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IBU: profile and news
United's expansion could lower health insurance costs 06 Mar 2006 Consumer - driven crossroads: Employers grapple with the best ... Mar 4, 2006 Avaya IP Telephony Design Specialist Mar 3, 2006 Year-Old Company Notes Customer Base Growth Feb 3, 2006 Need a Doctor? More Consumers Are Looking on the Internet Feb 21, 2006 Fresh approach working for Crokes Feb 18, 2006 CheckPoint HR and The Wilshire Group Empower Mid-Market ... Feb 20, 2006 Marketing to Asian Americans Forum Next Week in Las Vegas Feb 2, 2006 Year-Old Company Notes Customer Base Growth Feb 3, 2006 Marketing to Asian Americans Forum Next Week in Las Vegas Feb 2, 2006 Seasoned Health Care Leaders Join Vested Health Advisory Board Jan 10, 2006 Avaya IP Telephony Design Specialist Jan 30, 2006 Test Manager – Contact Centre technologies Jan 9, 2006 1st line Telephony Systems Support Jan 20, 2006 Consumer-driven health plans struggle 11 Dec 2005 UnitedHealthcare Enhances Affordable Health Care Options for Small ... 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Oct 4, 2005 Experts on Consumer-Driven Healthcare Available for Comment Oct 5, 2005 More walk-in clinics to open Oct 6, 2005 WellPoint acquires rival WellChoice for $6.5 billion Sep 28, 2005 VoIP rollouts generate heat, power concerns Sep 15, 2005 To Find a Doctor, Mine the Data Sep 22, 2005 Town eyes another business park: Committee will study best way to ... Sep 21, 2005 In-store clinics latest trend in health care Sep 8, 2005 Other information Indication For management of pain (muscular and rheumatic), sprains, strains, backache and neuralgia Pharmacology Ibuprofen is a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, that is thought to be associated with the inhibition of prostaglandin synthesis. Ibuprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain. Mechanism Of Action The exact mechanisms of action of Ibuprofen is unknown. Its antiinflammatory effects are believed to be due to inhibition of both cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2) which leads to the inhibition of prostaglandin synthesis, and results in the inhibition of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Drug Category Analgesics; Cyclooxygenase Inhibitors; Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs); ATC:C01EB16; ATC:G02CC01; ATC:M01AE01; ATC:M01AE14; ATC:M02AA13 Brand Names/Synonyms Actiprofen; Adran; Advil; Advil Liqui-Gels; Amersol; Amibufen; Anco; Andran; Anflagen; Apo-Ibuprofen; Apsifen; Apsifen-F; Artril 300; Bluton; Brufanic; Brufen; Brufort; Buburone; Butylenin; Cap-Profen; Children's Advil; Children's Elixsure; Children's Ibuprofen; Children's Motrin; Codral; Dolgin; Dolgirid; Dolgit; Dolo-Dolgit; Dolocyl; Ebufac; Emodin; Epobron; Femadon; Fenbid Spansule; Haltran; IP-82; Ibu; Ibu-Attritin; Ibu-Slo; Ibu-Tab; Ibu-Tab 200; Ibufen; Ibumetin; Ibuprin; Ibuprocin; Ibuprofen; Ibuprohm; Ibutid; Ifen; Inabrin; Inoven; Junior Strength Advil; Junior Strength Ibuprofen; Junior Strength Motrin; Lamidon; Lebrufen; Lidifen; Liptan; Medipren; Midol; Midol 200; Motrin; Mynosedin; Napacetin; Nobfelon; Nobfen; Nobgen; Novogent N; Novoprofen; Nuprin; Nurofen; P-Isobutylhydratropic Acid; Pantrop; Para-Isobutylhydratropic Acid; Paxofen; Pedia-Profen; Pediaprofen; Pediatric Advil; Profen; Rafen; Rebugen; Roidenin; Rufen; Seclodin; Suspren; Tab-Profen; Tabalon; Trendar; Urem Dosage Forms Tablet; Suspension Absorption rapidly absorbed Interactions Interactions for Ibuprofen: Coumarin-Type Anticoagulants: Several short-term controlled studies failed to wshow that ibuprofen significantly affected prothrombin times or a variety of other clotting factors when administered to individuals on coumarin-type anticoagulants. However, because bleeding has been reported when ibuprofen and other nonsteroidal anti-inflammatory agents have been administered to patients on coumarin-type anticoagulants, the physician should be cautious when administering ibuprofen to patients on anticoagulants. Aspirin: Animal studies wshow that aspirin given with nonsteroidal anti-inflammatory agents, including ibuprofen, yields a net decrease in anti-inflammatory activity with lowered blood levels of the non-aspirin drug. Single dose bioavailability studies in normal volunteers have failed to wshow an effect of aspirin on ibuprofen blood levels. Correlative clinical studies have not been performed. Methotrexate: Ibuprofen, as well as other nonsteroidal anti-inflammatory drugs, probably reduces the tubular secretion of methotrexate based on in vitro studies in rabbit kidney slices. This may indicate that ibuprofen could enhance the toxicity of methotrexate. Caution should be used if ibuprofen is administered concomitantly with methotrexate. H-2 Antagonists: In studies with human volunteers, co-administration of cimetidine or ranitidine with ibuprofen had no substantive effect on ibuprofen serum concentrations. Furosemide: Clinical studies, as well as random observations, have shown that ibuprofen can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with ibuprofen, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy. Lithium: Ibuprofen produced an elevation of plasma lithium levels and a reduction in renal lithium clearance in a study of eleven normal volunteers. The mean minimum lithium concentration increased 15% and the renal clearance of lithium was decreased by 19% during this period of concomitant drug administration. This effect has been attributed to inhibition of renal prostaglandin synthesis by ibuprofen. Thus, when ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. (Read circulars for lithium preparation before use of such concurrent therapy). Chemical IUPAC Name 2-[4-(2-methylpropyl)phenyl]propanoic acid Chemical Formula C13H18O2 Half Life 1.8-2.0 hours Drug Type Approved Drug # Accession No APRD00372 CAS Registry Number 15687-27-1 |
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