Lopid: profile and news
Lactose intolerance can be counteracted with enzymes Feb 19, 2006
...do so. Omacor is a new one. Niacin, Tricor and Lopid have been around longer and have been used successfully. As an afterthought ... - SouthCoastToday.com,
Lactose intolerance easily treated Feb 14, 2006
...medicines can usually do so. Omacor is a new one. Niacin, Tricor and Lopid have been around longer and have been used successfully. - Sarasota Herald-Tribune,
The Lowdown on High Triglycerides Feb 14, 2006
...you take niacin. Fibrates, which include gemfibrozil (Lopid) and fenofibrate (Tricor), are an alternative to niacin. They reduce ... - Gilroy Dispatch (subscription),
Statins may not affect CD4 cell count responses to HIV treatment ... Feb 1, 2006
...they prescribed the 103 patients (39%) with raised triglyceride levels either bezafibrate (Bezalip), fenofibrate (Lipantil) or gemfibrozil (Lopid), while the ... - Aidsmap,
The FDA's Label Fix Jan 18, 2006
The new label warned that giving Baycol with Lopid, a Pfizer (nyse: PFE - news - people ) cholesterol drug, substantially increased the likelihood of ... - Forbes
Statins may not affect CD4 cell count responses to HIV treatment ... Feb 1, 2006
...they prescribed the 103 patients (39%) with raised triglyceride levels either bezafibrate (Bezalip), fenofibrate (Lipantil) or gemfibrozil (Lopid), while the ... - Aidsmap,
Unlocking the Diabetes-Heart-Disease Connection Jan 9, 2006
Drugs like TriCor and Lopid, cholesterol-lowering drugs called fibrates that are used to treat atherosclerosis, act by regulating lipids. ... - New York Times,
`Good' Cholesterol Pills May Help Drugmakers' Financial Health 12 Dec 2005
A study found that Warner-Lambert Co.'s drug Lopid, which works in part by increasing HDL, cut the risk of heart attacks and dying from cardiovascular disease ... - Bloomberg
Abbott Misses The Golden Ring Nov 14, 2005
Lots of data had hinted at Tricor's potential. In one big study, a similar drug called Lopid had slashed the risk of cardiovascular problems by 22%. ... - Forbes
No good evidence that cholesterol drugs lower melanoma risk Nov 10, 2005
...prescribed to lower cholesterol. Brand names for these drugs include Mevacor, Lipitor, Zocor, Abitrate and Lopid. Earlier research in ... - Dominican Today,
Statins may not protect against melanoma Nov 7, 2005
Statins and fibrates are the most popular drugs prescribed to lower cholesterol. Brand names for the drugs include Mevacor, Lipitor, Zocor, Abitrate and Lopid. ... - Webindia123,
Lifestyle changes can boost HDL cholesterol Oct 3, 2005
The list of medications that can raise HDL cholesterol includes niacin, fibrates such as Lopid and statins such as Lipitor, Zocor and Pravachol. ... - Newark Star Ledger,
Diabetes Drug Cuts Heart Attacks Sep 12, 2005
PPAR alpha reduces the risk of heart disease and is the target of drugs like TriCor, from Abbott, and Lopid, from Pfizer (nyse: PFE - news - people ). ... - Forbes
Drug Treatments: Making the Right Choice Sep 24, 2005
Available drugs that can raise HDL either tend to cause unpleasant side effects (eg, niacin) or do not really raise HDL very much (eg, gemfibrozil, or Lopid). ... - Newsweek
Omega-3 fatty acids better than statins in reducing death Aug 11, 2005
Fibrates are a group of cholesterol-moderating drugs in use since the early 1960s that includes clofibrate (Atromid), gemfibrozil (Lopid), and fenofibrate ... - Health Sentinel
Consider dose size if taking fish oil Jul 26, 2005
Another option is a triglycerides-lowering prescription drug such as Lopid or TriCor, or niacin used under the supervision of a physician. ... - Contra Costa Times
Fish oil is better than flaxseed Jul 7, 2005
...two drugs, generally a statin drug (Lipitor, Mevacor, Zocor, Lescol, Pravachol, Crestor) combined with a triglycerides-lowering drug (Lopid, TriCor, niacin). ... - SunHerald.com
<**results**>
Flaxseed is no substitute for fish oil Jul 8, 2005
...two drugs, generally a statin drug (Lipitor, Mevacor, Zocor, Lescol, Pravachol, Crestor) combined with a triglycerides-lowering drug (Lopid, TriCor, niacin). ... - Fort Wayne News Sentinel
Emphasis Switches To Good Cholesterol Jul 5, 2005
...triglycerides. The fibrates, including gemfibrozil (Lopid) and fenofibrate (Tricor and Lofibra), raise HDL by 10 percent to 15 percent. ... - The Ledger
Insights on cholesterol may save more lives Jul 4, 2005
...triglycerides. The fibrates, including gemfibrozil (Lopid) and fenofibrate (Tricor and Lofibra), raise HDL by 10 percent to 15 percent. - Charlotte Observer,
Eat Fat to Lose Fat May 28, 2005
They gave the mice a drug -- a stronger version of human triglyceride-lowering medications that go by the trade names Lopid and Tricor. ... - PakTribune.com,
Quarterly Event Sprouts Focuses on 'The Future of Pharmaceutical ... Mar 29, 2005
Dr. Canter was involved with the clinical development of Lopid, in particular with the sNDA and the revised labeling after the Helsinki Heart Study. ... - Yahoo News
Taking liver-taxing drugs calls for periodic testing Apr 5, 2005
...felbamate (Felbatol), fenofibrate (Tricor), fluconazole (Diflucan), flutamide (Eulexin), fluvastatin (Lescol), gemfibrozil (Lopid), gemtuzumab (Mylotarg ... - Contra Costa Times,
Update on Risk Factors for Atherosclerosis: The Role of ... Feb 26, 2005
Fibric acid derivatives (gemfibrozil [Lopid], fenofibrate [Tricor], clofibrate [Abitrate]) are used to decrease triglyceride levels. ... - RedNova.com,
BCBSNC Launches New Prescription Drug Savings Initiative Feb 17, 2005
...generic Desyrel) LIPID-LOWERING AGENTS (Drugs to Treat High Cholesterol) cholestyramine (generic Questran) gemfibrozil (generic Lopid) lovastatin (generic ... - PR Newswire (press release)
Other information
Indication
For treatment of adult patients with very high elevations of serum triglyceride levels (Types IV and V hyperlipidemia) who present a risk of pancreatitis and who do not respond adequately to a determined dietary effort
Pharmacology
Gemfibrozil, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia.
Mechanism Of Action
Gemfibrozil increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Gemfibrozil also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL.
Drug Category
Antilipemic Agents; Fribic Acid Derivatives; ATC:C10AB04
Brand Names/Synonyms
Apo-Gemfibrozil; Ausgem; Bolutol; Brozil; CCRIS 318; CHEMBANK796; CI 719; CI-719; Cholespid; Clearol; Decrelip; Elmogan; Fetinor; Fibratol; Fibrocit; GFZ; Gem-S; Gemd; Gemfibril; Gemfibromax; Gemfibrozil; Gemfibrozil [Usan:Ban:Inn]; Gemfibrozilo [Inn-Spanish]; Gemfibrozilum [Inn-Latin]; Gemlipid; Gemnpid; Gen-Fibro; Genlip; Gevilon; Gevilon Uno; Gozid; Hidil; Hipolixan; Innogen; Ipolipid; Jezil; Lanaterom; Lifibron; Lipazil; Lipigem; Lipira; Lipizyl; Lipozid; Lipur; Litarek; Lopid; Low-Lip; Micolip; Normolip; Novo-Gemfibrozil; Nu-Gemfibrozil; Pilder; Po-Gemfibrozil; Polyxit; Progemzal; Reducel; Regulip; Renabrazin; Sinelip; Synbrozil; TEVA-A; Taborcil; Tentroc; Trialmin; Uno; Wl-Gemfibrozil; [Usan:Ban:Inn]
Dosage Forms
CAPSULE; TABLET
Absorption
Well absorbed from GI after oral administration (within 1-2 hours)
Interactions
-->Interactions for Gemfibrozil:
)
| |
| Clinical Laboratory |
| |
|
|
| |
|
|
| |
|
|
| |
|
|
| |
|
|
| |
|
|
| |
|
|
| |
|
|
| Hematopoietic |
|
|
| |
|
|
| |
|
|
| |
|
|
| Immunologic |
|
|
| |
|
|
| |
|
|
| Integumentary |
|
|
| |
|
|
| |
|
|
| |
|
|
Chemical IUPAC Name
5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid
Chemical Formula
C15H22O3
Half Life
1.5 hours
Drug Type
Approved Drug
# Accession No
APRD00293
CAS Registry Number
25812-30-0