Levodopa: profile and news
This is the end Mar 3, 2006
..."Are you allergic to Demerol?" she asked. Things began to look up. She gave me a gown and slippers to wear and a matching ID bracelet to complete the ensemble. ... - Inside Bay Area,
Give criminals fate worse than death Feb 28, 2006
He left in a haze of Demerol, a second drug that sent him into unconsciousness and a third one that ended the feeble beating of his heart. ... - Miami Herald,
Rx for Raw Recipes Mar 1, 2006
By PEGGY TOWNSEND. She would have debilitating headaches that required shots of Demerol to calm. Then came bouts of hypoglycemia, Epstein ... - Santa Cruz Sentinel,
ASK THE DOCTOR: Side effects from codeine just that, not allergic ... Feb 28, 2006
...tolerate it well. Itching, hives and flushing are common, especially with codeine, morphine and meperidine (Demerol). These symptoms ... - The Patriot Ledger,
Pakistan wants US to exert pressure for a deal on Kashmir ... Feb 28, 2006
...the US intelligence agencies is good but it could be better and it could be quicker (a dig at the US missile attack on the border town of Demerol which killed ... - PakTribune.com,
House Burning Down Feb 28, 2006
Dixieland of "World Without Sound" is both reassuring and out of reach, just like the certainty of Christianity, or at least the luxury of "Demerol and cashmere ... - Seattle Weekly,
Doctors find little humor in TV's handling of painkillers Feb 22, 2006
...recent random survey funded by Reckitt Benckiser Pharmaceuticals didn't understand that prescription painkillers such as OxyContin, codeine and Demerol are as ... - Seattle Times,
Invasion of The Body Snatchers Feb 25, 2006
Mastromarino, who once had a lucrative dental practice, surrendered his license in 2000 because he was addicted to the painkiller Demerol. ... - Newsweek
Ex-dentist indicted in plot to sell body parts Feb 23, 2006
He was arrested for possessing Demerol, a painkiller. Mastromarino, 42, and his wife, Barbara, live in a $1.5 million house on the Palisades in Fort Lee. ... - NorthJersey.com,
Make-A-Wish celebrates 25 years with plane trip Feb 22, 2006
But their mother, Kristine, was still nervous. Just a week earlier they were both in the hospital, sedated on Demerol, unable to walk, let alone fly in a jet. ... - Arizona Republic,
GenoMed Trial Results: Sickle Cell Disease - From Daily Pain to ... Feb 22, 2006
...[occasional] im [intramuscular] Demerol, was discharged a few weeks ago (12/22 to be exact) on [GenoMed's protocol, which uses a blood pressure medication] at ... - International News Service,
Man arrested over cache of stolen medical supplies Feb 25, 2006
...the rest of the missing supplies, which included a bottle of eye drops and a medical bag filled with drugs such as morphine, Valium, and Demerol, police Sgt. ... - Toledo Blade,
Ambulance official to be sentenced for theft Feb 7, 2006
Mitchell-Ackley was caught last July stealing drugs, such as the painkillers morphine and Demerol, out of boxes from Foote Hospital that paramedics take with ... - The Jackson Citizen-Patriot,
Attention News Editors: Feb 15, 2006
...never occur. - FALSE - Dr. Pop prescribed Demerol and cortisone in an abusive manner following the operation. - FALSE - The consent ... - Canada NewsWire (press release),
Ambulance official to be sentenced for theft Feb 7, 2006
Mitchell-Ackley was caught last July stealing drugs, such as the painkillers morphine and Demerol, out of boxes from Foote Hospital that paramedics take with ... - The Jackson Citizen-Patriot,
Nurse charged Jan 26, 2006
Officials there found discrepancies in orders for Demerol and Morphine. St. Landry parish investigators learned Leger was allegedly upping the dosages. ... - KATC,
Remodeling – A Cautionary Tale Jan 10, 2006
I pull my wool hat down to my eyebrows, trying to hold the last vestiges of the Demerol and that drug-that-makes-you-forget in my noggin. ... - New West,
Hospital increases services Jan 18, 2006
Evans said drugs such as Stadol and Demerol tend to affect the baby more; however, the drugs in epidurals have had fewer effects on babies. ... - Eastern Arizona Courier,
Heroin may be new menace, but its source is not Jan 28, 2006
A related group of synthetic opiates includes meperidine (known as Demerol), propoxyphene (known as Darvon), and pentazocine (known as Talwin). ... - New Philadelphia Times Reporter,
Cadaver probe centers on ex-doc Jan 29, 2006
...to state dental board records, Mastromarino tested positive for cocaine and the narcotic meperidine, and was arrested for possessing Demerol, a painkiller that ... - NorthJersey.com,
Three are in custody on drug charges Jan 25, 2006
...near schools with bond set at $150,000; Herbert F. Moore, 47, of Sikeston, possession of a controlled substance (methamphetamine and demerol) with bond set at ... - Skieston Standard Democrat,
The New Coffin Nail Marketing: Join a Club Near You Jan 30, 2006
..."Lucy In The Sky Exchanges" will enable those who have leftover OxyContin to trade it to others who might have leftover Vicodin or Demerol or something more ... - Mediapost.com,
Gunman Convicted of Attack on Lawyer Last October Jan 20, 2006
Strier's lawyer argued that his client was upset about a pending probate case and was under the influence of the drug Demerol at the time of the shooting and ... - Los Angeles Times,
Abortion Before Roe Jan 20, 2006
We gave Demerol for the severe cramping, diarrhea and vomiting that ensued from the prostaglandin (not only did it make the uterine contract, but it made other ... - CounterPunch,
Ask the Clinician: Answers to Readers' Questions Jan 9, 2006
She has at her disposal 180 Percocet pills a month, Demerol shots to use as needed, two anti-seizure medications (for she also has seizures), one of those ... - About - News & Issues,
Doctor faces suspension Jan 7, 2006
...and October 2004. Drugs prescribed included strong painkillers such as Demerol, methadone, morphine and oxycotin. The summary suspension ... - Beloit Daily News,
Prescription painkillers are gaining addicts -- and casualties 11 Dec 2005
For example, in 1998, Oklahoma City doctor Jeffrey H. Schimandle was accused of switching a patient's dose of Demerol with water so he could use the drug ... - NewsOK.com (subscription),
NEWS SPECIAL Jacko's people slam booze and pills overdose claim Dec 10, 2005
...reported that "Jackson family insiders" had tipped off police in Santa Barbara that the star had overdosed on a mixture of the painkiller Demerol and Jack ... - Glasgow Sunday Mail,
Michael Jackson 'breaking news' for tabloid Dec 9, 2005
Enquirer can reveal police in Santa Barbara, Calif., have been told by a source close to the singer's family that Jackson recently OD'd on Demerol and Jack ... - Munster Times,
The Agony and the Cholecystecomy or Where’s My Gizzard? Dec 9, 2005
There just isn’t enough Demerol in the world when a gallstone is making its wicked way through the cystic duct to the extrahepatic duct and on to your small ... - New West,
Speak No Evil´ is a Risky Policy for Avoiding Litigation Dec 8, 2005
Washington state. The anesthesiologist's association with the Louisiana facility had ended because of his suspected abuse of Demerol. The ... - Mondaq News Alerts,
New "walking epidural" technique developed at UW Medical Center Nov 30, 2005
...anesthesiologists at University of Washington Medical Center have refined the "walking epidural" technique by using meperidine (Demerol), thus minimizing ... - uwnews.org,
Polk Deputy Faces Drug Charge Nov 23, 2005
A Polk County sheriff's deputy has been charged with illegally obtaining Demerol from a Winter Haven pharmacy. Winter Haven police ... - The Ledger,
Sheriff's Deputy Arrested For Illegally Buying Painkillers Nov 22, 2005
Winter Haven police arrested Deputy Timothy Ellis on Monday night. Police said Ellis used a forged prescription to get Demerol from a Winter Haven pharmacy. ... - WFtv.com,
Deputy charged with forging Rx Nov 23, 2005
Winter Haven -- A Polk County deputy sheriff has been accused of illegally obtaining a prescription of the painkiller Demerol from a Winter Haven pharmacy. ... - Orlando Sentinel,
Knoxville nurse arrested on charges of stealing drugs from ... Nov 10, 2005
Tennessee Bureau of Investigation agents, ending an investigation that began in November 2004 after hospital officials discovered doses of Demerol were missing ... - WATE.com,
Take time to appreciate those who matter Nov 20, 2005
A punctured lung and three broken ribs, a few large, bulbous bruises and eyes glazed over from Demerol injections, she lies there with a smile to prevent me ... - News Record,
You say it's trivial, as if that's a bad thing Dec 2, 2005
It may signal a full-on feud with reality. But it was better than Demerol, and it was a nice way to spend a Saturday afternoon. ... - Orlando Sentinel,
Pharm Land Nov 18, 2005
..."Pain getting you down?" he wrote derisively in a dissenting 1976 Supreme Court opinion. "Insist that your physician prescribe Demerol. ... - New York Times,
Plastic Surgeon Charged With Girlfriend's Murder Nov 22, 2005
...severe infection. Her infection was from injection sites where she was given drugs including Ketamine, Demerol and morphine. Dr. Koulis ... - WCPO,
Back on track Nov 11, 2005
Webb's fever had spiked at 104.7 degrees. His blood pressure dropped, his mother said, to 70 over 40. He was given Demerol for the intensifying pain. ... - Bothell Herald,
Ex-doctor charged with murder in woman's overdose death Nov 23, 2005
He was accused of entering into a romantic relationship with two patients and stealing the painkiller Demerol for personal use. ... - The Tennessean,
Doctor accused of taking drugs from hospital Nov 14, 2005
McNeece said several substances, including two vials of Midazolam, two vials of Duramorph, several vials of Demerol and a syringe full of Fentanyl were ... - Princeton Daily Clarion,
Running to the future: Overcoming hidden obstacles Nov 17, 2005
...that side. His wife called the ambulance and he was taken to the hospital. Which led him to the first taste of Demerol. That was ... - Black Hills Pioneer,
Toral is Longshot in Trump's Apprentice Derby Oct 8, 2005
...a skating accident. Look for Toral and Markus to get the hookup while Becky is having Demerol dreams. Markus Garrison: Currently ... - Spoof News (satire)
Mulder’s pain is the Cardinals’ gain Oct 7, 2005
...arm to scream. Once it did, the pain registered on its usual gradient: Ouch, then ouch, then time for the Demerol. Mulder saw Cardinals ... - Kansas City Star,
Teens arrested on warrants Oct 5, 2005
27 at 1:30 am. Police said Wayne Scranton, 29, of 44 Warm Earth Road, was found in possession of Demerol pills not in a prescription bottle. ... - Milford Mirror,
Parkinson's Disease Data From the Aeolus Pharmaceuticals Pipeline ... Sep 20, 2005
4-phenyl-1, 2, 3, 6-tetrahydropyridine, or "MPTP," has been identified in underground laboratory preparations of a potent analog of meperidine (Demerol(TM)). ... - PR Newswire (press release),
Medical Utopia: Slicing through red tape to graft a young girl’s ... Sep 21, 2005
...“I’m asking for Demerol,� says one of the three recovery room nurses, checking Liz’s pulse, tucking yet another blanket around her, and checking a large ... - Montclair Times,
DR. HOOK- Hurts so bad: Pain drugs create quandary Sep 22, 2005
...narcotics. Once I had a patient in the hospital pass out on me saying, "I need just a little more dem... Demerol..." Snore. I had ... - The Hook,
Other information
Indication
For the treatment of idiopathic Parkinson's disease (Paralysis Agitans), postencephalitic parkinsonism, symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication, and manganese intoxication.
Pharmacology
Levodopa (L-dopa) is used to replace dopamine lost in Parkinson's disease because dopamine itself cannot cross the blood-brain barrier where its precursor can. However, L-DOPA is converted to dopamine in the periphery as well as in the CNS, so it is administered with a peripheral DDC (dopamine decarboxylase) inhibitor such as carbidopa, without which 90% is metabolised in the gut wall, and with a COMT inhibitor if possible; this prevents about a 5% loss. The form given therapeutically is therefore a prodrug which avoids decarboxylation in the stomach and periphery, can cross the blood-brain barrier, and once in the brain is converted to the neurotransmitter dopamine by the enzyme aromatic-L-amino-acid decarboxylase.
Mechanism Of Action
Striatal dopamine levels in symptomatic Parkinson's disease are decreased by 60 to 80%, striatal dopaminergic neurotransmission may be enhanced by exogenous supplementation of dopamine through administration of dopamine's precursor, levodopa. A small percentage of each levodopa dose crosses the blood-brain barrier and is decarboxylated to dopamine. This newly formed dopamine then is available to stimulate dopaminergic receptors, thus compensating for the depleted supply of endogenous dopamine.
Drug Category
Dopamine Agents; Antiparkinson Agents; Antidyskinetics; ATC:N04BA01; ATC:N04BA04
Brand Names/Synonyms
Atamet; Bendopa; Brocadopa; Cidandopa; DA; DOPA; Deadopa; Dopaflex; Dopaidan; Dopal; Dopal-Fher; Dopalina; Dopar; Doparkine; Doparl; Dopasol; Dopaston; Dopastral; Doprin; Eldopal; Eldopar; Eldopatec; Eurodopa; Helfo-Dopa; Insulamina; L-DOPA; L-Dihydroxyphenylalanine; L-Dopa; L-Dopa for Biochemistry 99+%; Laradopa; Larodopa; Ledopa; Levedopa; Levodopa; Levopa; Maipedopa; Parda; Pardopa; Prodopa; Sinemet; Sinemet Cr; Syndopa; Veldopa; Weldopa
Dosage Forms
Tablets, pink, scored, each containing levodopa 0.1 g
Absorption
Levodopa is rapidly absorbed from the proximal small intestine by the large neutral amino acid (LNAA) transport carrier system.
Interactions
Interactions for Levodopa:
No information provided.
Chemical IUPAC Name
2-amino-3-(3,4-dihydroxyphenyl)-propanoic acid
Chemical Formula
C9H11NO4
Half Life
50 to 90 minutes
Drug Type
Approved Drug
# Accession No
APRD00309
CAS Registry Number
59-92-7