Inderal: profile and news






Red ears cause embarrassment  Feb 5, 2006
...my patients. Ask your physician to prescribe a low dose of a beta blocker, such as 10 milligrams of Inderal (propranolol). If taken ... - Northwest Herald,

Wyeth closing  Feb 16, 2006
...planned for 2007. That’s when production of Rapamune Liquid, Inderal LA and Premarin Cream will end in Rouses Point. In 2008, with ... - Plattsburgh Press Republican,

Red ears cause embarrassment  Feb 5, 2006
...my patients. Ask your physician to prescribe a low dose of a beta blocker, such as 10 milligrams of Inderal (propranolol). If taken ... - Northwest Herald,

Happy Pills Don't Make Me Happy  Jan 20, 2006
Wellbutrin, Neurontin, Seroquel, Depakote, Effexor, Inderal, Trileptal, Paxil, Zyprexa, Lamictal, Abilify -- I've taken them all. ... - Pacific News Service,

AstraZeneca loses exclusive rights to drug  Jan 19, 2006
...treat hypertension. Far behind was Wyeth's drug Inderal, according to IMS Health, an industry monitoring and consulting firm. Both ... - philly.com,

Drug Counters Mental Effect of Stress  Nov 16, 2005
But Beversdorf's team also finds that taking a common drug -- a beta-blocker sold as Inderal and in generic forms -- restores problem-solving ability to people ... - WebMD

New age of medicine: Treatment tailored to your DNA, enzymes  Nov 13, 2005
Gwynne Wolin, a retired medical transcriber from Coconut Creek, Fla., said she had become sick from taking certain drugs like the heart drug Inderal. ... - San Francisco Chronicle,

Young, Assured and Playing Pharmacist to Friends  Nov 16, 2005
In another recent posting, a participant wrote that his supply of the beta blocker Inderal, acquired in Costa Rica, was running out. ... - The Ledger,

I-Team 10 Investigation: The hidden dangers of on-line drugs  Nov 14, 2005
We ordered the drugs Inderal and Norvasc for high blood pressure, Glucophage for diabetes, Prozac and Viagra, which was available in soft tablets, which ... - WHEC-TV,

Ask the Doctor  Nov 10, 2005
Thus doses of pills to bring down water retention, for example, should be reduced to avoid dehydration, while long-acting agents like Inderal LA or Tenormin ... - Egypt Today,

Ask the Clinician: Answers to Readers' Questions  Oct 4, 2005
...was so intense... 4) I was diagnosed with migraines when I was five years old and took Elavil and Inderal until high school. I am ... - headaches.about.com

Heart flutters only half-diagnosed  Sep 26, 2005
Inderal took care of the rapid heartbeat until he weaned me off the medication. The flutters returned. ... Inderal is a beta-blocker that slows the heart rate. ... - Monterey County Herald,

TREMOR OFTEN YIELDS TO SURGERY WHEN MEDICINES FAIL  Sep 6, 2005
...action. What medicines has your sister tried? Mysoline and Inderal are two popular ones. Topamax and Neurontin are two others. Your ... - Charlotte Sun-Herald,

Tarantula’s Heart Remedy Clues  Aug 24, 2005
...blockers to slow the heart beat and reduce the heart’s force of contraction. Wyeth’s drug Inderal is used frequently in HC cases. - Red Herring,

Public Often Misunderstands Heart Failure  Aug 30, 2005
Zestril. Beta-blockers inhibit hormones that make the heart beat hard and fast. Examples Tenormin, Inderal, and Corgard. False. ... - WebMD

Genetics of PTSD: A Neglected Area?  Aug 30, 2005
A recent review reported promising results for propranolol (Inderal) and cortisol as preventive agents (Pitman and Delahanty, 2005). ... - Psychiatric Times,

Drug not approved for stage fright  Jul 25, 2005
...the event. What is it and does it work? You are probably referring to a medication called propranolol (Inderal). This beta blocker ... - Charlotte Observer

Excess copper hurts brain, liver  Jul 16, 2005
Some forms of migraine can be prevented by the daily use of beta-blockers (such as Inderal) or calcium-channel blockers (such as verapamil). ... - The Spokesman Review (subscription)

Drug was not meant for anxiety  Jul 6, 2005
...event. Do you know what it is and if it works? You are probably referring to a medication called propranolol (Inderal). This beta ... - Daily Press

Sun And Some Medicines Don't Mix  Jul 26, 2005
...regulate our body temperature include the over-the-counter antihistamine Benedryl; beta blockers for high blood pressure like Inderal, Propranolol, Iopressor ... - NBC 10.com

Bill Phillips' blog  Jul 28, 2005
50 metre over 40: Major Mangat (first), Sabha Mangat (second); 50 metre over 50: Mastan Mangat (first), Inderal Virk (second); 100 metre 60 years: Lembar Singh ... - Williams Lake Tribune

Freelance oboist's memoir exposes classical music  Jul 7, 2005
She describes taking the stage-fright drug, the beta-blocker Inderal, when auditioning for a coveted oboe position with a symphony orchestra or playing a ... - Contra Costa Times

The right touch  Jul 18, 2005
Mayte's doctor prescribed the beta blocker Inderal to prevent the horrific headaches, but the drug slowed her heart rate so she felt tired all the time. ... - Great Falls Tribune <**results**>

Drug was not meant for anxiety  Jul 6, 2005
...event. Do you know what it is and if it works? You are probably referring to a medication called propranolol (Inderal). This beta ... - Daily Press

oboist's memoir exposes classical music  Jul 7, 2005
She describes taking the stage-fright drug, the beta-blocker Inderal, when auditioning for a coveted oboe position with a symphony orchestra or playing a ... - Contra Costa Times

Lingering Effects of Child Abuse and Neglect  Jun 12, 2005
...inhibitors (Prozac and others) may help, says the Harvard Mental Health Letter; other promising drugs include mifepristone (RU-486) and propranolol (Inderal). ... - Medical News Today

Multi-Modal Integrated Treatment for Youth With Bipolar Disorder  Jun 20, 2005
Buspirone may not be effective in all cases. Propranolol (Inderal) may be considered in cases of performance anxiety. Adverse events. ... - Psychiatric Times,

Fighting stage fright with a pill  Jun 21, 2005
...event. Do you know what it is and if it works? You are probably referring to a medication called propranolol (Inderal). This beta ... - Los Angeles Times,

Lingering Effects of Child Abuse and Neglect  Jun 12, 2005
...inhibitors (Prozac and others) may help, says the Harvard Mental Health Letter; other promising drugs include mifepristone (RU-486) and propranolol (Inderal). ... - Medical News Today,

Don't let restless legs keep you from sleeping  Jun 19, 2005
...event. Do you know what it is and if it works? A: You are probably referring to a medication called propranolol (Inderal). This ... - Houston Chronicle,

Multi-Modal Integrated Treatment for Youth With Bipolar Disorder  Jun 20, 2005
Buspirone may not be effective in all cases. Propranolol (Inderal) may be considered in cases of performance anxiety. Adverse events. ... - Psychiatric Times,

`Data protection is critical`  Jun 9, 2005
For instance, Inderal, which was launched in 1965 had a lead time of over 15 years before Lopresor hit the market, but in 2000 Vioxx was launched just six ... - Business Standard,

New Learning at American Home Products  Apr 25, 2005
By 1979 it had developed a broader line of new prescription drugs, beginning in 1968 with Inderal, a beta-blocker drug licensed from Imperial Chemical ... - Working Knowledge

Colorful foods can help fight a number of diseases  Apr 5, 2005
Bioflavonoids isolated from decaffeinated green tea have been found to have properties similar to the beta-blocker drug propanolal (Inderal) in lowering the ... - News Target

Making a blank canvas  Apr 8, 2005
...traumatic event. Another drug, called Inderal, is being sold online as a supposed post-trauma “forget pill �. Michael Anderson ... - Times Online

To: National Desk, Health and Consumer Reporter  Mar 28, 2005
The 20 mg dose of Inderal, the brand name version of propranolol, costs $44 a month. By the same token, some generics are more expensive than others. ... - U.S. Newswire

Sarason Liebler for VillageSoup Times: When the Dodgers left ...  Mar 30, 2005
...wonders of modern science I would expect they too now reach for the symphonic musician's favorite mellowing agent, the beta-blocker Inderal (see partialobserver ... - Knox Village Soup

Lower-Cost Drugs Can Help Heart Patients  Apr 1, 2005
...around $13 a month. The 20 mg once-daily dose of Inderal, the brand name version of propranolol, costs $44 a month. By the same ... - Consumer Affairs

Psychiatric Times February 2005 Vol. XXII Issue 2  Feb 28, 2005
Amantadine (Symmetrel) and propranolol (Inderal) appear promising for the treatment of patients who present with cocaine withdrawal symptoms. ... - Psychiatric Times,

Heart Attack Care May Be Worse for Women  Feb 21, 2005
...men to be treated with cholesterol-lowering drugs, such as Zocor and Lipitor, but less likely to receive beta-blockers, such as Lopressor and Inderal, used to ... - Reuters

Update on Risk Factors for Atherosclerosis: The Role of ...  Feb 26, 2005
For example, beta blockers, such as metoprolol (Lopressor), atenolol (Tenormin), and propanolol (Inderal) increase plasma triglycerides and decrease HDL ... - RedNova.com,

Management of Hypertension in Older Persons  Feb 21, 2005
Beta blockers that are lipophilic (eg, propranolol [Inderal]) cross the blood-brain barrier, possibly causing more sedation, depression, and sexual dysfunction ... - RedNova.com,

BCBSNC Launches New Prescription Drug Savings Initiative  Feb 17, 2005
...generic Tenormin) labetalol (generic Trandate, Normodyne) metoprolol (generic Lopressor) nadolol (generic Corgard) propranolol (generic Inderal) ACE INHIBITORS ... - PR Newswire (press release)


Other information


Indication
For the prophylaxis of migraine

Pharmacology
Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity.

Mechanism Of Action
Like atenolol and metoprolol, propranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles.

Drug Category
Vasodilator Agents; Anti-anxiety Agents; Antihypertensive Agents; Antiarrhythmic Agents; Adrenergic Agents; ATC:C07AA05

Brand Names/Synonyms
Angilol; Apsolol; Avlocardyl; Bedranol; Beprane; Berkolol; Beta-Neg; Beta-Propranolol; Beta-Tablinen; Beta-Timelets; Betachron; Betalong; Cardinol; Caridolol; Corpendol; Deralin; Dl-Propranolol Hydrochloride; Dociton; Duranol; Efektolol; Elbrol; Etalong; Euprovasin; Frekven; Inderal; Inderal La; Inderide; Indobloc; Innopran Xl; Intermigran; Kemi S; Obsidan; Oposim; Prano-Puren; Propanalol; Propanix; Propanolol; Prophylux; Propranalol; Propranolol; Propranolol Hcl; Propranolol Hcl Intensol; Propranolol Hydrochloride; Propranur; Proprasylyt; Pylapron; R,S-Propranolol Hydrochloride; Rapynogen; Reducor; Reducor Line; Sagittol; Servanolol; Sloprolol; Sumial; Tesnol

Dosage Forms
Tablets, I.V.

Absorption
Propranolol is almost completely absorbed from the GI tract; however, plasma concentrations attained are quite variable among individuals

Interactions
Interactions for Propranolol:

Patients receiving catecholamine-depleting drugs such as reserpine should be closely observed if Propranolol HCl is administered. The added catecholamine-blocking action may produce an excessive reduction of resting sympathetic nervous activity, which may result in hypotension, marked bradycardia, vertigo, syncopal attacks, or orthostatic hypotension.

Caution should be exercised when patients receiving a beta blocker are administered a calcium-channel blocking drug, especially intravenous verapamil, for both agents may depress myocardial contractility or atrioventricular conduction. On rare occasions, the concomitant intravenous use of a beta blocker and verapamil has resulted in serious adverse reactions, especially in patients with severe cardiomyopathy, congestive heart failure, or recent myocardial infarction.

Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by nonsteroidal anti-inflammatory drugs has been reported.

Hypotension and cardiac arrest have been reported with the concomitant use of propranolol and haloperidol.

Aluminum hydroxide gel: Greatly reduces intestinal absorption of propranolol.

Ethanol: Slows the rate of absorption of propranolol.

Phenytoin, phenobarbitone: and rifampin accelerate propranolol clearance.

Chlorpromazine: When used concomitantly with propranolol, results in increased plasma levels of both drugs.

Antipyrine: and lidocaine have reduced clearance when used concomitantly with propranolol.

Thyroxine: May result in a lower than expected T3 concentration when used concomitantly with propranolol.

Cimetidine Decreases the hepatic metabolism of propranolol, delaying elimination and incre:asing blood levels.

Theophylline: Clearance is reduced when used concomitantly with propranolol.



Chemical IUPAC Name
1-(1-methylethylamino)-3-naphthalen-1-yloxy-propan-2-ol

Chemical Formula
C16H21NO2

Half Life
4 hours

Drug Type
Approved Drug

# Accession No
APRD00194

CAS Registry Number
525-66-6

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