Interferon_gamma-1b: profile and news

InterMune to Present at the 24th Annual JPMorgan Healthcare ... 05 Jan 2006
PR Newswire (press release), HCV) infections. The pulmonology portfolio includes Actimmune(R) (interferon gamma-1b), pirfenidone and research programs. Actimmune ...

InterMune Announces Divestiture of Oritavancin Dec 27, 2005
Yahoo! News (press release) HCV) infections. The pulmonology portfolio includes Actimmune® (interferon gamma-1b), pirfenidone and research programs. Actimmune ...

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InterMune Announces First Quarter Financial Results and Business ... Apr 27, 2006
Total revenue for the first quarter of 2006 was $24.4 million, comprised solely of Actimmune® (interferon gamma-1b) sales compared to first quarter 2005 total ... - Yahoo! News (press release)

InterMune to Present at the Deutsche Bank 2006 Health Care ... Apr 26, 2006
The pulmonology portfolio includes Actimmune® (interferon gamma-1b), which is being evaluated in the INSPIRE Trial, a Phase III study in patients with IPF ... - Yahoo! News (press release)

Other information

Indication
For treatment of Chronic granulomatous disease, Osteopetrosis

Pharmacology
IFN gamma stimulates expression of the immunoglobulin heavy chain C gamma 3 and C gamma 2a germline transcripts in B cells. Many components of the antigen presentation pathways are also up-regulated by interferon gamma. It is also a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of type I interferons. Interferon gamma may also help the body regulate the activity of fibroblasts. By directly blocking the multiplication of fibroblasts and inhibiting the production and action of TGF-b, a potent scar-inducing molecule, Interferon gamma-1b may prevent excessive scarring.

Mechanism Of Action
Binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes.

Drug Category
Antiviral Agents; Immunomodulatory Agents

Brand Names/Synonyms
Interferon gamma precursor;IFN-gamma;Immune interferon; Actimmune (InterMune Inc)

Dosage Forms
Not Available

Absorption
Not Available

Interactions
Not Available

Chemical IUPAC Name
Human interferon gamma-1b

Chemical Formula
C761H1206N214O225S6

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
BIOD00017

CAS Registry Number
82115-62-6; 98059-61-1