Lidocaine: profile and news






Adolor Corporation to Present at the Lehman Brothers' Ninth Annual ...  07 Mar 2006
Adolor is developing a sterile lidocaine patch which isin Phase 2 clinical development for post-surgical incisional pain.Adolor also has a number of discovery ... - Finanzen.net,

Adolor Corporation to Present at the Lehman Brothers' Ninth Annual ...  07 Mar 2006
...indications. Adolor is developing a sterile lidocaine patch which is in Phase 2 clinical development for post-surgical incisional pain. ... - Business Wire (press release),

The Analgesic Effect of Nitroglycerin Added to Lidocaine on ...  Feb 21, 2006
...mynet.com. We evaluated the analgesic effect of nitroglycerine (NTG) when added to lidocaine in IV regional anesthesia. Thirty patients ... - Anesthesia & Analgesia (subscription),

Sontra eases the pain of needles  Mar 3, 2006
This means that an anaesthetic such as lidocaine can be applied topically with minimal or no pain in a procedure that lasts on average 15 seconds. ... - In-PharmaTechnologist.com,

Is TNS Really No Big Deal?  Feb 14, 2006
Dr. Lambert about the implications for patient safety of the transient neurologic symptoms (TNS) that sometimes develop after spinal anesthesia with lidocaine. ... - Anesthesia & Analgesia (subscription),

Yengo daughter tells  Mar 4, 2006
Cullen injected lidocaine, a local anesthetic, and heart medication into Yengo's intravenous line. He died of heart failure June 11, 1988. ... - The Jersey Journal,

Adolor Corporation Reports Year End 2005 Financial Results  Mar 2, 2006
...the wherewithal to accomplish this as well as the advancement of our pipeline products -- the opioid alvimopan co-formulation, the sterile lidocaine patch and ... - Genetic Engineering News,

Does Dexamethasone Improve the Quality of Intravenous Regional ...  Feb 6, 2006
We investigated the anesthetic and analgesic effectiveness of adding dexamethasone to lidocaine for IV regional anesthesia (IVRA). ... - Anesthesia & Analgesia (subscription),

Longtime judge dies at 76  Mar 3, 2006
Diaz to death in 1984 for killing 12 mostly elderly patients in Banning and Perris hospitals by injecting them with lethal doses of lidocaine, a heart drug. ... - Press-Enterprise (subscription),

Sontra Medical Introduces Generation 1.75 SonoPrep(R) Skin ...  Feb 7, 2006
Rolls Out New and Improved Ultrasonic Device for Topical Lidocaine Delivery FRANKLIN, Mass., Feb. 7/PRNewswire-FirstCall/-- Sontra ... - PR Newswire (press release),

Positive late stage data for Corgentech's painkiller  Feb 22, 2006
ALGRX 3268 utilizes a needleless injection system to locally deliver lidocaine into the skin to anesthetize the skin and relieve pain very rapidly. ... - Pharmaceutical Business Review

Corgentech kids' pain drug shows promise  Feb 21, 2006
ALGRX 3268 delivers lidocaine via needleless injection system into the skin to anesthetize the skin and relieve pain rapidly, Corgentech said. ... - United Press International

Blurred Vision as the only Symptom of a Positive Epidural Test ...  Feb 21, 2006
...the epidural space. After negative aspiration, a 3 mL test dose of 1.5% lidocaine with 1:200,000 epinephrine was given. Within 1 ... - Anesthesia & Analgesia (subscription),

Needle-wary dental patients now have option  Feb 21, 2006
Oraqix, a mixture of lidocaine and prilocaine, is applied as a liquid at room temperature using a blunt tip applicator to periodontal pockets. ... - Charlotte Observer,

Continuous Epidural Block Versus Continuous Popliteal Nerve Block ...  Feb 21, 2006
After general anesthesia, 0.5 to 1 mL/kg of an equal-volume mixture of 0.25% bupivacaine and 1% lidocaine with 1:200000 epinephrine was injected via epidural ... - Anesthesia & Analgesia (subscription),

Famous last words: 'This won't hurt a bit'  Feb 22, 2006
An antibiotic may also be given to prevent any possible infection. Some physicians use a local anesthetic with lidocaine to block the pain. ... - Times Herald-Record,

Nerve Blocks of the Lower Limb  Feb 22, 2006
...analgesia). Two types of local anesthetic agents are commonly used for diagnostic analgesia in equine practice--mepivacaine and lidocaine. ... - TheHorse.com,

Columbia Laboratories to Discuss Fourth Quarter and Year End 2005 ...  Feb 24, 2006
...is investigating the potential utility of Prochieve(R) 8% in the prevention of preterm birth and developing a vaginally-administered lidocaine product to ... - Business Wire (press release),

Fast-Acting Local Anesthetic Reduces Pain from Needles  Feb 22, 2006
ALGRX 3268 is an experimental, fast-acting local anesthetic. It uses a needleless device to deliver a powder form of lidocaine to the skin. ... - Cancer Consultants (press release),

Sontra Medical Introduces Generation 1.75 SonoPrep(R) Skin ...  Feb 7, 2006
Corporation (Nasdaq: SONT - News) announced today that it has introduced its Generation 1.75 SonoPrep® skin permeation device for topical lidocaine delivery. ... - Yahoo! News (press release)

Carl Hiaasen I’m not making this up … well, maybe I am  Jan 31, 2006
That passage seemed mighty peculiar to me, since the most commonly used anesthetic for tooth surgery – Lidocaine – isn’ta narcotic and isn’t addictive. ... - Tampa Bay Newspapers,

Sontra Medical Introduces Generation 1.75 SonoPrep(R) Skin ...  Feb 7, 2006
Sontra Medical Corporation announced today that it has introduced its Generation 1.75 SonoPrep(R) skin permeation device for topical lidocaine delivery. ... - International News Service,

FDA Warns About Risks of Throat-Numbing Spray  Feb 14, 2006
...methemoglobin reductase (diaphorase 1) deficiency, and pyruvate-kinase deficiency) may benefit from products with different active ingredients such as lidocaine ... - CNN

Mr. President, we need a national healthcare system  Feb 13, 2006
It turns out her chest pain was caused by an inflamed esophagus, and was diagnosed with fifty cents worth of antacid and viscous lidocaine in my office. ... - Napa Valley Register,

Chemical Eye on Genes Made for America  Feb 18, 2006
...was controlled. Probably with lidocaine hydrochloride, the water-soluble form of this synthetic alkaloid compound. The alkaloid ... - SitNews,

New mouthwash helps with pain linked to head and neck cancer  Feb 3, 2006
The doctors chose to concoct a tetracaine-based mouthwash instead of a lidocaine-based version because it was found to be four times more effective, worked ... - Innovations-Report,

Gut Reaction  Feb 8, 2006
Adolor's pipeline consists of a sterile lidocaine patch for postsurgical incisional pain that's currently in a Phase II clinical trial and some preclinical ... - Smartmoney.com

Endo reports strong quarter, year results  Feb 16, 2006
...percent in 2005, to $419.4 million. Lidoderm is a skin patch impregnated with lidocaine, a topical anesthetic. It is mainly used to ... - Chester Daily Local Online,

Adolor "buy," target price raised  Feb 9, 2006
According to the analyst, Adolor's new product opportunities going forward, such as the lidocaine patch for post-surgical incisional pain and the commencement ... - New Ratings

Journal of the American Podiatric Medical Association  Feb 9, 2006
Many patients, including all of those who underwent adjacent-interspace decompressions, had lidocaine nerve blocks of one of the affected interspaces to assess ... - Journal of the American Podiatric Medical Association

Pain relief: Finding the right drug  Feb 9, 2006
...in the works. A lidocaine patch (brand name Lidoderm) that can help with pain associated with shingles. Cymbalta, an antidepressant ... - Louisville Courier-Journal,

New dental pain reliever  Feb 13, 2006
Oraqix, a mixture of lidocaine and prilocaine, is applied at room temperature using a blunt-tip applicator to periodontal pockets as a liquid and transforms ... - Rocky Mountain News,

Hawkins deputy seizes drugs, handgun in traffic stop  Feb 14, 2006
Also allegedly found in the car was a pipe with marijuana residue in the front passenger seat and two Lidocaine patches in the back floorboard. ... - Kingsport Times News,

Anika gets EU OK to sell wrinkle filler  Feb 17, 2006
...scar remediation and lip augmentation, based on Anika’s chemically modified hyaluronic acid (HA) proprietary technology and incorporates lidocaine, a local ... - Boston Mass High Tech,

Study: Supplements can relieve arthritis pain  Feb 16, 2006
...injection therapy with hyaluronic acid (a component of connective tissue whose function is to cushion and lubricate the joints) or corticosteroids and lidocaine ... - Gainesville Sun,

Pain In Horses  Feb 4, 2006
...potential. The drugs lidocaine, bupivacaine, and mepivacaine are the most commonly used local anesthetics in veterinary medicine today. ... - TheHorse.com,

Risk of Serious Harm and/or Death With Potential IV/SC ...  Feb 15, 2006
Ventricular arrhythmias are uncommon, and should be treated with boluses of sodium bicarbonate as well as conventional anti-arrhythmics such as lidocaine. ... - DG News

Routine Inhaled Induction in Adults: A Safe Practice?  Feb 14, 2006
...other ways to achieve this, including, but not limited to, topical creams (EMLA and LMX), iontophoretic technology, local injection of lidocaine, and patient ... - Anesthesia & Analgesia (subscription),

Anika Therapeutics Receives CE Mark for its REDEFYNE(TM) Cosmetic ...  Feb 16, 2006
The product is based on Anika's chemically modified hyaluronic acid (HA) proprietary technology and incorporates lidocaine, a local anesthetic. ... - PR Newswire (press release),

Entereg’s Positive Phase III Data Drive Up Adolor’s Stock  Feb 8, 2006
...setting. In addition to Entereg, Adolor has a sterile lidocaine patch in Phase II development for postsurgical incisional pain. ... - BioWorld Online (subscription),

New mouthwash might help alleviate pain  Feb 1, 2006
Researchers selected a tetracaine-based mouthwash instead of a lidocaine-based version, since it was found to be four times more effective, worked faster and ... - Monsters and Critics.com,

Vyteris plans to lay off third of staff, citing high inventory  Feb 1, 2006
...only product. LidoSite is an electronic device with a patch that delivers the analgesic lidocaine directly to the skin. Vyteris, which ... - NorthJersey.com,

Sontra Medical Serves Patent Infringement Notice for Dermisonics' ...  Feb 1, 2006
Sontra is currently marketing the SonoPrep device and procedure tray for use with topical lidocaine to achieve rapid (within five minutes) skin anesthesia. ... - PR Newswire (press release),

Altea Therapeutics and Teikoku Seiyaku Co. Ltd. Enter into an ...  Feb 1, 2006
Lidoderm(R), Lidocaine Patches sold in the US are developed and manufactured by Teikoku Seiyaku. Teikoku Seiyaku is mainly proceeding in two directions. ... - PharmaLive.com (press release),


Other information


Indication
For use as Dermal anesthesia

Pharmacology
Lidocaine is an anesthetic agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Lidocaine appears to be similar to that of procaine, procainamide and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected. In contrast to the latter 3 drugs, Lidocaine in therapeutic doses does not produce a significant decrease in arterial pressure or in cardiac contractile force. In larger doses, lidocaine may produce circulatory depression, but the magnitude of the change is less than that found with comparable doses of procainamide.

Mechanism Of Action
Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action.

Drug Category
Antiarrhythmic Agents; Anesthetics; Antiarrhythmic Agents; ATC:C01BB01; ATC:C05AD01; ATC:D04AB01; ATC:N01BB02; ATC:R02AD02; ATC:S01HA07; ATC:S02DA01

Brand Names/Synonyms
Lignocaine; Cappicaine; Maricaine; Leostesin; Gravocain; Esracaine; Anestacon; Duncaine; Isicaina; After Burn Double Strength Gel; After Burn Double Strength Spray; After Burn Gel; After Burn Spray; Alphacaine; Anestacon Jelly; Dalcaine; DermaFlex; Dilocaine; Emla; L-Caine; Lanabiotic; Lidocaine; Lidoderm; Lidoject-1; Lidoject-2; Norwood Sunburn Spray; Octocaine; Octocaine-100; Octocaine-50; Rocephin Kit; Xylocaine; Xylocaine 5% Spinal; Xylocaine Dental Ointment; Xylocaine Endotracheal; Xylocaine Test Dose; Xylocaine Viscous; Xylocaine-MPF; Xylocaine-MPF with Glucose; Xylocard; Zilactin-L

Dosage Forms
CREAM; GEL; IMPLANT; JELLY; KIT; LIQUID; OINTMENT; SOLUTION; SPRAY

Absorption
Information derived from diverse formulations, concentrations and usages reveals that lidocaine is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent.

Interactions
Interactions for Lidocaine: The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe, prolonged hypertension. Phenothiazines and butyrophenones may reduce or reverse the pressor effect of epinephrine. Concurrent use of these agents should generally be avoided. In situations when concurrent therapy is necessary, careful patient monitoring is essential. Concurrent administration of vasopressor drugs (for the treatment of hypotension related to obstetric blocks) and ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents.

Chemical IUPAC Name
2-diethylamino-N-(2,6-dimethylphenyl)-ethanamide

Chemical Formula
C14H22N2O

Half Life
109 minutes

Drug Type
Approved Drug

# Accession No
APRD00479

CAS Registry Number
137-58-6

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