Isosorbide_Dinitrate: profile and news

For top nutrition,peppers are hot! Mar 2, 2006
When peppers begin to blossom, spray them with a mixture of four tablespoons Epsom salts (magnesium sulfate) per gallon of water to make them crisp and ... - Mail Tribune,

Which Water Is Tastiest? Feb 14, 2006
...that Coca-Cola tested Dasani in hundreds of focus groups until it hit on a markedly crisp quality, achieved by adding magnesium sulfate, potassium chloride and ... - New York Times,

It's time to fertilize the new crop of roses Feb 18, 2006
...improve soil chemistry and increase the exchange capacity of the soil before beginning fertilization, toss a cup of Epsom salts (magnesium sulfate) around each ... - East Valley Tribune,

Risk of Serious Harm and/or Death With Potential IV/SC ... Feb 15, 2006
...lidocaine. In the rare patient with torsades de pointes, IV magnesium sulfate and/or a pacemaker should be used. Extrapyramidal ... - DG News

Hospital in trouble over shorthand Feb 2, 2006
..."MS could mean morphine sulfate or magnesium sulfate," said Mary Kirkwood, director of quality and standards for Lee Memorial Health System. ... - The News-Press,

Cooler heads studied as treatment for strokes Jan 26, 2006
Treatment includes 24 hours of intravenous magnesium sulfate along with a widely used protein (Albumin), anticholesterol medication (Atorvastatin) and ... - Edmonton Journal,

Temple Gardens Mineral Spa Resort Hotel Jan 29, 2006
...geothermal well tapped into is ~10,000 parts per million total dissolved solids and it contains such things as Epsom Salts (magnesium sulfate) and Glauber's ... - About - News & Issues,

Sweet success Jan 10, 2006
...stop if they could. In addition to bed rest, doctors prescribe infusions of magnesium sulfate to delay labor. The injections have ... - Pioneer Press,

New stroke therapy showing promise Jan 27, 2006
This treatment can even be started by paramedics, who administer magnesium sulfate to stroke patients en route to the hospital. ... - Edmonton Sun,

Cooler heads may prevail in successfully treating strokes Jan 27, 2006
...patients. Patients in the study start their therapy in the ambulance, with a paramedic administering the first drug, magnesium sulfate. ... - Edmonton Journal,

Phew! Stinky Feet! Jan 12, 2006
...thrush, your veterinarian might recommend soaking the foot in various medicated solutions; I will often use a 10% warm epsom salt (magnesium sulfate) soak or 25 ... - TheHorse.com,

Parents hope, pray after baby arrives too early and so tiny Jan 16, 2006
Doctors have put her on a drip of magnesium sulfate to prevent seizures after the delivery — a possibility with preeclampsia. ... - Seattle Times,

When man alters nature wildlife loses — and wins Dec 8, 2005
The dominant soluble salts in Montana are sodium sulfate (Glauber's salt) and magnesium sulfate (Epsom salts.) Induced salinity can occur unintentionally, such ... - Great Falls Tribune,

Mr. Bubble, Meet the Sandman Nov 30, 2005
...the astral travelers from drowning. Epsom salts are composed of a chemical compound called magnesium sulfate. Broken apart by the ... - Boise Weekly,

Puncture Wounds in the Foot Nov 26, 2005
...evidence for the right place to explore further with the knife, the foot can be soaked in warm water or warm water containing magnesium sulfate (epsom salts ... - TheHorse.com,

Ingredients can surprise you Nov 12, 2005
That's "H2 O" as we learned in that same old chemistry class. Well, Dasani "water" contains "purified water, magnesium sulfate, potassium chloride and salt.". ... - The Free Lance-Star,

GROUND RULES: The miracle of birth is an understatement in itself Nov 23, 2005
...more weeks. She slept on her head for a couple nights and suffering through the rigors of something called magnesium sulfate. They ... - Silverton Appeal Tribune,

Macrominerals Needed By Cattle Sep 21, 2005
...season and environment. Both magnesium oxide and magnesium sulfate are good sources of supplemental magnesium. Potassium, the third ... - CattleNetwork.com,

WUSTL Mars team describes water detection at Gusev crater Sep 22, 2005
...from landing site to the Columbia Hills, Spirit dug three trenches, allowing researchers to detect relatively high levels of magnesium sulfate comprising more ... - Washington University Record,

Turkmen raw materials and commodity exchange functioned full-time ... Oct 3, 2005
...and cotton yarn by the US businessmen. Iranian businessmen bought magnesium sulfate. Seven contracts were made for the purchase ... - Turkmenistan.ru,

Rx for a better PRESCRIPTION Hospital bans doctors from using ... Sep 24, 2005
Other banned abbreviations include "MgSO4," the abbreviation for magnesium sulfate, which can be mistaken for "MSO4," the abbreviation for morphine sulfate. ... - The Free Lance-Star,

Krasnodar Territory Sep 13, 2005
It contains magnesium sulfate required in the production of high-quality artificial fiber. Magnesium compounds are also used in medicine. ... - Kommersant,

Other information

Indication
For the prevention of angina pectoris due to coronary artery disease

Pharmacology
Isosorbide Dinitrate is a moderate- to long-acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure.

Mechanism Of Action
Similar to other nitrites and organic nitrates, Isosorbide Dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (Atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.

Drug Category
Vasodilator Agents; Nitrates and Nitrites; ATC:C01DA08; ATC:D03AX08

Brand Names/Synonyms
Dilatrate; Isochron; Isordil; Titradose; Sorbitrate; Dinitrosorbide; Corosorbide; Carvanil; Carvasin; Cedocard; Claodical; Cornilat; Difutrat; Coronex; Flindix; 1,4:3, 6-Dianhydro-D-glucitol dinitrate; 1,4:3,6-Dianhydrosorbitol 2, 5-dinitrate; 87-33-2; AIDS-125686; AIDS125686; Cardio 10; Cardis; Carvanil; Carvasin; D-Glucitol, 1,4:3,6-dianhydro-, dinitrate; Dianhydrosorbitol 2,5-dinitrate; Dilatrate-SR; Dinitrosorbide; Emoper; Flindix; Glucitol, 1,4:3, 6-dianhydro-, dinitrate, D-; Harrical; IBD 20; ISD; ISDN; Ismotic; Iso-Bid; Isoket; Isorbid;; Isordil Tembids; Isosorbide Dinitrate; Isosorbide dinitrate(USAN); Isostat; Isotrate; Korodil; Lomilan; Maycor; Myorexon; Nitrosorbid; Nitrosorbide; Nitrosorbon; Nosim; Resoidan; Rifloc Retard; Rigedal; Sorbangil; Sorbide T.D.; Sorbide nitrate; Sorbide, dinitrate; Sorbidilat; Sorbidnitrate; Sorbislo; Sorbonit; Sorquad; Tinidil; Vascardin; Vasodilat; Vasorbate; Xanyl

Dosage Forms
Oral tablet

Absorption
Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver.The average bioavailability of isosorbide dinitrate is about 25%

Interactions
DRUG INTERACTIONS The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. Alcohol, in particular, has been found to exhibit additive effects of this variety.

Chemical IUPAC Name
4,8-dinitrooxy-2,6-dioxabicyclo[3.3.0]octane

Chemical Formula
C6H8N2O8

Half Life
1 hour

Drug Type
Approved Drug

# Accession No
APRD00455

CAS Registry Number
87-33-2