Librium: profile and news






Methamphetamine Propaganda  Mar 3, 2006
Set (TEDS).". Give me Librium or give me meth via e-mail: . (E-mail may be quoted by name unless the writer stipulates otherwise.). - Slate

FDA Warns Consumers Not to Use Two Brazilian Supplements for ...  Feb 8, 2006
They contain chlordiazepoxide HCl (the active ingredient in Librium), and fluoxetine HCl (the active ingredient in Prozac). Chlordiazepoxide ... - Diet Drug Report,

Prescription Drug Abuse Linked to Rising Number of Deaths  Feb 21, 2006
...of 40 percent. Another category of drug that showed and increase in use were sedatives such as Valium, Xanax and Librium. In 2005 ... - PR Web (press release),

ROCK, POP, ACOUSTIC  Feb 8, 2006
Fri: Mercury Rose, The Amateurs, Shaimus, Product, Fight from Above, 8:30. Sat: Ex-Paladin, Orkest, VIE, Aura, Librium, 8:30. Sun ... - LA City Beat,

Drug is a substitute for alcohol  Feb 1, 2006
In addition to Klonopin, police confiscated Ativan, Oxycontin, Valium, Xanax, Librium, Vicodin and marijuana from a 16-year-old, who they arrested and charged ... - Arlington Advocate,

Teens arrested on drug charges  Feb 1, 2006
The pills confiscated were nearly 500 Ativan, about 250 Klonopin, and numerous amounts of Oxycontin, Valium, Xanax, Librium and Vicodin. ... - Arlington Advocate,

FDA Warns Consumers Not to Use Two Brazilian Supplements for ...  09 Feb 2006
They contain chlordiazepoxide HCl (the active ingredient in Librium), and fluoxetine HCl (the active ingredient in Prozac). Chlordiazepoxide ... - Diet Drug Report,

ROCK, POP, ACOUSTIC  09 Feb 2006
Fri: Mercury Rose, The Amateurs, Shaimus, Product, Fight from Above, 8:30. Sat: Ex-Paladin, Orkest, VIE, Aura, Librium, 8:30. Sun ... - LA City Beat,

FDA warns diet drugs contain Prozac and Librium  Jan 16, 2006
Although Emagrece Sim and Herbathin are marketed as "dietary supplements", but they contain the prescription drugs Librium used to relieve anxiety and to ... - News-Medical.net,

FDA warns consumers on Brazilian diet pills  Jan 13, 2006
...are billed as all-natural but may contain active ingredients, including controlled substances, normally found only in prescription drugs like Librium and Prozac ... - Miami Herald,

Brazilian diet pill users warned  Jan 13, 2006
...are billed as all-natural but may contain active ingredients, including controlled substances normally found only in prescription drugs like Librium and Prozac ... - Houston Chronicle,

FDA Warns Of Harmful Diet Drugs  Jan 19, 2006
The Brazilian diet pills contain the active ingredients in two prescription drugs -- Librium and Prozac -- as well as an unapproved amphetamine-like stimulant ... - CBS News

FDA warns against Brazilian diet pills  Jan 16, 2006
Sim Dietary Supplement, also known as the Brazilian Diet Pill and Herbathin Dietary Supplement were found to contain the active ingredient in Librium and the ... - United Press International

Drug is a substitute for alcohol  Feb 1, 2006
In addition to Klonopin, police confiscated Ativan, Oxycontin, Valium, Xanax, Librium, Vicodin and marijuana from a 16-year-old, who they arrested and charged ... - Arlington Advocate,

Teens arrested on drug charges  Feb 1, 2006
The pills confiscated were nearly 500 Ativan, about 250 Klonopin, and numerous amounts of Oxycontin, Valium, Xanax, Librium and Vicodin. ... - Arlington Advocate,

FDA warns consumers on dangers of 2 diet pills  Jan 13, 2006
The pills are billed as all-natural but may contain active ingredients normally found only in prescription drugs such as Librium and Prozac. ... - Winston-Salem Journal,

FDA warns of 2 illegal Brazilian diet pills  Jan 14, 2006
...done at the behest of several people who faced losing their jobs after testing positive for amphetamines -- revealed the presence of both Librium, an anti ... - Fort Worth Star Telegram,

FDA issues warning on Brazilian diet pills  Jan 14, 2006
...as all-natural but might contain active ingredients, including controlled substances, normally found only in prescription drugs such as Librium and Prozac. ... - Columbia Daily Tribune,

FDA warns consumers to avoid Brazilian diet pills  Jan 13, 2006
The agency says they're billed as all-natural but may contain active ingredients normally found only in prescription drugs like Librium and Prozac. ... - KTVO,

FDA issues warning on Brazilian diet pills  Jan 14, 2006
...previously reported, the FDA confirmed on Friday the pills contain a type of amphetamine as well as tranquilizers (the generic for Librium) and antidepressants ... - Miami Herald,

FDA Warns Against Two Brazilian Diet Pills  Jan 13, 2006
Associated Press. The are advertised as all-natural, but they may contain controlled substances like Librium and Prozac. These can ... - All Headline News

FDA Warns Consumers that Two Popular Brazilian Diet Pills Contain ...  Jan 14, 2006
The FDA confirmed on Friday the pills contain a type of amphetamine as well as tranquilizers (the generic for Librium) and antidepressants (generic Prozac). ... - AXcess News,

FDA Warns Brazilian Diet Pills Can Have Serious Side Effects  Jan 16, 2006
The FDA also said that people should exercise caution in using any Brazilian diet pills because they contain the active ingredients in Librium and Prozac ... - NBC 10.com,

FDA warns about Brazilian diet pills, says they contain anti ...  Jan 15, 2006
These drugs are being sold as "dietary supplements" when in fact they contain many active ingredients found in prescription drugs like Prozac and Librium. ... - Earthtimes.org

FDA to Block Import of Diet Pills, Warns Public  Jan 16, 2006
The two products contain chlordiazepoxide HCl (the active ingredient in the drug Librium®), which is used to relieve anxiety and control symptoms of alcohol ... - Natural Products Industry Insider,

Teens popping pills more than other drugs  Jan 9, 2006
...after a substantial rise in use.". Sedative use also increased, including Valium, Xanax and Librium. In 2005, nearly 8 percent of ... - Boca Raton News,

Last-minute surge lifts United Way over the top  Jan 21, 2006
...led by Sue Folk and Pat Saylor, executive directors of United Way partner agencies Developmental Educational Services and Equi-librium respectively. ... - Pocono Record,

Mixing Up Drugs with Similar Names Can Cause Potentially Deadly ...  Nov 28, 2005
...wrong medication. The patient was given 60 times the recommended dose of Librium when he was supposed to have received Lithium. Even ... - Newsinferno.com,

ROCK, POP, ACOUSTIC  Dec 7, 2005
In the Front: Authority Zero, Redfield, The B Foundation, Chaser, Unfinished Business, Librium, Majority Lost, 7. Mon: Launching Liberty, Tomorrow and Forever ... - LA City Beat,

Avitar Enters Rapidly Expanding Oral Fluid-Based Laboratory Drug ...  Nov 29, 2005
Detects: All drugs tested by ORALscreenLAB5+, and Benzodiazepines: Alprazolam (Xanax(R)), Clonazepam (Klonopin(R)), Chlordiazepoxide (Librium(R)), Diazepam ... - PR Newswire (press release),

Media Watch  Nov 18, 2005
Though many people who spend sleepless nights are aware of a drug called Librium, many more would be only too well aware of Valium which became astonishingly ... - Organiser,

Morning Call publisher resigns  Nov 15, 2005
...serves on the boards of Community Services for Children, United Way of the Greater Lehigh Valley, Lehigh Valley Industrial Parks, Equi-librium, Lehigh Valley ... - Allentown Morning Call,

RX main bar  Nov 20, 2005
Sedative addicts typically detox using Librium, a sedative with a longer half-life that is much less addictive, said county treatment director Nance. ... - Provo Daily Herald,

Inventor of Valium, Librium dies at 97  Oct 1, 2005
Dr. Leo Sternbach, whose invention of Valium and Librium landed him in the National Inventors Hall of Fame this year, died Wednesday in Chapel Hill, NC He was ... - Akron Beacon Journal,

Inventor of Valium, other key drugs dies at 97  Sep 29, 2005
TRENTON, NJ -- Leo Sternbach, the inventor of a revolutionary new class of tranquilizers that included Librium and Valium, considered the first blockbuster drug ... - Newsday,

Leo Sternbach  Sep 30, 2005
In 1960 the drug was approved and released under the name Librium; the first benzodiazepine, it was a precursor to the more potent Valium (from the Latin verb ... - Telegraph.co.uk,

Leo Sternbach, 97, Valium Creator, Dies  Sep 30, 2005
...hypnotic drugs and compounds used in bloodless surgery, but he was most widely known for his contribution in producing Valium as well as Librium, a predecessor ... - New York Times,

Hospitals seek Rx for human error: Better technology, clearer ...  Sep 10, 2005
The errors in the Brockton Hospital case began when a hospital pharmacist ordered Librium, an antianxiety sedative, instead of the similar-sounding Lithium ... - The Patriot Ledger,

Rescued from War-torn Europe: Dr. Leo H. Sternbach and His Notable ...  Sep 29, 2005
...throughout the scientific world for his discovery of the benzodiazepine class of chemical compounds, the best known of which are Librium(R) (chlordiazepoxide ... - PR Newswire (press release),

Massachusetts Man Dies in Hospital from Medication Error  Sep 13, 2005
...wrong medication. The patient was given 60 times the recommended dose of Librium when he was supposed to have received Lithium. Even ... - Newsinferno.com,

Another error, and a patient doesn't survive  Sep 13, 2005
...and diazepam. Now a pharmacist at Brockton Hospital has confused Librium and lithium — possibly with fatal consequences. Will ... - Brockton Enterprise,

Report: Hospital gave patient 60 times recommended dose of ...  Sep 12, 2005
The errors began when a pharmacist ordered Librium, an antianxiety sedative, instead of the similar-sounding Lithium, the medicine the patient was supposed to ... - Boston Globe,

Leo Henryk Sternbach  Oct 6, 2005
He is known throughout the scientific world for his discovery of the benzodiazepine class of chemical compounds, the best known of which are Librium and Valium ... - Montclair Times,

Patient Dies of Sedative Overdose  Sep 12, 2005
Patients can safely take up to 600 milligrams of Lithium a day, but the recommended dose of Librium for elderly people is 5 milligrams two to four times a day. - Leading The Charge,

And another thing!  Sep 21, 2005
A doctor might prescribe her a muscle relaxant. Amazingly, the relaxant and the anti-anxiety drug are the same (Valium or Librium). ... - Telegraph.co.uk,

Many meds don't mix with the sun  Sep 21, 2005
Anti-anxiety/sleeping agents: Alprazolam (Xanax), chlordia-zepoxide (Librium), eszopiclone (Lunesta) zaleplon (Sonata), zolpidem (Ambien). ... - Pioneer Press,

Leo Sternbach, Valium's Inventor, Dies  Sep 29, 2005
Nicknamed "Mother's Little Helper" after the Rolling Stones song, it was three times more potent than its predecessor, Librium, another member of the class of ... - San Francisco Chronicle,

Chemist Leo Sternbach, 97, invented Valium, other drugs  Sep 30, 2005
Valium was the country's most-prescribed drug from 1969 to 1982. It was three times more potent than its predecessor, Librium, also a Sternbach invention. ... - Indianapolis Star,

Chemist Leo Henryk Sternbach dies at 97  Sep 30, 2005
...the National Inventors Hall of Fame in Akron, Ohio, this year for his discovery of the benzodiazepines, a class of compounds that includes Librium, used to ... - Science Daily (press release)

Creator of Valium Dies at 97  Sep 30, 2005
It became known as Librium, a mild drug far less likely to cause sleepiness or addiction than anything then on the market as a tranquilizer. - Washington Post,

Valium Inventor Leo Sternbach Dies At 97  Oct 3, 2005
...before it launched. Librium, a medicine related to Valium, was approved two and a half years after it was invented. Today, such ... - Forbes

Leo Sternbach, 97, an inventor of Valium  Sep 30, 2005
The benzodiazepine class of chemical compounds includes Librium, which is used to relieve anxiety disorders, and Valium, which relieves anxiety and relaxes ... - News & Observer,

Leo Sternbach, inventor of classic tranquilizer Valium  Oct 1, 2005
1982. It was three times as potent as its predecessor, Librium, another member of the class of tranquilizers invented by Sternbach. - Cleveland Plain Dealer,

He made resting easy  Sep 30, 2005
Nicknamed "Mother's Little Helper' after the Rolling Stones song, it was three times more potent than its predecessor, Librium, another member of the class of ... - Long Beach Press-Telegram,

Inventor Of Valium Dies At 97  Sep 30, 2005
It was three times more potent than its predecessor, Librium. Roche sold nearly 2.3 billion Valium pills during the drug's peak in 1978. ... - All Headline News

History of shame  Sep 18, 2005
...probation. In a state case, Jackson also was convicted of dealing the drug Librium, considered a controlled substance under Indiana law. ... - Munster Times,

Benzodiazepines effective against alcohol withdrawal seizures  Sep 3, 2005
...limited data," Ntais says. Among the commonly known benzodiazepines are Halcion, Versed, Librium, Xanax and Valium. In a second ... - I-Newswire.com (press release)

The Furies  Sep 2, 2005
...one, for her mother, another of the haunted, was an amateur prostitute and ran her house in Aldershot as a neighborhood bordello, where in a Librium-and-alcohol ... - The New York Review of Books

Alcohol withdrawal treatments studied  Aug 29, 2005
...limited data," Ntais said. Among the commonly known benzodiazepines are Halcion, Versed, Librium, Xanax and Valium. The review of ... - Monsters and Critics.com,

ROCK, POP, ACOUSTIC  Aug 17, 2005
Good Hurt, 12249 Venice Bl, West LA, (310) 390-1076. Goodhurt.net. Thur: Okest, Crypt Orchid, Revolve, August House, Librium, 8:30. ... - LA City Beat,

Reports Show Surge in Prescription Tranquilizer Abuse  Aug 23, 2005
...often prescribed for anxiety or insomnia. Other types of CNS depressants include Valium, Xanax and Librium. “We need to have drug ... - Emediawire (press release),

Photosensitive drugs  Aug 5, 2005
...name in parentheses. alprazolam (Xanax), chlordiazepoxide (Librium), eszopiclone (Lunesta) zaleplon (Sonata), zolpidem (Ambien). - Fort Wayne News Sentinel

Roche Posts Very Strong Interim Results  Jul 22, 2005
...named the top 10 Roche US Innovations of the last century, including the discovery of the benzodiazepine family of compounds that spawned Librium and Valium ... - Yahoo News (press release)


Other information


Indication
For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.

Pharmacology
Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The precise mechanism of action is not known. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals.

Mechanism Of Action
Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. BZDs enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties.

Drug Category
Anti-anxiety Agents; Hypnotics and Sedatives; Adjuvants, Anesthesia; Benzodiazepines; GABA Modulators; ATC:N05BA02

Brand Names/Synonyms
A-Poxide; Abboxide; Apo-Chlordiazepoxide; Balance; CD 2; CDO; CDP; Chloradiazepoxide; Chlordiazachel; Chlordiazepoxid; Chlordiazepoxide; Chlordiazepoxide Base; Chlordiazepoxide Hcl; Chlordiazepoxidum; Chloridazepoxide; Chloridiazepide; Chloridiazepoxide; Chlorodiazepoxide; Chlozepid; Clopoxide; Clordiazepossido; Contol; Control; Decacil; Eden; Elenium; Helogaphen; Ifibrium; Kalmocaps; Librax; Librelease; Librinin; Libritabs; Librium; Limbitrol; Limbitrol Ds; Lygen; Menrium; Mesural; Methaminodiazepoxide; Mildmen; Multum; Napoton; Napton; Novo-Poxide; Psicosan; Radepur; Risolid; Silibrin; Tropium; Viopsicol

Dosage Forms
CAPSULE (5 mg, 10 mg or 25 mg)

Absorption
Not Available

Interactions
Interactions for Chlordiazepoxide: Although clinical studies have not established a cause and effect relationship, physicians should be aware that variable effects an blood coagulation have been reported very rarely in patients receiving oral anticoagulants and chlordiazepoxide. The concomitant use of alcohol or other central nervous system depressants may have an additive effect.

Chemical IUPAC Name
10-chloro-3-hydroxy-N-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-1,6,8,10-tetraen-5-imine

Chemical Formula
C16H14ClN3O

Half Life
24-48 hours

Drug Type
Approved Drug

# Accession No
APRD00682

CAS Registry Number
58-25-3

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