Isordil: profile and news

Biovail to Spin Off Certain Products Nov 15, 2005
The brands also include Ativan, Vaseretic, Vasotec, Isordil and Tiazac in the United States, along with Cardizem CD in both the United States and Canada, whose ... - Forbes

Biovail to spin off its off-patent drug assets, announces first ... Nov 15, 2005
The spinoff assets include such brands as Cardizem CD, Ativan, Vaseretic, Vasotec, Isordil and Tiazac in the United States and Cardizem CD in Canada. ... - CBC News,

Biovail to spin off 'legacy' drugs into new company Nov 15, 2005
Biovail's off-patent products include the Cardizem CD, Ativan, Vaseretic, Vasotec, Isordil and Tiazac in the United States, and Cardizem CD in Canada. ... - CBC British Columbia (Audio),

Biovail to spin off its off-patent drug assets, announces first ... Nov 15, 2005
The assets to be spun off include such brands as Cardizem CD, Ativan, Vaseretic, Vasotec, Isordil and Tiazac in the United States and Cardizem CD in Canada. ... - National Post,

Biovail to spin off products, declares dividend Nov 15, 2005
The products include well-known brands Cardizem CD, Ativan, Vaseretic, Vasotec, Isordil and Tiazac in the United States and Cardizem in Canada. ... - Metro Toronto,

UPDATE 2-Biovail to spin off products, declares dividend Nov 15, 2005
They include well-known brands of hypertension drugs Cardizem CD and Tiazac, as well as Ativan, Vaseretic, Vasotec and Isordil in the United States and ... - Reuters

UPDATE 3-Biovail plans to spin off 'legacy' products Nov 15, 2005
They include hypertension drugs Cardizem CD and Tiazac, as well as Ativan, Vaseretic, Vasotec and Isordil in the United States and Cardizem in Canada. ... - Reuters

Biovail chairman in line for big dividend; firm to spin off its ... Nov 15, 2005
Those drugs include Cardizem CD, Ativan, Vaseretic, Vasotec, Isordil and Tiazac in the United States and Cardizem CD in Canada. ... - Canada.com,

Biovail pitches dividend plan, product spinoff to shareholders Nov 15, 2005
...drugs, which aren't actively promoted, include heart and central nervous system brands such as Cardizem CD, Ativan, Vaseretic, Vasotec, Isordil and Tiazac in ... - Globe and Mail,

Biovail to Spin off Legacy Assets Nov 15, 2005
Biovail's Legacy assets include the well-known brands Cardizem ® CD, Ativan ® , Vaseretic ® , Vasotec ® , Isordil ® and Tiazac ® in the United States and ... - CCNMatthews (press release),

Biovail to Spin off Legacy Assets Nov 15, 2005
Biovail's Legacy assets include the well-known brands Cardizem(R) CD, Ativan(R), Vaseretic(R), Vasotec(R), Isordil(R) and Tiazac(R) in the United States and ... - PharmaLive.com (press release),

Leader Speak Sep 21, 2005
Give us some details on the company’s acquisition of brand ‘ISORDIL’ from MNC for its trademark and technical know-how? ISORDIL ... - India Infoline.com, <**results**>

Good News for Heart Patients With Impotence Jun 28, 2005
Heart patients are often treated with drugs called oral nitrates, such as Nitro-Dur and Isordil, in addition to other medications. ... - WebMD

Book details frightening frequency of medical errors Apr 24, 2005
A Texas man, whose doctor intended to prescribe 120 tablets of the heart medication Isordil, instead received the much more powerful drug Plendil. ... - Boulder Daily Camera (subscription),

Trimetazidine Best Heart Drug for Viagra Users Feb 14, 2005
Reuters Health) - Trimetazidine, a drug that prevents heart-related chest pain, is a better choice than "nitrate" drugs, such as Nitro-DUR and Isordil, for men ... - Reuters

Other information

Indication
For the prevention of angina pectoris due to coronary artery disease

Pharmacology
Isosorbide Dinitrate is a moderate- to long-acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure.

Mechanism Of Action
Similar to other nitrites and organic nitrates, Isosorbide Dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (Atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.

Drug Category
Vasodilator Agents; Nitrates and Nitrites; ATC:C01DA08; ATC:D03AX08

Brand Names/Synonyms
Dilatrate; Isochron; Isordil; Titradose; Sorbitrate; Dinitrosorbide; Corosorbide; Carvanil; Carvasin; Cedocard; Claodical; Cornilat; Difutrat; Coronex; Flindix; 1,4:3, 6-Dianhydro-D-glucitol dinitrate; 1,4:3,6-Dianhydrosorbitol 2, 5-dinitrate; 87-33-2; AIDS-125686; AIDS125686; Cardio 10; Cardis; Carvanil; Carvasin; D-Glucitol, 1,4:3,6-dianhydro-, dinitrate; Dianhydrosorbitol 2,5-dinitrate; Dilatrate-SR; Dinitrosorbide; Emoper; Flindix; Glucitol, 1,4:3, 6-dianhydro-, dinitrate, D-; Harrical; IBD 20; ISD; ISDN; Ismotic; Iso-Bid; Isoket; Isorbid;; Isordil Tembids; Isosorbide Dinitrate; Isosorbide dinitrate(USAN); Isostat; Isotrate; Korodil; Lomilan; Maycor; Myorexon; Nitrosorbid; Nitrosorbide; Nitrosorbon; Nosim; Resoidan; Rifloc Retard; Rigedal; Sorbangil; Sorbide T.D.; Sorbide nitrate; Sorbide, dinitrate; Sorbidilat; Sorbidnitrate; Sorbislo; Sorbonit; Sorquad; Tinidil; Vascardin; Vasodilat; Vasorbate; Xanyl

Dosage Forms
Oral tablet

Absorption
Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver.The average bioavailability of isosorbide dinitrate is about 25%

Interactions
DRUG INTERACTIONS The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. Alcohol, in particular, has been found to exhibit additive effects of this variety.

Chemical IUPAC Name
4,8-dinitrooxy-2,6-dioxabicyclo[3.3.0]octane

Chemical Formula
C6H8N2O8

Half Life
1 hour

Drug Type
Approved Drug

# Accession No
APRD00455

CAS Registry Number
87-33-2