Keflex: profile and news
A sports scourge 07 Mar 2006
...is misdiagnosed. The bacteria is gaining resistance to antibiotics typically prescribed for skin infections, such as Keflex. The ... - Contra Costa Times,
Advancis Pharmaceutical Strengthens Sales and Marketing Capability ... Feb 28, 2006
James Bruno Rejoins the Company as Vice President of Sales; Sales and Marketing Resources Increased in Advance of Key Keflex Growth Initiatives GERMANTOWN, Md ... - PR Newswire (press release),
Advancis Pharmaceutical Strengthens Sales and Marketing Capability ... Feb 28, 2006
Bruno will be focused on developing Advancis' sales and commercialization infrastructure for its existing Keflex antibiotic franchise. ... - PharmaLive.com (press release),
Advancis brings back Bruno Feb 28, 2006
He will focus on developing Advancis' sales and commercialization infrastructure for its existing Keflex antibiotic product line, which it acquired in 2004 ... - Washington Business Journal,
Ex-ghostbuster seeks to become chart-buster Mar 5, 2006
...cabinet: "I’m on Ritalin, Coumadin, Zantac, Lipitor / Diazepam, Nexium, Prevacid, Percocet / Levitra, Levaquin, Elavil, Fosamax / Plavix, Keflex, Next day ... - Columbus Dispatch,
Advancis Pharmaceutical Reports Fourth Quarter and Full Year 2005 ... Feb 9, 2006
Company's Adult Amoxicillin PULSYS Phase III Trial Enrollment on Schedule; Keflex Antibiotic Product Sales Increase to $1.6 Million in Quarter; Phase III Trial ... - PR Newswire (press release),
Govt. Loses $553K in Med-Mal Suit Feb 4, 2006
The family of a Baltimore woman who died of an allergic reaction to the antibiotic Keflex won a $553,739 judgment against the federal government last week. ... - International News Service,
Infections spread as bug resists drugs Feb 26, 2006
...days for results. Moore, the La Canada resident, started on the common antibiotic Keflex and ended with rifampin. "When I think ... - SunHerald.com,
Advancis Pharmaceutical Reports Fourth Quarter and Full Year 2005 ... 09 Feb 2006
Company's Adult Amoxicillin PULSYS Phase III Trial Enrollment on Schedule; Keflex Antibiotic Product Sales Increase to $1.6 Million in Quarter; Phase III Trial ... - PR Newswire (press release),
Govt. Loses $553K in Med-Mal Suit Feb 4, 2006
The family of a Baltimore woman who died of an allergic reaction to the antibiotic Keflex won a $553,739 judgment against the federal government last week. ... - International News Service,
New, virulent staph infection sparks health fears Jan 20, 2006
Doctors have long prescribed popular drugs such as Keflex and Cipro to combat staph, which some feel may have contributed to the rise of the drug-resistant type ... - Pittsburgh Post Gazette,
Dear Doctor: How does MRSA spread? Nov 22, 2005
Oral drugs such as cephalexin (Keflex) and amoxicilin/pot clavulana (Augmentin), which had previously worked promptly, could not stem the worsening infections ... - Pittsburgh Post Gazette,
Advancis Starting Another Trial, Selling Keflex Rights For $12M Sep 15, 2005
Trimming its sails, Advancis is selling off US rights to its Keflex brand of cephalexin, acquired for $11 million last year from Indianapolis-based Eli Lilly ... - BioWorld Online (subscription),
Advancis Pharmaceutical to Conduct Additional Adult Amoxicillin ... Sep 15, 2005
Company Signs Term Sheet to Sell Keflex Brand That Could Result in $15 Million and Royalties on New Product Sales; Updated Financial Guidance Provided for 2005 ... - PR Newswire (press release),
Advancis Pharmaceutical to Conduct Additional Adult Amoxicillin ... Sep 15, 2005
Advancis also announced that it has reached an agreement in principle to sell the US rights to the Keflex(R) brand of cephalexin to a private company. ... - PharmaLive.com (press release),
Advancis to conduct new Phase III trial Sep 15, 2005
To help fund the company, Advancis also announced Thursday that it has reached an agreement in principle to sell the US rights to its Keflex product to a ... - Baltimore Business Journal,
Highlights of rising and falling US stocks Sep 15, 2005
Shares of Advancis Pharmaceutical (AVNC) jumped 28% after the company said it agreed to sell the US rights to its Keflex brand of cephalexin to a private ... - Investor's Business Daily (subscription)
Advancis to Start New Pulsys Study Sep 15, 2005
Revenue is expected to reach $16 million and $18 million, helped by the sale of the US rights for its Keflex anti-infective drug. ... - MSN Money
LOCAL BRIEFING Sep 15, 2005
Revenue is expected to reach $16 million to $18 million, helped by the sale of the US rights for the company's Keflex anti-infective drug. ... - Washington Post,
Staph Infections Are Becoming More Common Sep 15, 2005
The bug is called Methicillin-resistant Staphylococcus Aureus. It is resistant to most common antibiotics, such as penicillin, keflex and others. ... - Pittsburgh Channel.com,
DR. BROBSON LUTZ: Beware of myths, but health risks are real Sep 9, 2005
Louisiana, and we will see more methicillin-resistant Staphylococcus aureus (MRSA) infections that are resistant to previously useful antibiotics such as Keflex ... - Times Picayune,
Range of Medicines Needed for Storm Relief Sep 1, 2005
...vaccination within the last 10 years. _Antibiotics, particularly cephalosporins such as Keflex. In particular, staph and strep infections ... - San Francisco Chronicle,
Infections in Patients With Diabetes Aug 19, 2005
Outpatient antibiotic treatment of cellulitis for GAS and methicillin-susceptible Staphylococcus aureus (MSSA) includes dicloxacillin or cephalexin (Keflex). ... - Medscape (subscription)
Germantown-Based Advancis Suffers Another Setback, As Partner ... Aug 5, 2005
Keflex, he added, is a very small product for them. If the amoxicillin product should succeed, it could outstrip Keflex's performance. ... - RedNova.com
Quad City not RGV’s only enemy this week Aug 3, 2005
...big calf. Rasmussen was immediately treated with the antibiotics Keflex and Bactraban and the antibiotic ointment Bactrim. The Dorados ... - Monitor
Advancis Phase III trial fails Jul 22, 2005
..."With approximately $40 million of cash and equivalents currently on hand, along with product sales from our Keflex antibiotic franchise, we believe the ... - Washington Business Journal
Advancis Pharmaceutical Announces Results From Pediatric ... Jul 21, 2005
..."However, with approximately $40 million of cash and equivalents currently on hand, along with product sales from our Keflex antibiotic franchise, we believe ... - RedNova.com
Advancis considers cost-cutting, including layoffs Jul 26, 2005
...effectively. Advancis has about $40 million in cash available, and it generates modest revenue from sales of its Keflex antibiotic. ... - Washington Business Journal
Disappointing Test Results Sink Shares of Germantown, Md., Biotech ... Jul 22, 2005
Rudnic said Advancis can always draw from its $40 million in cash along with sales of Keflex -- a drug the company last year bought the US rights to manufacture ... - RedNova.com
Cancer Chronicles | Pulling for life Jul 25, 2005
...infection. But months of treatment with both oral and intravenous antibiotics - Keflex, vancomycin and Bactrim - didn't help. So ... - Philadelphia Inquirer
<**results**>
Advancis Pharmaceutical Corporation Launches Keflex(R) Powder for ... Jun 8, 2005
...a pharmaceutical company focused on developing and commercializing novel anti-infective products, announced today that it has launched Keflex® Powder for Oral ... - Yahoo News (press release)
Advancis plunges 59% on poor test results Jun 17, 2005
The gain was fueled by the Par partnership, reimbursement for research and development costs, and sales of Keflex, a drug the company bought the US rights to ... - Baltimore Sun,
Other information
Indication
For the treatment of the following infections (respiratory, skin, soft tissue, urinary tract infections, ear, nose, throat infectsion) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A ß-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph. Also used to treat acute bacterial bronchitis in patients with COPD
Pharmacology
Cefuroxime, a second-generation cephalosporin, is used to treat severe upper and lower respiratory tract infections, skin infections, otitis media, and surgical prophylaxis.
Mechanism Of Action
Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefuroxime interferes with an autolysin inhibitor.
Drug Category
Anti-bacterial Agents; Cephalosporins; ATC:J01DC02
Brand Names/Synonyms
Ancef; Biofuroksym; Ceclor; Ceclor Cd; Cedax; Cefditoren; Cefizox; Cefotan; Ceftin; Ceftizoxime Sodium; Cefurax; Cefuril; Cefuroxim; Cefuroxime; Cefuroxime Axetil; Cefuroxime Free Acid; Cefuroxime Sodium; Cefuroxime Sodium Salt; Cefuroxime [Usan:Ban:Inn]; Cefuroxime and Dextrose in Duplex Container; Cefuroximo [Inn-Spanish]; Cefuroximum [Inn-Latin]; Cefzil; Cephuroxime; Ceptaz; Duricef; Elobact; Fortaz; Keflex; Keftab; Kefurox; Kefurox in Plastic Container; Kerurox; Mandol; Maxipime; Mefoxin; Monocid; Omnicef; Oraxim; Rocephin; Sharox; Tazicef; Vantin; Velosef; Zinacef; Zinacef Danmark; Zinacef in Plastic Container; Zinat; Zinnat
Dosage Forms
POWDER; POWDER FOR SOLUTION; TABLET
Absorption
Well absorbed from the GI tract (bioavailability is 37-52%)
Interactions
-->Interactions for Cefuroxime:
Drug/Laboratory Test Interactions: A false-positive reaction for glucose in the urine may occur with copper
reduction tests (Benedictís or Fehlingís solution or with ClinitestÒ
tablets) but not with enzyme-based tests for glycosuria. As a false-negative result may occur in the ferricyanide
test, it is recommended that either the glucose oxidase or hexokinase method be used to determine blood plasma
glucose levels in patients receiving cefuroxime.
Cefuroxime does not interfere with the assay of serum and urine creatinine by the alkaline picrate method.
Chemical IUPAC Name
4-(carbamoyloxymethyl)-8-[2-(2-furyl)-2-methoxyimino-acetyl]amino-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid
Chemical Formula
C16H16N4O8S
Half Life
~80 minutes
Drug Type
Approved Drug
# Accession No
APRD00285
CAS Registry Number
55268-75-2