Ipratropium_Bromide: profile and news






Nebulizer-Associated Anisocoria  Mar 1, 2006
She received oxygen and nebulized albuterol (salbutamol) and ipratropium bromide through a face mask that was attached to a noninvasive bilevel positive-airway ... - New England Journal of Medicine (subscription),

James Le Fanu investigates some pillow ploys for runny noses  Jan 9, 2006
...person, is usually due to an imbalance in the nerves that control the blood flow to the nasal lining, and will respond to the nasal spray Ipratropium Bromide. - Telegraph.co.uk,

Breathe Easier!  Jan 22, 2006
Another drug in this class, called ipratropium bromide, is formulated for human patients and can be administered by aerosol inhalation. ... - TheHorse.com,

No Justification for Deep Cut in 2006 Medicare Dispensing Fee for ...  Nov 13, 2005
Two commonly dispensed drugs used in inhalation therapy are albuterol sulfate and ipratropium bromide, which are prescribed to treat diseases like chronic ... - Medical News Today (press release),

Diagnosing Airway Disease  Dec 2, 2005
Effect of salbutamol and ipratropium bromide on airway calibre and bronchial reactivity in asthma and chronic bronchitis. Eur Respir J. 1991;4:415-420. ... - Medscape (subscription)

Asthma and COPD Patients Find New Soft Mist Inhaler Highly ...  Sep 19, 2005
...patients with asthma and chronic obstructive pulmonary disease (COPD) are highly satisfied with Berodual ® Respimat ® (ipratropium bromide/fenoterol) Soft ... - PharmaLive.com (press release),

44% of Homecare Pharmacies Will Stop Providing Inhalation Drug ...  Oct 3, 2005
...fee schedule issued in August, CMS proposed an 89 percent reimbursement cut for the drugs, using the ASP formula, for albuterol sulfate and ipratropium bromide ... - Medical News Today (press release),

Head-to-Head Study Shows COPD Patients Achieve Significantly ...  Sep 18, 2005
2,10) Spiriva(R) also demonstrated superior and sustained improvements in lung function (FEV1) over Atrovent(R) (ipratropium bromide) Inhalation Aerosol, a ... - PR Newswire UK (press release),

Head-to-head Study Shows COPD Patients Achieve Significantly ...  Sep 19, 2005
2,10 Spiriva ® also demonstrated superior and sustained improvements in lung function (FEV 1 ) over Atrovent ® (ipratropium bromide) Inhalation Aerosol, a ... - PharmaLive.com (press release),

American Association for Homecare Opposes Any Cut to Dispensing ...  06 Aug 2005
...schedule issued last August, CMS proposed an 89 percent reimbursement cut for the drugs, using the ASP formula, for albuterol sulfate and ipratropium bromide. ... - I-Newswire.com (press release)

Photo: Edwina Pickles  Jul 6, 2005
The Gap: Although ipratropium bromide is a useful addition for drug treatment of severe asthma, it does not help mild to moderate asthma - however, it is used ... - Sydney Morning Herald (subscription)

Drug Company Settles Price-Fixing Case in Connecticut  Jul 20, 2005
The company has promised to donate more than 2 million vials of DuoNeb, Albuterol and Ipratropium Bromide -- all treatments for respiratory ailments such as ... - RedNova.com <**results**>

Photo: Edwina Pickles  Jul 6, 2005
The Gap: Although ipratropium bromide is a useful addition for drug treatment of severe asthma, it does not help mild to moderate asthma - however, it is used ... - Sydney Morning Herald (subscription)

Changes in Inhaler Devices for Asthma And COPD  Jun 19, 2005
First-line therapy for adult patients with acute asthma receiving a multiple dose protocol of ipratropium bromide plus albuterol in the emergency department. ... - RedNova.com

Ignorance of doctors is risking lives  Jun 24, 2005
Evidence shows ipratropium bromide - a drug which reduces mucus secretion - is useful in the treatment of severe asthma, but not in the treatment of mild or ... - Sydney Morning Herald (subscription),

Ignorance of doctors is risking lives  Jun 24, 2005
Evidence shows ipratropium bromide - a drug which reduces mucus secretion - is useful in the treatment of severe asthma, but not in the treatment of mild or ... - Sydney Morning Herald (subscription),

Changes in Inhaler Devices for Asthma And COPD  Jun 19, 2005
First-line therapy for adult patients with acute asthma receiving a multiple dose protocol of ipratropium bromide plus albuterol in the emergency department. ... - RedNova.com,

Chronic Obstructive Pulmonary Disease  Jun 8, 2005
An abstract in the British Veterinary Journal, printed in September 1997, reported on the use of ipratropium bromide, a bronchodilator, in treating horses with ... - TheHorse.com,

DATAMONITOR: Novel Combinations Breathe Life into COPD Market  Apr 26, 2005
Inhaled short-acting bronchodilators, such as Boehringer Ingelheim’s Atrovent (ipratropium bromide) and GSK’s Ventolin (salbutamol/albuterol), are ... - PharmaLive.com

Boehringer Ingelheim reports strong 2004  Apr 7, 2005
Revenues rose more than 10 per cent to just under €8.2 billion, with growth driven by surging sales for Spiriva (ipratropium bromide), Boehringer’s drug ... - in-PharmaTechnologist,

Texas Goes After Big Pharma  Mar 4, 2005
The state claims that Roxane knowingly inflated its prices on about 18 different drugs, including the asthma drug ipratropium bromide, and continued doing so ... - The Texas Observer,


Other information


Indication
For maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema

Pharmacology
Ipratropium bromide, a synthetic ammonium compound structurally similar to atropine, is used as a bronchodilator in the management of cholinergic-mediated bronchospasm associated with chronic obstructive pulmonary disease and in the treatment of rhinorrhea associated with the common cold or with allergic or nonallergic seasonal rhinitis.

Mechanism Of Action
Ipratropium bromide is an anticholinergic agent. It blocks muscarinic cholinergic receptors, without specificity for subtypes, resulting in a decrease in the formation of cyclic guanosine monophosphate (cGMP). Most likely due to actions of cGMP on intracellular calcium, this results in decreased contractility of smooth muscle.

Drug Category
Bronchodilator Agents; Cholinergic Antagonists; Antimuscarinics; Antispasmodics; ATC:R01AX03; ATC:R03BB01

Brand Names/Synonyms
Aerovent; Apo-Ipravent; Apovent; Atronase; Atrovent; Atrovent Aerosol; Atrovent Hfa; Atrovent Nasal; Bitrop; Disne-Asmol; IPRATROPIUM; Ipatropium Bromide; Ipratropium; Ipratropium Bromide; Ipravent; Ipvent; Kendral-Ipratropium; N-Isopropylatropine; Narilet; Rhinotrop; Rhinovent; Rinatec; Rinoberen; Rinovagos; Vagos

Dosage Forms
AEROSOL (WITH PROPELLANTS); LIQUID; METERED-DOSE (AEROSOL); METERED-DOSE (PUMP); SOLUTION

Absorption
Inhalation (local)-minimal; Nasal-rapid and minimal

Interactions
Interactions for Ipratropium:

ATROVENT Inhalation Aerosol has been used concomitantly with other drugs, including sympathomimetic bronchodilators, methylxanthines, and steroids, commonly used in the treatment of chronic obstructive pulmonary disease. With the exception of albuterol, there are no formal studies fully evaluating the interaction effects of ATROVENT Inhalation Aerosol and these drugs with respect to effectiveness.

Anticholinergic agents: Although ipratropium bromide is minimally absorbed into the systemic circulation, there is some potential for an additive interaction with concomitantly used anticholinergic medications. Caution is therefore advised in the coadministration of ATROVENT Inhalation Aerosol with other anticholinergic-containing drugs.



Chemical IUPAC Name
[8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]oct-3-yl]3-hydroxy-2-phenyl-propanoate

Chemical Formula
C20H30NO3

Half Life
~2 hours

Drug Type
Approved Drug

# Accession No
APRD00537

CAS Registry Number
60205-81-4

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