Lopid: profile and news






Lactose intolerance can be counteracted with enzymes  Feb 19, 2006
...do so. Omacor is a new one. Niacin, Tricor and Lopid have been around longer and have been used successfully. As an afterthought ... - SouthCoastToday.com,

Lactose intolerance easily treated  Feb 14, 2006
...medicines can usually do so. Omacor is a new one. Niacin, Tricor and Lopid have been around longer and have been used successfully. - Sarasota Herald-Tribune,

The Lowdown on High Triglycerides  Feb 14, 2006
...you take niacin. Fibrates, which include gemfibrozil (Lopid) and fenofibrate (Tricor), are an alternative to niacin. They reduce ... - Gilroy Dispatch (subscription),

Statins may not affect CD4 cell count responses to HIV treatment ...  Feb 1, 2006
...they prescribed the 103 patients (39%) with raised triglyceride levels either bezafibrate (Bezalip), fenofibrate (Lipantil) or gemfibrozil (Lopid), while the ... - Aidsmap,

The FDA's Label Fix  Jan 18, 2006
The new label warned that giving Baycol with Lopid, a Pfizer (nyse: PFE - news - people ) cholesterol drug, substantially increased the likelihood of ... - Forbes

Statins may not affect CD4 cell count responses to HIV treatment ...  Feb 1, 2006
...they prescribed the 103 patients (39%) with raised triglyceride levels either bezafibrate (Bezalip), fenofibrate (Lipantil) or gemfibrozil (Lopid), while the ... - Aidsmap,

Unlocking the Diabetes-Heart-Disease Connection  Jan 9, 2006
Drugs like TriCor and Lopid, cholesterol-lowering drugs called fibrates that are used to treat atherosclerosis, act by regulating lipids. ... - New York Times,

`Good' Cholesterol Pills May Help Drugmakers' Financial Health  12 Dec 2005
A study found that Warner-Lambert Co.'s drug Lopid, which works in part by increasing HDL, cut the risk of heart attacks and dying from cardiovascular disease ... - Bloomberg

Abbott Misses The Golden Ring  Nov 14, 2005
Lots of data had hinted at Tricor's potential. In one big study, a similar drug called Lopid had slashed the risk of cardiovascular problems by 22%. ... - Forbes

No good evidence that cholesterol drugs lower melanoma risk  Nov 10, 2005
...prescribed to lower cholesterol. Brand names for these drugs include Mevacor, Lipitor, Zocor, Abitrate and Lopid. Earlier research in ... - Dominican Today,

Statins may not protect against melanoma  Nov 7, 2005
Statins and fibrates are the most popular drugs prescribed to lower cholesterol. Brand names for the drugs include Mevacor, Lipitor, Zocor, Abitrate and Lopid. ... - Webindia123,

Lifestyle changes can boost HDL cholesterol  Oct 3, 2005
The list of medications that can raise HDL cholesterol includes niacin, fibrates such as Lopid and statins such as Lipitor, Zocor and Pravachol. ... - Newark Star Ledger,

Diabetes Drug Cuts Heart Attacks  Sep 12, 2005
PPAR alpha reduces the risk of heart disease and is the target of drugs like TriCor, from Abbott, and Lopid, from Pfizer (nyse: PFE - news - people ). ... - Forbes

Drug Treatments: Making the Right Choice  Sep 24, 2005
Available drugs that can raise HDL either tend to cause unpleasant side effects (eg, niacin) or do not really raise HDL very much (eg, gemfibrozil, or Lopid). ... - Newsweek

Omega-3 fatty acids better than statins in reducing death  Aug 11, 2005
Fibrates are a group of cholesterol-moderating drugs in use since the early 1960s that includes clofibrate (Atromid), gemfibrozil (Lopid), and fenofibrate ... - Health Sentinel

Consider dose size if taking fish oil  Jul 26, 2005
Another option is a triglycerides-lowering prescription drug such as Lopid or TriCor, or niacin used under the supervision of a physician. ... - Contra Costa Times

Fish oil is better than flaxseed  Jul 7, 2005
...two drugs, generally a statin drug (Lipitor, Mevacor, Zocor, Lescol, Pravachol, Crestor) combined with a triglycerides-lowering drug (Lopid, TriCor, niacin). ... - SunHerald.com <**results**>

Flaxseed is no substitute for fish oil  Jul 8, 2005
...two drugs, generally a statin drug (Lipitor, Mevacor, Zocor, Lescol, Pravachol, Crestor) combined with a triglycerides-lowering drug (Lopid, TriCor, niacin). ... - Fort Wayne News Sentinel

Emphasis Switches To Good Cholesterol  Jul 5, 2005
...triglycerides. The fibrates, including gemfibrozil (Lopid) and fenofibrate (Tricor and Lofibra), raise HDL by 10 percent to 15 percent. ... - The Ledger

Insights on cholesterol may save more lives  Jul 4, 2005
...triglycerides. The fibrates, including gemfibrozil (Lopid) and fenofibrate (Tricor and Lofibra), raise HDL by 10 percent to 15 percent. - Charlotte Observer,

Eat Fat to Lose Fat  May 28, 2005
They gave the mice a drug -- a stronger version of human triglyceride-lowering medications that go by the trade names Lopid and Tricor. ... - PakTribune.com,

Quarterly Event Sprouts Focuses on 'The Future of Pharmaceutical ...  Mar 29, 2005
Dr. Canter was involved with the clinical development of Lopid, in particular with the sNDA and the revised labeling after the Helsinki Heart Study. ... - Yahoo News

Taking liver-taxing drugs calls for periodic testing  Apr 5, 2005
...felbamate (Felbatol), fenofibrate (Tricor), fluconazole (Diflucan), flutamide (Eulexin), fluvastatin (Lescol), gemfibrozil (Lopid), gemtuzumab (Mylotarg ... - Contra Costa Times,

Update on Risk Factors for Atherosclerosis: The Role of ...  Feb 26, 2005
Fibric acid derivatives (gemfibrozil [Lopid], fenofibrate [Tricor], clofibrate [Abitrate]) are used to decrease triglyceride levels. ... - RedNova.com,

BCBSNC Launches New Prescription Drug Savings Initiative  Feb 17, 2005
...generic Desyrel) LIPID-LOWERING AGENTS (Drugs to Treat High Cholesterol) cholestyramine (generic Questran) gemfibrozil (generic Lopid) lovastatin (generic ... - PR Newswire (press release)


Other information


Indication
For treatment of adult patients with very high elevations of serum triglyceride levels (Types IV and V hyperlipidemia) who present a risk of pancreatitis and who do not respond adequately to a determined dietary effort

Pharmacology
Gemfibrozil, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia.

Mechanism Of Action
Gemfibrozil increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Gemfibrozil also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL.

Drug Category
Antilipemic Agents; Fribic Acid Derivatives; ATC:C10AB04

Brand Names/Synonyms
Apo-Gemfibrozil; Ausgem; Bolutol; Brozil; CCRIS 318; CHEMBANK796; CI 719; CI-719; Cholespid; Clearol; Decrelip; Elmogan; Fetinor; Fibratol; Fibrocit; GFZ; Gem-S; Gemd; Gemfibril; Gemfibromax; Gemfibrozil; Gemfibrozil [Usan:Ban:Inn]; Gemfibrozilo [Inn-Spanish]; Gemfibrozilum [Inn-Latin]; Gemlipid; Gemnpid; Gen-Fibro; Genlip; Gevilon; Gevilon Uno; Gozid; Hidil; Hipolixan; Innogen; Ipolipid; Jezil; Lanaterom; Lifibron; Lipazil; Lipigem; Lipira; Lipizyl; Lipozid; Lipur; Litarek; Lopid; Low-Lip; Micolip; Normolip; Novo-Gemfibrozil; Nu-Gemfibrozil; Pilder; Po-Gemfibrozil; Polyxit; Progemzal; Reducel; Regulip; Renabrazin; Sinelip; Synbrozil; TEVA-A; Taborcil; Tentroc; Trialmin; Uno; Wl-Gemfibrozil; [Usan:Ban:Inn]

Dosage Forms
CAPSULE; TABLET

Absorption
Well absorbed from GI after oral administration (within 1-2 hours)

Interactions
-->Interactions for Gemfibrozil:
)
 
 Clinical Laboratory
 

increased creatine

positive antinuclear

 

phosphokinase

antibody

 

increased bilirubin

 
 

increased liver

 
 

transaminases (AST

 
 

(SGOT), ALT (SGPT)

 
 

increased alkaline

 
 

phophatase

 
 Hematopoietic

anemia

thrombocytopenia

 

leukopenia

 
 

bone marrow hypoplasia

 
 

eosinophilia

 
 Immunologic

angioedema

anaphylaxis

 

laryngeal edema

Lupus-like syndrome

 

urticaria

vasculitis

 Integumentary

exfoliative dermatitis

alopecia

 

rash

 
 

dermatitis

 
 

pruritus

 




Chemical IUPAC Name
5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid

Chemical Formula
C15H22O3

Half Life
1.5 hours

Drug Type
Approved Drug

# Accession No
APRD00293

CAS Registry Number
25812-30-0

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