Idamycin: profile and news

/SECOND AND FINAL ADD -- NYTU041B -- Pfizer Inc Earnings/ Apr 19, 2005
FirstRESOURCE: Aromasin, Camptosar, Celebrex, Ellence, Emcyt, Idamycin, Trelstar, and Zinecard are made available to eligible low-income uninsured oncology ... - PR Newswire

Other information

Indication
For the treatment of acute myeloid leukemia (AML) in adults. This includes French-American-British (FAB) classifications M1 through M7.

Pharmacology
Idarubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Idarubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Idarubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Mechanism Of Action
Idarubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Idarubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Drug Category
Antibiotics; Antineoplastic Agents; ATC:L01DB06

Brand Names/Synonyms
IDARUBICIN; Idamycin; Idamycin Pfs; Idarubicin; Idarubicin Aglycone; Idarubicin Hcl; Idarubicin Hcl Pfs; Idarubicin Hydrochloride; Idarubicina [Inn-Spanish]; Idarubicine [Inn-French]; Idarubicinum [Inn-Latin]

Dosage Forms
POWDER FOR SOLUTION

Absorption
Not Available

Interactions
Interactions for Idarubicin:

No Information Provided.

Chemical IUPAC Name
9-acetyl-7-(4-amino-5-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-6,9,11-trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione

Chemical Formula
C26H27NO9

Half Life
22 hours

Drug Type
Approved Drug

# Accession No
APRD00126

CAS Registry Number
58957-92-9