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Other information

Indication
For treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Hyoscyamine may also be used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis

Pharmacology
L-Hyoscyamine, the active optical isomer of atropine (dl-hyoscyamine), is a tertiary amine anticholinergic gastrointestinal agent. Hyoscyamine is used to manage peptic ulcer disease, biliary tract disorders, cystitis, severe allergic rhinitis, hypermotility disorders of the lower urinary tract, infant colic, and to control salivation and excessive secretions before an operation.

Mechanism Of Action
Hyoscyamine competes favorably with acetylcholine for binding at muscarinic receptors in the salivary, bronchial, and sweat glands as well as in the eye, heart, and gastrointestinal tract. The actions of hyoscyamine result in a reduction in salivary, bronchial, gastric and sweat gland secretions, mydriasis, cycloplegia, change in heart rate, contraction of the bladder detrusor muscle and of the gastrointestinal smooth muscle, and decreased gastrointestinal motility.

Drug Category
Mydriatics; Bronchodilator Agents; Antiarrhythmic Agents; Adjuvants; Antimuscarinics; Antispasmodics; ATC:A03BA03

Brand Names/Synonyms
ATROPINE; Anaspaz; Cystospaz; Daturine; Duboisine; Duretter; Egacene; Egazil; Gastrosed; Hyocyamine; Hyoscyamine; Hyoscyamine, L-; L-Atropine; L-Hyopscyamine; L-Hyoscamine; L-Hyoscyamine; L-Hyoscyamine Free Base; L-Tropine Tropate; Levbid; Levsin; Levsinex; OIN; Peptard; Scopolia Extract

Dosage Forms
Oral tablets, oral drops, elixir, injection

Absorption
absorbed totally and completely by sublingual administration as well as oral administration

Interactions
Interactions for Hyoscyamine:

Additive adverse effects resulting from cholinergic blockade may occur when LEVSIN is administered concomitantly with other antimuscarinics, amantadine, haloperidol, phenothiazines, monoamine oxidase (MAO) inhibitors, tricyclic antidepressants or some antihistamines. Antacids may interfere with the absorption of LEVSIN. Administer LEVSIN before meals; antacids after meals.

Chemical IUPAC Name
(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)3-hydroxy-2-phenyl-propanoate

Chemical Formula
C17H23NO3

Half Life
2-3 1/2 hours

Drug Type
Approved Drug

# Accession No
APRD00607

CAS Registry Number
101-31-5