfing cold and flu medicines? Feb 1, 2006
...do not cause drowsiness are available by prescription, but only Tavist ND and Claritin, which both contain the same antihistamine, loratadine, are available ... - South Bend Tribune,
CAFC Underscores Need to Corroborate Reduction to Practice Feb 7, 2006
Rolabos 827 patent and Medichems 100 patent both claim a process for making loratadine, the active ingredient in the allergy medication Claritin. ... - Patent Baristas,
Non-Inventors Sloppy Lab Notebook Cannot Corroborate Reduction to ... Feb 8, 2006
The parties here are sparing over rights to a novel process for making loratadine, the active ingredient of Claratin®. Rolabo filed ... - Patently-O,
warning on cough medicines Feb 7, 2006
But newer non-drowsy antihistamines -- such as loratadine, found in Claritin -- are ineffective at reducing cough tied to the common cold, Irwin said. ... - NorthJersey.com,
Schering-Plough swings to profit in Q4 Jan 31, 2006
On the plus side, turnover of Clarinex in other territories grew 16% to $63 million, and prescriptions of Claritin (loratadine), Clarinex' predecessor, were up ... - Pharma Times (subscription),
Need help surfing cold and flu medicines? Feb 1, 2006
...do not cause drowsiness are available by prescription, but only Tavist ND and Claritin, which both contain the same antihistamine, loratadine, are available ... - South Bend Tribune,
You may not be able to find your favorite decongestant Dec 6, 2005
In the drug realm, antihistamines such as diphenhydramine (Benadryl), chlorpheniramine (Chlor-Trimeton), cetirizine (Zyrtec), and loratadine (Claritin) can ... - DetNews.com,
Generics Take Off Nov 8, 2005
Schering-Plough beat generics companies to the punch by launching Clarinex, an over-the-counter version of its own Claritin (loratadine), shortly after ... - Drug Discovery & Development (subscription),
Saving Money On Prescription Drugs Sep 28, 2005
Loratadine for allergies is a good example of an over-the-counter (OTC) medicine that is less expensive than brand-name prescription alternatives, Hunter says. ... - FDA.gov
Many meds don't mix with the sun Sep 21, 2005
Orinase). Antihistamines: Cetirizine (Zyrtec), cyproheptadine (Periactin), diphenhydramine (Bena-dryl), loratadine (Claritin). Anti ... - Pioneer Press,
Earnings: BATM cuts losses as sales rise 08 Sep 2005
...development. In addition, the company booked charges of $6.6m. for the recalls of loratadine and infant drop products. Excluding ... - Jerusalem Post,
Perrigo merger in pain Sep 7, 2005
Since November, Perrigo has been hammered by a series of recalls, including loratadine syrup for hayfever and infant pain relievers that were packed with ... - The Grand Rapids Press,
Perrigo Company Reports Fiscal Year 2005 Financial Results Sep 7, 2005
...acquired 23.4 18.2 * Estimated settlement of class action lawsuits 4.5 2.9 $426.7 $415.6 Net income was also impacted by charges for the loratadine and infant ... - PR Newswire (press release),
Perrigo, Agis Industries suffer post-merger blues Sep 1, 2005
Just a week after the announcement, it said it was initiating a retail-level recall of all lots of loratadine syrup, a liquid antihistamine used for relieving ... - International Herald Tribune,
Pocketbook Relief for Allergy Sufferers: Consumer Reports Project ... Aug 11, 2005
...name prescription drug can find just as effective relief at a sixth the cost - or even less - by considering the over-the-counter drug loratadine, the latest ... - WebWire (press release),
Sneezing a lot? Blame allergies Sep 1, 2005
...your reaction. He suggests loratadine, a generic, over-the-counter nonsedating antihistamine. Claritin is one brand name. Once you ... - Kansas.com,
Patient Power: Over-the-Counter Drugs Brief Analysis Aug 22, 2005
...an OTC version, a month’s supply of OTC Claritin is available for $22.37, and generic OTC versions with the same active ingredient (loratadine) sell for less ... - National Center for Policy Analysis,
Govt decides to appoint 2 directors on Morepen board as co ... Jul 6, 2005
...public. Morepen’s woes are linked to its miscalculation of the patent term renewal of an anti-allergy medicine called Loratadine. ... - Economic Times
Schering-Plough Expands Its Presence in Asia Pacific; Commercial ... Jul 6, 2005
Corporation will continue to market and sell several of the company's primary care products, including the allergy products CLARITIN(R) (loratadine) and NASONEX ... - PharmaLive.com (press release)
FDA Approves Orally Disintegrating Prescription Antihistamine, Re ... Jul 23, 2005
Products from the company's research efforts include the CLARITIN( R ) ( loratadine ) family and NASONEX( R ) ( mometasone furoate monohydrate ) Nasal Spray ... - I-Newswire.com (press release)
Over the counter: antihistamines Jul 8, 2005
But generic versions of the same treatments — chlorphenamine, cetirizine and loratadine (all available OTC) — are £1.20 for 28, £2.54 for 30 and £1.98 ... - Times Online
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Schering-Plough Expands Its Presence in Asia Pacific; Commercial ... Jul 7, 2005
Corporation will continue to market and sell several of the company's primary care products, including the allergy products CLARITIN® (loratadine) and NASONEX ... - Pharmaceutical Processing
Govt decides to appoint 2 directors on Morepen board as co ... Jul 6, 2005
...public. Morepen’s woes are linked to its miscalculation of the patent term renewal of an anti-allergy medicine called Loratadine. ... - Economic Times
A Question Of Health Jun 28, 2005
Both the Boots brand and Clarityn contain 10mg of loratadine. ... These also contain 10mg of loratadine, but only cost 39p for seven tablets. ... - Independent
Over the counter: antihistamines Jul 8, 2005
But generic versions of the same treatments — chlorphenamine, cetirizine and loratadine (all available OTC) — are £1.20 for 28, £2.54 for 30 and £1.98 ... - Times Online
Fewer Prescriptions, Lower Costs Follow Claritin's OTC Switch, USA Jun 12, 2005
...became available without a prescription in 2002, insurance plans and consumers spent less on the prescription form of its main ingredient, loratadine, and all ... - Medical News Today
NASONEX(R) (mometasone furoate monohydrate) Effective for Nasal ... Jun 29, 2005
Products from the company's research efforts include the CLARITIN® (loratadine) family of nonsedating antihistamines, CLARINEX® (desloratadine) syrup and ... - Yahoo News (press release)
Chronic Fatigue Syndrome Jul 1, 2005
...ibuprofen. Antihistamines such as loratadine, and decongestants that contain pseudoephedrine may relieve allergy-like symptoms. ... - Health24.com
Allergy medications: Know your options Jun 25, 2005
Newer, second-generation antihistamines — such as loratadine (Claritin), which is available over-the-counter — are less likely to cause sedation. ... - MayoClinic.com
Pollen attacking region's noses Jun 17, 2005
For people with less severe symptoms, Shah recommends an over-the-counter medication such as Loratadine (Claritin, Alavert) or Benadryl. ... - Foster's Daily Democrat,
Other information
Indication
For the relief of symptoms of seasonal allergic rhinitis, pruritus, reduction in the number of hives in patients with chronic idiopathic urticaria.
Pharmacology
Desloratadine is a long-lasting antihistamine. Desloratadine is a second-generation H1-receptor antagonist which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, for example, swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergy. Desloratadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Desloratadine does not enter the brain from the blood and, therefore, does not cause drowsiness.
Mechanism Of Action
Like other H1-blockers, Desloratadine competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Drug Category
Antihistamines; Antihistamines; ATC:R06AX27
Brand Names/Synonyms
Aerius; Alavert; Clarinex; Clarinex Reditabs; Claritin; Claritin Reditabs; Descarboethoxyloratadine; Descarboethoxyoratidine; Desloratadine; Desloratadine [Usan]; Desloratidine; Loratadine; Sch 34117
Dosage Forms
SYRUP; TABLET
Absorption
Not Available
Interactions
-->Interactions for Desloratadine:
In two controlled crossover clinical pharmacology studies in healthy male (n=12 in each study) a nd
female (n=12 in each study) volunteers, desloratadine 7.5 mg (1.5 times the daily dose) once daily was coadministered
with erythromycin 500 mg every 8 hours or ketoconazole 200 mg every 12 hours for 10 days. In three separate
controlled, parallel group clinical pharmacology studies, desloratadine at the clinical dose of 5 mg has been
coadministered with azithromycin 500 mg followed by 250 mg once daily for 4 days (n=18) or with fluoxetine 20 mg once
daily for 7 days after a 23 day pretreatment period with fluoxetine (n=18) or with cimetidine 600 mg every 12 hours
for 14 days (n=18) under steady state conditions to normal healthy male and female volunteers. Although increased
plasma concentrations (C max and AUC 0-24 hrs) of desloratadine and 3-hydroxydesloratadine were observed ,
there were no clinically relevant changes in the safety profile of desloratadine, as assessed by electrocardiographic
parameters (including the corrected QT interval), clinical laboratory tests, vital signs, and adverse events.
Table 1
Changes in Desloratadine and 3-Hydroxydesloratadine Pharmacokinetics in Healthy Male and Female Volunteers |
|
|
Desloratadine |
3-Hydroxydesloratadine |
|
|
C max |
AUC
0-24 hrs |
C max |
AUC
0-24 hrs |
|
Erythromycin
|
|
(500 mg Q8h)
|
+24% |
+14% |
+43% |
+40% |
|
Ketoconazole
|
|
(200 mg Q12h)
|
+45% |
+39% |
+43% |
+72% |
|
Azithromycin
|
|
(500 mg day 1,
250 mg QD × 4 days)
|
+15% |
+5% |
+15% |
+4% |
|
Fluoxetine
|
|
(20 mg QD)
|
+15% |
+0% |
+17% |
+13% |
|
Cimetidine
|
|
(600 mg Q12h)
|
+12% |
+19% |
-11% |
-3% |
Chemical IUPAC Name
Not Available
Chemical Formula
C19H19ClN2
Half Life
50 hours
Drug Type
Approved Drug
# Accession No
APRD00324
CAS Registry Number
100643-71-8