Lisinopril: profile and news
Aurobindo gets USFDA nod for 'Lisinopril' tabs Feb 23, 2006
MUMBAI: Aurobindo Pharma Ltd on Friday said that it has got final approval from US Food Drug Administration (US FDA) for its 'Lisinopril' tablets. ... - Hindu Business Line,
Aurobindo gets USFDA nod for Lisinopril tabs Feb 23, 2006
Aurobindo Pharma has recieved approval from the US Food and Drug Administration (USFDA) for Lisinopril tablets of 2.5, 5, 10, 20, 30 and 40 mg. ... - Business Standard,
Cardiovascular Outcomes in High-Risk Hypertensive Patients ... Feb 8, 2006
...the efficacy of first-step treatment with a calcium-channel blocker (amlodipine) or an angiotensin-converting enzyme inhibitor (lisinopril), each compared with ... - Annals of Internal Medicine
Bilateral adrenal masses: phaeochromocytoma or melanoma? Feb 28, 2006
...local hospital where he was seen a month later and was found to be hypertensive, with a blood pressure of 190/96 mmHg, for which he was commenced on lisinopril ... - Journal of the Royal Society of Medicine
A New Way to Buy Prescriptions Feb 10, 2006
...price comparison. Costco sells that same medication for $130.67. I also checked Lisinopril (blood pressure). CVS charges $13.39 ... - DailyIndia.com,
Serial magnetic resonance imaging based assessment of the early ... Feb 8, 2006
Three groups of animals were analyzed: sham-operated rats (n = 6), MI rats receiving lisinopril (n = 11), and MI rats receiving placebo (n = 8). LV dilation ... - HeartZine,
Dalal Street Spikes: UTI Bank in limelight Feb 24, 2006
...the counter. Aurobindo has gained 1% to Rs 558 after the company received the final USFDA approval for Lisinopril tablets. Earlier ... - Business Standard,
Indian shares flat, Colombo rallies on peace hopes Feb 23, 2006
Aurobindo Pharma Ltd. rose more than 2 percent to 565 rupees after it received US FDA approval for hypertension drug lisinopril. * Jagson Airlines Ltd. ... - Reuters India,
Packaging to Feb 7, 2006
The study found that patients taking lisinopril – a medication used to treat chronic high blood pressure – were more likely to have their prescriptions ... - Ferret,
Necrotizing Fasciitis in a Patient with Type 2 Diabetes Mellitus Feb 9, 2006
...included type 2 diabetes mellitus, hypertension, and depression, which were medically managed with injectable insulin glargine, lisinopril, and paroxetine ... - Journal of the American Podiatric Medical Association
Serial magnetic resonance imaging based assessment of the early ... Feb 8, 2006
Three groups of animals were analyzed: sham-operated rats (n = 6), MI rats receiving lisinopril (n = 11), and MI rats receiving placebo (n = 8). LV dilation ... - HeartZine,
Packaging to Feb 7, 2006
The study found that patients taking lisinopril – a medication used to treat chronic high blood pressure – were more likely to have their prescriptions ... - Ferret,
The colorful ending of the licorice story Jan 17, 2006
Lots of things influence human waste, even corn, but we're not going there. What are the side effects of lisinopril? Does it cause impotence? - Newsday,
Medicure Announces Financial Results for Fiscal Second Quarter ... Jan 10, 2006
...in research and development expenditures was also due to the clinical development program of MC-4232, a combination of MC-1 and the ACE inhibitor, lisinopril. ... - CCNMatthews (press release),
'Working poor' join ranks of uninsured Jan 18, 2006
Phoenix. His prescriptions had been running about $20 a month. His monthly supply of blood-pressure medicine, Lisinopril, costs $7. He ... - AZ Central.com,
At 3:15 am, Decisions Made In The Dark Jan 22, 2006
..."Well, she is 87 years old and has diabetes, congestive heart failure on Toprol XL 25 mg; hypertension on lisinopril 5 mg a day; a bit of asthma on prn meds ... - Hartford Courant,
Food dyes cause colorful waste Jan 19, 2006
Many anti-gas formulas produce bright orange, scaring new moms who use those infant drops. Dear Pharmacist: What are the side effects of lisinopril? ... - Sun-Sentinel.com,
Stock Watch Jan 24, 2006
It received two ANDA approvals viz. for Lisinopril Tablets and Cephalexin suspension respectively during the quarter under review. ... - Express Pharma Pulse,
Loss of taste, smell often tied to high blood pressure, meds Jan 24, 2006
...diuretics (water pills) such as hydrochlorothiazide, and ACE inhibitors such as captopril (Capoten), enalapril (Vasotec), and lisinopril (Prinivil, Zestril). ... - Charlotte Observer,
Blue Cross dispensing generics Dec 9, 2005
To that extent, even if doctors hand out brand-name samples, their patients could still fill their prescriptions with generics – with lisinopril instead of ... - Providence Business News,
Lupin receives USFDA approval for Cephalexin capsules Dec 1, 2005
...the USFDA. The company had received approvals from the US FDA for Lisinopril tablets and Cephalexin for Oral Suspension. A main ... - Myiris.com,
Lupin receives US FDA approval for Cephalexin capsules Dec 1, 2005
Earlier this year, the company had received approvals from the US FDA for Lisinopril tablets and Cephalexin for oral suspension. ... - domain-B,
Medicare's drug-plan finder can be daunting Nov 14, 2005
To narrow that list, we entered four drugs that a beneficiary might take: Humulin, a type of insulin; Lisinopril, a blood pressure medicine; Neurontin, a pain ... - USA Today
Web site errors add to Medicare confusion Dec 3, 2005
Last week, the cost had dropped to $688. The driving force behind the plan's shifting cost was Lisinopril, a blood-pressure medication that Borreca takes. ... - Houston Chronicle,
Lupin gets nod for antibiotic Cephalexin Dec 1, 2005
...year, Lupin said. Earlier this year, Lupin received approvals for Lisinopril tablets and Cephalexin for Oral Suspension. The latest ... - India Infoline.com,
Choosing Mom's new drug benefit gave me a headache Nov 17, 2005
...there. Calling the druggist, we enter its full name hydrochlorothiazide. But do we want it alone or with lisinopril? And so it went. ... - Boston Globe,
US drug industry's credibility gap Nov 14, 2005
Overall, the number of prescriptions continues to rise slightly, but an increasing share is going to generic drugs like lisinopril, a blood pressure medicine ... - International Herald Tribune,
For The Drug Industry, A Number Of Bitter Pills Nov 14, 2005
Overall, the number of prescriptions continues to rise slightly, but an increasing share are going to generic drugs like lisinopril, a blood pressure medicine ... - TheDay (subscription),
Gender-related differences in left ventricular structural and ... Nov 23, 2005
Long-term effects of amlodipine and lisinopril on left ventricular mass and diastolic function in elderly, previously untreated hypertensive patients: the ... - Nature.com (subscription),
Aging just one cause for loss of taste Nov 21, 2005
...diuretics (water pills) such as hydrochlorothiazide, and ACE inhibitors, such as captopril (Capoten), enalapril (Vasotec) and lisinopril (Prinivil, Zestril). ... - Charleston Post Courier (subscription),
Lupin gets USFDA nod for Lisinopril tablets Sep 13, 2005
The US Food and Drug Administration (USFDA) has approved the abbreviated new drug application (ANDA) of Lupin for Lisinopril tablets USP. ... - Business Standard,
Lupin gets USFDA approval for Lisinopril ANDA Sep 13, 2005
DELHI: Pharma major, Lupin Ltd on Tuesday said that it has got approval from the US FDA of its abbreviated new drug application (ANDA) for Lisinopril tablets. ... - Hindu Business Line,
Lupin gets US nod for lisinopril tablets Sep 13, 2005
...said on Tuesday it had received approval from the US Food and Drug Administration to market lisinopril tablets, a generic form of AstraZeneca Plc's Zestril drug ... - Sify,
Lupin receives FDA approval for lisinopril tablets Sep 23, 2005
Lupin announced that the US Food and Drug Administration (USFDA) has approved the company’s Abbreviated New Drug Application (ANDA) for Lisinopril Tablets USP ... - Express Pharma Pulse,
Medicure Meets Primary Endpoints in Phase II Diabetic Hypertension ... Sep 14, 2005
The study evaluated MC-4232, a combination of MC-1 and the ACE inhibitor, lisinopril, in the treatment of coexisting diabetes and hypertension. ... - Business Wire (press release),
Lupin gets USFDA approval for ANDA Sep 13, 2005
NEW DELHI: Pharma major Lupin Ltd Tuesday said it has got approval from the US FDA of its Abbreviated New Drug Application (ANDA) for Lisinopril Tablets. ... - Economic Times,
Changing of hair color unusual reaction to drug Sep 29, 2005
I'm also on lisinopril for blood pressure and Lanoxin for my heart. I would appreciate any information about diet and nutrition with respect to my medications. ... - The Republican,
Medicure shares rise after cardioprotective drug gets on FDA fast ... Sep 21, 2005
The study evaluated MC-4232, a combination of MC-1 and the ACE inhibitor, lisinopril, in the treatment of co-existing diabetes and hypertension. ... - Canada.com,
Medicure achieves 'primary endpoints' in diabetic hypertension ... Sep 14, 2005
The so-called MATCHED study evaluated MC-4232, a combination of MC-1 and the ACE inhibitor, lisinopril, in the treatment of co-existing diabetes and ... - National Post,
Best Treatments: Managing Heart Failure Sep 24, 2005
Angiotensin-converting-enzyme (ACE) inhibitors like lisinopril or ramipril lower blood pressure, reduce the risk of premature death by 15 to 20 percent and ... - Newsweek
Medicure surges on positive test results Sep 15, 2005
MC-4232 is a combination of Medicure's flagship MC-1 cardiovascular drug and the angiotensin-converting enzyme (ACE) inhibitor lisinopril. ... - Globe and Mail,
Wrap up: Sensex ends at a new high Sep 13, 2005
US Food and Drug Administration (USFDA) has approved Lupin Ltd`s Abbreviated New Drug Application (ANDA) for Lisinopril Tablets USP. ... - Myiris.com,
People on the Move Sep 21, 2005
Dr. Raza was also involved in the development and launch of Zestril. Composed of lisinopril, Zestril is also marketed by Merck & Co. (merck.com) as Prinivil. ... - R&D Directions (subscription),
FDA Safety Labeling Changes: Requip, Lodine, Zestril Aug 24, 2005
...in elderly or debilitated patients and those with a prior history of peptic ulcer disease and/or gastrointestinal bleeding; and lisinopril therapy has been ... - Medscape (subscription)
FDA Safety Labeling Changes: Clozaril, Pegasys, Zestoretic Aug 17, 2005
...regularly for granulopoietic suppression; use of peginterferon alfa-2a injection may cause or exacerbate autoimmune disorders; and the lisinopril component of ... - Medscape (subscription)
Top 20 drugs sought on Internet Aug 12, 2005
The top 20 drugs are, in order, Lipitor, Levoxyl, Fosamax, Viagra, Zocor, Advair Diskus, Celebrex, Zoloft, Lisinopril, Norvasc, Premarin, Cialis, Actonel ... - Honeycomb Connect,
Cholesterol drug has surprising, hairy side effect Aug 31, 2005
I'm also on lisinopril for blood pressure and Lanoxin for my heart. I would appreciate any information about diet and nutrition with respect to my medications. ... - Daily Press,
Drugs lower cholesterol -- and may turn gray hair dark Aug 22, 2005
I'm also on lisinopril for blood pressure and Lanoxin for my heart. Your wife was trying to help, but don't use the salt substitute. ... - Charlotte Observer,
Senior Corner: Be ready to choose among drug plans Aug 16, 2005
A few examples: Lisinopril (Zestril): lowers blood pressure; 100 tablets, 20 mg. Canada: $83.56, US: $31.39; Lovastatin (Mevacor): 100 tablets, 20 mg. ... - Santa Cruz Sentinel,
Other information
Indication
For the treatment of hypertension, heart failure and acute myocardial infarction. It may be used alone or in combination with thiazide diuretics
Pharmacology
Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension, congestive heart failure (CHF), postmyocardial infarction, and diabetic nephropathy or retinopathy. Although it is the lysine ester of enalaprilat, the active form of the prodrug enalapril, lisinopril is active unchanged.
Mechanism Of Action
Lisinopril competes with angiotensin I for its binding site on the angiotensin-converting enzyme (ACE), an enzyme which converts angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin II plasma levels result in decreased blood pressure and increased plasma renin activity. Baroreceptor reflex mechanisms, stimulated by the fall in blood pressure, release kininase II, an enzyme identical to ACE that degrades bradykinin, a vasodilator.
Drug Category
Cardiotonic Agents; Antihypertensive Agents; Angiotensin-converting Enzyme Inhibitors; ATC:C09AA03
Brand Names/Synonyms
Acercomp; BL 19; BL-19; HSDB 6852; Inhibril; Linopril; Lisinopril; Lisinopril Dihydrate; Lisipril; Lysinopril; Noperten; Presiten; Prinivil; Prinzide; Renacor; Sinopril; Zestoretic; Zestril
Dosage Forms
Tablets
Absorption
Approximately 25%, but widely variable between individuals (6 to 60%)
Interactions
-->Interactions for Lisinopril:
Hypotension - Patients on Diuretic Therapy: Patients on diuretics, and especially those in
whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure
after initiation of therapy with PRINIVIL. The possibility of hypotensive effects with PRINIVIL can be minimized by
either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with PRINIVIL. If it
is necessary to continue the diuretic, initiate therapy with PRINIVIL at a dose of 5 mg daily, and provide close
medical supervision after the initial dose until blood pressure has stabilized. When a diuretic is added to the
therapy of a patient receiving PRINIVIL, an additional antihypertensive effect is usually observed. Studies with ACE
inhibitors in combination with diuretics indicate that the dose of the ACE inhibitor can be reduced when it is given
with a diuretic.
Non-steroidal Anti-inflammatory Agents: In some patients with compromised renal function who
are being treated with non-steroidal anti-inflammatory drugs, the co-administration of lisinopril may result in a
further deterioration of renal function. These effects are usually reversible.
Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors, including
lisinopril. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE
inhibitors.
In a study in 36 patients with mild to moderate hypertension where the antihypertensive effects of
PRINIVIL alone were compared to PRINIVIL given concomitantly with indomethacin, the use of indomethacin was
associated with a reduced antihypertensive effect, although the difference between the two regimens was not
significant.
Other Agents: PRINIVIL has been used concomitantly with nitrates and/or digoxin without
evidence of clinically significant adverse interactions. This included post myocardial infarction patients who were
receiving intravenous or transdermal nitroglycerin. No clinically important pharmacokinetic interactions occurred
when PRINIVIL was used concomitantly with propranolol or hydrochlorothiazide. The presence of food in the stomach
does not alter the bioavailability of PRINIVIL.
Agents Increasing Serum Potassium: PRINIVIL attenuates potassium loss caused by thiazide-type
diuretics. Use of PRINIVIL with potassium-sparing diuretics (e.g., spironolactone, triamterene, or amiloride),
potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Therefore, if concomitant use of these agents is indicated because of demonstrated hypokalemia, they should be used
with caution and with frequent monitoring of serum potassium. Potassium sparing agents should generally not be used
in patients with heart failure who are receiving PRINIVIL.
Lithium: Lithium toxicity has been reported in patients receiving lithium concomitantly with
drugs which cause elimination of sodium, including ACE inhibitors. Lithium toxicity was usually reversible upon
discontinuation of lithium and the ACE inhibitor. It is recommended that serum lithium levels be monitored frequently
if PRINIVIL is administered concomitantly with lithium.
Chemical IUPAC Name
1-[6-amino-2-(1-carboxy-3-phenyl-propyl)amino-hexanoyl]pyrrolidine-2-carboxylic acid dihydrate
Chemical Formula
C21H31N3O5
Half Life
12 hours
Drug Type
Approved Drug
# Accession No
APRD00560
CAS Registry Number
83915-83-7