Isosorbide_Mononitrate: profile and news

What is Viagra Feb 13, 2006
...as: nitroglycerin ( sprays, ointments, skin patches or pastes, and tablets that are swallowed or dissolved in the mouth ) isosorbide mononitrate and isosorbide ... - I-Newswire.com (press release)

VA cheaper than drug cards Sep 27, 2005
...than 226%. The most extreme example by percentage came from a generic drug, isosorbide mononitrate in the extended release form. It ... - MarketWatch

Heart-friendly herbs Aug 27, 2005
...randomised, double-blind study, 58 males with chronic stable angina (NYHA class II-III) received either Terminalia arjuna or isosorbide mononitrate or a ... - Malaysia Star,

Other information

Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.

Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.

Mechanism Of Action
Similar to other nitrites and organic nitrates, Isosorbide Mononitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (Atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.

Drug Category
Vasodilator Agents; Nitrates and Nitrites; Nitric Oxide Donors; ATC:C01DA14

Brand Names/Synonyms
AHR 4698; CCRIS 1911; Conpin; Conpin Retardkaps; Corangin; Corangin Sr; Duride; Edistol; Elan; Elantan; Elantan Long; Elantan Retard; Epicordin; Etimonis; Fem-Mono; IHD; IS 5MN; ISMN; ISMN AL; ISOSORBIDE MONONITRATE; Imazin; Imdur; Imdur 60; Imdur Durules; Imodur; Imtrate; Ismexin; Ismn Abz; Ismn Apogepha; Ismn Atid; Ismn Basics; Ismn Heumann; Ismn Hexal; Ismn Lannacher; Ismn Stada; Ismo; Ismo-20; Ismotic; Ismox; Isomon; Isomonat; Isomonit; Isopen-20; Isosorbide Mononitrate; Isosorbidi Mononitras [Latin]; Isotrate; Iturol; Medocor; Monicor; Monis; Monisid; Monit; Monit 20; Monizid; Mono Corax; Mono Corax Retard; Mono Mack; Mono-Mack; Mono-Sanorania; Monocedocard; Monoclair; Monocord 20; Monocord 40; Monocord 50 Sr; Monodur Durules; Monoket; Monoket Od; Monoket Retard; Monolong; Monolong 40; Monolong 60; Mononit; Mononit 20; Mononit 40; Mononit Retard 50; Mononitrate d'Isosorbide [French]; Mononitrato de Isosorbida [Spanish]; Monopront; Monosigma; Monosorb; Monosorbitrate; Monosordil; Monotrate; Multitab; Nitex; Nitramin; Olicard; Olicardin; Orasorbil; Pentacard; Pentacard 20; Percorina; Pertil; Plodin; Promocard; Sigacora; Sorbimon; Titarane; Turimonit; UN3251; Uniket; Vasdilat; Vasotrate

Dosage Forms
Immediate Release and Extended release tablets

Absorption
100%

Interactions
Drug Interactions for Isosorbide Mononitrate:

The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators. Alcohol, in particular, has been found to exhibit additive effects of this variety.

Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination. Dose adjustments of either class of agents may be necessary.

Chemical IUPAC Name
8-nitrooxy-2,6-dioxabicyclo[3.3.0]octan-4-ol

Chemical Formula
C6H9NO6

Half Life
5 hours

Drug Type
Approved Drug

# Accession No
APRD00528

CAS Registry Number
16051-77-7