Lomotil: profile and news

Modern Marco Polos Feb 5, 2006
We got a letter from the medical director of Starquest, giving us general hygiene tips: Bring our own diarrhea kit (Cipro, Lomotil, Imodium), get a ... - Indianapolis Star,

Banned drugs freely available in Punjab Jan 21, 2006
Some of these banned drugs include Compose, Valium, Pentotil, Lomotil, Proxyvon, Corex Syrup, Parvondex and Phensydyl, Mr Gurbinder Singh, (DDO) of the Health ... - SikhSangat News

Enforcement of Tradedress as IP-A Case Study Dec 2, 2005
Searle is the registered proprietor of the famous anti diarrhea drug LOMOTIL. The trademark LOMOTIL is an ‘inventive word’ derived ... - Mondaq News Alerts,

CONSTIPATION OR BOWEL OBSTRUCTION? Nov 18, 2005
DONOHUE: Recently I was told I have collagenous colitis. I have taken the following for it: Asacol, Lomotil and Imodium. I am now taking four drops of opium. ... - Charlotte Sun-Herald,

A plate of nachos means gut-wrenching pain Nov 22, 2005
...things out. She also takes Lomotil, an anti-diarrheal, before meals and when she feels the first signs of cramping. Irritable bowel ... - The News Journal,

Fired campus bus driver had history of auto accidents Nov 16, 2005
Bloomington Police Department Capt. Joe Qualters. The drug, an antidiarrheal, is sold under the brand name Lomotil. "It appears it was ... - Indiana Daily Student

Moving toward safe health care Nov 9, 2005
...names. Take for example Lamictal (antiepileptic), Lamisil (antifungal) Ludiomil (antidepressant) and Lomotil (antidiarrheic). More ... - Naples Sun Times,

P2.3-BILLION ILLEGAL DRUGS DESTROYED IN CAVITE Oct 3, 2005
...of shabu, 444 liters of liquid shabu; more than kilos of marijuana; 248 liters of elixir syrup; 1.32 kilos of Phenobarbital; 1.76 kilos of Lomotil, and 37.9 ... - Philippine Headline News,

Home health care executive charged with drug trafficking Aug 18, 2005
Home Medical, Inc. in Nashville, is charged with possession for resale of cocaine, Xanax, Lortab, Lomotil and Klonopin. Talley also ... - WATE.com,

Prevention is still better Aug 28, 2005
...taste. OTC (over the counter) anti-motility agents such as lomotil or lomofen can decrease the frequency of the stools immediately. ... - Newindpress on Sunday,

Home health care executive charged with drug trafficking Aug 17, 2005
...president and CEO of Tennessee Home Medical Incorporated in Nashville, is charged with possession for resale of cocaine, Xanax, Lortab, Lomotil and Klonopin. ... - WVLT,

That gut feeling Jul 21, 2005
25. In 1837, treatment for indigestion was limited — there was no Lomotil or Imodium to soothe and quieten his troubled guts. ... - Times Online

Radiation Therapy and Chronic Diarrhea Jul 5, 2005
...to slow down the gastrointestinal tract. Examples of these medications are Lomotil and Immodium. These medications are very safe ... - Saturday Evening Post

One Dead Guinea Pig Jul 27, 2005
...was exam for complaints of diarrhea… [I] ordered study meds to be discontinued (abnormal electrolyte results) diet clear fluids and lomotil as instructed.". - Houston Press

Cryptosporidiosis Presenting As Acute Appendicitis: A Case Report Jul 8, 2005
...symptomatic patients usually involves a combination therapy of an antimicrobial (nitazoxanide, paromomycin, azithromycin) and an antidiarrheal (Lomotil) agent. ... - RedNova.com <**results**>

Drug controllers raid pharmacists Jun 20, 2005
Similarly, 42 bottles of cough syrups were seized with 68 injections, 1,480 lomotil tablets which are often used as intoxicants. ... - Ludhiana Newsline,

REGION AL BRIEFS Jun 4, 2005
Day duty officer Gurpreet Singh and chief warden Kashmira Singh recovered 200 tablets of lomotil and 10 capsules of hypnotix from him during routine checking. ... - The Tribune,

Peel Regional Police - Dangerous drugs stolen during break and ... Apr 1, 2005
Codeine Tablets - PMS-Morphine Sulphate, 15, 30 and 60 mgs - Coactifed Tablets - Tenuate - Louamine - Oxycocet - Endocet - Statix 5 mgs - Lomotil - Ritalin SR ... - CNW Telbec (Communiqués de presse)

Proteins can cause infections Mar 30, 2005
Entocort is a cortisone medicine. There are other, noncortisone medicines: Azulfidine, azathioprine, WelChol, Imodium and Lomotil. ... - Yuma Sun,

Other information

Indication
For as adjunctive therapy in the management of diarrhea

Pharmacology
Diphenoxylate, an antidiarrheal, is effective as adjunctive therapy in the management of diarrhea. Diphenoxylate is rapidly and extensively metabolized in man by ester hydrolysis to diphenoxylic acid (difenoxine), which is biologically active and the major metabolite in the blood.

Mechanism Of Action
Diphenoxylate is an opiate receptor agonists that stimulate mu receptors in GI to decrease the peristalsis and constrict the sphincters. Diphenoxylate has a direct effect on circular smooth muscle of the bowel, that conceivably results in segmentation and prolongation of gastrointestinal transit time. The clinical antidiarrheal action of diphenoxylate may thus be a consequence of enhanced segmentation that allows increased contact of the intraluminal contents with the intestinal mucosa.

Drug Category
Narcotics; Antidiarrheals; Antiperistaltic; ATC:A07DA01

Brand Names/Synonyms
Dea No. 9170; Difenossilato [Dcit]; Difenoxilato [Inn-Spanish]; Difenoxilato [Spanish]; Diphenoxalate; Diphenoxylate; Diphenoxylate Hydrochloride; Diphenoxylate-Atropine; Diphenoxylatum [Inn-Latin]; Diphenoxylatum [Latin]; HSDB 3067; Lomotil; R 1132; R-1132

Dosage Forms
Oral Solution; Tablet

Absorption
90%

Interactions
Interactions for Diphenoxylate:

Known drug interactions include barbiturates, tranquilizers, and alcohol. Diphenoxylate HCl and atropine sulfate may interact with MAO inhibitors

In studies with male rats, diphenoxylate hydrochloride was found to inhibit the hepatic microsomal enzyme system at a dose of 2 mg/kg/day.

Therefore, diphenoxylate has the potential to prolong the biological half-lives of drugs for which the rate of elimination is dependent on the microsomal drug metabolizing enzyme system.

Chemical IUPAC Name
ethyl 1-(3-cyano-3,3-diphenyl-propyl)-4-phenyl-piperidine-4-carboxylate

Chemical Formula
C30H32N2O2

Half Life
12-14 hours

Drug Type
Approved Drug

# Accession No
APRD00366

CAS Registry Number
915-30-0