Lanoxin: profile and news






Uninsured NY'ers pay more than double for meds  Jan 12, 2006
Price differences ranged from 13 percent more for Lanoxin, which is used to treat congestive heart failure, to 384 percent more for Doxycycline, which treats ... - New York Daily News,

BITTER PILL$ FOR NYERS  Jan 13, 2006
Price differences ranged from 13 percent more for Lanoxin, used to treat congestive heart failure, to 384 percent more for Doxycycline, which treats bacterial ... - New York Post,

Report: Uninsured pay far too much for their prescriptions  Jan 13, 2006
The differences ranged from 13 percent more for Lanoxin, a heart drug, to 384 percent more for Doxycycline, which fights infections. ... - Poughkeepsie Journal,

Reduce platelet aggregation, blood clotting, inflammation, nervous ...  Jan 12, 2006
SJW should not be used together with any other prescription antidepressants. It should also not be used together with digoxin (Lanoxin). - Health24.com,

Advances in the treatment of heart failure  Nov 8, 2005
It’s not uncommon for a patient with heart failure to be taking an ACE inhibitor, a so-called loop diuretic (Bumex, Lasix), digoxin (Lanoxin), an aldosterone ... - ITP.net,

Changing of hair color unusual reaction to drug  Sep 29, 2005
I'm also on lisinopril for blood pressure and Lanoxin for my heart. ... Take your Lanoxin an hour before or two hours after you eat bran for breakfast. ... - The Republican,

Rx for a better PRESCRIPTION Hospital bans doctors from using ...  Sep 24, 2005
The idea behind the hospital's "Dangerous Abbreviations and Dose Designations" list is to make patient stays safer. "If you're supposed to get Lanoxin, a heart ... - The Free Lance-Star,

Cholesterol drug has surprising, hairy side effect  Aug 31, 2005
I'm also on lisinopril for blood pressure and Lanoxin for my heart. ... Take your Lanoxin an hour before or two hours after you eat bran for breakfast. ... - Daily Press,

Balancing diet and medicines  Aug 22, 2005
I'm also on lisinopril for blood pressure and Lanoxin for my heart. ... Take Lanoxin an hour before or two hours after you eat bran for breakfast. ... - Los Angeles Times,

Pharmacists filling gaps in seniors' care  Aug 2, 2005
Enter Bryan Bray, who reviewed medications and lab results and discovered a toxic concentration of Lanoxin, a heart medicine, in the woman's blood. ... - Charlotte Observer

Pharmacists could face baby liability  Jun 4, 2005
Doctors sometimes prescribe Cytotec (misoprostol) to prevent stomach ulcers. I've been taking Lanoxin (digoxin) and verapamil for irregular heartbeats. ... - Bradenton Herald,

Allergies can make spring a dangerous time to drive  May 15, 2005
...hazards. Lipitor is affected by grapefruit and can interact with some drugs, including Maalox TC, Lanoxin or birth-control pills. ... - Houston Chronicle

Antiperspirant dries sweaty feet  May 14, 2005
Lipitor is affected by grapefruit and can interact with some drugs, including Maalox TC, Lanoxin or birth-control pills. Joe Graedon is a pharmacologist. ... - Bradenton Herald

A career shaped when she was a teen, Pat Martel recalls 40 years ...  May 9, 2005
Prior to the catheterization, bed rest, oxygen and the use of the medication Lanoxin to strengthen the heart muscle were the chief methods for treating heart ... - Quad City Times,

Nursing home, doctor sued over woman's death  Mar 10, 2005
However, she was administered Lanoxin by mistake by the facility pharmacy, NeighborCareùAllentown. Lanoxin is prescribed for heart patients. ... - The Express Times,

Webster v. NFL: A family's fight  Mar 12, 2005
...potassium (for kidney and blood levels), Dicloxacillin (antibiotic), Eldepryl (for Parkinson's disease), Klonopin (anti-convulsant), Lanoxin (for the heart ... - Pittsburgh Post Gazette,

Don't kiss your dog on the mouth!  Feb 19, 2005
...interact with dozens of other medications, including birth control pills, the blood thinner Coumadin, the heart medicine digoxin (Lanoxin) and cyclosporine (a ... - Bradenton Herald,


Other information


Indication
For the treatment and management of Congestive cardiac insufficiency,arrhythmias and heart failure

Pharmacology
Digoxin, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.

Mechanism Of Action
Digoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

Drug Category
Cardiotonic Agents; Antiarrhythmic Agents; ATC:C01AA02; ATC:C01AA05; ATC:C01AA08

Brand Names/Synonyms
Cardoxin; Cogoxin; Cordioxil; Davoxin; Digacin; Digitalis Glycoside; Digitekt; Digoxin; Digoxin Pediatric; Dilanacin; Dixina; Dokim; Dynamos; Eudigox; Homolle's Digitalin; Lanacordin; Lanacrist; Lanicor; Lanoxicaps; Lanoxin; Lenoxicaps; Lenoxin; Longdigox; Neo-Lanicor; Neodioxanin; Rougoxin; Sk-Digoxin; Stillacor; Vanoxin

Dosage Forms
tablets, capsules, injection

Absorption
Absorption of digoxin from the elixir pediatric formulation has been demonstrated to be 70% to 85% complete (90% to 100% from the capsules, and 60% to 80% for tablets).

Interactions
Interactions for Digoxin:

Potassium-depleting diuretics are a major contributing factor to digitalis toxicity. Calcium, particularly if administered rapidly by the intravenous route, may produce serious arrhythmias in digitalized patients. Quinidine, verapamil, amiodarone, propafenone, indomethacin, itraconazole, alprazolam, and spironolactone raise the serum digoxin concentration due to a reduction in clearance and/or in volume of distribution of the drug, with the implication that digitalis intoxication may result. Erythromycin and clarithromycin (and possibly other macrolide antibiotics) and tetracycline may increase digoxin absorption in patients who inactivate digoxin by bacterial metabolism in the lower intestine, so that digitalis intoxication may result. The risk of this interaction may be reduced if digoxin is given as capsules. Propantheline and diphenoxylate, by decreasing gut motility, may increase digoxin absorption. Antacids, kaolin-pectin, sulfasalazine, neomycin, cholestyramine, certain anticancer drugs, and metoclopramide may interfere with intestinal digoxin absorption, resulting in unexpectedly low serum concentrations. Rifampin may decrease serum digoxin concentration, especially in patients with renal dysfunction, by increasing the non-renal clearance of digoxin. There have been inconsistent reports regarding the effects of other drugs (e.g., quinine, penicillamine) on serum digoxin concentration. Thyroid administration to a digitalized, hypothyroid patient may increase the dose requirement of digoxin. Concomitant use of digoxin and sympathomimetics increases the risk of cardiac arrhythmias. Succinylcholine may cause a sudden extrusion of potassium from muscle cells, and may thereby cause arrhythmias in digitalized patients. Although beta-adrenergic blockers or calcium channel blockers and digoxin may be useful in combination to control atrial fibrillation, their additive effects on AV node conduction can result in advanced or complete heart block.

Due to the considerable variability of these interactions, the dosage of digoxin should be individualized when patients receive these medications concurrently. Furthermore, caution should be exercised when combining digoxin with any drug that may cause a significant deterioration in renal function, since a decline in glomerular filtration or tubular secretion may impair the excretion of digoxin.



Chemical IUPAC Name
4-[3-[5-[5-(4,5-dihydroxy-6-methyl-tetrahydropyran-2-yl)oxy-4-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-4-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one

Chemical Formula
C41H64O14

Half Life
3.5 to 5 days

Drug Type
Approved Drug

# Accession No
APRD00098

CAS Registry Number
20830-75-5

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