Levoxyl: profile and news






King Pharmaceuticals Reports Year-End and Fourth-Quarter 2005 ...  Feb 28, 2006
Levoxyl(R) (levothyroxine sodium tablets, USP) net sales totaled $22.1 million during the fourth quarter of 2005 compared to $21.3 million during the fourth ... - PR Newswire (press release),

King Pharmaceuticals Reports Year-End and Fourth-Quarter 2005 ...  Feb 28, 2006
Levoxyl® (levothyroxine sodium tablets, USP) net sales totaled $22.1 million during the fourth quarter of 2005 compared to $21.3 million during the fourth ... - Yahoo! News (press release)

King Pharmaceuticals reports $94.6 million loss in 4th quarter  Feb 28, 2006
Hypothyroid drug Levoxyl was $22 million and $140 million. For more information on King Pharmaceuticals visit its Web site at www.kingpharm.com. - Kingsport Times News,

KV Pharmaceutical Reports Record Revenues for Fiscal 2006 Third ...  Feb 7, 2006
We are also currently waiting approvals for Diltiazem (Tiazac(R) - Biovail/Forest) and Levothyroxine (Levoxyl(R) - King), which we expect to receive this ... - PR Newswire (press release),

Cholesterol-lowering drugs and memory may not mix  Feb 6, 2006
...been responsible. After I was diagnosed with hypothyroidism and prescribed Levoxyl, my metabolism sure seemed to perk up. I went ... - Houston Chronicle,

Reader's lip-balm addiction is maddening: PEOPLE'S PHARMACY  Feb 6, 2006
After I was diagnosed with hypothyroidism and prescribed Levoxyl, my metabolism seemed to perk up. I went from constantly constipated to relatively regular. ... - St. Louis Post-Dispatch,

KV Pharmaceutical Reports Record Revenues for Fiscal 2006 Third ...  Feb 7, 2006
We are also currently waiting approvals for Diltiazem (Tiazac® - Biovail/Forest) and Levothyroxine (Levoxyl® - King), which we expect to receive this fiscal ... - Yahoo! News (press release)

KV Pharmaceutical Reports Record Revenues for Fiscal 2006 Third ...  Feb 7, 2006
We are also currently waiting approvals for Diltiazem (Tiazac(R) - Biovail/Forest) and Levothyroxine (Levoxyl(R) - King), which we expect to receive this ... - PR Newswire (press release),

Reader's lip-balm addiction is maddening: PEOPLE'S PHARMACY  Feb 6, 2006
After I was diagnosed with hypothyroidism and prescribed Levoxyl, my metabolism seemed to perk up. I went from constantly constipated to relatively regular. ... - St. Louis Post-Dispatch,

The lowdown on thyroid slowdown  12 Dec 2005
...hormone. It’s available in the generic form and under such brand names as Euthyrox, Levothroid, Levoxyl, and Synthroid. Although ... - ITP.net,

Why Low TSH means Less Medicine and Other Confusing Thyroid Issues  12 Dec 2005
If you're being treated with thyroid hormone drugs (such as Synthroid, Levoxyl, Armour, Thyrolar, etc.), if your TSH comes back as too low, most doctors will ... - About - News & Issues,

Medication makes sense if symptoms persist  Dec 5, 2005
...thyroid hormone. It's available in the generic form and under such brand names as Euthyrox, Levothroid, Levoxyl and Synthroid. All ... - Charleston Post Courier (subscription),

A Light-hearted Look at How To Cope with Winter  Dec 5, 2005
...chicks. The Levoxyl I’m on seems to help a bit, thank goodness. But I still keep the Land’s End sweater catalogs handy. Until ... - About - News & Issues,

King Pharmaceuticals Reports Third-Quarter 2005 Financial Results  Nov 9, 2005
Levoxyl(R) (levothyroxine sodium tablets, USP) net sales equaled $36.1 million during the third quarter ended September 30, 2005 compared to $23.2 million ... - PR Newswire (press release),

Are your thyroid hormones really normal?  Nov 14, 2005
...therapy. The most widely prescribed drug is levothyroxine, sold as a generic or under brands like Synthroid, Levoxyl and Unithroid. ... - Deccan Herald,

Thanksgiving Ruminations of a New Thyroid Patient  Nov 23, 2005
That way, I can figure out which one is going to get me fewer carrots and more gravy on the mashed potatoes. That bottle of Levoxyl with my name on it. ... - About - News & Issues,

King Pharmaceuticals Reports Third-Quarter 2005 Financial Results  Nov 9, 2005
Levoxyl® (levothyroxine sodium tablets, USP) net sales equaled $36.1 million during the third quarter ended September 30, 2005 compared to $23.2 million ... - Yahoo! News (press release)

Sulfite Sensitivity  Oct 6, 2005
...sulfites in the dyes used. I contacted Synthroid directly. Levoxyl and Armour do not contain sulfites.". Be sure to let your doctor ... - allergies.about.com

King Pharmaceuticals Reports Second-Quarter 2005 Financial Results  Sep 9, 2005
Levoxyl(R) (levothyroxine sodium tablets, USP) net sales equaled $41.3 million during the second quarter ending June 30, 2005 compared to $31.8 million during ... - Investor's Business Daily (subscription)

King again tops forecast  Aug 9, 2005
Net sales of clotting agent Thrombin-JMI were $52.9 million, a 67 percent increase compared to last year, while sales of thyroid treatment Levoxyl were $41.3 ... - Bristol Herald Courier,

PharmacyChecker.com Identifies Top 20 Drugs Sought on Internet  Aug 11, 2005
The top 20 drugs are, in order, Lipitor, Levoxyl, Fosamax, Viagra, Zocor, Advair Diskus, Celebrex, Zoloft, Lisinopril, Norvasc, Premarin, Cialis, Actonel ... - PR Newswire (press release),

Good to Be the King Again  Aug 4, 2005
King's four major branded products are Altace, a so-called ACE inhibitor that lowers cardiovascular risk; Levoxyl, a thyroid hormone pill that's shaped like a ... - Smartmoney.com (subscription)

Insect repellent and sunscreen available together  Jul 20, 2005
...meeting (May 23, 2005), the Food and Drug Administration concluded that all generic levothyroxine (T4) is equal to brand-name products like Synthroid or Levoxyl ... - Daily Press

Do Thyroid Patients Feel Better with T3 added?  Jul 21, 2005
Some patients can't convert the T4 from their thyroid gland or the T4 in their thyroid medication, like synthroid, levoxyl or levethroid. ... - Bella Online <**results**>

When two hormones are needed  Jul 4, 2005
...meeting (May 23, 2005), the Food and Drug Administration concluded that all generic levothyroxine (T4) is equal to brand-name products like Synthroid or Levoxyl ... - Los Angeles Times

Take care when using both sunscreen and bug repellent  Jul 4, 2005
At a recent meeting, the Food and Drug Administration concluded that all generic levothyroxine (T4) is equal to brand-name products like Synthroid or Levoxyl. ... - Charlotte Observer

Sulfite Sensitivity  Jun 27, 2005
...sulfites in the dyes used. I contacted Synthroid directly. Levoxyl and Armour do not contain sulfites.". Be sure to let your doctor ... - allergies.about.com


Other information


Indication
For use as replacement or supplemental therapy in patients of any age or state (including pregnancy) with hypothyroidism of any etiology except transient hypothyroidism during the recovery phase of subacute thyroiditis or primary hypothyroidism resulting from thyroid dysfunction.

Pharmacology
Levothyroxine (T4) is a synthetically prepared levo isomer of thyroxine, a hormone secreted by the thyroid gland. Levothyroxine is used alone or in combination with antithyroid agents to treat hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, or stupor.

Mechanism Of Action
Levothyroxine acts like the endogenous thyroid hormone thyroxine (T4, a tetra-iodinated tyrosine derivative). In the liver and kidney, T4 is converted to T3, an active metabolite. In order to increase solubility, the thyroid hormones attach to thyroid hormone binding proteins, thyroxin-binding globulin and thyroxin-binding prealbumin (transthyretin). Transport to thyroid hormone receptors in the cytoplasm and nucleus then takes place.

Drug Category
Antithyroid Agents; Anticoagulants; ATC:H03AA01

Brand Names/Synonyms
D-Thyroxine; Eltroxin; Euthyrox; Iodine; L-T4; L-THYROXIN SODIUM, 99%; L-Thyroxine; L-Thyroxine Sodium; L-Thyroxine Sodium Salt; L-Thyroxine Sodium Salt Hydrate; L-Thyroxine.Na; Laevothyroxinum; Laevoxin; Letter; Levaxin; Levo-T; Levolet; Levothroid; Levothyrox; Levothyroxine; Levothyroxine Sodium; Levoxine; Levoxyl; Novothyrox; Oroxine; Sodium Levothyroxine; Synthroid; Synthroid Sodium; Tetraiodothyronine; Thyratabs; Thyrax; Thyreoideum; Thyro-Tabs; Thyro-Tapbs; Thyroxevan; Thyroxin; Thyroxinal; Thyroxine; Unithroid

Dosage Forms
LIQUID; POWDER; TABLET

Absorption
Varies from 48% to 80%

Interactions
-->Interactions for Levothyroxine:

The magnitude and relative importance of the effects noted below are likely to be patient specific and may vary by such factors as age, gender, race, intercurrent illnesses, dose of either agent, additional concomitant medications, and timing of drug administration. Any agent that alters thyroid hormone synthesis, secretion, distribution, effect on target tissues, metabolism, or elimination may alter the optimal therapeutic dose of levothyroxine sodium.

Levothyroxine Sodium Absorption: The following agents may bind and decrease absorption of levothyroxine sodium from the gastrointestinal tract: aluminum hydoxide, cholestyramine resin, colestipol hydrochloride, ferrous sulfate, sodium polystyrene sulfonate, soybean flour (e.g., infant formula), sucralfate.

Binding to Serum Proteins: The following agents may either inhibit levothyroxine sodium binding to serum proteins or alter the concentrations of serum binding proteins: androgens and related anabolic hormones, asparaginase, clofibrate, estrogens and estrogen-containing compounds, 5-fluorouracil, furosemide, glucocorticoids, meclofenamic acid, mefenamic acid, methadone, perphenazine, phenylbutazone, phenytoin, salicylates, tamoxifen.

Thyroid Physiology: The following agents may alter thyroid hormone or TSH levels, generally by effects on thyroid hormone synthesis, secretion, distribution, metabolism, hormone action, or elimination, or altered TSH secretion: aminoglutethimide, p-aminosalicylic acid, amiodarone, androgens and related anabolic hormones, complex anions (thiocyanate, perchlorate, pertechnetate), antithyroid drugs, b-adrenergic blocking agents, carbamazepine, chloral hydrate, diazepam, dopamine and dopamine agonists, ethionamide, glucocorticoids, heparin, hepatic enzyme inducers, insulin, iodinated cholestographic agents, iodine- containing compounds, levodopa, lovastatin, lithium, 6-mercaptopurine, metoclopramide, mitotane, nitroprusside, phenobarbital, phenytoin, resorcinol, rifampin, somatostatin analogs, sulfonamides, sulfonylureas, thiazide diuretics.

Adrenocorticoids: Metabolic clearance of adrenocorticoids is decreased in hypothyroid patients and increased in hyperthyroid patients, and may therefore change with changing thyroid status.

Amiodarone: Amiodarone therapy alone can cause hypothyroidism or hyperthyroidism.

Anticoagulants (Oral): The hypoprothrombinemic effect of anticoagulants may be potentiated, apparently by increased catabloism of vitamin K-dependent clotting factors.

Antidiabetic Agents (Insulin, Sulfonylureas): Requirements for insulin or oral antidiabetic agents may be reduced in hypothyroid patients with diabetes mellitus and may subsequently increase with the initiation of thyroid hormone replacement therapy.

b-Adrenergic Blocking Agents: Actions of some of beta-blocking agents may be impaired when hypothyroid patients become euthyroid.

Cytokines (interferon, interleukin): Cytokines have been reported to induce both hyperthyroidism and hypothyroidism.

Digitalis Glycosides: Therapeutic effects of digitalis glycosides may be reduced. Serum digitalis levels may be decreased in hyperthyroidism or when a hypothyroid patient becomes euthyroid.

Ketamine: Marked hypertension and tachycardia have been reported in association with concomitant administration of levothyroxine sodium and ketamine.

Maprotiline: Risk of cardiac arrhythmias may increase.

Sodium Iodide (123I and 131I), Sodium Pertechnetate Tc99m: Uptake of radiolabeled ions may be decreased.

Somatrem/Somatropin: Excessive concurrent use of thyroid hormone may accelerate epiphyseal closure. Untreated hypothyroidism may interfere with the growth response to somatrem or somatropin.

Theophylline: Theophylline clearance may decrease in hypothyroid patients and return toward normal when a euthyroid state is achieved.

Tricyclic Antidepressants: Concurrent use may increase the therapeutic and toxic effects of both drugs, possibly due to increased catecholamine sensitivity. Onset of action of tricyclics may be accelerated.

Sympathomimetic Agents: Possible increased risk of coronary insufficiency in patients with coronary artery disease.



Chemical IUPAC Name
2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]-propanoicacid

Chemical Formula
C15H11I4NO4

Half Life
6 to 7 days

Drug Type
Approved Drug

# Accession No
APRD00235

CAS Registry Number
25416-65-3

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