Ismo: profile and news
AC/DC's Entire Output Played In 15-Hour Marathon - Mar. 1, 2006 Mar 1, 2006
15 hours. The Finnish lineup included LENINGRAD COWBOYS, QUINTESSENCE, EMMI, ISMO ALANKO AND FREUD, MARX, ENGELS and JUNG. LIVE ... - Blabbermouth.net,
Turvatiimi Oyj : Addition to turvatiimi nomination committee's ... Feb 8, 2006
...to Turvatiimi Nomination Committee's proposal to the Board of Directors on 1 February 2006 the Committee will propose that also Mr. Ismo Heikkonen, Director of ... - Kauppalehti (press release),
Dundalk doctor takes up two year fellowship in US Cancer Center Feb 23, 2006
...to the opportunity to take up residence in the Sloan Kettering for Dr. John McCaffrey, President of the Irish Society of Medical Oncology (ISMO) spent seven ... - Dundalk Argus,
East Kaua'i's Nightowl, Boro wake up against Kuku's Aces Feb 17, 2006
...and 4 RBI's to Tomlinson. Ernest Domingo, Ismo Yoshishige and Bernard Mahuiki all had a single home run. For the Rookies: Paul Cassier ... - Lihue Garden Island,
Sticky Carpet Feb 16, 2006
On the other side of the world, bands including the Leningrad Cowboys and Ismo Alanko will play AC/DC songs for 15 hours straight at the Atria club, in Oulu ... - The Age,
Business Consultant Feb 17, 2006
1. Support all global and local functions served by AZ IS – OBS ie, Operations, Finance, HR, PS& L, ISMO, Business Services, and R& D. ... - Internetworld,
Rookies take two in senior softball action Feb 8, 2006
For Lihu'eA's: Ismo Yoshishige, Ed Bales, and Randy Tomlinson went 2 for 3, with Yoshishige credited with a homerun and Tomlinson credited with 7 RBI's. ... - Lihue Garden Island,
THE NEW SCENESTERS Feb 8, 2006
Elsa Melendez, a printmaker who makes three-dimensional renderings of distorted animals; abstract painter Sebastian Vallejo; graffiti artist Bik Ismo; Coa Group ... - Artnet,
Turvatiimi Oyj : Addition to turvatiimi nomination committee's ... 09 Feb 2006
...to Turvatiimi Nomination Committee's proposal to the Board of Directors on 1 February 2006 the Committee will propose that also Mr. Ismo Heikkonen, Director of ... - Kauppalehti (press release),
Rookies take two in senior softball action Feb 8, 2006
For Lihu'eA's: Ismo Yoshishige, Ed Bales, and Randy Tomlinson went 2 for 3, with Yoshishige credited with a homerun and Tomlinson credited with 7 RBI's. ... - Lihue Garden Island,
THE NEW SCENESTERS Feb 8, 2006
Elsa Melendez, a printmaker who makes three-dimensional renderings of distorted animals; abstract painter Sebastian Vallejo; graffiti artist Bik Ismo; Coa Group ... - Artnet,
AC/DC overdrive Jan 10, 2006
Leningrad Cowboys, Ismo Alanko as well as Freud, Marx, Engels and Jung, among others, will play songs from 13 of AC/DC's 14 albums on February 18 in the Atria ... - NEWS.com.au,
All AC/DC songs to be played in Finnish charity event Jan 10, 2006
17 hours. The Finnish lineup includes Leningrad Cowboys, Quintessence, Emmi, Ismo Alanko and Freud, Marx, Engels & Jung. Live Wire ... - Newsroom Finland,
Finnish doctors back health warnings on alcohol bottles Jan 11, 2006
Ismo Tuominen of the Ministry of Health and Social Affairs and Health told the Finnish News Agency (STT) on Tuesday that also the warning label issue was on ... - Newsroom Finland,
AC/DC Marathon To Be Held In Finland - Jan. 10, 2006 Jan 10, 2006
17 hours. The Finnish lineup includes LENINGRAD COWBOYS, QUINTESSENCE, EMMI, ISMO ALANKO AND FREUD, MARX, ENGELS and JUNG. LIVE ... - Blabbermouth.net,
Finland: On resale of radio frequencies Nov 14, 2005
According to Ismo Kosonen from the Ministry of Transport and Communications, the worst case scenario is that telecommunications companies acquire all the ... - eFinland,
Norway and Germany prove too much for Finnish women skiers in ... Nov 21, 2005
Norway on Sunday. Nevertheless, Ismo Hämäläinen, the coach of the women's team, was relatively pleased with the result. "We were ... - Helsingin Sanomat,
Construction Trade Union threatens strike at nuclear plant ... 31 Oct 2005
The union's organisational secretary Jukka Asikainen and regional chief Ismo Mansikka were turned away at the gate as they were trying to enter the building ... - Helsingin Sanomat,
"The Paintings of Ismo Jokiaho 2000-2005" Oct 13, 2005
Artist Ismo Jokiaho is painter, whose works You can see often in Finnish galleries and exhibitions around the country. Ismo Jokiaho ... - Absolutearts.com
ALMA MEDIA: City24 real estate internet business portal opened in ... Oct 11, 2005
We are also considering the feasibility of starting business in other Eastern Europe countries," says Ismo Repka, Regional Director for the Baltic States at ... - Kauppalehti (press release),
Go online before heading to Argentina or Chile Oct 22, 2005
...homework. Start at the official Argentina tourism Web site, www.tur ismo.gov.ar for information on destinations, activities and climate. ... - Daily Press,
Appointments in Metsäliittos new Wood Supply organisation Oct 5, 2005
...and IT Business Controller, Arto Kesseli Development Manager and Service Centre Manager, Katriina Korpi Manager, Data Administration, Ismo Somero Manager ... - Pressi.com (press release)
CRAZY WORLD To Release Debut Album This Month - Oct. 2, 2005 Oct 2, 2005
SINERGY, KOTIPELTO) on bass, Mika Järvinen (FIVE FIFTEEN) on vocals, Esa Kotilainen (WIGWAM) on keyboards, Timo Kämäräinen (ISMO ALANKO, BEACON) on guitar ... - Blabbermouth.net,
ALMA MEDIA: City24 real estate internet business portal opened in ... 11 Oct 2005
We are also considering the feasibility of starting business in other Eastern Europe countries," says Ismo Repka, Regional Director for the Baltic States at ... - Kauppalehti (press release),
ELISA: Elisa selects Alcatel's IP solution to converge fixed and ... Sep 12, 2005
..."With this infrastructure investment we are well positioned to deliver a competitive portfolio of flexible, user-centric services," said Ismo Heino, director ... - Kauppalehti (press release),
Appointments in Metsäliittos new Wood Supply organisation Oct 5, 2005
...and IT Business Controller, Arto Kesseli Development Manager and Service Centre Manager, Katriina Korpi Manager, Data Administration, Ismo Somero Manager ... - Pressi.com (press release)
American Defense School Honors Three African Soldiers Sep 20, 2005
According to the Web site of the recently renamed International Student Management Office (ISMO), a prime goal of the fellows program is "to prepare future ... - AllAfrica.com,
CRAZY WORLD To Release Debut Album This Month - Oct. 2, 2005 Oct 2, 2005
SINERGY, KOTIPELTO) on bass, Mika Järvinen (FIVE FIFTEEN) on vocals, Esa Kotilainen (WIGWAM) on keyboards, Timo Kämäräinen (ISMO ALANKO, BEACON) on guitar ... - Blabbermouth.net,
Alcatel Lands Turkish, Finnish IP/MPLS Jobs Sep 12, 2005
According to Ismo Heino, director of Elisa's Access and Carrier Services, “IP/MPLS is the key technology for the converged, multiservice networks of the ... - Telecomweb
The Helsinki Conference 2005: From Words to Action Sep 23, 2005
His teacher and inspiration was the late Tanzanian musician Hukwe Zawose. Ismo Alanko, the leading Finish rock singer and guitarist, performed much later. ... - Global Voices Online,
Side Lines for Thursday — September 08, 2005 08 Sep 2005
Masa Arakawa, and Mel Mandrigues. In the "B" division, Ismo Yoshishige beat out Glenn Shibuya for the title. Yoshi Nakao, Bette Goo ... - Lihue Garden Island,
Mobile phone scare over, or is it a Wind-Up? Aug 14, 2005
The company that manufacturers the Wind-Up, Ismo Ltd, originally produced it to act as a cable tidier - it's a reel that takes up the slack from the cable. ... - Register,
Most bodies of Finnish tsunami victims returned to Finland Sep 1, 2005
Ismo Kopra, an officer of the National Bureau of Investigation (NBI), who heads the Finnish unit of the international victim identification group in the Thai ... - Helsingin Sanomat,
US Basketball Aug 21, 2005
Development League/ Tennessee '03). Head coach of the USA contingent isMo McHone, a former USA Basketball and CBA head coach. Named as his ... - Sports Features Communications (press release),
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Computer Screen Made From Fog Jun 22, 2005
..."The interactive screen is quite new and has not been used anywhere," said Ismo Rakkolainen, chief technology officer at Seinäjoki, Finland-based Fogscreen ... - Discovery Channel
K-Makule comes up big Jun 28, 2005
Lihue came up with three runs in the third with base hit singles from Ismo Yoshishige, Rittmeiste, Domingo, Bardago, and Akina. ... - Lihue Garden Island,
Computer Screen Made From Fog Jun 22, 2005
..."The interactive screen is quite new and has not been used anywhere," said Ismo Rakkolainen, chief technology officer at Seinäjoki, Finland-based Fogscreen ... - Discovery Channel
Other information
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Mechanism Of Action
Similar to other nitrites and organic nitrates, Isosorbide Mononitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (Atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
Drug Category
Vasodilator Agents; Nitrates and Nitrites; Nitric Oxide Donors; ATC:C01DA14
Brand Names/Synonyms
AHR 4698; CCRIS 1911; Conpin; Conpin Retardkaps; Corangin; Corangin Sr; Duride; Edistol; Elan; Elantan; Elantan Long; Elantan Retard; Epicordin; Etimonis; Fem-Mono; IHD; IS 5MN; ISMN; ISMN AL; ISOSORBIDE MONONITRATE; Imazin; Imdur; Imdur 60; Imdur Durules; Imodur; Imtrate; Ismexin; Ismn Abz; Ismn Apogepha; Ismn Atid; Ismn Basics; Ismn Heumann; Ismn Hexal; Ismn Lannacher; Ismn Stada; Ismo; Ismo-20; Ismotic; Ismox; Isomon; Isomonat; Isomonit; Isopen-20; Isosorbide Mononitrate; Isosorbidi Mononitras [Latin]; Isotrate; Iturol; Medocor; Monicor; Monis; Monisid; Monit; Monit 20; Monizid; Mono Corax; Mono Corax Retard; Mono Mack; Mono-Mack; Mono-Sanorania; Monocedocard; Monoclair; Monocord 20; Monocord 40; Monocord 50 Sr; Monodur Durules; Monoket; Monoket Od; Monoket Retard; Monolong; Monolong 40; Monolong 60; Mononit; Mononit 20; Mononit 40; Mononit Retard 50; Mononitrate d'Isosorbide [French]; Mononitrato de Isosorbida [Spanish]; Monopront; Monosigma; Monosorb; Monosorbitrate; Monosordil; Monotrate; Multitab; Nitex; Nitramin; Olicard; Olicardin; Orasorbil; Pentacard; Pentacard 20; Percorina; Pertil; Plodin; Promocard; Sigacora; Sorbimon; Titarane; Turimonit; UN3251; Uniket; Vasdilat; Vasotrate
Dosage Forms
Immediate Release and Extended release tablets
Absorption
100%
Interactions
Drug Interactions for Isosorbide Mononitrate:
The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators. Alcohol, in
particular, has been found to exhibit additive effects of this variety.
Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates
were used in combination. Dose adjustments of either class of agents may be necessary.
Chemical IUPAC Name
8-nitrooxy-2,6-dioxabicyclo[3.3.0]octan-4-ol
Chemical Formula
C6H9NO6
Half Life
5 hours
Drug Type
Approved Drug
# Accession No
APRD00528
CAS Registry Number
16051-77-7