Klonopin: profile and news

New cancer drugs reduce recurrence 06 Mar 2006
Three new drugs -- Femara, Arimidex and Aromasin -- block the conversion of androgens (male hormones) to estrogen. Women do make male hormones. ... - Contra Costa Times,

NCCN Announces Important Updates to Ovarian Cancer Clinical ... 06 Mar 2006
Guidelines panel broadened the listing of acceptable recurrence modalities for ovarian cancer to include anastrazole (Arimidex, AstraZeneca), bevacizumab ... - Genetic Engineering News,

Healthy woman's cancer trial intrigue 06 Mar 2006
The 10-year Ibis II trial was launched to test anastrozole - also known as Arimidex - which has already been shown to be the most effective hormone treatment ... - ic Wales,

PGA TOUR: Woods wins for charity at Ford Championship at Doral Mar 5, 2006
...a wide range of products that make significant contributions to treatment options and patient care including CRESTOR, NEXIUM, SEROQUEL, ARIMIDEX, and PULMICORT ... - noticias.info,

Toprol XL uncertainty weighs heavy on AstraZeneca Feb 3, 2006
...for gastrointestinal drug Nexium (esomeprazole), Seroquel (quetiapine) for schizophrenia, lipid-lowerer Crestor (rosuvastatin), Arimidex (anastrozole) for ... - Pharma Times (subscription),

Healthwrap: breast cancer drug, pregnancy complications and ... Feb 3, 2006
...to 24 months. It’s possible newer breast cancer drugs, like Arimidex, may be useful for women unfit for surgery. But the bottom ... - WTNH,

Competition brings cancer drug bonus, but still concerns at cost Feb 18, 2006
Otherwise patients pay $100 or more a month. AstraZenena already subsidises its drug, Arimidex, so patients only pay $30 a month. ... - Radio New Zealand,

AstraZeneca "buy," estimates raised Feb 3, 2006
4Q05 results at the top-end of the consensus and ahead of the estimates, driven by robust sales of its Nexium, Toprol XL, Seroquel, Symbicort and Arimidex drugs ... - New Ratings

Acupuncture provides cancer patients with much-needed relief Feb 9, 2006
She had a lumpectomy and 35 treatments of radiation while she was taking the drug Arimidex. The pain in her joints, especially her back, was really unbearable. ... - Newstarget.com,

Seniors struggle with confusing drug Feb 2, 2006
...work. Ms. Wright, 71, needed a refill of Arimidex, which helps keep the breast cancer she defeated two years ago at bay. While she's ... - Frederick News Post (subscription),

AstraZeneca sees healthy 34-pct jump in profits Feb 2, 2006
The company's five key products -- Nexium, Seroquel, Crestor, Arimidex and Symbicort -- reported a combined 27-percent rise in sales. ... - TODAYonline,

AstraZeneca to concentrate on pipeline Feb 2, 2006
...portfolio now has 10 products with annual sales of $1bn or more with a strong performance from key products Nexium, Seroquel, Crestor, Arimidex and Symbicort ... - Life Style Extra,

New medicines are Brennan's priority Feb 2, 2006
...priority.". Cholesterol-busting drug Crestor and breast cancer treatment Arimidex enjoyed the strongest rises in sales last year. - Manchester Evening News,

AstraZeneca withdraws blood clotting drug Feb 14, 2006
AstraZeneca's key products include the stomach ulcer drug Nexium, the cholesterol buster Crestor and breast cancer treatment Arimidex. - The Local,

Drug firm stock falls despite big profit gain Feb 3, 2006
...said sales rose 27 percent for five key products - Nexium for heartburn, the antipsychotic Seroquel, Crestor for high cholesterol, Arimidex for cancer, and ... - Philadelphia Inquirer,

2005 banner year for AstraZeneca Feb 3, 2006
Four other key products -- Seroquel; Crestor, a drug to lower cholesterol; breast cancer treatment Arimidex; and respiratory drug Symbicort -- each posted ... - The News Journal,

AstraZeneca annual results in line, sees double-digit growth in ... Feb 2, 2006
...bln. Asthma product Symbicort sales rose 22 pct to just over 1 bln usd, and breast cancer drug Arimidex soared 44 pct to 1.18 bln. - Forbes

AstraZeneca 4Q earnings jump 32 percent Feb 2, 2006
...key products, sales of asthma drug Symbicort rose 22 percent to US$1.01 billion (euro840 million) and sales of breast cancer treatment Arimidex increased 44 ... - BusinessWeek

AstraZeneca Fourth-Quarter Profit Grows Feb 2, 2006
...out AstraZeneca's five key products, sales of asthma drug Symbicort rose 22 percent to $1.01 billion and sales of breast cancer treatment Arimidex increased 44 ... - Houston Chronicle,

Drugs firm AstraZeneca reports 33% rise in fourth-quarter Feb 2, 2006
Strong performance from five key products (NexiumTM, SeroquelTM, CrestorTM, Arimidex and Symbicort), with combined sales reaching $10,849 million, up 27 ... - FinFacts Ireland,

AstraZeneca Profit Boom Feb 2, 2006
Imdur, Plendil, Tenoretic, Tenormin, Zestoretic, Zestril, Accolate, Bambec, Bricanyl, Oxis, Pulmicort, Rhinocort, Symbicort, Arimidex, Casodex, Faslodex, Iressa ... - Spotlighting News

AstraZeneca Fourth-Quarter Profit Grows Feb 2, 2006
AstraZeneca‘s five key products, sales of asthma drug Symbicort rose 22 percent to $1.01 billion and sales of breast cancer treatment Arimidex increased 44 ... - Leading The Charge,

Survival benefit for Arimidex in early breast cancer compared with ... Jan 10, 2006
Data presented at the San Antonio Breast Cancer Symposium ( SABCS ), Texas has found that Arimidex ( Anastrozole ) is the first aromatase inhibitor to provide ... - Xagena.it,

Breast Cancer: Topical Estrogen Risky Jan 26, 2006
...women. Drugs such as Arimidex, Femara, and Aromasin keep breast cancers from growing by interfering with the production of estrogen. ... - WebMD

Women With Breast Cancer Beware Jan 25, 2006
According to research using such aromatase inhibitors as anastrozole (Arimidex), letrozole (Femara) and exemestane (Aromasin) may stop new cancer drugs from ... - Ivanhoe,

Phosphagenics initiates anti-cancer compound animal trials Jan 25, 2006
The gold-standard hormonal treatment for breast cancer, Nolvadex, achieved global sales of over $1bn in 2001, and Arimidex (anastrozole) sales of $0.8 billion ... - BiopharmaReporter.com,

PGA TOUR: Holmes wins for charity Feb 5, 2006
...a wide range of products that make significant contributions to treatment options and patient care including CRESTOR, NEXIUM, SEROQUEL, ARIMIDEX, and PULMICORT ... - noticias.info,

Aromatase inhibitors may slow growth of lung cancer in women Jan 14, 2006
The team treated their cells with the drug Anastrozole ( Arimidex ) for 48 hours, finding that it did in fact shut down aromatase activity and retard tumor ... - Xagena.it,

Pa. grocery store offers hormone-free meats Jan 14, 2006
Magnotto found that her own cancer was hormone driven and she now takes Arimidex, a hormone-blocking drug meant to help prevent future cancer. ... - Youngstown Vindicator,

Storm sweeps away health insurance Jan 9, 2006
Since then, Maldonado has been taking Arimidex, an expensive hormone blocker that could help prevent the cancer from recurring. ... - San Luis Obispo Tribune,

Surgery Best for Controlling Breast Cancer in Elderly Women Jan 30, 2006
Newer breast cancer drugs such as Femara and Arimidex, which lower the amount of estrogen produced by the body, may be useful treatments for older women who ... - SeniorJournal.com,

Surge in cases of breast cancer Jan 25, 2006
...the trial. Those eligible will be given either anastrozole, also known as Arimidex, or tamoxifen for five years. Anastrozole is ... - Yorkshire Post Today,

Breast Cancer Prevention: Femara, Coffee Consumption Jan 6, 2006
...another may not be the same because they have different hereditary factors or genetic risks.". The other two aromatase inhibitors are Arimidex and Aromasin. ... - KLAS-TV,

The drug that may improve the outcome for high-risk women Jan 20, 2006
These three drugs for the hormonal treatment of breast cancer are Arimidex (anastrozole), Femara (letrozole) and Aromasin (exemestane). ... - Times Online,

Other information

Indication
Used as an anticonvulsant in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures.

Pharmacology
Clonazepam, a benzodiazepine, is used primarily as an anticonvulsant in the treatment of absence seizures, petit mal variant seizures (Lennox-Gastaut syndrome), akinetic and myoclonic seizures, and nocturnal myoclonus.

Mechanism Of Action
Allosteric interactions between central benzodiazepine receptors and gamma-aminobutyric acid (GABA) receptors potentiate the effects of GABA. As GABA is an inhibitory neurotransmitter, this results in increased inhibition of the ascending reticular activating system. Benzodiazepines, in this way, block the cortical and limbic arousal that occurs following stimulation of the reticular pathways.

Drug Category
Anticonvulsants; Benzodiazepines; ATC:N03AE01

Brand Names/Synonyms
Antelepsin; Antilepsin; Chlonazepam; Cloazepam; Clonazepam; Clonazepamum; Clonopin; Iktorivil; Klonopin; Klonopin Rapidly Disintegrating; Landsen; RO4023; Rivotril

Dosage Forms
Tablets - scored and unscored

Absorption
Clonazepam is rapidly and completely absorbed after oral administration. The absolute bioavailability of clonazepam is about 90%.

Interactions
Interactions for Clonazepam:

Effect of Clonazepam on the Pharmacokinetics of Other Drugs: Clonazepam does not appear to alter the pharmacokinetics of phenytoin, carbamazepine, or phenobarbital. The effect of clonazepam on the metabolism of other drugs has not been investigated.

Effect of Other Drugs on the Pharmacokinetics of Clonazepam: Literature reports suggest that ranitidine, an agent that decreases stomach acidity, does not greatly alter clonazepam pharmacokinetics.

In a study in which the 2 mg clonazepam orally disintegrating tablet was administered with and without propantheline (an anticholinergic agent with multiple effects on the GI tract) to healthy volunteers, the AUC of clonazepam was 10% lower and the C_max of clonazepam was 20% lower when the orally disintegrating tablet was given with propantheline compared to when it was given alone.

Fluoxetine does not affect the pharmacokinetics of clonazepam. Cytochrome P-450 inducers, such as phenytoin, carbamazepine and phenobarbital, induce clonazepam metabolism, causing an approximately 30% decrease in plasma clonazepam levels. Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents, should be used cautiously in patients receiving clonazepam.

Pharmacodynamic Interactions: The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs.

Chemical IUPAC Name
6-(2-chlorophenyl)-9-nitro-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one

Chemical Formula
C15H10ClN3O3

Half Life
30-40 hours

Drug Type
Approved Drug

# Accession No
APRD00054

CAS Registry Number
1622-61-3