Lantus: profile and news
Apidra (insulin glulisine [rDNA origin] injection) Now Available ... Feb 28, 2006
Apidra should normally be used in regimens that include a longer-acting insulin or basal insulin analog such as Lantus® (insulin glargine [rDNA origin ... - DG News
Apidra(R) - a New Rapid-Acting Insulin Analog - Is Now Available ... Feb 28, 2006
New prandial insulin with the OptiClik(R) delivery system can work with longer-acting insulins, such as basal insulin Lantus(R), providing a complementary ... - PR Newswire (press release),
Pharmac committees need urgent review Mar 1, 2006
...“Take the saga of the diabetic insulin drug Lantus. ... "Lantus was then referred to the diabetes sub-committee, which took a staggering 10 months to meet. ... - Scoop.co.nz (press release),
Sanofi Launches Apidra Just In Nick Of Time Mar 1, 2006
0935 GMT [Dow Jones]--Sanofi's (SNY) launch of Apidra "comes just at the right time to support the sales momentum of Lantus in the US," says CM-CIC Securities ... - New Ratings
Euro RSCG Tonic Takes On Diabetes Feb 28, 2006
NEW YORK Sanofi-Aventis will break in March a new campaign for Lantus, a once-a-day insulin injection that fights diabetes symptoms for 24 hours. ... - Adweek,
Controlling Diabetes Feb 28, 2006
In addition, a new long-acting insulin called Lantus recently became available on the market, granting still more promise for diabetics eager to control their ... - KPHO Phoenix,
Sanofi's Apidra hits the US market Mar 2, 2006
...says Apidra (insulin glulisine rDNA origin injection) is to be used in regimens that include a longer-acting insulin or basal insulin analog such as Lantus. ... - Pharmaceutical Business Review
Latest Diabetes ZOOM Market Report(TM) Released Mar 3, 2006
Lantus is being presented with a consistent message globally, with emphasis on the convenience of the injection device, compared to other insulins. ... - Yahoo! News (press release)
Sanofi-Aventis' Battered Charm Mar 1, 2006
Key brands, such as Plavix, Taxotere and Eloxatin oncology treatments, Lantus antidiabetes agent, and Avapro -- an antihypertensive -- will likely drive the ... - BusinessWeek
How Will We Dilute Insulin? Jan 31, 2006
But one unit of Lantus will also lower the adult’s blood glucose by about 40 mg/dl. ... “But you can’t dilute Lantus,� he says. ... - Diabetes Interview,
Are Insulins on the Market Safe? Feb 2, 2006
...insulin options. For example, Trecroci asks if Lantus is really all that safe and if it has long-term cancer potential. ...people ... - The Common Voice,
Diabetes Health Magazine Asks, 'Where Have All the Insulins Gone?' Jan 31, 2006
The only thing that remains as a long-acting insulin option is the popular-and pricey-Lantus insulin. But, is Lantus really all that safe? ... - PR Newswire (press release),
Amylin's Competitor Concerns For Byetta Seen Unwarranted Feb 6, 2006
...introductions generally add to the growth in the diabetes market, citing three historical examples including Byetta's impact on Sanofi-Aventis' Lantus in June ... - Forbes
New posters on diabetes risks Feb 13, 2006
Amputation may be the outcome of infections in the wounds. Sanofi-aventis is the manufacturer of Lantus, a medication for the treatment of Type 1 diabetes. - Scoop.co.nz (press release),
Sanofi 4Q overshadowed by impending legislation Feb 1, 2006
The company saw sales for its blood thinner Lovenox rise by 14 per cent last year to $2.59 billion. Most impressive was the company's Lantus insulin. ... - In-PharmaTechnologist.com,
And Then There Were Some Jan 30, 2006
...that by eliminating Ultralente and Lente, Eli Lilly gives insulin-using diabetics no other choice but to take the long-acting insulin Lantus (Sanofi-Aventis ... - Diabetes Interview,
Are Insulins on the Market Safe? Feb 2, 2006
...insulin options. For example, Trecroci asks if Lantus is really all that safe and if it has long-term cancer potential. ...people ... - The Common Voice,
How Will We Dilute Insulin? Jan 31, 2006
But one unit of Lantus will also lower the adult’s blood glucose by about 40 mg/dl. ... “But you can’t dilute Lantus,� he says. ... - Diabetes Interview,
Diabetes Health Magazine Asks, 'Where Have All the Insulins Gone?' Jan 31, 2006
The only thing that remains as a long-acting insulin option is the popular-and pricey-Lantus insulin. But, is Lantus really all that safe? ... - International News Service,
Amylin's Competitor Concerns For Byetta Seen Unwarranted Feb 6, 2006
...introductions generally add to the growth in the diabetes market, citing three historical examples including Byetta's impact on Sanofi-Aventis' Lantus in June ... - Forbes
Sanofi-aventis Posts Dynamic Growth in 2005 Full-Year Consolidated ... Jan 30, 2006
Over 2005 as a whole, sales growth in Europe was boosted by a dynamic performance across the entire portfolio, especially Lantus® (up 40.5%), Eloxatin® (up ... - Yahoo! News (press release)
Sanofi 4Q overshadowed by impending legislation Feb 1, 2006
The company saw sales for its blood thinner Lovenox rise by 14 per cent last year to $2.59 billion. Most impressive was the company's Lantus insulin. ... - In-PharmaTechnologist.com,
Lehman Brothers Ups Novo Nordisk Estimates Jan 30, 2006
Adds that strength of the 4Q US insulin franchise bodes well for 06 as it appears to show no impact of competition from either Lantus or Byetta. ... - New Ratings
MannKind Corporation Announces Positive Results From a Phase 2b ... Jan 17, 2006
...to evaluate the effect of different mealtime doses of Technosphere(R) Insulin added to a single fixed daily injection of basal insulin glargine (Lantus(R)) in ... - PR Newswire (press release),
The insulin market – moving with the times Jan 23, 2006
Aventis managed to grab a chunk of the market in 2000 with the introduction of its novel once-daily long acting human insulin, Lantus, achieving worldwide ... - In-PharmaTechnologist.com,
Diabetes management gets a shot in the arm Jan 17, 2006
Now he takes two injections a day of a long-acting insulin called Lantus, which, thanks to the islet cells that are still working, hold his sugar as steady as ... - Times Herald-Record,
The Doctor's Choice Awards Dec 9, 2005
...categories. Sanofi-Aventis won for Lantus (insulin) in the diabetes category and for Uroxatral (alfuzosin) in urologicals. Wyeth ... - Medgadget.com,
Over time, high blood sugar level can lead to a stroke, heart ... Dec 4, 2005
...a day. He uses Lantus and Novolog insulin with devices called pens, which resemble the writing devices they're named after. At the ... - St. George Daily Spectrum,
Sanofi-aventis Third Quarter 2005: Adjusted EPS(1) up 27.4%, Net ... Nov 7, 2005
R) 422 +28.3% 1,141 +35.2% Taxotere(R) 420 +13.8% 1,184 +11.9% Stilnox(R)/Ambien(R) 419 +5.5% 1,089 +7.6% Allegra(R) 367 -0.8% 1,185 +8.3% Lantus(R) 325 +44.4 ... - PR Newswire (press release),
Sanofi-aventis Third Quarter 2005: Adjusted EPS(1) up 27.4%, Net ... Nov 7, 2005
In Europe, third-quarter sales growth was propelled by a strong showing from the entire portfolio, and in particular from Lantus® (up 44.5%), Eloxatin® (up ... - Yahoo! News (press release)
Drug firms enlist patients as allies Nov 27, 2005
The group is lobbying government to subsidise Lantus, a long-acting insulin, in response to requests from its members, and previously had accepted unrelated ... - Sydney Morning Herald (subscription),
SemBioSys reports positive plant produced insulin data Nov 29, 2005
...with 54 per cent (Humalog and Humulin, each grossing about $1 billion) and Sanofi-Aventis, with a 16 per cent share of the worldwide market (Lantus, about $0.8 ... - DrugResearcher.com,
Sanofi-Aventis adj. profit climbs 29% Nov 8, 2005
...which had 28.3% growth to 422 million euros; breast cancer drug Taxotere, which had 13.8% growth to 420 million euros; and insulin drug Lantus, which had 44.4 ... - MarketWatch
Sanofi-Aventis beats forecasts Nov 8, 2005
...respectively. The next top two sellers, chemotherapy drugs Taxotere and Eloxatin, also grew strongly, as did Lantus, a diabetes drug. ... - MSNBC
Drug Sales Lift Sanofi-Aventis Prifit Nov 8, 2005
Sales of Lantus insulin also rose 44 percent to euro325 million (US$384.3 million), and multiple sclerosis drug Copaxone boosted sales by 24 percent to euro240 ... - Forbes
Profit Rises 29% at Sanofi Nov 8, 2005
Sales of Lantus insulin rose 44 percent, to 325 million euros, and the multiple sclerosis drug Copaxone lifted sales by 24 percent, to 240 million euros. - New York Times,
Company News Nov 12, 2005
And on the diabetes front, booming sales of Lantus and expected US approval for Acomplia promise to sustain Sanofi’s sales through 2006. ... - Business Online,
Aventis to up headcount, will focus on diabetes Nov 8, 2005
800. Sanofi-Aventis believes that India is key market for its diabetes products like Lantus, Daonil, Insuman and metformin. Metformin ... - International Herald Tribune,
PBAC goes public with reasons for its decisions Nov 8, 2005
A spokesman for pharmaceutical company Sanofi-Aventis, which recently had its application for insulin glargine (Lantus) rejected for the fourth time (see below ... - AustralianDoctor.com (subscription),
Despair after diabetes drug not PBS listed Oct 4, 2005
...has been rejected for inclusion on the Pharmaceutical Benefits Scheme (PBS) has disappointed local diabetics who rely on the life-saving drug Lantus to manage ... - Dubbo Daily Liberal,
Beating the barriers Oct 11, 2005
...visiting endocrinologist at Sydney’s Prince of Wales and Children’s hospitals, is so incensed about the non-listing of glargine insulin (Lantus) on the PBS ... - AustralianDoctor.com (subscription),
Tea Pizza Ranch will be idle for a while Sep 30, 2005
...on the building and property, but he hasn't been able to take ownership and open the restaurant because of problems with contractor Lantus Development Co. LLP. ... - Sioux Falls Argus Leader,
Youngster with diabetes inspires others in walk Oct 19, 2005
Four insulin injections are given throughout the day, three through a Novolog pen syringe and a bedtime dose of Lantus, which provides the base rate for her ... - Asbury Park Press,
Winners Announced For 'The Doctors' Choice' Awards Oct 12, 2005
Merck (Vytorin for cardiovasculars--jointly marketed with Schering-Plough -- and Fosamax for obstetricals/gynecologicals), Sanofi-Aventis (Lantus for diabetic ... - Yahoo! News (press release)
Diabetics may turn to inhaled insulin Oct 3, 2005
...vial out of the regular insulin administration equation, many patients still would require a long-acting basal insulin by injection, such as Lantus, which is ... - El Paso Times,
Sanofi-aventis Provides Relief to Hurricane Victims Sep 29, 2005
Nearly 20,000 additional vials of Lantus have also been delivered recently to the disaster area through bulk and much needed individual shipments, and the ... - PR Newswire (press release),
Beating the barriers 11 Oct 2005
...visiting endocrinologist at Sydney’s Prince of Wales and Children’s hospitals, is so incensed about the non-listing of glargine insulin (Lantus) on the PBS ... - AustralianDoctor.com (subscription),
Despair after diabetes drug not PBS listed Oct 4, 2005
...has been rejected for inclusion on the Pharmaceutical Benefits Scheme (PBS) has disappointed local diabetics who rely on the life-saving drug Lantus to manage ... - Dubbo Daily Liberal,
Data at EASD suggests better glycaemic control possible using ... Sep 15, 2005
Association for the Study of Diabetes (EASD), Athens show that a strictly enforced titration schedule with intensive monitoring of Lantus® (insulin glargine ... - Läkemedelsindustriföreningen (pressmeddelande),
Tea Pizza Ranch will be idle for a while Sep 30, 2005
...on the building and property, but he hasn't been able to take ownership and open the restaurant because of problems with contractor Lantus Development Co. LLP. ... - Sioux Falls Argus Leader,
Sanofi rejects Novo suit, new drug may face delay Sep 23, 2005
The OptiClik device, which is produced for Sanofi by Switzerland's Ypsomed, has been available on the US market with Sanofi's insulin drug Lantus since early ... - Reuters
Sanofi-aventis Provides Relief to Hurricane Victims Sep 29, 2005
Nearly 20,000 additional vials of Lantus have also been delivered recently to the disaster area through bulk and much needed individual shipments, and the ... - PR Newswire (press release),
Diabetics may turn to inhaled insulin Oct 3, 2005
...vial out of the regular insulin administration equation, many patients still would require a long-acting basal insulin by injection, such as Lantus, which is ... - El Paso Times,
America’s Pharmaceutical Companies Continue Relief Efforts; More ... Sep 14, 2005
...victims. Delivered 20,000 vials of Lantus, an injectable insulin treatment for diabetes, to the hurricane disaster region. · Pledged ... - PharmaLive.com (press release),
Medical lifelines lost to the storm Sep 13, 2005
..."Help! Sherry Deakle needs glucometer, lancets, lantus insulin, ascensia strips, preferred. Hers lost due to storm... ," read an e-mail posted Sept. ... - philly.com,
Study Shows Exenatide Improves Blood Sugar Levels as Effectively ... Sep 12, 2005
Nasdaq: AMLN) today announced results from a study indicating that exenatide improves blood sugar levels as effectively as insulin glargine (Lantus(R), Sanofi ... - news aktuell (Pressemitteilung),
GS provides diabetes pipeline update. Sep 12, 2005
Sanofi Aventis has multiple points of interest in diabetes. First, it is one of three leading insulin makers, and analogue Lantus has been highly successful. ... - Drug Researcher.com,
Diabetic pleads for help as drug price soars Sep 6, 2005
But it was no longer effective at controlling her condition so she had to switch, on doctor's orders, to another type, Lantus, which costs more than $125 a vial ... - Hawke's Bay Today,
Information Regarding Insulin Storage and Switching Sep 3, 2005
Likewise, these insulins may also be substituted for long-acting insulins (such as Lantus and Ultralente) on a unit-per-unit basis, or vice versa. ... - Community Dispatch (press release)
Sanofi-Aventis: A Mix of News Aug 31, 2005
...company's total. Market-leading drugs like Lovenox, Plavix, and Lantus were all quite strong and posted double-digit growth. The ... - Motley Fool
Diabetes Treatment Aug 28, 2005
...reliable control. Long-acting insulin, such as Lantus, helps maintain normal blood-sugar levels for up to 24 hours. Fast-acting ... - eDiets.com,
Drug for needle-shy diabetics said near Aug 30, 2005
..."[Exubera] is a fast-acting insulin and right now, most of the market is going towards long-lasting insulin, like Lantus," said Rauch, referring to an ... - CNN
Heart failure drug advised for PBS Aug 30, 2005
Rejection of long-acting insulin glargine (Lantus) for the PBS listing for the second time on the basis of an “unacceptably high� cost-effectiveness ratio. ... - AustralianDoctor.com (subscription),
Other information
Indication
For treatment of diabetes (type I and II)
Pharmacology
Used in the treatment of type I and type II diabetes. The primary activity of insulin is the regulation of glucose metabolism. In muscle and other tissues (except the brain), insulin causes rapid transport of glucose and amino acids intracellularly. It also promotes anabolism, and inhibits protein catabolism. In the liver, insulin promotes the uptake and storage of glucose in the form of glycogen, inhibits gluconeogenesis, and promotes the conversion of excess glucose into fat.
Mechanism Of Action
Insulin binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor is able to autophosphorylate and phosphorylate numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. These activated proteins, in turn, lead to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC) which play a critical role in metabolism and catabolism.
Drug Category
Hypoglycemic Agents; insulins (68:20.08)
Brand Names/Synonyms
Lantus; Lantus
Dosage Forms
SOLUTION
Absorption
Not Available
Interactions
Not Available
Chemical IUPAC Name
Recombinant human insulin
Chemical Formula
C267H408N72O77S6 >B chain
Half Life
30 hours (mammalian reticulocytes, in vitro)
Drug Type
Approved Drug
# Accession No
BIOD00045
CAS Registry Number
160337-95-1