IBU: profile and news






United's expansion could lower health insurance costs  06 Mar 2006
He says the United's $9.2 billion acquisition of PacifiCare Health Systems Inc. in late 2005, and its December 2004 acquisition of Definity Health Corp. ... - MSNBC

Consumer - driven crossroads: Employers grapple with the best ...  Mar 4, 2006
In 2005, consumer-driven health plans "became mainstream," notes Meredith Baratz, Definity Health's vice president of strategic solutions. ... - Benefitnews.com,

Avaya IP Telephony Design Specialist  Mar 3, 2006
You will design and integrate the Avaya product suite (including Definity & MultiVantage) into multi-vendor voice & data networks as well as with other ... - ComputerWeekly.com,

Year-Old Company Notes Customer Base Growth  Feb 3, 2006
James Camm, the general manager of the Namibia's Least Cost Routing (LCR) provider, Definity Telecom Namibia, said this week that the company now boosts of ... - AllAfrica.com,

Need a Doctor? More Consumers Are Looking on the Internet  Feb 21, 2006
And last year, UnitedHealth Group bought Definity Health, a company that, like Lumenos, operates high-deductible health savings plans and provides comparative ... - International News Service,

Fresh approach working for Crokes  Feb 18, 2006
...year we have been fresher. It definity, definity helps to get that out of the system and move on from it. “It’s been a long ... - Daily Ireland,

CheckPoint HR and The Wilshire Group Empower Mid-Market ...  Feb 20, 2006
HR, the workshop provides an industry forum where HR thought leaders from the following companies will offer their strategic vision: Definity Health, a ... - Paypershop.com (press release),

Marketing to Asian Americans Forum Next Week in Las Vegas  Feb 2, 2006
Cendant Citibank NA Countrywide Home Loans Crossroads Associates Cultural Access Group, A Division Of Phoenix Marketing International Definity Marketing Ethos ... - PR Newswire (press release),

Year-Old Company Notes Customer Base Growth  Feb 3, 2006
James Camm, the general manager of the Namibia's Least Cost Routing (LCR) provider, Definity Telecom Namibia, said this week that the company now boosts of ... - AllAfrica.com,

Marketing to Asian Americans Forum Next Week in Las Vegas  Feb 2, 2006
Cendant Citibank NA Countrywide Home Loans Crossroads Associates Cultural Access Group, A Division Of Phoenix Marketing International Definity Marketing Ethos ... - PR Newswire (press release),

Seasoned Health Care Leaders Join Vested Health Advisory Board  Jan 10, 2006
Chris Delaney - former chief marketing officer of Definity Health, the nation's leading consumer-driven health plan (CDHP) provider. ... - PR Newswire (press release),

Avaya IP Telephony Design Specialist  Jan 30, 2006
You will design and integrate the Avaya product suite (including Definity & MultiVantage) into multi-vendor voice & data networks as well as with other ... - ComputerWeekly.com,

Test Manager – Contact Centre technologies  Jan 9, 2006
4 years relevant Testing and Test Management experience working with contact centre technologies (such as the Genesys suite, IVR, Ayava Definity, CTI etc). ... - ComputerWeekly.com,

1st line Telephony Systems Support  Jan 20, 2006
Remote Investigation of faults on the voice network. • Good knowledge of Siemens DX/Realitis and/or Avaya Definity PABX programming and fault diagnosis . ... - ComputerWeekly.com,

Consumer-driven health plans struggle  11 Dec 2005
...purchased Lumenos, and last year, UnitedHealth Group Inc. bought Definity Health Corp., after purchasing HSA provider Golden Rule Financial Corp. in 2003. ... - Fort Wayne Journal Gazette,

UnitedHealthcare Enhances Affordable Health Care Options for Small ...  Dec 7, 2005
Called UnitedHealthcare's Definity HRA, the plan option will help small businesses access affordable health care through the comprehensive focus on consumer ... - Business Wire (press release),

The anatomy of a win  Nov 21, 2005
There was this health-care company, Definity Health, that had an interest in expanding in the Buffalo Niagara region. While Definity ... - MSNBC

Insurers use personalized statements to improve employee health ...  Nov 12, 2005
...a personal message campaign next year for all health plans that the insurer now only uses for consumer-driven health plans in its Definity Health division. ... - Benefitnews.com,

Vendor Network Architectures—Part I: Avaya  Dec 6, 2005
The software is designed to run on a variety of Avaya’s Media Servers, including the DEFINITY server, or a number of the Media Servers that utilize the Linux ... - InternetNews.com

Giambra blasts ECIDA on tax breaks  Nov 15, 2005
Webb noted that the availability of space in the Colvin Woods development played an important role in luring Definity Health and its 500 jobs to the region. ... - Buffalo News,

CEUS shows metastases' hypervascularity  Nov 27, 2005
CEUS was performed with low-mechanical-index (low-MI) continuous scanning with Definity contrast microspheres (Bristol-Myers Squibb, Billerica, MA). ... - AuntMinnie (subscription),

Avtex Honored as Interactive Intelligence Preferred Partner of the ...  Nov 28, 2005
...currently supports more than 600 customers worldwide including American Family Insurance, Capella University, Creative Memories, Definity Health/UnitedHealth ... - Business Wire (press release),

Winners and losers  Nov 21, 2005
..."Some people expect big wins every week," Kucharski said. "They are expecting a General Motors, a Definity or a Geico to happen every week.". ... - MSNBC

ECIDA haggles over Amherst project  Nov 14, 2005
Secondly, as recent deals such as those involving Definity Health and Geico have proven, the region needs readily available office space for prospective tenants ... - Buffalo Business First,

N.Ky. workers absorb health costs  Nov 18, 2005
Greg Kimball, vice president of consumer solutions for Uniprise/Definity, a division of Minnetonka, Minn.-based United Healthcare, told about 200 attendees ... - Cincinnati Enquirer,

Type of content: VENDOR WHITE PAPER  Nov 22, 2005
Messaging, and Avaya Intuity messaging platforms, the Avaya Interchange platform, as well as the Avaya Communication Manager, Avaya Definity, and Nortel ... - InformationWeek,

UnitedHealthcare unveils plan with 'core' hospitals  Oct 10, 2005
The product will be marketed under the Definity brand name. UnitedHealth Group, UnitedHealthcare's parent, acquired Definity Health ... - MSNBC

Consumers fear portability rip-off  Oct 10, 2005
Definity Telecom GM Greg Rood notes that based on the current model, a consumer who calls a number he/she assumes is on-network could end up paying extra ... - MyADSL,

RightNow Telephony Application Programming Interface Opens Voice ...  Oct 4, 2005
...including: * Tools for integration with both on-premise PBXs (including specific connectors for popular platforms such as Avaya Definity and Nortel Meridian ... - PR Newswire (press release),

Experts on Consumer-Driven Healthcare Available for Comment  Oct 5, 2005
Prior to that, he was president and COO of Definity Health where he was instrumental in bringing the company to fully operational status by building a ... - PR Newswire (press release),

More walk-in clinics to open  Oct 6, 2005
...participates with a network of major Maryland insurers’ preferred provider organizations, including Aetna, Carefirst BCBS, Definity, Johns Hopkins Employer ... - Business Gazette,

WellPoint acquires rival WellChoice for $6.5 billion  Sep 28, 2005
...million. Nov. 2004: UnitedHealth agreed to buy Definity Health for $300 million, in order to offer more health savings accounts. Sept. ... - AZ Central.com,

VoIP rollouts generate heat, power concerns  Sep 15, 2005
The company recently upgraded its Avaya Definity phone switch to a network of Avaya S8700 IP PBXs , which are tied together over IP. ... - Techworld.com,

To Find a Doctor, Mine the Data  Sep 22, 2005
And last year, UnitedHealth Group bought Definity Health, a company that, like Lumenos, operates high-deductible health savings plans and provides comparative ... - Wilmington Morning Star,

Town eyes another business park: Committee will study best way to ...  Sep 21, 2005
...one year ago. The park now houses Definity Health, John W. Danforth Co. and the US Border Patrol, among other businesses. Plans to ... - Tonawanda News,

In-store clinics latest trend in health care  Sep 8, 2005
...care moves quickly toward a consumer-driven model, said Tomas Valdivia, chief health consumer officer for health benefits plan provider Definity Health, also ... - Pittsburgh Tribune-Review,


Other information


Indication
For management of pain (muscular and rheumatic), sprains, strains, backache and neuralgia

Pharmacology
Ibuprofen is a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, that is thought to be associated with the inhibition of prostaglandin synthesis. Ibuprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain.

Mechanism Of Action
The exact mechanisms of action of Ibuprofen is unknown. Its antiinflammatory effects are believed to be due to inhibition of both cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2) which leads to the inhibition of prostaglandin synthesis, and results in the inhibition of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.

Drug Category
Analgesics; Cyclooxygenase Inhibitors; Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs); ATC:C01EB16; ATC:G02CC01; ATC:M01AE01; ATC:M01AE14; ATC:M02AA13

Brand Names/Synonyms
Actiprofen; Adran; Advil; Advil Liqui-Gels; Amersol; Amibufen; Anco; Andran; Anflagen; Apo-Ibuprofen; Apsifen; Apsifen-F; Artril 300; Bluton; Brufanic; Brufen; Brufort; Buburone; Butylenin; Cap-Profen; Children's Advil; Children's Elixsure; Children's Ibuprofen; Children's Motrin; Codral; Dolgin; Dolgirid; Dolgit; Dolo-Dolgit; Dolocyl; Ebufac; Emodin; Epobron; Femadon; Fenbid Spansule; Haltran; IP-82; Ibu; Ibu-Attritin; Ibu-Slo; Ibu-Tab; Ibu-Tab 200; Ibufen; Ibumetin; Ibuprin; Ibuprocin; Ibuprofen; Ibuprohm; Ibutid; Ifen; Inabrin; Inoven; Junior Strength Advil; Junior Strength Ibuprofen; Junior Strength Motrin; Lamidon; Lebrufen; Lidifen; Liptan; Medipren; Midol; Midol 200; Motrin; Mynosedin; Napacetin; Nobfelon; Nobfen; Nobgen; Novogent N; Novoprofen; Nuprin; Nurofen; P-Isobutylhydratropic Acid; Pantrop; Para-Isobutylhydratropic Acid; Paxofen; Pedia-Profen; Pediaprofen; Pediatric Advil; Profen; Rafen; Rebugen; Roidenin; Rufen; Seclodin; Suspren; Tab-Profen; Tabalon; Trendar; Urem

Dosage Forms
Tablet; Suspension

Absorption
rapidly absorbed

Interactions
Interactions for Ibuprofen:

Coumarin-Type Anticoagulants: Several short-term controlled studies failed to wshow that ibuprofen significantly affected prothrombin times or a variety of other clotting factors when administered to individuals on coumarin-type anticoagulants. However, because bleeding has been reported when ibuprofen and other nonsteroidal anti-inflammatory agents have been administered to patients on coumarin-type anticoagulants, the physician should be cautious when administering ibuprofen to patients on anticoagulants.

Aspirin: Animal studies wshow that aspirin given with nonsteroidal anti-inflammatory agents, including ibuprofen, yields a net decrease in anti-inflammatory activity with lowered blood levels of the non-aspirin drug. Single dose bioavailability studies in normal volunteers have failed to wshow an effect of aspirin on ibuprofen blood levels. Correlative clinical studies have not been performed.

Methotrexate: Ibuprofen, as well as other nonsteroidal anti-inflammatory drugs, probably reduces the tubular secretion of methotrexate based on in vitro studies in rabbit kidney slices. This may indicate that ibuprofen could enhance the toxicity of methotrexate. Caution should be used if ibuprofen is administered concomitantly with methotrexate.

H-2 Antagonists: In studies with human volunteers, co-administration of cimetidine or ranitidine with ibuprofen had no substantive effect on ibuprofen serum concentrations.

Furosemide: Clinical studies, as well as random observations, have shown that ibuprofen can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with ibuprofen, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy.

Lithium: Ibuprofen produced an elevation of plasma lithium levels and a reduction in renal lithium clearance in a study of eleven normal volunteers. The mean minimum lithium concentration increased 15% and the renal clearance of lithium was decreased by 19% during this period of concomitant drug administration.

This effect has been attributed to inhibition of renal prostaglandin synthesis by ibuprofen. Thus, when ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. (Read circulars for lithium preparation before use of such concurrent therapy).



Chemical IUPAC Name
2-[4-(2-methylpropyl)phenyl]propanoic acid

Chemical Formula
C13H18O2

Half Life
1.8-2.0 hours

Drug Type
Approved Drug

# Accession No
APRD00372

CAS Registry Number
15687-27-1

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