Imitrex: profile and news
Mirapex - Two Victims - Same Horror Story Feb 21, 2006
The daily gambling binges continued for two full years because that's how long it took for Joe to find out that, Mirapex, the drug he had been taking for ... - OpEdNews
EAR MALFUNCTION CAN SET THE WORLD SPINNING Mar 5, 2006
DEAR DR. DONOHUE: My husband was put on Mirapex for restless leg syndrome. It helped him immensely. ... Mirapex (pramipexole) is a closely related drug. ... - Charlotte Sun-Herald,
Is there any way to treat restless legs syndrome? Mar 5, 2006
...problem. A similar drug called Mirapex is up for FDA review now. Restless legs syndrome is not fatal, but it can be a life-wrecker. ... - Boston Globe,
Second Parkinson’s Drug, Requip, Blamed for Compulsive Gambling ... Feb 26, 2006
Up until now, Mirapex has been the medication most often associated with the mounting medical evidence linking certain drugs used to treat Parkinson’s ... - Newsinferno.com,
Date Published: Wednesday, February 15th, 2006 Feb 15, 2006
...has been mounting with respect to the rather odd connection between certain drugs used to treat Parkinson’s disease (PD), especially Mirapex, and the ... - Newsinferno.com,
Doctor sues drug company, casinos after losing $14 million Feb 22, 2006
...cites a 2005 Mayo Clinic study that found 11 Parkinson's patients who developed compulsive gambling habits while taking Requip and a similar drug called Mirapex ... - Oxford Press,
Gambler sues drugs giant for $15m loss Feb 25, 2006
...to the lawsuit, Dr Wells, who was diagnosed with Parkinson's in 2000, was an occasional gambler who became compulsive when he took a drug called Mirapex in 2004 ... - Telegraph.co.uk,
Parkinson's medicine has odd side effect: gambling Mar 4, 2006
Medications used to treat Parkinson's accounted for most of those, but one Parkinson's drug stood out: Pramipexole or Mirapex had 39 reports of gambling. ... - Asbury Park Press,
Parkinson's Drug May Cause Compulsive Gambling Feb 15, 2006
The agency said an analysis of adverse drug effects found that the strongest association with gambling was for Mirapex (pramipexole), which accounted for 39 ... - Consumer Affairs
Analysis: Parkinsons patch helps symptoms Feb 27, 2006
...controlled with levodopa to either add-on rotigotine, to a leading add-on oral treatment called pramipexole -- sold under the brand name Mirapex -- or to ... - United Press International
Gambler blames Parkinson's for his addiction Feb 24, 2006
Dr. Max Wells says the drug company failed to warn patients that Requip and a similar drug called Mirapex could cause compulsive gambling. ... - MSNBC
Retired Pathologist Sues Las Vegas Casinos and Drug Company after ... Feb 24, 2006
Mayo Clinic in 2005, which found that 11 individuals with Parkinson's developed compulsive gambling habits while taking Requip and a similar drug called Mirapex ... - Big OC News
Tied to the Mast Feb 26, 2006
As the Austin newspaper story has it, Wells had started on another Parkinson's drug, Mirapex, in 2004 and lost several thousand dollars gambling, both online ... - Corante,
Parkinson's profile suggested: hard workers, straight arrows Feb 24, 2006
...of more than 2 million reports of adverse effects from drugs, there were 67 reports of compulsive gambling, and 39 of those were linked with Mirapex, an anti ... - Boston Globe,
Drugs linked to gambling compulsion Feb 15, 2006
German drugmaker Boehringer Ingelheim, which markets pramipexole under the brand Mirapex, said it was investigating the relationship "if any" between its drug ... - United Press International
Controlling Your Impulses After Parkinson's Treatment Feb 6, 2006
...drugs have been linked to these side effects, the major culprit appears to be the so-called dopamine agonists, such as Requip and Mirapex, which are more ... - ABC News
New Help for Fibromyalgia Jan 27, 2006
..."If I couldn't take it, I think I'd cry.". For five years, Fuller has taken the drug MIRAPEX (pramipexole dihydrochloride) every night. ... - ABC30.com,
Controlling Your Impulses After Parkinson's Treatment Feb 6, 2006
...drugs have been linked to these side effects, the major culprit appears to be the so-called dopamine agonists, such as Requip and Mirapex, which are more ... - ABC News
Pfizer Fourth-Quarter and Full-Year 2005 Financial Results Reflect ... Jan 19, 2006
143 - - ALL OTHER 997 981 2 553 554 (1) 444 427 5 ZYRTEC/ ZYRTEC D 327 349 (6) 327 349 (6) - - - - ALLIANCE REVENUE (Aricept, Macugen, Mirapex, Olmetec, Rebif ... - PR Newswire (press release),
Ventricular fibrillation can kill within minutes Jan 23, 2006
Fibromyalgia destroys normal sleep cycles. Mirapex (pramipexole), a medicine used in Parkinson’s disease, helps some fibromyalgia patients. ... - Columbus Dispatch,
Ventricular fibrillation is a major cause of sudden death Jan 23, 2006
Mirapex (pramipexole), a medicine used in Parkinson's disease, has recently been reported to benefit some fibromyalgia patients. ... - SouthCoastToday.com,
Those restless legs Jan 15, 2006
Other dopamine agonists include pergolide, sold as Permax, and pramipexole, sold as Mirapex. Both are used to treat moderate to severe RLS. ... - Pittsburgh Tribune-Review,
New Help For Fibromyalgia Dec 7, 2005
The drug, dopamine receptor agonist pramipexole, or Mirapex, Normally used to treat Parkinson's disease, this drug stimulates dopamine production by binding to ... - WFtv.com,
New Drug Offers Hope For Fibromyalgia Patients Nov 28, 2005
Fuller has taken the drug Mirapex every night for five years. ... A new study shows Mirapex reduces fibromyalgia pain better than any other drug. ... - NBC 10.com,
New Treatment for Fybromyalgia Nov 18, 2005
A drug called Mirapex, originally developed for Parkinson's patients, is showing promise. ... Side effects from Mirapex include nausea and weight loss. ... - KLAS-TV,
Drug made me casino nut Nov 13, 2005
...to fund her obsession. She got the brain condition Parkinson’s in 2003 and was prescribed a pill called Mirapex. But she soon ... - The Sun,
Barr to challenge Mirapex patent Sep 28, 2005
...confirmed that it will challenge Boehringer-Ingelheim Pharmaceuticals' patent on Parkinson's disease treatment Mirapex in court. ... - BusinessWeek
Barr Confirms Patent Challenge of Mirapex(R) Sep 28, 2005
...(NYSE: BRL), today announced that it is challenging the patents protecting Boehringer Ingelheim Pharmaceuticals, Inc.'s Mirapex(R) (Pramipexole Dihydrochloride ... - PR Newswire (press release),
Fear of falling can affect walking Oct 7, 2005
July 13, 2005) -- Eleven Parkinson's disease patients reportedly developed compulsive gambling behaviors after taking the drug Mirapex, prescribed for their ... - Science Daily (press release)
NEWS- 'Our only hope': ALS patients get drug Oct 6, 2005
Bennett found pramipexole, the chemical mirror image of a Parkinson's drug called Mirapex. While both drugs act as free radical ... - The Hook,
Drug Pramipexole Usage Linked To Gambling Addiction In Parkinsons ... Sep 17, 2005
The drug manufacturers Boehringer Ingelheim Pharmaceuticals producing Pramipexole (Mirapex) have mentioned the pathologic gambling addiction as a side effect ... - MedIndia,
Study briefs, 9/20: Common drugs appear linked to bouts of ill ... Sep 20, 2005
Those who took drugs called dopamine agonists — including pramipexole (Mirapex), ropinirole (Requip) and pergolide (Permax) — were nearly three times more ... - Lincoln Journal Star,
Barr challenges patent for Parkinson's drug Sep 28, 2005
...(BRL.N: Quote, Profile, Research) on Wednesday said it will challenge patents protecting Boehringer Ingelheim Pharmaceuticals Inc.'s Mirapex drug used to treat ... - Reuters
(PRN) - First American Title Launches Diversity Program in Houston ... Sep 28, 2005
...[+]. (PRN) - Barr Confirms Patent Challenge of Mirapex(R) ... [. PRN) - Guess? and Callanen Sign New License Agreement for Guess? Watches Worldwide ... [+. ... - Bolsamania.com,
Parkinson's drugs may trigger gambling obsession Sep 16, 2005
In the packaging insert for Mirapex, the trade name Boehringer Ingelheim Pharmaceuticals markets pramipexole under, pathological gambling is listed as a side ... - ABC News
Other information
Indication
For the treatment of migraine attacks with or without aura in adults
Pharmacology
Sumatriptan, an antimigraine drug, is structurally similar to serotonin. It is thought that the cerebral blood vessel constriction induced by activation of 5-HT1 receptors on those vessels may contribute to the antimigrainous effect of sumatriptan in humans.
Mechanism Of Action
Sumatriptan stimulates 5-HT receptors of the 1D subtype, most likely presynaptic receptors, resulting in selective vasoconstriction of inflamed and dilated cranial blood vessels in the carotid circulation. Sumatriptan also blocks the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during migraine and may inhibit the release of inflammatory mediators from the trigeminal nerve.
Drug Category
Vasoconstrictor Agents; Selective Serotonin Agonists; ATC:N02CC01
Brand Names/Synonyms
CHEMBANK1724; Imigran; Imitrex; Sumatran; Sumatriptan; Sumatriptan Succinate; Sumatriptanum [Inn-Latin]; Sumax
Dosage Forms
Tablets; Injection; Nasal spray
Absorption
~15%
Interactions
Interactions for Sumatriptan:
Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Because there is a theoretical
basis that these effects may be additive, use of ergotamine-containing or ergot-type medications (like
dihydroergotamine or methysergide) and sumatriptan within 24 hours of each other should be avoided.
MAO-A inhibitors reduce sumatriptan clearance, significantly increasing systemic exposure. Therefore, the use of
sumatriptan succinate tablets in patients receiving MAO-A inhibitors is contraindicated .
Selective serotonin reuptake inhibitors (SSRIs) (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline)
have been reported, rarely, to cause weakness, hyperreflexia, and incoordination when coadministered with
sumatriptan. If concomitant treatment with sumatriptan and an SSRI is clinically warranted, appropriate observation
of the patient is advised.
Chemical IUPAC Name
1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide
Chemical Formula
C14H21N3O2S
Half Life
2.5 hours
Drug Type
Approved Drug
# Accession No
APRD00379
CAS Registry Number
103628-46-2