Hyoscyamine: profile and news

From the analyst's couch: The IBS market Feb 15, 2006
...c and antidiarrhoeal agents such as loperamide for IBS-d. The pain associated with IBS can be addressed with antispasmodics such as dicyclomine and hyoscyamine ... - Nature.com (subscription),

Inkine Pharmaceutical Announces Approval of Merger with Salix ... Sep 30, 2005
...colonoscopy. InKine's second product, IB-Stat(R), is an oral hyoscyamine spray for the treatment of a variety of indications. Additionally ... - Business Wire (press release),

InKine Reports Seven INKP-102 Study Data Abstracts Accepted for ... Aug 4, 2005
...colonoscopy. InKine's second product, IB-Stat(R), is an oral hyoscyamine spray for the treatment of a variety of indications. Additionally ... - Forbes <**results**>

Italy: Lettuce uncovered as sexual stimulant Jun 29, 2005
...and lettuce, " he said. Typical tropane alkaloids are atropine, hyoscyamine, scopolamine and cocaine. According to Samorini, tropane ... - FreshPlaza

InKine Announces Final Court Approval in Securities Class Action ... Jun 16, 2005
...colonoscopy. InKine's second product, IB-Stat(R), is an oral hyoscyamine spray for the treatment of a variety of indications. Additionally ... - Genetic Engineering News,

Inkine's Visicol Tablets Associated with Significantly Less After ... May 19, 2005
...colonoscopy. InKine's second product, IB-Stat(R), is an oral hyoscyamine spray for the treatment of a variety of indications. Additionally ... - Business Wire,

InKine CEO To Present at the Rodman & Renshaw Techvest 2nd Annual ... 29 Apr 2005
...colonoscopy. InKine's second product, IB-Stat(R), is an oral hyoscyamine spray for the treatment of a variety of indications. Additionally ... - Business Wire,

Inappropriate medication prescribed to elderly Mar 8, 2005
The medications cited as ''Always avoid'' are: barbiturates, belladonna alkaloids, chlorpropamide, dicyclomine, flurazepam, hyoscyamine, meperidine, meprobamate ... - Helena Independent Record,

Almost One In Three Seniors Given Inappropriate Meds Feb 26, 2005
Specifically, the study showed that at least 1 percent of the seniors received the antispasmodic drugs belladonna alkaloids, hyoscyamine and dicyclomine, all ... - RedNova.com,

InKine to Present at BIO CEO & Investor Conference Feb 17, 2005
...colonoscopy. InKine's second product, IB-Stat(R), is an oral hyoscyamine spray for the treatment of a variety of indications. Additionally ... - PharmaLive.com (press release),

Almost One In Three Seniors Given Inappropriate Meds Feb 25, 2005
Specifically, the study showed that at least 1 percent of the seniors received the antispasmodic drugs belladonna alkaloids, Hyoscyamine and Dicyclomine, all ... - drkoop.com

With Positive INKP-102 Results, InKine Prepares For NDA Filing Feb 22, 2005
Along with Visicol, InKine has another marketed product, IB-STAT, an oral spray formulation of hyoscyamine sulfate for irritable bowel syndrome in adult women ... - BioWorld Online (subscription)

Other information

Indication
For treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Hyoscyamine may also be used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis

Pharmacology
L-Hyoscyamine, the active optical isomer of atropine (dl-hyoscyamine), is a tertiary amine anticholinergic gastrointestinal agent. Hyoscyamine is used to manage peptic ulcer disease, biliary tract disorders, cystitis, severe allergic rhinitis, hypermotility disorders of the lower urinary tract, infant colic, and to control salivation and excessive secretions before an operation.

Mechanism Of Action
Hyoscyamine competes favorably with acetylcholine for binding at muscarinic receptors in the salivary, bronchial, and sweat glands as well as in the eye, heart, and gastrointestinal tract. The actions of hyoscyamine result in a reduction in salivary, bronchial, gastric and sweat gland secretions, mydriasis, cycloplegia, change in heart rate, contraction of the bladder detrusor muscle and of the gastrointestinal smooth muscle, and decreased gastrointestinal motility.

Drug Category
Mydriatics; Bronchodilator Agents; Antiarrhythmic Agents; Adjuvants; Antimuscarinics; Antispasmodics; ATC:A03BA03

Brand Names/Synonyms
ATROPINE; Anaspaz; Cystospaz; Daturine; Duboisine; Duretter; Egacene; Egazil; Gastrosed; Hyocyamine; Hyoscyamine; Hyoscyamine, L-; L-Atropine; L-Hyopscyamine; L-Hyoscamine; L-Hyoscyamine; L-Hyoscyamine Free Base; L-Tropine Tropate; Levbid; Levsin; Levsinex; OIN; Peptard; Scopolia Extract

Dosage Forms
Oral tablets, oral drops, elixir, injection

Absorption
absorbed totally and completely by sublingual administration as well as oral administration

Interactions
Interactions for Hyoscyamine:

Additive adverse effects resulting from cholinergic blockade may occur when LEVSIN is administered concomitantly with other antimuscarinics, amantadine, haloperidol, phenothiazines, monoamine oxidase (MAO) inhibitors, tricyclic antidepressants or some antihistamines. Antacids may interfere with the absorption of LEVSIN. Administer LEVSIN before meals; antacids after meals.

Chemical IUPAC Name
(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)3-hydroxy-2-phenyl-propanoate

Chemical Formula
C17H23NO3

Half Life
2-3 1/2 hours

Drug Type
Approved Drug

# Accession No
APRD00607

CAS Registry Number
101-31-5