Levofloxacin: profile and news
Antidepressants Double Children's Suicidal Thinking, Study Says 07 Mar 2006
Wellbutrin, Pfizer Inc.'s Zoloft, Wyeth's Effexor, Bristol-Myers Squibb Co.'s Serzone, Forest Laboratories Inc.'s Celexa, Akzo Nobel NV's Remeron and Solvay ... - Bloomberg
Antidepressants Linked to Modest Risk of Non-Fatal Thoughts in ... 07 Mar 2006
...citalopram), Luvox (fluvoxamine), Paxil (paroxetine), Prozac and Serafem (fluoxetine), Zoloft (sertraline), Effexor (venlafaxine), and Remeron (mirtazapine). ... - MedPage Today,
Aurobindo Pharma receives final US FDA approval for Mirtazapine ... Mar 2, 2006
Mirtazapine orally disintegrating tablet (ODT). Mirtazapine ODT is the generic version of Organon's Remeron SolTab. Last year, it had ... - domain-B,
Antidepressants and your libido Feb 28, 2006
Antidepressants found to have fewer sexual effects include Wellbutrin, Serzone (nefazodone), Remeron (mirtazapine) or Zyban (bupropion). ... - Health24.com,
Akzo plans share offering for its lagging drug unit Feb 7, 2006
...percent in 2005, less than half the average increase in the pharmaceuticals industry, as the unit struggled with the patent loss for its Remeron antidepressant ... - International Herald Tribune,
STAR*D Preliminary Findings Provide Clearer Picture of Major ... Feb 27, 2006
...without remission after two adequate trials with antidepressants could proceed to Level 3. Options at Level 3 were mirtazapine (Remeron) or nortriptyline ... - Psychiatric Times,
EARNINGS PREVIEW: Akzo Nobel 4Q 05 Net Pft Up To EUR195M Feb 3, 2006
...to EUR140M. Profit seen down on falling Organon sales, lower revenue of key product Remeron and higher R&D costs. Analysts also ... - New Ratings
Evelyn Pringle: Poisoning In the Womb – SSRIs Feb 19, 2006
In a case that most people have heard about, Andrea Yates drowned all five of her children in the bathtub while taking Effexor and Remeron in November 2004. ... - Scoop.co.nz (press release),
Akzo Plans to Sell Shares in Drug Unit to Public (Update4) Feb 7, 2006
Organon's sales fell in 2004 and 2003 as the antidepressant Remeron lost patent protection. Arnhem, Netherlands-based Akzo is working with Pfizer Inc. ... - Bloomberg
Akzo Plans to Sell Shares in Drug Unit to Public (Update2) Feb 7, 2006
The drug unit's sales rose 3 percent last year, less than half the industry's average increase, as the antidepressant Remeron faced more competition. ... - Bloomberg
Akzo Nobel planning IPO for pharma business Feb 7, 2006
...business posted a 3% rise in revenues to 2.45 billion euros, returning to growth after several years of decline since antidepressant Remeron (mirtazapine) lost ... - Pharma Times (subscription),
Akzo plans share offering for its lagging drug unit Feb 7, 2006
...percent in 2005, less than half the average increase in the pharmaceuticals industry, as the unit struggled with the patent loss for its Remeron antidepressant ... - International Herald Tribune,
Link between antidepressants, violence unclear Jan 29, 2006
I couldn't.". In October, she said, she was hospitalized for "suicidal tendencies" and began treatment with Remeron. "I started to ... - Charlotte Observer,
Combining Mirtazapine (Remeron) with Other Antidepressants ... Nov 11, 2005
By Steve Pridgeon. VANCOUVER, CANADA -- November 11, 2005 -- Depressed patients taking mirtazapine together with fluoxetine (Sarafem ... - DG News
Experts say Prozac might not be the most effective antidepressant Dec 8, 2005
Results were mixed: Prozac was found less effective than Prothiaden (dothiepin), Zoloft, Remeron (mirtazapine) and Effexor but more effective than the ... - Dominican Today,
Assessing and Treating Sleep Disturbances in Patients With ... Dec 5, 2005
Trazodone (Desyrel) and mirtazapine (Remeron) can be tried, but no controlled trials have been reported, so safety, efficacy and dosages have not been ... - Psychiatric Times,
In the Name of “Mental Health�: An Antipsychiatry Perspective ... Nov 30, 2005
...activist Tooker Gomberg jumped to his death in Halifax in the spring of 2003, a few weeks after being prescribed the antidepressant Remeron (mirtazapine). ... - New Socialist Group,
Cynthia George traded her small childhood home for a castle, where ... Dec 4, 2005
She did confide in a counselor, who noted in court testimony that George had become so stressed by early 2001 that she was taking the antidepressant Remeron. ... - Akron Beacon Journal,
Antidepressants under scrutiny Nov 25, 2005
The warning covers 10 of the current popular antidepressants, Prozac, Zoloft, Paxil, Effexor, Celexa, Lexapro, Wellbutrin, Luvox, Remeron and Serzone. ... - Ironwood Daily Globe,
Fast-Dissolving Antidepressant, Remeron SolTab®, Enhances ... Oct 9, 2005
Two-thirds of depressed patients prefer Remeron SolTab®, a fast dissolving antidepressant tablet to the antidepressant's conventional tablet formulation. ... - Medical News Today (press release),
Make sure prescription has been filled correctly Oct 10, 2005
I take 15 mg of Remeron daily for depression. Recently I called in a refill. When I opened the bottle, I noticed that the pills ... - Charlotte Observer,
Rapid dissolving antidepressant enhances compliance in 50 per cent ... Oct 5, 2005
Ongoing global preference survey confirms patients prefer Remeron RD(R) TORONTO, Oct. 5 /CNW/ - Two-thirds of depressed patients ... - Canada NewsWire (press release),
Rapid dissolving antidepressant enhances compliance in 50 per cent ... Oct 5, 2005
5 /CNW/ - Two-thirds of depressed patients prefer Remeron RD(R), a rapid dissolving antidepressant tablet in comparison to the antidepressant's conventional ... - Biotech Intelligence (press release),
CNW Group summary of releases for Evening, Wednesday, October 5 ... Oct 5, 2005
...at Indigo (Kim- Cattrall-Indigo) C7595 - TORONTO : Rapid dissolving antidepressant enhances compliance in 50 per cent of patients (Remeron-global-survey) C7604 ... - CNW Telbec (Communiqués de presse),
Second-Generation Antidepressants Equally Effective Sep 20, 2005
Four non-SSRI second-generation antidepressants were also assessed -- bupropion (Wellbutrin), duloxetine (Cymbalta), mirtazapine (Remeron) and venlafaxine ... - Forbes
Antidepressants, Depression and Suicide Sep 12, 2005
...venlafaxine (Effexor), escitalopram (Lexapro), fluvoxamine (Luvox), paroxetine (Paxil), fluoxetine (Prozac), mirtazapine (Remeron), nefazodone (Serzone ... - Bella Online
Book Review - The PDR Family Guide to Prescription Drugs Sep 17, 2005
These include Arthritis, Antibiotics for ulcers, Burcitis, Cefzil, Gigantism, Heart Valve Replacement, Pancreatic Cancer, Remeron and Vomiting as a symptom of ... - Bella Online
Many meds don't mix with the sun Sep 21, 2005
...escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (To-franil), maprotiline (Ludiomil), mirtazapine (Remeron), nefazo-done ... - Pioneer Press,
Other information
Indication
For the treatment of Bacterial infection of; Respiratory tract, Urinary tract, GI, CNS and Immuno compromised patients caused by: S.pneumoniae, H.influenzae, M.catarrhalis, S.aureus, H.parainfluenzae, P.aeruginosa, S.marcescens, E.coli, K.pneumoniae, C.pn
Pharmacology
Levofloxacin, a fluoroquinolone antiinfective, is the optically active L-isomer of ofloxacin. Levofloxacin is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community-acquired pneumonia and pneumonia caused by penicillin-resistant strains of Streptococcus pneumoniae, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis.
Mechanism Of Action
Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited.
Drug Category
Anti-bacterial Agents; Anti-Infectives; Quinolones; ATC:J01MA12; ATC:S01AX19
Brand Names/Synonyms
Cravit; Cravit Ophthalmic; Elequine; Floxel; IQUIX; Leroxacin; Lesacin; Levaquin Leva-Pak; Levaquin; Levokacin; Levox; Levoxacin; Mosardal; Nofaxin; Quixin; Reskuin; Tavanic; Volequin
Dosage Forms
TABLET, LIQUID, SOLUTION
Absorption
Absorption of ofloxacin after single or multiple doses of 200to 400 mg is predictable, and the amount of drug absorbed increases proportionately with the dose.
Interactions
Interactions for Levofloxacin:
Specific drug interaction studies have not been conducted with Levofloxacin. However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, and enhance the effects of the oral anticoagulant warfarin and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving systemic cyclosporine concomitantly.
Chemical IUPAC Name
(-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7Hpyrido[1,2,3-de]-1,4 benzoxazine-6-carboxylic acid hemihydrate
Chemical Formula
C36H42F2N6O9
Half Life
6-8 hours .
Drug Type
Approved Drug
# Accession No
APRD00477
CAS Registry Number
100986-85-4