Leuprolide: profile and news






New Formulation of Leuprolide Administered Every Six Months  Feb 21, 2006
An experimental formulation of leuprolide, administered by injection every six months, safely and effectively reduced serum testosterone levels in men with ... - Cancer Consultants (press release),

Voyager Pharmaceutical Corporation Adds Six New Board Members  Mar 3, 2006
Voyager's most advanced product candidate is Memryte, a proprietary, small, biodegradable implant that is comprised of leuprolide acetate and a polymer, that ... - Carolina Newswire (press release),

Rich Daly Joins TAP As Senior Marketing Executive  Feb 2, 2006
...marketing strategy and initiatives for TAP's current and future brands - including Prevacid(R) (lansoprazole) and Lupron Depot(R) (leuprolide acetate for depot ... - International News Service,

Depot Delivery System Maintains Steady Drug Level in Prostate ...  Feb 16, 2006
2006 (Reuters Health) - LA-2585 (Atrix Laboratories), an extended release subcutaneous formulation for the long-term delivery of leuprolide acetate, appears to ... - Cancerpage.com,

MediGene’s Prostate Cancer Drug* Launched in France and Other ...  Feb 17, 2006
The drug* (active substance: leuprolide acetate) combines standard hormone therapy with a novel, patient-friendly and efficient drug delivery system, the ... - WebWire (press release),

Rich Daly Joins TAP as Senior Marketing Executive  Feb 2, 2006
...overall marketing strategy and initiatives for TAP's current and future brands - including Prevacid® (lansoprazole) and Lupron Depot® (leuprolide acetate for ... - Yahoo! News (press release)

Rich Daly Joins TAP As Senior Marketing Executive  Feb 2, 2006
...marketing strategy and initiatives for TAP's current and future brands - including Prevacid(R) (lansoprazole) and Lupron Depot(R) (leuprolide acetate for depot ... - International News Service,

Rich Daly Joins TAP as Senior Marketing Executive  Feb 2, 2006
...overall marketing strategy and initiatives for TAP's current and future brands - including Prevacid® (lansoprazole) and Lupron Depot® (leuprolide acetate for ... - Yahoo! News (press release)

Abbott Reports Record Sales, Earnings and Cash Flow in 2005  Jan 25, 2006
...$272 10.4 Ultane/Sevorane $91 14.7 $142 7.8 (b) $233 10.4 Omnicef $189 27.5 --- -- $189 27.5 Synthroid $141 (0.1) $15 9.8 $156 0.8 Leuprolide --- -- $54 (0.2 ... - MSN Money

Teva and Ivax Cleared to Complete Merger  Jan 27, 2006
In addition, generic distribution relationships that Ivax had with respect to certain amoxicillin, amoxicillin and clavulanate, leuprolide, and calcitriol ... - International News Service,

Joseph DeVeaugh-Geiss, MD, Expands Role as Interim Chief Medical ...  Jan 16, 2006
...along with the Phase II and Phase III double-blind, placebo-controlled trials (ALADDIN) investigating the safety and effectiveness of leuprolide acetate as a ... - Biotech Intelligence (press release),

Teva-Ivax merger likely to create shifts in pharma sector  Jan 23, 2006
...also said that generic distribution relationships that Ivax had with respect to certain amoxicillin, amoxicillin and clavulanate, leuprolide, and calcitriol ... - Hindu Business Line,

FTC gives Ivax and Teva final go-ahead for merger  Jan 23, 2006
In addition, the companies said generic distribution relationships Ivax had for certain amoxicillin, amoxicillin and clavulanate, leuprolide, and calcitriol ... - South Florida Business Journal,

CMS Issues Final Rule on Competitive Acquisition of Medicare Part ...  Jan 20, 2006
Because all carriers have adopted LCA policies for injectable forms of leuprolide acetate, CMS has not included this product in the CAP. ... - Mondaq News Alerts,

Voyager Pharmaceutical Names Interim Chief Medical Officer  Jan 16, 2006
DeVaugh-Geiss has been involved in all three phases of trials for Voyager’s drug leuprolide acetate, which is seen as a potential treatment for Alzheimer’s ... - Local Tech Wire,

Preserving Competition, FTC Requires Divestitures Before Allowing ...  Jan 23, 2006
...to Par; 3) pergolide mesylate tablets from Teva, to be divested to Par; 4) estazolam tablets from IVAX, to be divested to Par; 5) leuprolide acetate injection ... - PharmaLive.com (press release),

Voyager Pharmaceutical Corporation Announces Revised Terms for IPO  Dec 8, 2005
Voyager's most advanced product candidate is Memryte, a proprietary, small, biodegradable implant that is comprised of leuprolide acetate and a polymer, that ... - PharmaLive.com (press release),

Prostate cancer: awaiting innovation  Dec 8, 2005
...releasing hormone (LHRH) agonist monotherapy remains the most commonly used drug therapy for prostate cancer, and agents such as leuprolide and goserelin are ... - Pharmaceutical Business Review

Docs Assess Three Therapy Approaches for Poor IVF Responders  Nov 30, 2005
The so-called stop protocol at the clinic involved the use of Lupron (leuprolide acetate), a GnRH agonist given during the mid-luteal phase of the patient's ... - Fertility Neighborhood,

MediGene's Drug Eligard® Launched in Spain and Further European ...  Nov 15, 2005
Eligard® (active substance: leuprolide acetate) combines standard hormone therapy with a novel, patient-friendly and efficient drug delivery system, the ... - Biotech Intelligence (press release),

Norwood Immunology - Phase II Clinical Trial - Melanoma Cancer ...  Nov 17, 2005
...for commercialization in the United States, utilizing TAP's GnRH analogue, Lupron Depot(R) (leuprolide acetate for depot suspension). ... - Business Wire (press release),

Projects seek to unravel Alzheimer's causes  Nov 13, 2005
UNMC is just kicking off a trial designed to show if the drug leuprolide can slow the progress of Alzheimer's disease, said Daniel Murman, Ph.D., associate ... - Council Bluffs Daily Nonpareil,

Pediatric Obesity, Clinical Trial Designs For Devices Are Topics ...  Oct 6, 2005
The committee will also review the recommendation by its Pediatric Ethics Subcommittee on the ethics of a protocol using a leuprolide test for puberty disorders ... - FDA Advisory Committee

A case of raging hormones?  Sep 17, 2005
...a prostate cancer patient who also had Alzheimer's saw his Alzheimer's symptoms become stabilized after he started taking the drug leuprolide acetate, which ... - Milwaukee Journal Sentinel,

MediGene's First Drug Eligard® Is Launched  Oct 3, 2005
Eligard® (active substance: leuprolide acetate) combines standard hormone therapy with a novel, patient-friendly and efficient drug delivery system, the ... - Biotechnology Investment Today (Press Release),

Devil in the details on Voyager  Sep 19, 2005
The company's drug, a previously approved medication called leuprolide acetate that is combined with an undisclosed polymer, has been tested on about 258 ... - MSNBC

Voyager Pharmaceutical Files for Initial Public Offering  Sep 9, 2005
Voyager's most advanced product candidate is Memryte, a proprietary, small, biodegradable implant that is comprised of leuprolide acetate and a polymer, that ... - Yahoo! News (press release)

Voyager files for IPO  Sep 9, 2005
The company's drug, which is generically called leuprolide acetate, is currently approved to stem the flow of sex hormones and is prescribed for the treatment ... - Bizjournals.com,

TAP Expands Gastroenterological Pipeline by Signing Licensing ...  Sep 8, 2005
...of Osaka, Japan. TAP markets Prevacid(R) (lansoprazole) and Lupron Depot(R) (leuprolide acetate for depot suspension). For more ... - PR Newswire (press release),

TAP Expands Gastroenterological Pipeline by Signing Licensing ...  Sep 8, 2005
...of Osaka, Japan. TAP markets Prevacid® (lansoprazole) and Lupron Depot® (leuprolide acetate for depot suspension). For more information ... - Yahoo! News (press release)

US FDA Authorizes the Start of a Phase III Multicenter Clinical ...  08 Sep 2005
...that on August 25th 2005 the FDA authorized the start in the US of a Phase III multi-center clinical study for it’s depot formulation of Leuprolide Acetate 3 ... - PharmaLive.com (press release),

TAP Expands Gastroenterological Pipeline by Signing Licensing ...  08 Sep 2005
...of Osaka, Japan. TAP markets Prevacid(R) (lansoprazole) and Lupron Depot(R) (leuprolide acetate for depot suspension). For more ... - PR Newswire (press release),

Joint pain and estrogen deprivation  Sep 3, 2005
In a study of leuprolide, a hormonal agent used to treat ... The pain was resolved in all women between 2 and 12 weeks after stopping the leuprolide therapy. ... - Medical News Today (press release),

Estrogen deprivation and joint pain  Sep 3, 2005
In a study of Leuprolide ( Lupron ), a hormonal agent used to treat infertility and a variety of gynecological disorders, 102 premenopausal women experienced ... - Xagena.it,

Company Information Center  Sep 1, 2005
Enzon's product development collaboration with Nektar, which was formed in January 2002, the companies were jointly developing inhaled leuprolide acetate and ... - Business Wire (press release),

International Approvals: Adderall XR, Gynazole-1, Leuplin SR  Aug 29, 2005
...and Singapore for the treatment of vulvovaginal candidiasis; Japan's Ministry of Health, Labor, and Welfare has approved leuproreline (leuprolide) acetate 11.25 ... - Medscape (subscription)

Breast Cancer Treatment Linked to Joint Pain  Sep 2, 2005
A study of a hormonal drug used to treat infertility and gynecological conditions called leuprolide showed that premenopausal women can suffer joint pain ... - WebMD

Breast Cancer Adjuvant Therapy May Trigger Joint Pain  Sep 2, 2005
Lupron (leuprolide), a gonadotropin-releasing hormone agonist used to treat infertility and a variety of gynecological disorders, blocks estrogen production. ... - MedPage Today,

A Father's Battle With Prostate Cancer Makes His Urologist Son ...  Aug 31, 2005
...prostate cancer is manageable; hormonal therapies can help manage the symptoms of the disease, but treatments such as Eligard, or leuprolide acetate for ... - PR Newswire (press release),

ABBOTT LABORATORIES: Court rejects appeal to delay Lupron ...  Aug 19, 2005
Lupron Depot allows patients to inject the compound leuprolide once a month, or once every three or four months, rather than once a day as patients are ... - Chicago Tribune,

American College of Gastroenterology Announces 2005 Junior Faculty ...  Aug 16, 2005
...of Osaka, Japan. TAP currently markets Lupron Depot(r) (leuprolide acetate for depot suspension) and Prevacid(r) (lansoprazole). ... - U.S. Newswire (press release),

Norwood Immunology -- Publication in Leading Scientific Journal  Aug 11, 2005
...for commercialization in the United States, utilizing TAP's GnRH analogue, Lupron Depot(R) (leuprolide acetate for depot suspension). ... - Genetic Engineering News,

Prostate Cancer  Aug 14, 2005
...option. It's called Viadur(r). Viadur is an implant system that contains the hormone medication, leuprolide acetate. The implant ... - WOWT,

Cooking to Reduce the Burn: Heartburn-Friendly Recipes and Tips ...  Aug 2, 2005
Limited, of Osaka, Japan. TAP markets Prevacid and Lupron Depot® (leuprolide acetate for depot suspension). For more information ... - Yahoo News (press release)

Abbott Reports 17.5 Percent Sales Increase in the Second Quarter  Jul 13, 2005
11.9(c) $226 17.7 TriCor $219 22.9 --- -- $219 22.9 Synthroid $113 (36.1) $14 (9.7) $127 (34.0) Omnicef* $85 62.8 --- -- $85 62.8 Leuprolide --- -- $57 17.2 ... - Yahoo News (press release)

DURECT Corporation Announces Second Quarter 2005 Financial Results  Jul 22, 2005
The increase was primarily attributable to the higher development expenses for SABER-Bupivacaine, TRANSDUR-Sufentanil, DURIN-Leuprolide and certain other ... - Yahoo News (press release)

CMS Issues Interim Final Rule on Competitive Acquisition of ...  Jul 19, 2005
4 Because every carrier has applied an LCA policy to injectable forms of leuprolide, which would have the effect of requiring vendors to supply the drug at the ... - Mondaq News Alerts


Other information


Indication
For treatment of prostate cancer, endometriosis, uterine fibroids and premature puberty

Pharmacology
Used in the palliative treatment of advanced prostate cancer. Leuprolide is a luteinizing hormone agonist that results in suppression of testicular or follicular steroidogenesis.

Mechanism Of Action
Leuprolide binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion.

Drug Category
Antineoplastic Agents; Anti-Estrogen Agents

Brand Names/Synonyms
Eligard; Eligard (Atrix Labs/QLT Inc)

Dosage Forms
Not Available

Absorption
Not Available

Interactions
Not Available

Chemical IUPAC Name
5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide

Chemical Formula
C59H84N16O12

Half Life
~3 hours

Drug Type
Approved Drug

# Accession No
BIOD00009

CAS Registry Number
74381-53-6

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