Lexapro: profile and news






Adjuvant Docetaxel More Effective Than Vinorelbine for Early ...  Feb 23, 2006
NEW YORK FEB 22, 2006 (Reuters Health) - Docetaxel is more effective than vinorelbine when administered prior to fluorouracil, epirubicin and cyclophosphamide ... - Cancerpage.com,

Adjuvant Docetaxel or Vinorelbine with or without Trastuzumab for ...  Feb 22, 2006
Background We compared docetaxel with vinorelbine for the adjuvant treatment of early breast cancer. Women with tumors that overexpressed ... - New England Journal of Medicine (subscription),

Adjuvant Taxotere® and Herceptin® Effective for Breast Cancer ...  Mar 6, 2006
Researchers affiliated with the FinHer Study have reported that Taxotere® (docetaxel) is superior to Navelbine® (vinorelbine) when given in addition to 5-FU ... - Cancer Consultants (press release),

Breast Cancer Drugs Limit Post-Surgery Recurrence  Feb 22, 2006
22 (HealthDay News) -- A new head-to-head study finds the chemotherapy drug docetaxel (Taxotere) beating another, vinorelbine (Navelbine), in helping extend ... - Forbes

Breast meds limit recurrence  Feb 23, 2006
A new head-to-head study finds the chemotherapy drug docetaxel (Taxotere) beating another, vinorelbine (Navelbine), in helping extend patient survival after ... - Health24.com,

Trails to detect effective breast cancer drugs that reduces ...  Feb 23, 2006
...cancer surgery. The chemotherapy drugs docetaxel (Taxotere) and vinorelbine (Navelbine) are tested to analyze the outcomes. It was ... - MedIndia,

Recurrence-Free Survival Improved with Taxotere® Compared to ...  Feb 23, 2006
...with the chemotherapy agent Taxotere® (docetaxel) improves recurrence-free survival compared with the chemotherapy agent Navelbine® (vinorelbine) for the ... - Cancer Consultants (press release),

Nitroglycerin May Enhance Chemotherapy for Non-Small Cell Lung ...  Feb 6, 2006
Researchers from Japan have reported that the use of nitroglycerin combined with the chemotherapy drugs Navelbine® (vinorelbine) and Platinol® (cisplatin ... - Cancer Consultants (press release),

Nitroglycerin May Enhance Chemotherapy for Non-Small Cell Lung ...  Feb 6, 2006
Researchers from Japan have reported that the use of nitroglycerin combined with Navelbine® (vinorelbine) and Platinol® (cisplatin) may improve response ... - Cancer Consultants (press release),

Optimising Herceptin-based Therapy in HER2-positive Metastatic ...  Feb 22, 2006
Other researchers are also evaluating combinations of trastuzumab and other chemotherapy schedules, including trastuzumab/vinorelbine, which was highly active ... - DG News

Anti-angiogenesis Therapy With Avastin (Bevacizumab): Presented at ...  Feb 21, 2006
...with locally advanced/recurrent malignant breast cancer, in combination with a number of other therapeutic agents, including vinorelbine, docetaxel, Tarceva(R ... - DG News

Options Expanding With First-line Capecitabine (Xeloda) ...  Feb 22, 2006
One such is capecitabine/vinorelbine (XN), which has been tested as either first- or second-line treatment over a range of trials of metastatic breast cancer. ... - DG News

AUDIO SUMMARY  Feb 22, 2006
Featured are articles on glucosamine and chondroitin sulfate for osteoarthritis of the knee, docetaxel or vinorelbine for breast cancer, denosumab in ... - New England Journal of Medicine (subscription),

Novacea Files for Initial Public Offering  Feb 10, 2006
The Company has one product candidate, DN-101, which is in a Phase 3 clinical trial for prostate cancer and a second product candidate, vinorelbine oral, which ... - Market Wire (press release)

Innocent victims of a judgmental attitude  Feb 3, 2006
In certain centres a new drug, Navelbine (a form of vinorelbine), which can be taken by mouth, is now used in some forms of lung cancer almost immediately ... - Times Online,

Results From ADVENTRX Vinorelbine Preclinical Studies Accepted for ...  Jan 19, 2006
...(Amex: ANX) today announced that data from preclinical studies of ANX-530 (vinorelbine emulsion) will be presented at the 2006 American Association for Cancer ... - PR Newswire (press release),

Nitroglycerin May Enhance Chemotherapy for Non-Small Cell Lung ...  Feb 6, 2006
Researchers from Japan have reported that the use of nitroglycerin combined with the chemotherapy drugs Navelbine® (vinorelbine) and Platinol® (cisplatin ... - Cancer Consultants (press release),

Nitroglycerin May Enhance Chemotherapy for Non-Small Cell Lung ...  Feb 6, 2006
Researchers from Japan have reported that the use of nitroglycerin combined with Navelbine® (vinorelbine) and Platinol® (cisplatin) may improve response ... - Cancer Consultants (press release),

Update on Adjuvant Therapy for Breast Cancer: The Expanding Role ...  Jan 30, 2006
The FinHer study [4] was a 2-way randomized trial in which patients were assigned to treatment with vinorelbine cyclophosphamide, epirubicin, 5-flourouracil ... - Medscape (subscription)

Novel Strategies for Treating Lung Cancer: Chemotherapy  Jan 24, 2006
Great Britain) [9] using cisplatin combined with either vindesine, mitomycin, ifosfamide, or with mitomycin and vinblastine, or with vinorelbine -- failed to ... - Medscape (subscription)

Innocent victims of a judgmental attitude  Feb 3, 2006
In certain centres a new drug, Navelbine (a form of vinorelbine), which can be taken by mouth, is now used in some forms of lung cancer almost immediately ... - Times Online,

FDA Approves EMEND(R) (aprepitant), in Combination with Other ...  Jan 11, 2006
...agents and the number of aprepitant patients exposed follows: etoposide (106), fluorouracil (100), gemcitabine (89), vinorelbine (82), paclitaxel (52 ... - Business Wire (press release),

Optimata Granted Patent for Use of Virtual Patient Technology in ...  Jan 25, 2006
...completing a clinical trial to predict breast cancer therapy outcomes for cancer drugs such as Adriamycin, Docetaxel, Paclitaxel, Vinorelbine and Tamoxifen at ... - Genetic Engineering News,

(PRN) - XATANET Expands Into New Verticals in First Quarter ... ...  Jan 19, 2006
B ... [+. PRN) - Results From ADVENTRX Vinorelbine Preclinical Studies Accepted for Presentation at AACR Annual Meeting ... [+. ... - Bolsamania.com,

SD Pharmaceuticals Completes Pivotal Pre-Clinical Efficacy Study ...  Jan 11, 2006
The product candidates in the company's portfolio include novel formulations of vinorelbine, paclitaxel, docetaxel, clarithromycin and vancomycin. ... - Business Wire (press release),

Adventrx to present data  Jan 19, 2006
...(AMEX: ANX, News) announced Thursday that data from preclinical studies of its chemotherapy drug ANX-530, an emulsion formulation of vinorelbine, will be ... - San Diego Daily Transcript (subscription),

Short Course of Herceptin® in Patients with Breast Cancer  Dec 9, 2005
In breast cancer patients treated with docetaxel or vinorelbine followed by FEC (5-fluorouracil, epirubicin, cyclophosphamide), a nine-week course of Herceptin ... - Cancer Consultants (press release),

Treatment of Breast Cancer with Herceptin for Nine Weeks  Dec 10, 2005
The women included in the study received docetaxel or vinorelbine and then FEC (5-fluorouracil, epirubicin, cyclophosphamide).Those whose HER-2 protein were ... - MedIndia,

ADVENTRX Announces Positive FDA Pre-IND Meeting Outcome  Dec 7, 2005
...with the US Food and Drug Administration (FDA) regarding the proposed 505(b)(2) New Drug Application (NDA) regulatory plan for ANX-530 (vinorelbine emulsion). ... - Biotech Intelligence (press release),

Prostate Cancer: New choice for hormone refractory patients  Dec 8, 2005
...s recent co-development with Pierre Fabre means that Novacea is likely to investigate the use of its drug DN-101 with oral Navelbine (vinorelbine) for HRPC. ... - PharmaLive.com (press release),

INEX Appoints President & CEO and Updates Reorganization Timetable  Dec 6, 2005
...focus on extracting value via partnering from its late-stage Targeted Chemotherapy platform including Marqibo(TM), INX-0125 (sphingosomal vinorelbine) and INX ... - PR Newswire (press release),

Induction Chemotherapy and Concomitant Chemoradiotherapy Promising ...  Dec 6, 2005
IIIB NSCLC. The median age was 59 years. Induction chemotherapy involved three cycles of gemcitabine and vinorelbine. This was followed ... - Cancer Consultants (press release),

INEX to Spin Off Targeted Immunotherapy Assets  Nov 17, 2005
...to continue its focus on extracting value from its late stage Targeted Chemotherapy platform including Marqibo(TM), INX-0125 (sphingosomal vinorelbine) and INX ... - PR Newswire (press release),

INEX Releases Third Quarter 2005 Operating Results  Nov 10, 2005
...quarter the Company continued its focus on partnering its Targeted Chemotherapy platform assets, including Marqibo, INX-0125 (sphingosomal vinorelbine) and INX ... - PR Newswire (press release),

ADVENTRX Announces 2005 Third Quarter Financial Results  Nov 14, 2005
...develop drugs that address issues such as safety, we announced the acquisition of certain rights to ANX-530, a novel formulation of vinorelbine tartrate that ... - PR Newswire (press release),

Induction Chemotherapy Promising in Stage III Non-Small Cell Lung ...  Dec 2, 2005
NSCLC. The median age of the patients was 59 years. Induction chemotherapy involved three cycles of gemcitabine and vinorelbine. This ... - Cancer Consultants (press release),

(Euronext Paris) - Transgene : Clinical Pipeline Update  Nov 29, 2005
II trial of TG4010 were presented at ASCO in May 2005 showing that the combination of TG4010 with chemotherapy (cisplatin and vinorelbine) compared favourably ... - Euronext,

INEX to Transfer Targeted Immunotherapy Assets to a New Company  Nov 17, 2005
...license or partner its targeted chemotherapy technology platform and product candidates, including Marqibo(TM), INX-0125 (sphingosomal vinorelbine) and INX ... - TechFinance,

Despite Poor Prognosis, New Treatment Options for Mesothelioma May ...  Nov 15, 2005
A phase 2 trial of vinorelbine and oxaliplatin as a first-line treatment resulted in a mean progression-free survival of 4.7 months and 1-year survival ... - DG News

Premenopausal Women Have Improved Survival with Xyotax® for ...  Nov 11, 2005
...compared Xyotax/Paraplatin®(Paraplatin) to Paraplatin/Taxol (STELLAR3) or Xyotax as a single agent to Gemzar®(gemcitabine)/Navelbine®(vinorelbine) (STELLAR 4 ... - Cancer Consultants (press release),

Novacea Announces Appointment of Daniel M. Bradbury to Board of ...  Nov 14, 2005
Products ready for Phase 3 studies are DN-101, for the treatment of advanced prostate cancer, and vinorelbine oral, for the treatment of breast or lung cancer. ... - Market Wire (press release)

Premenopausal Women with Non-Small Cell Lung Cancer Have Improved ...  Nov 17, 2005
STELLAR3 compared Xyotax plus carboplatin to paclitaxel plus carboplatin, and STELLAR4 compared Xyotax as a single agent to gemcitabine plus vinorelbine. ... - Cancer Consultants (press release),

Gamma-linolenic acid inhibits action of Her-2/neu, responsible for ...  Nov 20, 2005
...with GLA sensitizes breast cancer cells to some chemotherapeutic drugs, such as Paclitaxel ( Taxol ), Docetaxel ( Taxotere ) and Vinorelbine ( Navelbine ). ... - Xagena.it,

ADVENTRX Acquires Additional Oncology Drug Through Exclusive ...  Oct 4, 2005
Pharma) today announced SD Pharma's grant to ADVENTRX of an exclusive license of certain rights to ANX-530, a novel emulsion formulation of vinorelbine tartrate ... - Genetic Engineering News,

NTN trims management jobs  Oct 5, 2005
Adventrx Pharmaceuticals said it would license rights to a novel emulsion formulation of vinorelbine tartate, a therapy used in combination with other drugs ... - San Diego Union Tribune,

British delays keep new drugs from cancer patients  Oct 1, 2005
In addition to the shortage of Herceptin, Britain performs well below the European average for access to the new lung cancer drugs gemcitabine and vinorelbine. ... - Times Online,

Taxol®, Ifex® and Platinol® Effective Second-Line Therapy for ...  Sep 22, 2005
Doxil® (doxorubicin), Ellence®, Navelbine® (vinorelbine), Hycamtin® (topotecan), or biologic agents such as a suramin and retinoic acid have not ... - Cancer Consultants (press release),


Other information


Indication
For the treatment of depression

Pharmacology
Citalopram is one of a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of Citalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. In vitro studies show that Citalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Citalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of Citalopram was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Citalopram does not inhibit monoamine oxidase.

Mechanism Of Action
The antidepressant, antiobsessive-compulsive, and antibulimic actions of Citalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Citalopram blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.

Drug Category
Antidepressants; Selective Serotonin Reuptake Inhibitors (SSRIs); ATC:N06AB04; ATC:N06AB10

Brand Names/Synonyms
CHEMBANK1660; Celexa; Cipram; Citalopram; Citalopram Hydrobromide; Citalopram [Ban:Inn]; Citalopramum [Inn-Latin]; Lexapro; Nitalapram

Dosage Forms
Oral solution and tablets

Absorption
80%

Interactions
Central nervous system depressant (CNS) drugs including alcohol, antidepressants, antihistamines, antipsychotics, blood pressure medications (reserpine, methyldopa, beta-blockers), motion sickness medications, muscle relaxants, narcotics, sedatives, sleeping pills and tranquilizers

Chemical IUPAC Name
1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Chemical Formula
C20H21FN2O

Half Life
35 hours

Drug Type
Approved Drug

# Accession No
APRD00147

CAS Registry Number
59729-33-8

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