|
|
|
|
|
Hytrin: profile and news
Saw Palmetto Wilts as Benign Prostate Hyperplasia Treatment Feb 9, 2006 Saw Palmetto Wilts as Benign Prostate Hyperplasia Treatment 09 Feb 2006 Drug company did no wrong, jury finds Dec 8, 2005 Label Change for Flomax Following Report of Cataract Surgery ... Nov 22, 2005 Prostate problems, treatments Aug 15, 2005 July 15 deadline for Hytrin claims Jul 7, 2005 Attorney General Hatch Announces Minnesota Consumers May File For ... Jul 13, 2005 Abbott Labs Settles Lawsuit Jul 8, 2005 Deadline nears for claims in class-action drug settlement Jul 11, 2005 Rival says drug tops Abbott’s Jul 12, 2005 Around town Jul 6, 2005 July 15 deadline for Hytrin claims Jul 7, 2005 Tennesseans eligible for refund of Hytrin purchases Jun 29, 2005 Buyers Of Hypertension, Enlarged Prostate Drug Hytrin Should Make ... Jun 12, 2005 Wisconsin consumers share in $30.7M Hytrin settlement Jun 6, 2005 Abbott Labs Settles Lawsuit Jul 8, 2005 In brief Jun 13, 2005 Around town Jul 6, 2005 Living with benign prostatic hyperplasia Jun 21, 2005 Consumers Eligible for Refunds in Hytrin Antitrust Settlement Jun 20, 2005 Refunds Available To Mainers Who Bought Drug Hytrin Jun 4, 2005 Wisconsin consumers share in $30.7M Hytrin settlement Jun 6, 2005 North Dakotans Who Bought Drug Hytrin May be Able to get Refunds Jun 9, 2005 Living with benign prostatic hyperplasia Jun 21, 2005 In brief Jun 13, 2005 Floridians who bought Hytrin may get refunds over delay in generic ... Apr 1, 2005 Abbott, Geneva Pharmaceuticals to pay $30.7 mln in settlement Mar 31, 2005 Your Health Mar 7, 2005 Other information Indication For the treatment of symptomatic benign prostatic hyperplasia (BPH) and also for hypertension. Pharmacology Terazosin, classified as a quinazoline, is similar to doxazosin and prazosin. As an alpha-adrenergic blocking agent, terazosin is used to treat hypertension and benign prostatic hypertrophy (BPH). Terazosin produces vasodilation and reduces peripheral resistance but in general has slight effect on cardiac output. Antihypertensive effect with chronic dosing is usually not accompanied by reflex tachycardia. Mechanism Of Action Terazosin selectively and competitively inhibits vascular postsynaptic alpha(1)-adrenergic receptors, resulting in peripheral vasodilation and a reduction of vascular resistance and blood pressure. Unlike the nonselective alph-adrenergic blockers phenoxybenzamine and phentolamine, terazosin does not block presynaptic alpha(2)-receptors and, hence, does not cause reflex activation of norepinephrine release to produce reflex tachycardia. Drug Category Antineoplastic Agents; Adrenergic alpha-Antagonists; Platelet Aggregation Inhibitors; ATC:G04CA03 Brand Names/Synonyms Abbott 45975; Blavin; CHEMBANK1722; Flumarc; Fosfomic; Heitrin; Hytracin; Hytrin; Hytrinex; Itrin; Terazosin; Terazosin Hcl; Terazosin Hydrochloride; Terazosina [Inn-Spanish]; Terazosine; Terazosine [Inn-French]; Terazosinum [Inn-Latin]; Trazosin Hcl; Urodie; Vasocard; Vasomet; Vicard Dosage Forms TABLET Absorption Essentially completely absorbed in man (90% bioavailability). Interactions -->Interactions for Terazosin: In controlled trials, terazosin has been added to diuretics, and several beta-adrenergic blockers; no unexpected interactions were observed. Terazosin has also been used in patients on a variety of concomitant therapies; while these were not formal interaction studies, no interactions were observed. Terazosin has been used concomitantly in at least 50 patients on the following drugs or drug classes: 1) analgesic/anti-inflammatory (e.g., acetaminophen, aspirin, codeine, ibuprofen, indomethacin); 2) antibiotics (e.g., erythromycin, trimethoprim and sulfamethoxazole); 3) anticholinergic/sympathomimetics (e.g., phenylephrine hydrochloride, phenylpropanolamine hydrochloride, pseudoephedrine hydrochloride); 4) antigout (e.g., allopurinol); 5) antihistamines (e.g., chlorpheniramine); 6) cardiovascular agents (e.g., atenolol, hydrochlorothiazide, methyclothiazide, propranolol); 7) corti-costeroids; 8) gastrointestinal agents (e.g., antacids); 9) hypoglycemics; 10) sedatives and tranquilizers (e.g., diazepam). Use with Other Drugs In a study (n=24) where terazosin and verapamil were administered concomitantly, terazosin’s mean AUC0-24 increased 11% after the first verapamil dose and after 3 weeks of verapamil treatment it increased by 24% with associated increases in Cmax (25%) and Cmin (32%) means. Terazosin mean Tmax decreased from 1.3 hours to 0.8 hours after 3 weeks of verapamil treatment. Statistically significant differences were not found in the verapamil level with and without terazosin. In a study (n=6) where terazosin and captopril were administered concomitantly, plasma disposition of captopril was not influenced by concomitant administration of terazosin and terazosin maximum plasma concentrations increased linearly with dose at steady-state after administration of ter-azosin plus captopril. |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |