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Kariva: profile and news
Barr's Generics 'Should Continue To Bear Fruit' Dec 7, 2005 Savient Pharmaceuticals Finalizes Agreement for the Settlement of ... Dec 2, 2005 Akzo settles patent dispute with Barr Dec 2, 2005 Cars looted near Clare Hall Nov 15, 2005 Employment Seen Higher Dec 2, 2005 Barr, Organon and Savient Finalize Mircette(R) Settlement and ... Dec 1, 2005 UM team excels in race Dec 2, 2005 Prestige releases new numbers Dec 3, 2005 Barr, Organon and Savient Announce Letter of Intent Regarding ... 08 Sep 2005 Other information Indication For the prevention of pregnancy in women who elect to use this product as a method of contraception. Pharmacology Desogestrel is used as a female contraceptive. Desogestrel is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Desogestrel tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries. Mechanism Of Action Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like desogestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. Drug Category Contraceptives, Oral, Synthetic; ATC:G03AC09 Brand Names/Synonyms Cerazette; Cyclessa; DESOGESTREL; Desogen; Desogestrel; Desogestrel [Usan:Ban:Inn]; Desogestrelum [Inn-Latin]; HSDB 3593; Kariva; Mircette; ORG 2969; Org-2969, Cerazette; Ortho-Cept Dosage Forms TABLET Absorption Following oral administration, the relative bioavailability of desogestrel compared to a solution, as measured by serum levels of etonogestrel, is approximately 100%. Interactions -->Interactions for Desogestrel: Reduced efficacy and increased incidence of breakthrough bleeding and menstrual irregularities have been associated with concomitant use of rifampin. A similar association, though less marked, has been suggested with barbiturates, phenyl-butazone, phenytoin sodium, carbamazepine and possibly with griseofulvin, ampicillin, and tetracyclines (72). |
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