Inversine: profile and news

Advance Patch Helps Smokers Quit Feb 1, 2006
...patches and some received placebo patches. All participants were given the smoking cessation drug Inversine. A month later, half the ... - CBS News

Targacept tries again to make IPO work Jan 17, 2006
...products. Targacept markets the drug Inversine, a treatment for hypertension, but it has no other source of product revenue. According ... - Winston-Salem Journal,

Ispronicline Joins Effort to Find Alzheimer’s Cure Jul 6, 2005
Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in clinical development for cognitive impairment, including ... - SeniorJournal.com <**results**>

Targacept compounds show long-lasting improvement in cognition Jul 4, 2005
Targacept has a marketed product, Inversine® ( mecamylamine hydrochloride ), product candidates in clinical development for cognitive impairment, including ... - I-Newswire.com (press release)

Targacept to Present at Pacific Growth Equities 2005 Life Sciences ... Jun 2, 2005
Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in clinical development for cognitive impairment, including ... - PR Newswire (press release)

Targacept to Present at the Deutsche Bank 30th Annual Health Care ... Apr 28, 2005
Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in clinical development for cognitive impairment, including ... - PR Newswire

Targacept to Present at the Deutsche Bank 30th Annual Health Care ... 29 Apr 2005
Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in clinical development for cognitive impairment, including ... - PR Newswire

Targacept to Present at the CIBC Biotechnology Conference Mar 31, 2005
Targacept has a marketed product, Inversine®, product candidates in clinical development for cognitive impairment, including Alzheimer's disease and age ... - Yahoo News

Targacept Presents Promising Results at the 7th International ... Mar 30, 2005
Targacept has a marketed product, Inversine® (mecamylamine hydrochloride), product candidates in clinical development for cognitive impairment, including ... - New Age Media Concepts

Targacept Postpones Its Initial Public Offering Mar 1, 2005
In addition to a marketed product, Inversine(R), Targacept has product candidates in clinical development for cognitive impairment, including Alzheimer's ... - dBusinessNews Triad (press release),

Other information

Indication
For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension

Pharmacology
Mecamylamine is a potent, oral antihypertensive agent and ganglion blocker, and is a secondary amine. Mecamylamine is indicated for the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension. Mecamylamine reduces blood pressure in both normotensive and hypertensive individuals. A small oral dosage often produces a smooth and predictable reduction of blood pressure. Although this antihypertensive effect is predominantly orthostatic, the supine blood pressure is also significantly reduced. Mecamylamine crosses the blood-brain and placental barriers.

Mechanism Of Action
Mecamylamine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Mecamylamine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural.

Drug Category
Antihypertensive Agents; Nicotinic Receptor Antagonist ATC:C02BB01

Brand Names/Synonyms
Versamine; Inversine; Revertina; Inversine hydrochloride; Mecamilamina; Mecamine; Mecamine hydrochloride; Mecamylamine Hydrochloride; Mekamin hydrochloride; Mekamine; Mevasin hydrochloride; Mevasine; 2-Methylamino-2,3,3-trimethylnorbornane; 2-Methylaminoisocamphane; 2-Norbornanamine, N,2,3,3-tetramethyl-; 2-Norbornanamine, N,2,3,3-tetramethyl-, hydrochloride; 3-Methylaminoisocamphane; 3-Methylaminoisocamphane hydrochloride

Dosage Forms
Tablets

Absorption
Mecamylamine is almost completely absorbed from the gastrointestinal tract

Interactions
Interactions for Mecamylamine: Patients receiving antibiotics and sulfonamides generally should not be treated with ganglion blockers. The action of Mecamylamine may be potentiated by anesthesia, other antihypertensive drugs and alcohol.

Chemical IUPAC Name
N,2,3,3-tetramethylnorbornan-2-amine

Chemical Formula
C11H21N

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00458

CAS Registry Number
60-40-2