Librax: profile and news

Health Canada warns on weight-loss aids Feb 22, 2006
...compound fluoxetine HCl (the active ingredient in Prozac), the controlled substance chlordiazepoxide HCl (an ingredient in the muscle-relaxer Librax) and the ... - Hamilton Spectator,

Valeant Pharmaceuticals Reports Fourth Quarter and Full Year 2005 ... Feb 28, 2006
Disease 6,414 (a) -- 21,465 (a) -- Neurology Diastat(P) (b) 10,639 -- -- 47,631 -- -- Mestinon(R) (G)(P) 11,031 11,304 (2%) 43,531 41,631 5% Librax(P) 8,367 ... - Genetic Engineering News,

Health Canada Warning: Brazilian Diet Pills Contain Active ... Feb 22, 2006
...compound fluoxetine HCl (the active ingredient in Prozac), the controlled substance chlordiazepoxide HCl (an active ingredient in Librax) and the controlled ... - Halifax Live,

Hearing held for Jackson woman subdued by police officer Jan 31, 2006
A criminal complaint filed in the case identified the pills as Klonopin, an anti-anxiety medication, and Librax, a medication for the treating of peptic ulcer ... - Southeast Missourian,

Police: woman with stun gun stripped during call about dog Jan 11, 2006
Also found were four pills of Klonopin, an anti-anxiety medication, and seven pills of Librax, a medication for the treating of peptic ulcer disease, the ... - Southeast Missourian,

Valeant Pharmaceuticals Reports First Quarter 2005 Results ... May 5, 2005
R)(G) 1,896 1,377 38% Infectious Disease Virazole(R)(G)(T) 4,195 4,817 (13%) Neurology Mestinon(R)(G)(T) 9,860 8,911 11% Diastat(T) 5,177 - - Librax(R)(T ... - Business Wire,

Other information

Indication
For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.

Pharmacology
Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The precise mechanism of action is not known. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals.

Mechanism Of Action
Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. BZDs enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties.

Drug Category
Anti-anxiety Agents; Hypnotics and Sedatives; Adjuvants, Anesthesia; Benzodiazepines; GABA Modulators; ATC:N05BA02

Brand Names/Synonyms
A-Poxide; Abboxide; Apo-Chlordiazepoxide; Balance; CD 2; CDO; CDP; Chloradiazepoxide; Chlordiazachel; Chlordiazepoxid; Chlordiazepoxide; Chlordiazepoxide Base; Chlordiazepoxide Hcl; Chlordiazepoxidum; Chloridazepoxide; Chloridiazepide; Chloridiazepoxide; Chlorodiazepoxide; Chlozepid; Clopoxide; Clordiazepossido; Contol; Control; Decacil; Eden; Elenium; Helogaphen; Ifibrium; Kalmocaps; Librax; Librelease; Librinin; Libritabs; Librium; Limbitrol; Limbitrol Ds; Lygen; Menrium; Mesural; Methaminodiazepoxide; Mildmen; Multum; Napoton; Napton; Novo-Poxide; Psicosan; Radepur; Risolid; Silibrin; Tropium; Viopsicol

Dosage Forms
CAPSULE (5 mg, 10 mg or 25 mg)

Absorption
Not Available

Interactions
Interactions for Chlordiazepoxide: Although clinical studies have not established a cause and effect relationship, physicians should be aware that variable effects an blood coagulation have been reported very rarely in patients receiving oral anticoagulants and chlordiazepoxide. The concomitant use of alcohol or other central nervous system depressants may have an additive effect.

Chemical IUPAC Name
10-chloro-3-hydroxy-N-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-1,6,8,10-tetraen-5-imine

Chemical Formula
C16H14ClN3O

Half Life
24-48 hours

Drug Type
Approved Drug

# Accession No
APRD00682

CAS Registry Number
58-25-3