Lodine: profile and news

Beethoven's Ninth a Musical Treat By ESO  07 Mar 2006
The finale featured pristine performances by soprano Jonita Lattimore, mezzo- soprano Emily Lodine, tenor Robert Bracey and bass Stephen Morscheck and the ECU. ... - International News Service,

Oratorio explores joy of live  Mar 5, 2006
Grand Rapids soprano Diane Penning, Calvin College bass baritone Keith Brautigam and guest mezzo-soprano Emily Lodine will be soloists in the 70-minute program ... - The Grand Rapids Press,

/FIRST AND FINAL ADD -- LNTH005 -- Shire plc: Strong 2005 ...  Feb 23, 2006
8,276 +25% 2% FOSRENOL 29,032 - N/A 6% CALCICHEW 10,359 10,727 -3% 2% REMINYL/REMINYL XL 4,136 2,865 +44% 1% SOLARAZE 3,754 3,244 +16% 1% LODINE 3,114 2,663 +17 ... - PR Newswire (press release),

Shire plc: Strong 2005 Performance Supports Positive Outlook  Feb 23, 2006
TM) (I2S) (idursulfase) EQUETRO(TM) (carbamazepine extended-release capsules) FOSRENOL(R) (lanthanum carbonate) GA-GCB(R) (gene-activated) LODINE (R) (etodolac ... - PR Newswire (press release),

THIS BUD'S FOR YOU  Feb 7, 2006
Others adding to the success of the uplifting service were: Sis. Lodine Jenkins, Rev. Iver Williams, Mins. Kenneth Niblack, Marie Wells and Mins. ... - Houston African-American News,

THIS BUD'S FOR YOU  Feb 7, 2006
Others adding to the success of the uplifting service were: Sis. Lodine Jenkins, Rev. Iver Williams, Mins. Kenneth Niblack, Marie Wells and Mins. ... - Houston African-American News,

Joyful noise for the holidays  Nov 25, 2005
For this performance, the WCO and conductor Andrew Sewell will be joined by guest soloists soprano Sarah Hibbard, alto Emily Lodine, tenor Robert Bracey and ... - The Capital Times,

Sleep deprivation makes driving dangerous  Sep 18, 2005
Then he prescribed Lodine (etodolac). In the flap over Vioxx, I have never seen it mentioned. I've taken Lodine for 10 years when I need it. ... - Houston Chronicle,

Even if you wash hands, restroom germs still lurk  Sep 19, 2005
...tablets a day, he said: "Mary, you have two choices: Either change your medication, or die in a pool of your own blood." Then he prescribed Lodine (etodolac). ... - Charlotte Observer,

CHEESE 2005 – Fiore sardo, the oldest cheese in the ...  Sep 19, 2005
...to protect traditional Fiore sardo in its area of origin: the province of Nuoro in general, and the small communes of Gavoi, Ollolai, Ovodda, Lodine, Fonni and ... - Slow food,

FDA Safety Labeling Changes: Requip, Lodine, Zestril  Aug 24, 2005
On May 24, the FDA approved revisions to the safety labeling for etodolac (Lodine capsules and tablets, made by Wyeth Pharmaceuticals, Inc.) to warn of the ... - Medscape (subscription)

The Bad Old Days  Aug 29, 2005
16, 1901, the local marshal, CJ Lodine, was contacted by telephone - a very new invention for the two-year-old town - to be on the lookout for two men and a ... - Storm Lake Pilot Tribune,

The Medical Minute: Pain - the fifth vital sign  Aug 31, 2005
Prescription nonsteroidal anti-inflammatories include Naprosyn, Motrin, Relafen, Daypro, Feldene, Lodine, Indocin, Mobic, Celebrex, Bextra, Vioxx and others. ... - Penn State Live,

Vital Signs Older pain drugs set for comeback  Aug 23, 2005
Ingelheim and Abbott Laboratories (ABT: news, chart, profile) , along with generic diclofinac, sold as Voltaren, and etodolac, sold as Lodine, mimic the Cox-2 ... - MarketWatch

Regatta, rods, 'Vettes in the Park this weekend  Aug 11, 2005
Tuesday night. Mezzo-soprano Emily Lodine will be singing at the Lakes Art Center tomorrow night accompanied by Karen Carr. The ... - Sioux City Journal,

Rising Opera Stars Have Connection To Scott County  Aug 17, 2005
FOREST--Magnolia Manor resident Lodine McNeese enjoyed a visit with two special guests last week - rising opera stars from Chicago. ... - Scott County Times,

Mayes makes this her 47th season at Okoboji  Aug 4, 2005
Saturday night will see mezzo-soprano Emily Lodine accompanied by Karen Carr at the Lakes Art Center, in a concert entitled Love and Broadway, featuring light ... - Sioux City Journal

Drug Name Confusion Can Be Deadly, Says FDA Magazine  Jul 19, 2005
There have been others: Serzone, an antidepressant, for Seroquel, used to treat schizophrenia, and iodine for Lodine, a non-steroidal anti-inflammatory drug. ... - SeniorJournal.com

Chicagoans Look Deep Inside Their Pizzas and Find Art  Jul 19, 2005
2.). Deep-dish pizza may be Mr. Smith's muse, but for Emily Lodine, a mezzo-soprano, her culinary creative spark comes from chocolate cake and Julia Child. ... - New York Times <**results**>

Wyeth’s Tygacil antibiotic will be manufactured in Carolina ...  Jun 24, 2005
...site produces such injectable antibiotics as Zosyn and the new Tygacil, while the plant in Guayama manufactures Premarin, Effexor, Lodine, and anticonvulsives ... - Puerto Rico Herald

Some drug prices go up after rivals leave market  Jun 6, 2005
Consumer Reports says the average retail price for painkiller Lodine, made by Wyeth Pharmaceuticals, rose 13.3% from September to March. ... - Middle East North Africa Financial Network,

ACE-inhibitors

Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.

Antacids

The concomitant administration of antacids has no apparent effect on the extent of absorption of Lodine. However, antacids can decrease the peak concentration reached by 15% to 20% but have no detectable effect on the time-to-peak.

Aspirin

When Lodine is administered with aspirin, its protein binding is reduced, although the clearance of free etodolac is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of Lodine and aspirin is not generally recommended because of the potential of increased adverse effects.

Cyclosporine, Digoxin, Methotrexate

Lodine, like other NSAIDs, through effects on renal prostaglandins, may cause changes in the elimination of these drugs leading to elevated serum levels of cyclosporine, digoxin, methotrexate, and increased toxicity. Nephrotoxicity associated with cyclosporine may also be enhanced. Patients receiving these drugs who are given Lodine, or any other NSAID, and particularly those patients with altered renal function, should be observed for the development of the specific toxicities of these drugs.

Diuretics

Etodolac has no apparent pharmacokinetic interaction when administered with furosemide or hydrochlorothiazide. Nevertheless, clinical studies, as well as postmarketing observations have shown that Lodine can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with NSAIDs, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy.

Glyburide

Etodolac has no apparent pharmacokinetic interaction when administered with glyburide.

Lithium

NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. The mean minimum lithium concentration increased 15% and the renal clearance was decreased by approximately 20%. These effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID. Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.

Phenylbutazone

Phenylbutazone causes increase (by about 80%) in the free fraction of etodolac. Although in vivo studies have not been done to see if etodolac clearance is changed by coadministration of phenylbutazone, it is not recommended that they be coadministered.

Phenytoin

Etodolac has no apparent pharmacokinetic interaction when administered with phenytoin.

Warfarin

The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than that of users of either drug alone. Short-term pharmacokinetic studies have demonstrated that concomitant administration of warfarin and Lodine^Ò (etodolac capsules and tablets) results in reduced protein binding of warfarin, but there was no change in the clearance of free warfarin. There was no significant difference in the pharmacodynamic effect of warfarin administered alone and warfarin administered with Lodine as measured by prothrombin time. Thus, concomitant therapy with warfarin and Lodine should not require dosage adjustment of either drug. However, caution should be exercised because there have been a few spontaneous reports of prolonged prothrombin times, with or without bleeding, in etodolac-treated patients receiving concomitant warfarin therapy.

Drug/Laboratory Test Interactions

The urine of patients who take Lodine can give a false-positive reaction for urinary bilirubin (urobilin) due to the presence of phenolic metabolites of etodolac. Diagnostic dip-stick methodology, used to detect ketone bodies in urine, has resulted in false-positive findings in some patients treated with Lodine. Generally, this phenomenon has not been associated with other clinically significant events. No dose relationship has been observed.

Lodine treatment is associated with a small decrease in serum uric acid levels. In clinical trials, mean decreases of 1 to 2 mg/dL were observed in arthritic patients receiving etodolac (600 mg to 1000 mg/day) after 4 weeks of therapy. These levels then remained stable for up to 1 year of therapy.