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Lanoxin: profile and news
Uninsured NY'ers pay more than double for meds Jan 12, 2006 BITTER PILL$ FOR NYERS Jan 13, 2006 Report: Uninsured pay far too much for their prescriptions Jan 13, 2006 Reduce platelet aggregation, blood clotting, inflammation, nervous ... Jan 12, 2006 Advances in the treatment of heart failure Nov 8, 2005 Changing of hair color unusual reaction to drug Sep 29, 2005 Rx for a better PRESCRIPTION Hospital bans doctors from using ... Sep 24, 2005 Cholesterol drug has surprising, hairy side effect Aug 31, 2005 Balancing diet and medicines Aug 22, 2005 Pharmacists filling gaps in seniors' care Aug 2, 2005 Pharmacists could face baby liability Jun 4, 2005 Allergies can make spring a dangerous time to drive May 15, 2005 Antiperspirant dries sweaty feet May 14, 2005 A career shaped when she was a teen, Pat Martel recalls 40 years ... May 9, 2005 Nursing home, doctor sued over woman's death Mar 10, 2005 Webster v. NFL: A family's fight Mar 12, 2005 Don't kiss your dog on the mouth! Feb 19, 2005 Other information Indication For the treatment and management of Congestive cardiac insufficiency,arrhythmias and heart failure Pharmacology Digoxin, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Mechanism Of Action Digoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential. Drug Category Cardiotonic Agents; Antiarrhythmic Agents; ATC:C01AA02; ATC:C01AA05; ATC:C01AA08 Brand Names/Synonyms Cardoxin; Cogoxin; Cordioxil; Davoxin; Digacin; Digitalis Glycoside; Digitekt; Digoxin; Digoxin Pediatric; Dilanacin; Dixina; Dokim; Dynamos; Eudigox; Homolle's Digitalin; Lanacordin; Lanacrist; Lanicor; Lanoxicaps; Lanoxin; Lenoxicaps; Lenoxin; Longdigox; Neo-Lanicor; Neodioxanin; Rougoxin; Sk-Digoxin; Stillacor; Vanoxin Dosage Forms tablets, capsules, injection Absorption Absorption of digoxin from the elixir pediatric formulation has been demonstrated to be 70% to 85% complete (90% to 100% from the capsules, and 60% to 80% for tablets). Interactions Interactions for Digoxin: Potassium-depleting diuretics are a major contributing factor to digitalis toxicity. Calcium, particularly if administered rapidly by the intravenous route, may produce serious arrhythmias in digitalized patients. Quinidine, verapamil, amiodarone, propafenone, indomethacin, itraconazole, alprazolam, and spironolactone raise the serum digoxin concentration due to a reduction in clearance and/or in volume of distribution of the drug, with the implication that digitalis intoxication may result. Erythromycin and clarithromycin (and possibly other macrolide antibiotics) and tetracycline may increase digoxin absorption in patients who inactivate digoxin by bacterial metabolism in the lower intestine, so that digitalis intoxication may result. The risk of this interaction may be reduced if digoxin is given as capsules. Propantheline and diphenoxylate, by decreasing gut motility, may increase digoxin absorption. Antacids, kaolin-pectin, sulfasalazine, neomycin, cholestyramine, certain anticancer drugs, and metoclopramide may interfere with intestinal digoxin absorption, resulting in unexpectedly low serum concentrations. Rifampin may decrease serum digoxin concentration, especially in patients with renal dysfunction, by increasing the non-renal clearance of digoxin. There have been inconsistent reports regarding the effects of other drugs (e.g., quinine, penicillamine) on serum digoxin concentration. Thyroid administration to a digitalized, hypothyroid patient may increase the dose requirement of digoxin. Concomitant use of digoxin and sympathomimetics increases the risk of cardiac arrhythmias. Succinylcholine may cause a sudden extrusion of potassium from muscle cells, and may thereby cause arrhythmias in digitalized patients. Although beta-adrenergic blockers or calcium channel blockers and digoxin may be useful in combination to control atrial fibrillation, their additive effects on AV node conduction can result in advanced or complete heart block. Due to the considerable variability of these interactions, the dosage of digoxin should be individualized when patients receive these medications concurrently. Furthermore, caution should be exercised when combining digoxin with any drug that may cause a significant deterioration in renal function, since a decline in glomerular filtration or tubular secretion may impair the excretion of digoxin. Chemical IUPAC Name 4-[3-[5-[5-(4,5-dihydroxy-6-methyl-tetrahydropyran-2-yl)oxy-4-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-4-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one Chemical Formula C41H64O14 Half Life 3.5 to 5 days Drug Type Approved Drug # Accession No APRD00098 CAS Registry Number 20830-75-5 |
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