Indocin: profile and news

LOSS OF BOWEL CONTROL IS OFTEN TREATABLE  Mar 1, 2006
...do so. Familiar names of anti-inflammatory medicines include Advil, Voltaren, Motrin, Ibuprofen and Indocin. DEAR DR. DONOHUE: From ... - Charlotte Sun-Herald,

Loss of bowel control is distressing, but treatable  Mar 1, 2006
...to do so. Familiar names of anti-inflammatory medicines include Advil, Voltaren, Motrin, Ibuprofen and Indocin. Readers may write ... - SouthCoastToday.com,

SSRIs harm baby's breath?  Feb 24, 2006
Use of some medications during pregnancy - nonsteroidal anti-inflammatory drugs (aspirin, indomethacin/Indocin, naproxene/ Aleve, diclofenac/Voltaren, etc.). ... - myDNA.com,

KEN RUCKER SUSPENDED  Dec 10, 2005
...before receiving another six. Indomethacin is commonly known as Indocin and is used to treat humans for gout. According to Ezzo, Rucker ... - Harnesslink,

Crime Reports  Dec 1, 2005
Nov. 19 or 20. Post Office, 1527 Highland Ave. Toyota Corolla. Nov. 18 or 19. 3600 block of Indocin Court. Purse, cash, credit cards. Between Nov. 15 and 17. - Louisville Courier-Journal,

STOPPING MEDICINE WITHOUT TELLING THE DOCTOR IS DANGEROUS  Nov 30, 2005
ANSWER: Aleve and the many other related drugs, such as aspirin, Voltaren, Motrin, Indocin, Advil and Orudis, can irritate the stomach and can give rise to ... - Charlotte Sun-Herald,

Brown Can Look and Learn  Nov 20, 2005
..."Feels good when I'm on these [anti-inflammatory] drugs," Brown said of his hamstring. "That Indocin is some powerful stuff.". Luke ... - Los Angeles Times,

Notebook: Brown has hamstring injury  Nov 21, 2005
...way he ran. "It feels good now," he said. "That Indocin (medication) is some power stuff. But I'm just not ready to go.". Brown had ... - Press-Enterprise (subscription),

Hand-washing no shield against spread of germs  Oct 27, 2005
They include diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon), ibuprofen (Motrin, Advil), indomethacin (Indocin), nabumetone (Relafen ... - The Republican,

Popular pain medications: Help or harm? Rx ANSWERS WILKES ...  Oct 11, 2005
...worked better, but because they were developed to be “safer� on the stomach than traditional medications such as Advil, Aleve and Indocin (Non-Steroidal ... - Wilkes Barre Times-Leader,

Popular pain medications: Help or harm? Rx ANSWERS WILKES ...  11 Oct 2005
...worked better, but because they were developed to be “safer� on the stomach than traditional medications such as Advil, Aleve and Indocin (Non-Steroidal ... - Wilkes Barre Times-Leader,

What Ails You by Jackie Randa  Sep 20, 2005
Your doctor will probably prescribe non-steroidal anti-inflammatory drug (NSAID) such as indomethacin (Indocin) or naproxen sodium (Naprosyn). ... - Desert Dispatch,

Even if you wash hands, restroom germs still lurk  Sep 19, 2005
They include diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon), ibuprofen (Motrin, Advil), indomethacin (Indocin), nabumetone (Relafen ... - Charlotte Observer,

The Medical Minute: Pain - the fifth vital sign  Aug 31, 2005
Prescription nonsteroidal anti-inflammatories include Naprosyn, Motrin, Relafen, Daypro, Feldene, Lodine, Indocin, Mobic, Celebrex, Bextra, Vioxx and others. ... - Penn State Live,

Guam's bout with gout  06 Aug 2005
They discuss gout medicines in great detail, espousing multi-syllabic cures from their pharmacopoeia, such as Indocin, Dexamethasone and Colchicine. ... - Agana Pacific Daily News <**results**>

Ask Dr. Husty: Aspirin Alternative During Heart Attack?  Jun 20, 2005
They include non-aspirin anti-inflammatories, such as ibuprofen, Motrin or Advil; naproxen products, such as Alleve; or prescription drugs, such as Indocin. ... - WESH.com

Most Painkillers Up Heart Attack Risk  Jun 17, 2005
...warnings. Indomethacin (Indocin) and sulindac (Clinoril) -- both traditional NSAIDs -- had the highest risk in the new study. Indomethacin ... - FOX News

Ask Dr. Husty: Aspirin Alternative During Heart Attack?  Jun 20, 2005
They include non-aspirin anti-inflammatories, such as ibuprofen, Motrin or Advil; naproxen products, such as Alleve; or prescription drugs, such as Indocin. ... - WESH.com,

Most Painkillers Up Heart Attack Risk  Jun 17, 2005
...warnings. Indomethacin (Indocin) and sulindac (Clinoril) -- both traditional NSAIDs -- had the highest risk in the new study. Indomethacin ... - FOX News

CONFERENCE REPORT: Less Cancer With NSAIDs But More Cardiovascular ...  Apr 18, 2005
...against oral cancers, the protective effect works equally well for aspirin, Advil, Motrin (ibuprofen), Aleve (naproxen), Indocin (indomethacine), Feldene ... - MedPage Today

Sarcoidosis isn'ta laughing matter  Apr 14, 2005
Treatments include nonsteroidal anti-inflammatory drugs, such as Indocin and ibuprofen; antibiotics; cortisone-type drugs; and medicine to suppress or alter ... - Louisville Courier-Journal

FDA pulls painkiller Bextra, orders new warnings  Apr 8, 2005
Included are Voltaren, Cataflam, Arthrotec, Dolobid, Lodine, Nalfon, Ansaid, Indocin, Indomethegan, Toradol, Ponstel, Mobic, Relafen, Daypro, Feldene, Disalcid ... - Seattle Times

Another painkiller, Bextra, ordered pulled  Apr 8, 2005
...naproxen), Relafen (nabumetone), Motrin (ibuprofen), Clinoril (sulindac), Trilisate (magnesium trisalicylate), Lodine (etodolac) and Indocin (indomethacin). ... - San Diego Union Tribune

Painkiller Bextra pulled from shelves  Apr 8, 2005
The drugs include Voltaren, Cataflam, Arthrotec, Dolobid, Lodine, Nalfon, Ansaid, Indocin, Indomethegan, Toradol, Ponstel, Mobic, Relafen, Daypro, Feldene ... - Miami Herald,

Worry over drug safety adds to patients’ pain  Mar 6, 2005
...“People say go back to the old drugs like Indocin, but for me it’d be the worst possible outcome. I wouldn’t let it happen without a fight.�. ... - Laconia Citizen,

Is a new culture pending for Food & Drug Administration?  Feb 26, 2005
...study of California Medicaid patients and in preliminary results found what he believed were alarming signs that some older painkillers, Indocin and Mobic ... - Minneapolis Star Tribune (subscription),

Old proverb about gout does not apply  Feb 11, 2005
Fortunately, there is treatment for gout (Indocin and other anti-inflammatory drugs), as well as a medication (allopurinol) to prevent this uncomfortable ... - Monterey County Herald,

FDA Panel Says Celebrex Should Stay on Market  Feb 18, 2005
But Dr. Graham also condemned Indocin and Mobic, both popular painkillers. A study of California Medicaid patients found that Indocin ... - New York Times

FDA Scientist Says All Cox-2 Drugs Pose a Risk  Feb 18, 2005
...is on the label.". Merck markets indomethacin and sulindac under the brand names Indocin and Clinoril. "The numbers presented were ... - Los Angeles Times,

FDA scientist sees problems with entire class of painkillers  Feb 18, 2005
...the preliminary data from his study also showed an increased risk of cardiovascular problems in the drug indomethacin, marketed by Merck as Indocin, calling it ... - Sun-Sentinel.com,

Merck executive raises the possibility of Vioxx's return  Feb 18, 2005
Advil and Motrin. Indomethacin is marketed under such brand names as Indocin, and meloxicam under the brand name Mobic. The FDA ... - Philadelphia Inquirer (subscription),

FDA Panel Urges Caution on Many Anti-Inflammatory Drugs  Feb 24, 2005
He described his preliminary results from an epidemiologic study of Medicaid patients; those taking Indocin (generically, endomethacin) had nearly double the ... - Science Magazine (subscription)

Hearings show more openness by FDA on drugs  Feb 20, 2005
...study of California Medicaid patients and in preliminary results found what he thought were alarming signs that some older painkillers, Indocin and Mobic, were ... - Kansas City Star (subscription),

In normal volunteers receiving indomethacin, the administration of diflunisal decreased the renal clearance and significantly increased the plasma levels of indomethacin. In some patients, combined use of INDOCIN and diflunisal has been associated with fatal gastrointestinal hemorrhage. Therefore, diflunisal and INDOCIN should not be used concomitantly.

In a study in normal volunteers, it was found that chronic concurrent administration of 3.6 g of aspirin per day decreases indomethacin blood levels approximately 20%.

The concomitant use of INDOCIN with other NSAIDs is not recommended due to the increased possibility of gastrointestinal toxicity, with little or no increase in efficacy.

Clinical studies have shown that INDOCIN does not influence the hypoprothrombinemia produced by anticoagulants. However, when any additional drug, including INDOCIN, is added to the treatment of patients on anticoagulant therapy, the patients should be observed for alterations of the prothrombin time. In post-marketing experience, bleeding has been reported in patients on concomitant treatment with anticoagulants and INDOCIN. Caution should be exercised when INDOCIN and anticoagulants are administered concomitantly.

When INDOCIN is given to patients receiving probenecid, the plasma levels of indomethacin are likely to be increased. Therefore, a lower total daily dosage of INDOCIN may produce a satisfactory therapeutic effect. When increases in the dose of INDOCIN are made, they should be made carefully and in small increments.

Caution should be used if INDOCIN is administered simultaneously with methotrexate. INDOCIN has been reported to decrease the tubular secretion of methotrexate and to potentiate its toxicity.

Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal prostacyclin. NSAIDs should be used with caution in patients taking cyclosporine, and renal function should be carefully monitored.

Capsules INDOCIN 50 mg t.i.d. produced a clinically relevant elevation of plasma lithium and reduction in renal lithium clearance in psychiatric patients and normal subjects with steady state plasma lithium concentrations. This effect has been attributed to inhibition of prostaglandin synthesis. As a consequence, when INDOCIN and lithium are given concomitantly, the patient should be carefully observed for signs of lithium toxicity. (Read circulars for lithium preparations before use of such concomitant therapy.) In addition, the frequency of monitoring serum lithium concentration should be increased at the outset of such combination drug treatment.

INDOCIN given concomitantly with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. Therefore, when INDOCIN and digoxin are used concomitantly, serum digoxin levels should be closely monitored.

In some patients, the administration of INDOCIN can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. Therefore, when INDOCIN and INDOCIN. (Indomethacin) diuretics are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

INDOCIN reduces basal plasma renin activity (PRA), as well as those elevations of PRA induced by furosemide administration, or salt or volume depletion. These facts should be considered when evaluating plasma renin activity in hypertensive patients.

It has been reported that the addition of triamterene to a maintenance schedule of INDOCIN resulted in reversible acute renal failure in two of four healthy volunteers. INDOCIN and triamterene should not be administered together.

INDOCIN and potassium-sparing diuretics each may be associated with increased serum potassium levels. The potential effects of INDOCIN and potassium-sparing diuretics on potassium kinetics and renal function should be considered when these agents are administered concurrently.

Most of the above effects concerning diuretics have been attributed, at least in part, to mechanisms involving inhibition of prostaglandin synthesis by INDOCIN.

Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by non-steroidal antiinflammatory drugs including INDOCIN has been reported. Therefore, when using these blocking agents to treat hypertension, patients should be observed carefully in order to confirm that the desired therapeutic effect has been obtained. INDOCIN can reduce the antihypertensive effects of captopril and losartan.

False-negative results in the dexamethasone suppression test (DST) in patients being treated with INDOCIN have been reported. Thus, results of the DST should be interpreted with caution in these patients.